Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,762 recruiting studies in this area right now.
By phase
- Not applicable2,682
- Phase 2280
- Phase 1239
- Phase 3209
- Phase 1/Phase 2208
- Phase 495
- Phase 2/Phase 349
Top conditions
- Sickle Cell Disease133
- Atopic Dermatitis124
- Congenital Heart Disease83
- Cystic Fibrosis77
- Down Syndrome51
- Genetic Disease42
- Cystic Fibrosis (CF)37
- Duchenne Muscular Dystrophy36
- Fabry Disease36
- Hemophilia A36
- Cardiac Amyloidosis35
- Retinitis Pigmentosa33
- Huntington Disease31
- Lynch Syndrome31
- Heart Failure30
- Bronchopulmonary Dysplasia29
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)29
Leading sponsors
- Assistance Publique - Hôpitaux de Paris57
- Mayo Clinic39
- Boston Children's Hospital38
- National Institute of Allergy and Infectious Diseases (NIAID)38
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Children's Hospital Medical Center, Cincinnati31
- Hospices Civils de Lyon29
- Children's Hospital of Philadelphia23
- National Human Genome Research Institute (NHGRI)23
- St. Jude Children's Research Hospital23
Where studies are running
- California324
- Maryland160
- Alabama133
- Massachusetts107
- Arizona88
- New York84
- Texas70
- Minnesota68
- Pennsylvania64
- Florida59
Recruiting studies3,762 total
- NCT07340008Recruiting
Comparing medicines for calm stitch removal in children after cleft surgery
This study compares three different medicines (ketamine, nalbuphine, and dexmedetomidine) to help keep children calm and comfortable while their stitches are removed after cleft surgery. It may help find the best way to reduce pain and anxiety in young children during this procedure.
LjubljanaAges 6 months–3 years - NCT07334444Recruiting
Improving sleep apnea care for children with Down syndrome
This study looks at how sleep apnea is managed in children with Down syndrome. It aims to find better treatment approaches by reviewing data from kids who visited ear, nose, and throat (ENT) or sleep specialists in Strasbourg.
StrasbourgAges birth–17 years - NCT07341763Recruiting
Brain stimulation for better mobility in vision loss
This study tests whether a safe, noninvasive brain stimulation technique (called tDCS) can help people with vision loss from retinitis pigmentosa, rod-cone dystrophy, or advanced glaucoma move around more easily and safely. Participants will do walking and orientation tasks while receiving the stimulation.
Waterloo, OntarioAges 18 years+ - NCT07336394Recruiting
Study on rare heart muscle diseases using advanced MRI
This study uses a special heart MRI to better diagnose and understand rare heart muscle diseases. It may help doctors predict risks and make more accurate treatment decisions.
BeijingAges Any age - NCT07338370Recruiting
PGE2 levels and heart duct closure in preterm babies
This trial measures a substance called prostaglandin E2 (PGE2) in preterm babies to see if it can predict whether a heart blood vessel (ductus arteriosus) will close on its own or need treatment. This could help doctors decide when to use medication to close the vessel.
Cairo, AbbasiaAges 1 day–1 week - NCT07341412Enrolling by invitation
Study of sex chromosome disorders in fetuses and children
This study looks at the genetic and physical health of babies and children who have a sex chromosome disorder (like having an extra or missing X or Y chromosome). It also compares them to children without these conditions. The goal is to learn more about how these disorders affect development.
AarhusAges birth–50 years - NCT06849635Recruiting
Cera ASD closure device long-term follow-up study
This study follows up with patients who already received the Cera ASD occluder device to close a hole in the heart (atrial septal defect). It looks at how well the device is working over time and checks for any late problems.
MyszkówAges Any age - NCT06860919Recruiting
Transition care for young adults with esophageal atresia
This trial studies a special follow-up program for young adults born with a connection problem in their esophagus (the tube that carries food). The goal is to see if a transitional consultation helps manage long-term health needs.
ParisAges 18–30 - NCT06862895Recruiting
Chest therapy for babies with bronchiolitis
This trial tests whether gentle chest physiotherapy can help babies with bronchiolitis (a lung infection) recover better. It looks at how the therapy affects their breathing and overall health.
Erbil, KurdistanAges 1 month–1 year - NCT05942924Recruiting
NEU-STIM for breathing support in very premature newborns
This trial studies whether NEU-STIM can help support breathing and oxygen levels in babies born very early. If your baby is born before 32 weeks, the study may include them after you provide consent.
