Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,762 recruiting studies in this area right now.
By phase
- Not applicable2,682
- Phase 2280
- Phase 1239
- Phase 3209
- Phase 1/Phase 2208
- Phase 495
- Phase 2/Phase 349
Top conditions
- Sickle Cell Disease133
- Atopic Dermatitis124
- Congenital Heart Disease83
- Cystic Fibrosis77
- Down Syndrome51
- Genetic Disease42
- Cystic Fibrosis (CF)37
- Duchenne Muscular Dystrophy36
- Fabry Disease36
- Hemophilia A36
- Cardiac Amyloidosis35
- Retinitis Pigmentosa33
- Huntington Disease31
- Lynch Syndrome31
- Heart Failure30
- Bronchopulmonary Dysplasia29
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)29
Leading sponsors
- Assistance Publique - Hôpitaux de Paris57
- Mayo Clinic39
- Boston Children's Hospital38
- National Institute of Allergy and Infectious Diseases (NIAID)38
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Children's Hospital Medical Center, Cincinnati31
- Hospices Civils de Lyon29
- Children's Hospital of Philadelphia23
- National Human Genome Research Institute (NHGRI)23
- St. Jude Children's Research Hospital23
Where studies are running
- California324
- Maryland160
- Alabama133
- Massachusetts107
- Arizona88
- New York84
- Texas70
- Minnesota68
- Pennsylvania64
- Florida59
Recruiting studies3,762 total
- NCT07090057Recruiting
Targeting the plantaris muscle in ankle surgery for children
This study tests if removing the plantaris muscle during surgery improves ankle movement in children with tight heel cords. It aims to see if this extra step leads to better outcomes.
Edmonton, AlbertaAges 4–17 - NCT07095374Enrolling by invitation
How jaw widening affects premolar tilt
This study looks at how widening the upper jaw with a special device (rapid palatal expander) affects the tilt of certain teeth (premolars). It may help doctors understand how to plan better orthodontic treatments.
Pavia, LombardyAges 6–14 - NCT07088705Enrolling by invitation
Subthreshold laser for retinitis pigmentosa
This trial tests a gentle laser treatment (SML) for people with retinitis pigmentosa (RP), an inherited eye disease that slowly causes vision loss. The goal is to see if the laser can help slow or improve vision problems like night blindness and tunnel vision.
SzczecinAges 18–70 - NCT07090668Recruiting
Ear stimulation for pain in sickle cell disease
This trial tests a safe, non-drug device that gently stimulates the ear to help reduce pain in children with sickle cell disease who are in the hospital for a pain crisis. It may offer a new way to manage pain without extra medication.
Atlanta, GeorgiaAges 7–18 - NCT07086963Recruiting
Comparing two surgeries for hypospadias repair
This study compares a standard surgery (TIP) to one that uses a small graft (DIG) to see which gives better results for boys with hypospadias. It may help determine if adding the graft improves healing and reduces complications.
CairoAges 6 months–10 years - NCT07086989Recruiting
Heart health study for kids with chronic conditions
This study looks at heart disease risk in children and young adults (ages 6-25) with long-term health conditions like certain heart, kidney, or diabetes disorders. The goal is to better understand and manage heart risks early.
BudapestAges 6–25 - NCT07092540Recruiting
Baby Duchenne Study: Early Years in Boys With DMD
This study tracks development and health in young boys with Duchenne muscular dystrophy during the first three years of life. It aims to better understand early signs and how the condition progresses, which may help improve care and future treatments.
Rochester, New YorkAges birth–3 years - NCT07092644Recruiting
Preeclampsia and baby heart defects: mother's heart study
This study looks at the link between preeclampsia (a pregnancy complication with high blood pressure) and a mother's heart health when her baby has a heart problem. The goal is to understand how the mother's heart adapts during pregnancy in these cases.
RomaAges 18 years+ - NCT07092358Recruiting
Hereditary ataxia study in the Yangtze Delta region
This study looks at genetic ataxia (a condition that affects coordination) and uses advanced testing to learn more about it. It aims to help understand the disease better and find new ways to treat it.
Hangzhou, ZhejiangAges Any age - NCT07087782Recruiting
Early high-calorie formula for infants with single ventricle heart condition
This trial tests whether starting a special high-calorie formula (Fortini) early helps infants with a single ventricle heart condition grow better and have fewer health problems between surgeries. It might improve outcomes before their next surgery.
