Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,762 recruiting studies in this area right now.
By phase
- Not applicable2,682
- Phase 2280
- Phase 1239
- Phase 3209
- Phase 1/Phase 2208
- Phase 495
- Phase 2/Phase 349
Top conditions
- Sickle Cell Disease133
- Atopic Dermatitis124
- Congenital Heart Disease83
- Cystic Fibrosis77
- Down Syndrome51
- Genetic Disease42
- Cystic Fibrosis (CF)37
- Duchenne Muscular Dystrophy36
- Fabry Disease36
- Hemophilia A36
- Cardiac Amyloidosis35
- Retinitis Pigmentosa33
- Huntington Disease31
- Lynch Syndrome31
- Heart Failure30
- Bronchopulmonary Dysplasia29
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)29
Leading sponsors
- Assistance Publique - Hôpitaux de Paris57
- Mayo Clinic39
- Boston Children's Hospital38
- National Institute of Allergy and Infectious Diseases (NIAID)38
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Children's Hospital Medical Center, Cincinnati31
- Hospices Civils de Lyon29
- Children's Hospital of Philadelphia23
- National Human Genome Research Institute (NHGRI)23
- St. Jude Children's Research Hospital23
Where studies are running
- California324
- Maryland160
- Alabama133
- Massachusetts107
- Arizona88
- New York84
- Texas70
- Minnesota68
- Pennsylvania64
- Florida59
Recruiting studies3,762 total
- NCT07077304Recruiting
Cardiac imaging study for inflammatory heart diseases
This study uses heart scans (MRI or nuclear imaging) to better understand inflammatory heart conditions. If you have a suspected inflammatory heart disease and are already scheduled for one of these scans, you may be able to join.
ParisAges 18 years+ - NCT07083713Enrolling by invitation
Group coaching for life goals with chronic conditions
This study tests if group coaching helps people with certain chronic conditions set and achieve life goals. You would join phone or video sessions with a coach and others like you.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07081711Recruiting
Testing new heart MRI technology in volunteers
This study is testing a new way to take pictures of the heart using MRI. It is looking for healthy volunteers to help make sure the technology works correctly.
Cleveland, OhioAges 18 years+ - NCT06330350Recruiting
Talking about family planning for genetic skin conditions
This study interviews people with inherited skin conditions (genodermatoses) who want to have children, and the doctors who care for them. The goal is to learn how to better support family planning decisions, like counseling about genetics and pregnancy risks.
Maastricht, LimburgAges Any age - NCT06874010RecruitingPhase 1/Phase 2
Study of DT-216P2 in adults with Friedreich's ataxia
This trial tests an investigational drug called DT-216P2 in people with Friedreich's ataxia. It aims to find the right dose and see how safe and tolerable it is.
Sydney, New South WalesAges 18–65 - NCT06977672Recruiting
Yoga for writing skills in children with Down syndrome
This study tests whether a simple yoga pose (Downward Dog) can help children with Down syndrome improve the fine motor skills they need for writing. It is designed for children ages 4 to 8 who can stand and walk on their own.
Lahore, Punjab ProvinceAges 4–8 - NCT06979037Recruiting
Genetics of diabetic ulcers and personalized treatment
This study looks for genetic markers in people with type 2 diabetes and diabetic ulcers to help find better, personalized treatments. If you join, researchers will track your health to understand which treatments work best for your specific needs.
Hengyang, HunanAges 18 years+ - NCT06972641RecruitingPhase 2/Phase 3
Gene-based maintenance therapy after stem cell transplant
This trial tests different maintenance therapies based on the specific gene mutations in your leukemia or MDS after a stem cell transplant. Your doctor will choose the right drug for your mutation type to help keep the cancer from coming back.
Shanghai, Shanghai MunicipalityAges 14–75 - NCT05982119Recruiting
Assessing muscle disease patients with activity monitors
This study assesses physical activity in people with different muscle diseases (like Duchenne, FSHD, and others) and in healthy volunteers. It helps doctors understand how these conditions affect daily movement and function.
LiègeAges 1–80 - NCT06229769Recruiting
Angelman syndrome natural history study
This study follows people with Angelman syndrome over time to learn more about the condition. You can join if you have a confirmed genetic diagnosis and your caregiver agrees to take part.
