Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,762 recruiting studies in this area right now.
By phase
- Not applicable2,682
- Phase 2280
- Phase 1239
- Phase 3209
- Phase 1/Phase 2208
- Phase 495
- Phase 2/Phase 349
Top conditions
- Sickle Cell Disease133
- Atopic Dermatitis124
- Congenital Heart Disease83
- Cystic Fibrosis77
- Down Syndrome51
- Genetic Disease42
- Cystic Fibrosis (CF)37
- Duchenne Muscular Dystrophy36
- Fabry Disease36
- Hemophilia A36
- Cardiac Amyloidosis35
- Retinitis Pigmentosa33
- Huntington Disease31
- Lynch Syndrome31
- Heart Failure30
- Bronchopulmonary Dysplasia29
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)29
Leading sponsors
- Assistance Publique - Hôpitaux de Paris57
- Mayo Clinic39
- Boston Children's Hospital38
- National Institute of Allergy and Infectious Diseases (NIAID)38
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Children's Hospital Medical Center, Cincinnati31
- Hospices Civils de Lyon29
- Children's Hospital of Philadelphia23
- National Human Genome Research Institute (NHGRI)23
- St. Jude Children's Research Hospital23
Where studies are running
- California324
- Maryland160
- Alabama133
- Massachusetts107
- Arizona88
- New York84
- Texas70
- Minnesota68
- Pennsylvania64
- Florida59
Recruiting studies3,762 total
- NCT07101926Recruiting
Monitoring anti-TFPI in severe hemophilia patients on Marstacimab
This study looks at how a medicine called Marstacimab affects your body's natural anti-clotting protein (TFPI) in people with severe hemophilia A or B who are already taking it. It involves blood tests to see how well the treatment works.
BronAges 18 years+ - NCT07098975RecruitingPhase 2
Statin for severe early-onset placental insufficiency
This trial tests if taking pravastatin (a statin) can improve blood flow to the placenta in pregnant people with either severe early-onset preeclampsia (high blood pressure) or a baby not growing well. The goal is to help the pregnancy last longer and improve outcomes.
BarcelonaAges 18 years+ - NCT07095881Recruiting
Gum healing with a custom zirconia healing cap
This study tests how well the gum tissue heals around a special custom healing cap made from a strong white material (zirconia composite) placed on a dental implant. It may be a good option if you need a single tooth replaced and have healthy gums and bone.
Cairo, AbaseyaAges 20–50 - NCT07096622Recruiting
Visual training for kids after lens surgery
This study tests whether special visual and perceptual training exercises can help improve eyesight in children who have had surgery for a naturally dislocated lens (congenital ectopia lentis). It is for kids aged 4–12 whose vision is still below normal after their second eye surgery.
Guangzhou, GuangdongAges 4–12 - NCT07103863Enrolling by invitation
Imaging test for predicting AL cardiac amyloidosis outcomes
This study uses two types of imaging (PET/CT and MRI) to see if they can better predict outcomes for people with AL cardiac amyloidosis. The goal is to improve how doctors understand and manage the disease.
Beijing, Beijing MunicipalityAges Any age - NCT07101640RecruitingPhase 1/Phase 2
Montelukast study for breathing problems in premature infants
This trial tests if the medicine montelukast can help very premature babies on breathing machines. It aims to see if it improves lung development and makes it easier for them to breathe on their own.
Little Rock, ArkansasAges 1 week–4 weeks - NCT07104812RecruitingPhase 2
Testing low-dose osilodrostat for mild cortisol excess
This study tests whether a low dose of the drug osilodrostat can help people with mild cortisol excess (MACS) caused by benign adrenal tumors. It may improve related health problems like high blood pressure, diabetes, or bone thinning.
Rochester, MinnesotaAges 18 years+ - NCT07102043Enrolling by invitation
Glucose study in cystic fibrosis related diabetes
This study looks at how the body handles sugar in people with cystic fibrosis related diabetes. Researchers want to learn more about glucose metabolism to improve care for people with CFRD.
Birmingham, AlabamaAges 21–75 - NCT07102394RecruitingPhase 1
Testing talimogene laherparepvec for skin bumps in adults with NF1
This trial tests a drug called IMLYGIC (talimogene laherparepvec) to see if it is safe and tolerable for treating skin bumps (cutaneous neurofibromas) in adults with NF1. The drug is injected directly into the bumps, and the study will check if it can shrink them or improve symptoms.
Baltimore, MarylandAges 18 years+ - NCT07100379Recruiting
Balloon time study for esophageal narrowing after surgery
This study compares two balloon inflation times (30 seconds vs 60 seconds) to see which works better for treating narrow spots in the esophagus that form after esophageal atresia repair.
