Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,762 recruiting studies in this area right now.
By phase
- Not applicable2,682
- Phase 2280
- Phase 1239
- Phase 3209
- Phase 1/Phase 2208
- Phase 495
- Phase 2/Phase 349
Top conditions
- Sickle Cell Disease133
- Atopic Dermatitis124
- Congenital Heart Disease83
- Cystic Fibrosis77
- Down Syndrome51
- Genetic Disease42
- Cystic Fibrosis (CF)37
- Duchenne Muscular Dystrophy36
- Fabry Disease36
- Hemophilia A36
- Cardiac Amyloidosis35
- Retinitis Pigmentosa33
- Huntington Disease31
- Lynch Syndrome31
- Heart Failure30
- Bronchopulmonary Dysplasia29
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)29
Leading sponsors
- Assistance Publique - Hôpitaux de Paris57
- Mayo Clinic39
- Boston Children's Hospital38
- National Institute of Allergy and Infectious Diseases (NIAID)38
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Children's Hospital Medical Center, Cincinnati31
- Hospices Civils de Lyon29
- Children's Hospital of Philadelphia23
- National Human Genome Research Institute (NHGRI)23
- St. Jude Children's Research Hospital23
Where studies are running
- California324
- Maryland160
- Alabama133
- Massachusetts107
- Arizona88
- New York84
- Texas70
- Minnesota68
- Pennsylvania64
- Florida59
Recruiting studies3,762 total
- NCT07109375Recruiting
Long-term study of pegunigalsidase alfa for Fabry disease
This study observes how well the medication pegunigalsidase alfa works over a long period in people with Fabry disease. It helps doctors learn more about managing the condition in everyday life.
ArezzoAges 18 years+ - NCT06967831Recruiting
Testing existing drugs for mitochondrial disorders
This trial looks at whether drugs already approved for other conditions might help people with Leigh syndrome, a rare mitochondrial disorder. Researchers will study cells made from your skin to see how these drugs work.
Düsseldorf, North Rhine-WestphaliaAges Any age - NCT07110220Enrolling by invitation
How well do ceramic dental restorations hold up over time?
This study looks at how well ceramic dental restorations (like crowns and bridges) have lasted over time. If you've had one placed at the University Hospital of Liège, your experience could help dentists understand how to improve future treatments.
LiègeAges Any age - NCT07111858Recruiting
Pavlik harness vs monitoring for hip dysplasia in babies
This trial compares using a soft brace (Pavlik harness) versus simply monitoring for babies diagnosed with a certain type of hip condition (Graf type 2b or 2c). Researchers want to see which approach leads to better hip development and avoids the need for more intensive treatment.
Royal Tunbridge WellsAges birth–4 months - NCT07112703Recruiting
Breathing exercise study for children with thalassemia
This study tests if a breathing exercise device (incentive spirometer) can improve lung function and daily activity in children with thalassemia who receive regular blood transfusions. It aims to help them breathe easier and be more active.
ZagazigAges 6–10 - NCT07110987Recruiting
Adding a Medicine to Light Therapy for Newborn Jaundice
This study tests whether adding a medicine called Ursodeoxycholic Acid (UDCA) to standard light therapy (phototherapy) helps treat newborn jaundice more quickly. Jaundice causes yellow skin and eyes, and this trial looks at babies whose jaundice is severe enough to need light treatment.
LatakiaAges Up to 1 month - NCT07112066Recruiting
Heart imaging study for ATTR amyloidosis patients
This study uses heart imaging to track disease progression in people with ATTR cardiac amyloidosis who are about to start tafamidis treatment. It aims to understand how the disease changes over time.
Zurich, Canton of ZurichAges Any age - NCT07112287Recruiting
Germline testing for myeloid cancer risk
This trial studies whether certain inherited genes increase the risk of myeloid cancers or bone marrow failure. You will provide a DNA sample via a skin biopsy to look for these genetic changes.
Boston, MassachusettsAges 18 years+ - NCT07109856Recruiting
A new tool to predict infection in newborns
This study tests a simple non-invasive score that uses blood flow in muscles to predict if a newborn has or will develop high inflammation levels (C-reactive protein). It may help doctors start treatment earlier in babies with breathing problems.
