Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,762 recruiting studies in this area right now.
By phase
- Not applicable2,682
- Phase 2280
- Phase 1239
- Phase 3209
- Phase 1/Phase 2208
- Phase 495
- Phase 2/Phase 349
Top conditions
- Sickle Cell Disease133
- Atopic Dermatitis124
- Congenital Heart Disease83
- Cystic Fibrosis77
- Down Syndrome51
- Genetic Disease42
- Cystic Fibrosis (CF)37
- Duchenne Muscular Dystrophy36
- Fabry Disease36
- Hemophilia A36
- Cardiac Amyloidosis35
- Retinitis Pigmentosa33
- Huntington Disease31
- Lynch Syndrome31
- Heart Failure30
- Bronchopulmonary Dysplasia29
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)29
Leading sponsors
- Assistance Publique - Hôpitaux de Paris57
- Mayo Clinic39
- Boston Children's Hospital38
- National Institute of Allergy and Infectious Diseases (NIAID)38
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Children's Hospital Medical Center, Cincinnati31
- Hospices Civils de Lyon29
- Children's Hospital of Philadelphia23
- National Human Genome Research Institute (NHGRI)23
- St. Jude Children's Research Hospital23
Where studies are running
- California324
- Maryland160
- Alabama133
- Massachusetts107
- Arizona88
- New York84
- Texas70
- Minnesota68
- Pennsylvania64
- Florida59
Recruiting studies3,762 total
- NCT07332988Enrolling by invitation
Light therapy for dry eyes in Graves' disease
This trial tests if low-level light therapy can improve dry eye symptoms in people with Graves' disease whose dry eyes haven't gotten better with standard treatments like artificial tears.
Iași, IaşiAges 18 years+ - NCT06866912Recruiting
Observational study of amyloidosis and TTR gene carriers
This study is observing people with amyloidosis or those who carry a specific gene mutation (transthyretin) to learn more about the condition. It does not test any new treatment, but may help researchers understand how the disease affects people.
BolognaAges 18–99 - NCT06031025Recruiting
Study of tummy problems in at-risk infants
This study looks at how common stomach and gut issues are in babies who were born early or had problems at birth, and how these issues change over time.
RomaAges 3 months–2 years - NCT06863350Recruiting
Closing a heart hole to treat drug-resistant epilepsy
This trial tests if closing a small hole in the heart (called a PFO) can reduce seizures in people whose epilepsy isn't controlled by medication. It might offer a new treatment option for those who have both drug-resistant epilepsy and this heart condition.
Chengdu, SichuanAges 18–60 - NCT04934462Recruiting
Non-surgical or arthroscopic treatment for hip microinstability
This study looks at treatment options that may help people with “hip microinstability,” where the hip can feel unstable or not sit perfectly. Researchers will compare non-surgical care and a minimally invasive surgery option to see what works best and why it helps.
GothenburgAges 18 years+ - NCT07316426Recruiting
Preparing for ventral hernia surgery
This trial tests a pre-surgery optimization program for people with ventral hernias. It aims to improve outcomes before and after the operation.
Gällivare, Norrbotten CountyAges 18 years+ - NCT07316855Recruiting
Iron-based covered stent for aortic narrowing
This trial tests a new type of stent made from iron that slowly dissolves in the body. It is designed to treat narrowing of the aorta (CoA) or narrowing that happens after CoA surgery. The goal is to see if the stent is safe and works well over one year.
Zhengzhou, HenanAges 1–60 - NCT07323082Recruiting
Testing purine-related compounds for PXE
This trial tests a compound that affects certain chemicals in your body (purines) to see if it helps people with pseudoxanthoma elasticum (PXE), a rare genetic condition affecting skin, eyes, and blood vessels.
AngersAges 18 years+ - NCT07316478Recruiting
Stress Management and Mindfulness for Sickle Cell Disease
This study tests a stress management and mindfulness program designed to help people with sickle cell disease cope better. It aims to see if these techniques can reduce pain and improve your quality of life.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07316465Recruiting
Tracking immune markers in newborns at risk for eczema
This study follows newborns for two years to see how their immune system develops, especially if they have a family history of eczema, asthma, or hay fever. Researchers want to learn if certain immune markers appear early in babies who later develop eczema.