Boston, MassachusettsAges Up to 18 years - NCT07102966Recruiting
Genetic study for babies with birth defects in Texas
This study looks for genetic causes of birth defects in newborn babies. If your baby has a suspected genetic condition and other tests haven't found a clear cause, this study may help find answers.
Houston, TexasAges 1 day–3 months - NCT07097337Recruiting
Quick fibrinogen test for trauma patients with heavy bleeding
This trial checks if a fast bedside test for fibrinogen (a protein that helps blood clot) can help guide treatment for trauma patients who are actively bleeding. It may lead to better care in the emergency department.
Rotterdam, South HollandAges 16 years+ - NCT06356246Recruiting
Oral health survey for adults with cystic fibrosis
This study uses an online survey to learn about the oral health of adults with cystic fibrosis. Your answers can help doctors understand and improve dental care for people like you.
Ivry-sur-Seine, Île-de-France RegionAges 18 years+ - NCT06647927Recruiting
Genetic study for better Brugada diagnosis
This study looks at the genes of people with Brugada Syndrome to find new markers that can help doctors diagnose it more accurately. If you have Brugada Syndrome, joining could help improve understanding and care for this condition.
San Donato Milanese, MilanAges 18 years+ - NCT06969924Recruiting
How CRT works for adults with congenital heart disease
This study looks at how well cardiac resynchronization therapy (CRT) works for adults who were born with a heart defect. Researchers will review medical records to see if the therapy helps improve heart function.
Leiden, South HollandAges 18 years+ - NCT06242379RecruitingPhase 1/Phase 2
Testing stem cell particles for retinitis pigmentosa
This trial tests whether tiny particles from stem cells, called extracellular vesicles, can help people with retinitis pigmentosa. It aims to see if these particles are safe and can improve vision.
Bangkok Noi, BangkokAges 18 years+ - NCT06434389Recruiting
Rapid fibrinogen test during aortic dissection surgery
This trial tests a new device that quickly measures fibrinogen (a protein that helps blood clot) from a small blood sample during surgery for type A aortic dissection. It aims to help doctors make faster decisions about blood clotting treatments.
Hangzhou, ZhejiangAges 18 years+ - NCT07094971Recruiting
Muscle toning and strengthening for abs, thighs, and glutes
This trial tests a device treatment to strengthen and tone your abdomen, quadriceps, and glutes. It is for people who want to improve muscle definition without surgery or major lifestyle changes.
Eugene, OregonAges 25–60 - NCT07094035Recruiting
Green tea and probiotics for constipation-predominant IBS
This study tests whether a supplement containing green tea extract and probiotics can improve bowel function in people with irritable bowel syndrome (IBS) that mainly causes constipation. If you have chronic constipation and abdominal pain, this could help.
NaplesAges 18–70 - NCT07086521RecruitingPhase 1
Stem cell therapy for facioscapulohumeral muscular dystrophy
This trial tests a new stem cell treatment (ULSC) for people with FSHD, a type of muscular dystrophy. It aims to see if the treatment is safe and if it can help improve arm strength and daily movement.
Palo Alto, CaliforniaAges 15 years+ - NCT07088991Recruiting
Study of adults with NF1 and plexiform neurofibromas in Russia
This study is collecting information about adults in Russia with Neurofibromatosis type 1 who have symptomatic plexiform neurofibromas and have not yet been treated with a MEK inhibitor. It aims to better understand the condition and its treatment in real-world settings.
ArkhangelskAges Any age - NCT07089875RecruitingPhase 3
Testing dotinurad vs allopurinol for people with gout
This study compares a new gout medicine called dotinurad to the common medicine allopurinol. It is for people who have had gout for at least a year, have had at least 2 gout attacks in the last year, and are already taking a stable dose of allopurinol but still have high uric acid levels.
Birmingham, AlabamaAges 18–75 - NCT07087262RecruitingPhase 1
Study of a new medicine called SNH-119014 in healthy volunteers
This trial tests a new drug called SNH-119014 for the first time in humans. It involves healthy volunteers to check the drug's safety and how the body processes it. It may be a step toward a new treatment for certain conditions.
Hefei, AnhuiAges 18–45 - NCT07088055Recruiting
Chewing device vs. oral motor therapy for jaw alignment in kids
This study tests whether a special chewing device (Myo Munchee) can help improve jaw alignment and muscle function in children ages 3–5 who have both jaw alignment problems and orofacial myofunctional disorders. It compares the device to standard oral motor therapy.
Chicago, IllinoisAges 3–5
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,762 recruiting medical genetics studies from the U.S. registry right now, out of 5,482 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.