Corpus Christi, TexasAges birth–6 months - NCT07095062Recruiting
EEG brain mapping study for Friedreich's ataxia
This study uses an EEG (a painless test that records your brain's electrical activity) to map the brain connections in people with Friedreich's ataxia. It aims to better understand how the condition affects the brain.
Conegliano, TrevisoAges 8–60 - NCT06935253Recruiting
AI to Improve Cardiology Care
This trial tests whether large language models (a type of AI that understands human language) can help cardiologists give better care. If you are a qualified cardiologist who currently treats patients, you may be eligible.
Palo Alto, CaliforniaAges 18 years+ - NCT06184503Recruiting
How velmanase alfa works in children under 3 with alpha-mannosidosis
This study looks at how the drug velmanase alfa (Lamzede) works in the body of young children with alpha-mannosidosis. It's for children who started the drug before age 3.
Miami, FloridaAges Up to 3 years - NCT06512168Recruiting
Measuring aided language development in children
This study tests whether using an iPad communication app helps children with Down syndrome or cerebral palsy who have trouble speaking. It looks at how their language skills grow over time.
Orlando, FloridaAges 3.5 years–5 years - NCT06970158Recruiting
Smart scan for babies with one-sided cleft lip and palate
This study tests using a smart camera (artificial intelligence) to help plan surgery for newborns with a single-sided cleft lip and palate. Your baby will have a quick and painless 3D scan of their mouth to guide their doctors, and you'll be closely supported throughout.
ChennaiAges 1 day–6 months - NCT06974890Recruiting
Balance training for children with mild cognitive impairment
This study tests if special balance exercises can help improve walking, balance, and posture control in children with mild cognitive impairment. It may help your child move more confidently and safely.
Lahore, Punjab ProvinceAges 6–12 - NCT07082725RecruitingPhase 3
Study of oral nizubaglustat for Niemann-Pick type C
This study tests an oral medication called nizubaglustat for people with Niemann-Pick type C disease who cannot take or are not satisfied with the current treatment miglustat. It aims to see if the drug can help with symptoms like coordination and movement problems.
Oakland, CaliforniaAges 4 years+ - NCT06976606Recruiting
A study of adults with PKP2-linked arrhythmogenic cardiomyopathy
This study follows people with a confirmed PKP2 genetic mutation and arrhythmogenic cardiomyopathy (ACM) to understand how their condition changes over time. It may help doctors learn more about the disease and plan future treatments.
Redwood City, CaliforniaAges 18–65 - NCT07077447Recruiting
Study on cancer in the upper urinary tract
This trial is for people diagnosed with a rare type of cancer in the upper urinary tract (UTUC). Researchers hope to learn more about this condition and find better ways to treat it.
Aarhus NAges 18 years+ - NCT07083531Recruiting
Bone health study for older Black women with sickle cell trait
This study looks at how carrying the sickle cell trait (not the disease) affects bone density, physical function, and frailty in older African American women. It aims to help understand bone loss risk and prevent fractures.
Farmington, ConnecticutAges 50 years+ - NCT07077473Recruiting
Comparing FMF treatments used in daily care
This study looks at how well and safely different real-world treatments work for people with Familial Mediterranean Fever (FMF). It aims to find which medicines help best for this inherited inflammatory disorder.
Wuhan, HubeiAges Any age - NCT07077304Recruiting
Cardiac imaging study for inflammatory heart diseases
This study uses heart scans (MRI or nuclear imaging) to better understand inflammatory heart conditions. If you have a suspected inflammatory heart disease and are already scheduled for one of these scans, you may be able to join.
ParisAges 18 years+ - NCT07083557Recruiting
Validation study for lab tests on hormones and metabolism
This study checks if lab tests used for hormone, heart, metabolism, and muscle disorders are accurate and reliable. You might be eligible if you are an adult with a body mass index between 16 and 60.
Columbia, MissouriAges 18–100 - NCT07081620Recruiting
Freezing rib nerves before chest-wall repair
This study tests how the timing of a nerve-freezing procedure (cryoneurolysis) in the ribs affects recovery from pectus excavatum surgery. It may help reduce pain after the operation.
Bergamo, BGAges 12–40
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,762 recruiting medical genetics studies from the U.S. registry right now, out of 5,482 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.