GrazAges Up to 7 months - NCT06864975RecruitingPhase 4
Different doses of ADVATE for immune tolerance in boys with hemophilia A and inhibitors
This trial tests how different doses and schedules of the factor VIII medicine ADVATE can train the immune system to accept factor VIII again in boys with hemophilia A who have developed inhibitors. The goal is to find a better way to help their bodies stop blocking the treatment.
Beijing, Beijing MunicipalityAges birth–18 years - NCT07325097RecruitingPhase 1
Corneal implant for swelling of the cornea
This trial tests a new corneal implant to treat corneal swelling caused by Fuchs' dystrophy or after cataract surgery. It aims to improve vision and reduce the need for a full corneal transplant.
YerevanAges 18 years+ - NCT07326709RecruitingPhase 3
Votoplam for Huntington's disease: a Phase 3 study
This study tests an investigational drug called Votoplam for people with Huntington's disease. It aims to see if the drug can slow progression of symptoms like movement and thinking problems.
Birmingham, AlabamaAges 21–70 - NCT07326657Enrolling by invitationPhase 4
Fish skin graft for deep partial-thickness burns
This trial tests if a fish skin graft can help heal deep burns and reduce the need for a skin graft from your own body. It compares the fish skin graft to standard care for burns on the torso or arms and legs.
Maywood, IllinoisAges 18 years+ - NCT07332091RecruitingPhase 2
Study of vamifeport for adults with iron overload from hereditary hemochromatosis
This study tests an investigational drug called vamifeport to see if it can reduce iron levels in the body and improve outcomes for people with hereditary hemochromatosis (a genetic condition causing too much iron absorption). Participation may help manage iron overload and potentially reduce the need for regular blood removal treatments.
Gilbert, ArizonaAges 18 years+ - NCT07330934RecruitingPhase 2
Study of IBI356 for moderate to severe eczema
This study tests a new medication called IBI356 for people with moderate to severe eczema that hasn't improved with standard creams. The goal is to see if this medicine can safely reduce the redness, itching, and rash.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07333599Recruiting
Study of low oxygen in full-term newborns
This study looks at full-term babies born with very low cord blood pH (a sign of oxygen shortage). It aims to understand different patterns of low oxygen and how they affect newborns. Doctors hope this can improve care for babies with similar issues.
StrasbourgAges birth–1 day - NCT07333378Recruiting
Keeping vernix on newborns to prevent eczema
This study tests whether leaving the white, waxy coating (vernix caseosa) on a newborn’s skin after birth can help prevent the development of eczema (atopic dermatitis) in early childhood. It compares standard bathing practices with preserving this natural skin barrier.
Las Condes, RMAges birth+ - NCT07330089Recruiting
Sealant study: pit and fissure sealing for kids
This trial will see if dental sealants work better on healthy teeth versus those with early signs of decay. If you have a child between 7 and 18 with fully grown back molars that have no fillings, they may be able to join.
Islamabad, FederalAges 7–18 - NCT07325487Recruiting
Brain stimulation for walking and balance in SCA6 ataxia
This study tests a new kind of deep brain stimulation that adjusts automatically to improve balance and coordination in adults with SCA6, a genetic form of ataxia. It may help patients who can still walk but have moderate to severe symptoms.
Gainesville, FloridaAges 21–89 - NCT07332598Enrolling by invitation
Mayo Clinic precure study for prevention of blood cancers
This study aims to learn how to prevent blood cancers. You will provide samples over time so researchers can look for early signs of cancer.
Rochester, MinnesotaAges 18 years+ - NCT07332013Recruiting
Urine titin test for Duchenne muscular dystrophy
This study measures a protein called titin in urine to see if it can help track muscle damage in boys with Duchenne or Becker muscular dystrophy. It also includes healthy boys for comparison.
Philadelphia, PennsylvaniaAges 2–10 - NCT07330830Recruiting
Genetics and fatty liver disease in Caribbean and Indian Ocean populations
This study looks at how a specific gene (PNPLA3) might affect non-alcoholic fatty liver disease (MASLD) in people from Guadeloupe, French Guiana, and Réunion Island. It aims to understand genetic differences that could explain why some people get the disease.
CayenneAges 18 years+ - NCT07332988Enrolling by invitation
Light therapy for dry eyes in Graves' disease
This trial tests if low-level light therapy can improve dry eye symptoms in people with Graves' disease whose dry eyes haven't gotten better with standard treatments like artificial tears.
Iași, IaşiAges 18 years+
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,762 recruiting medical genetics studies from the U.S. registry right now, out of 5,482 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.