Liège, LiègeAges Any age - NCT06316752Recruiting
Natural history study of sialidosis type I
This study follows people with sialidosis type I over time to understand how the condition progresses. Participants will have regular exams, blood draws, brain scans, and eye tests.
Taipei, TaipeiAges 12–80 - NCT06587685RecruitingPhase 3
PG-011 gel for eczema in teens and adults
This trial tests a new gel called PG-011 for people with mild to moderate eczema (atopic dermatitis). The gel is applied to the skin, and the study will check if it helps improve symptoms safely.
Shenyang, LiaoningAges 12–75 - NCT06668389RecruitingPhase 4
Testing a diabetes medicine for repaired tetralogy of Fallot
This study tests a type of diabetes medicine (SGLT2 inhibitor) to see if it can help people who had surgery for tetralogy of Fallot feel better and have stronger heart and lung function. It may be a good fit if you are an adult with repaired tetralogy of Fallot and do not have certain other health problems.
Hong KongAges 18 years+ - NCT06092463Recruiting
Immune system study in newborn intestines
This study looks at how the immune system develops in the intestines of newborns, including those born early or with a blocked intestine (atresia). It may help doctors understand inflammation and improve care for sick babies.
CopenhagenAges Up to 1 year - NCT05686473Recruiting
Parent teaching program for children with prenatal alcohol exposure
This study offers a structured teaching program for parents of children who were exposed to alcohol before birth (prenatal alcohol exposure). It aims to help families better understand the child’s needs and how to support development and daily functioning.
ArendalAges 2–18 - NCT06983132Recruiting
Natural history of familial cavernous malformations: CCM study
This study follows people with a hereditary form of cavernous malformations (clusters of abnormal blood vessels in the brain). It aims to understand how the condition changes over time, without testing any new treatments.
BariAges Any age - NCT07075393Recruiting
Kidney health in Wilson's disease
This study looks at how Wilson's disease affects the kidneys. It aims to describe kidney problems in people with Wilson's disease, which may help doctors better monitor and treat this condition.
ParisAges 7 years+ - NCT06982417Recruiting
RP2 Genetic Condition Registry
This registry study collects information from people who have a genetic change in the RP2 gene (a cause of inherited eye disease) and their families. It helps researchers learn more about the condition and how it affects daily life.
Göttingen, Lower SaxonyAges Any age - NCT07073014Enrolling by invitationPhase 3
Long-term continuation of a follow-up study for a children's genetic condition called something in the world of a person who is like a head or foot specialist? Probably? (shortest version? of? a? person? condition? that? is? so? far? less? than? 60?? (time? of? a? person? limited???)?
this study is a long-term extension of the main study for the drug which from Bio? bi? whatever? in the name? by?...????
Phoenix, ArizonaAges Any age - NCT07070999RecruitingPhase 1/Phase 2
Gene therapy GB221 for infants with SMA type 1
This trial tests a new gene therapy called GB221 for infants with SMA type 1, a rare muscle-weakening disease. It aims to see if this treatment can improve muscle strength and development, and it is for babies who have not had prior gene therapy.
Porto Alegre, Rio Grande do SulAges 2 weeks–1 year - NCT07072676Enrolling by invitation
Can a walker help prevent falls in neuromuscular disease?
This study tests if using assistive walking devices, after a short training period, can lower the risk of falls in people with neuromuscular diseases. It aims to help you stay steady and safe on your feet.
Bad FeilnbachAges 65–65 - NCT07071324Recruiting
CF Wellness Program for Fatigue
This wellness program tests if coaching sessions can help people with cystic fibrosis who feel tired. It is a remote program you can join using your phone or computer, as long as you get CF care at a participating center.
Denver, ColoradoAges 18 years+ - NCT07073378Recruiting
Brain-computer help for youth with severe disabilities
This study tests if a brain-computer interface (a device that reads brain signals) can help children and teens with severe physical or communication challenges do things at home, like moving a cursor or expressing themselves.
Calgary, AlbertaAges 5–18 - NCT07065747Recruiting
Understanding inflammation in uveitis using advanced eye imaging
This study uses a special eye scan (OCT) to measure and classify inflammatory cells inside the eye. It aims to better understand different types of uveitis and improve diagnosis and treatment.
Portland, OregonAges 5–85
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,762 recruiting medical genetics studies from the U.S. registry right now, out of 5,482 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.