Graz, StyriaAges birth–6 hours - NCT07111598Recruiting
Iron supplements and the immune system in HHT
This study looks at how iron supplements affect the immune system in people with HHT (a genetic condition that causes bleeding from abnormal blood vessels). You may be placed in one of three groups depending on your iron and ferritin levels.
Bron, RhoneAges 18–99 - NCT07115108Recruiting
High-energy feeding for growth and brain development in infants with heart disease
This study tests a special high-energy formula for babies with congenital heart disease who are at nutritional risk. It aims to see if this feeding helps them grow and develop better before and after heart surgery.
Shanghai, Shanghai MunicipalityAges birth–6 months - NCT07106359Recruiting
Learning about Lynch syndrome genetic services for families
This study tests a program to help families talk about genetic services for Lynch syndrome. It aims to support people who may be at risk but haven't yet had genetic counseling or testing.
Birmingham, AlabamaAges 18 years+ - NCT07106853Recruiting
New prenatal DNA test for high-risk pregnancies
This study tests a new blood test that can screen for genetic problems in babies during pregnancy. It may find more conditions than standard tests, especially for pregnancies with certain ultrasound findings or other risk factors.
Hangzhou, ZhejiangAges 18 years+ - NCT06333067Recruiting
Ultrasound treatment for lifting sagging skin and wrinkles
This study tests a new ultrasound device to lift sagging facial skin and reduce wrinkles. It is for people who want a non-surgical option to tighten their face and neck.
La Mesa, CaliforniaAges 35–80 - NCT06969209Recruiting
Brain aging in adults with PKU
This study looks at how the brain ages in adults with PKU. It uses an MRI scan to compare brain changes between people with PKU and healthy volunteers.
BernAges 18 years+ - NCT06966635RecruitingPhase 4
Potassium citrate for gout treatment
This study tests whether a potassium citrate tablet can help people with gout lower uric acid and prevent flares. It is for adults on stable gout medication who are not having a current flare.
ShanghaiAges 18–70 - NCT07099651Recruiting
Social understanding in spinocerebellar ataxia
This study looks at how people with certain genetic types of spinocerebellar ataxia (a condition that affects movement and coordination) understand social situations. It aims to see if there are differences in social thinking compared to people without the condition.
AngersAges 18–100 - NCT07099313Recruiting
Hemophilia treatment burden and daily life study
This study looks at how prophylactic treatment for hemophilia affects your daily life, sleep, and feelings about your health. It compares different types of clotting factor concentrates to see if one is easier to manage than the other.
Oviedo, Principality of AsturiasAges 18 years+ - NCT07096349Recruiting
Chronic pain study in severe hemophilia A
This study looks at chronic pain in people with severe hemophilia A. It aims to understand pain better through questionnaires and joint health checks.
Oviedo, Principality of AsturiasAges 18 years+ - NCT07101640RecruitingPhase 1/Phase 2
Montelukast study for breathing problems in premature infants
This trial tests if the medicine montelukast can help very premature babies on breathing machines. It aims to see if it improves lung development and makes it easier for them to breathe on their own.
Little Rock, ArkansasAges 1 week–4 weeks - NCT07099456Recruiting
Fertility and sexual health in adrenal gland disorder
This study looks at fertility and sexual function in people with congenital adrenal hyperplasia (CAH), a condition affecting hormone production. It aims to understand how CAH impacts these areas.
Rome, ItalyAges 18–65 - NCT07097337Recruiting
Quick fibrinogen test for trauma patients with heavy bleeding
This trial checks if a fast bedside test for fibrinogen (a protein that helps blood clot) can help guide treatment for trauma patients who are actively bleeding. It may lead to better care in the emergency department.
Rotterdam, South HollandAges 16 years+ - NCT07095881Recruiting
Gum healing with a custom zirconia healing cap
This study tests how well the gum tissue heals around a special custom healing cap made from a strong white material (zirconia composite) placed on a dental implant. It may be a good option if you need a single tooth replaced and have healthy gums and bone.
Cairo, AbaseyaAges 20–50 - NCT07095829Recruiting
Predicting circulation after birth for severe pulmonary valve blockage
This study looks at babies with a severe heart defect where the pulmonary valve is blocked and the wall between the heart's lower chambers is intact. It aims to predict how well blood will flow after birth using ultrasound images taken during pregnancy.
MadridAges 4 months–6 months
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,762 recruiting medical genetics studies from the U.S. registry right now, out of 5,482 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.