Jette, Brussels CapitalAges 1 hour–2 years - NCT07321977Recruiting
Walking test with a portable device for neuromuscular disease
This study tests a portable device that analyzes walking without markers. It aims to see if it can help assess walking in people with neuromuscular diseases and healthy volunteers, which could lead to simpler check-ups.
ParisAges 18–65 - NCT07317193Recruiting
Genetic causes of adult bile duct disease
This study looks for new genes that might cause abnormal liver test results or specific bile duct diseases in adults, when standard testing hasn't found a clear cause. It also uses healthy blood donors as a comparison group.
Milan, MilanoAges 18–65 - NCT07316075Enrolling by invitation
Heart and metabolic health in silent pheochromocytoma or paraganglioma
This study looks at heart and metabolic health in people who have pheochromocytomas or paragangliomas that do not produce extra hormones. It aims to understand whether these 'silent' tumors affect cardiovascular and metabolic health, and how they compare to other cases.
AthensAges 18 years+ - NCT07319780Recruiting
Comparing two surgical methods for hypospadias repair
This trial compares two surgical techniques to fix a common birth defect where the opening of the urethra is on the underside of the penis. It tests whether a new method using a special glue is better than the standard method.
Jakarta, DKI JakartaAges 6 months–7 years - NCT07319091Recruiting
Cystinosis and Mitochondrial Energy Study
This study looks at how cystinosis affects the energy centers (mitochondria) in your cells. It may help doctors understand how cysteamine treatment works in patients with kidney cystinosis.
BronAges 2 years+ - NCT05927688Recruiting
Using patient reports to adjust treatment for autoimmune diseases
This study looks at whether doctors consider patient “electronic reports” (completed online/phone) when deciding how often to change treatment. It may help improve how well treatment plans match how patients feel over time.
StrasbourgAges 18 years+ - NCT05825170Recruiting
Hyaluronic acid lip filler for lip deformity after cleft surgery
This trial tests a hyaluronic acid filler (placed in the lips) to improve lip shape in people who had cleft lip and palate surgery. It looks at how well the filler works and how safe it is for your lips and surrounding skin.
Lille, NordAges 18 years+ - NCT07314047Recruiting
A study of a liquid gel for brain AVM treatment
This trial tests a liquid embolic agent (a gel-like material) injected into the blood vessels of a brain arteriovenous malformation (AVM) to block abnormal blood flow. It’s for people aged 18 to 80 with certain types of AVMs that doctors think can be treated this way.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT07314983Recruiting
Long-term blood thinning in severe hemophilia A
This study looks at using long-term blood thinners (anticoagulants) in adults with severe hemophilia A, a bleeding disorder. It aims to understand if this treatment can be safe and effective for patients who may need it.
StrasbourgAges 18 years+ - NCT07307612RecruitingPhase 1/Phase 2
High-energy breast milk diets for extremely preterm infants
This trial tests whether feeding extremely premature babies (born at 28 weeks or earlier) a higher-energy breast milk diet in the first two weeks of life can reduce the risk of bronchopulmonary dysplasia (BPD), a serious lung condition. It aims to find a safe and effective way to support lung development in these tiny infants.
Birmingham, AlabamaAges 1 day–3 days - NCT07312448Recruiting
Comparing two ways to fix a sunken chest in teens
This trial looks at two surgical methods for correcting pectus excavatum (a sunken chest) in teens. It compares the modified Nuss technique with the classic one to see which works best.
StrasbourgAges 11–18 - NCT07308704Recruiting
Using AI to spot heart muscle disease on echocardiograms
This study at Mayo Clinic is testing an artificial intelligence (AI) tool that analyzes echocardiograms (ultrasound of the heart) to find early signs of four types of heart muscle disease. If the AI flags a high-risk pattern, doctors can learn whether acting on that alert helps catch the condition sooner.
Rochester, MinnesotaAges 18 years+ - NCT07312734Recruiting
Testing new ways to find lung germs in CF
This study tests a new method to detect bacteria in the lungs of people with cystic fibrosis (CF) by analyzing mucus samples. It aims to improve how we diagnose and treat lung infections.
La Jolla, CaliforniaAges 16 years+ - NCT07314229Recruiting
Breathing limits during exercise in cystic fibrosis patients on ETI
This study measures how often people with cystic fibrosis who take elexacaftor-tezacaftor-ivacaftor (ETI) experience breathing limitations during exercise and what factors are linked to this.
LilleAges 18 years+
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,762 recruiting medical genetics studies from the U.S. registry right now, out of 5,482 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.