Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,762 recruiting studies in this area right now.
By phase
- Not applicable2,682
- Phase 2280
- Phase 1239
- Phase 3209
- Phase 1/Phase 2208
- Phase 495
- Phase 2/Phase 349
Top conditions
- Sickle Cell Disease133
- Atopic Dermatitis124
- Congenital Heart Disease83
- Cystic Fibrosis77
- Down Syndrome51
- Genetic Disease42
- Cystic Fibrosis (CF)37
- Duchenne Muscular Dystrophy36
- Fabry Disease36
- Hemophilia A36
- Cardiac Amyloidosis35
- Retinitis Pigmentosa33
- Huntington Disease31
- Lynch Syndrome31
- Heart Failure30
- Bronchopulmonary Dysplasia29
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)29
Leading sponsors
- Assistance Publique - Hôpitaux de Paris57
- Mayo Clinic39
- Boston Children's Hospital38
- National Institute of Allergy and Infectious Diseases (NIAID)38
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Children's Hospital Medical Center, Cincinnati31
- Hospices Civils de Lyon29
- Children's Hospital of Philadelphia23
- National Human Genome Research Institute (NHGRI)23
- St. Jude Children's Research Hospital23
Where studies are running
- California324
- Maryland160
- Alabama133
- Massachusetts107
- Arizona88
- New York84
- Texas70
- Minnesota68
- Pennsylvania64
- Florida59
Recruiting studies3,762 total
- NCT07073612Recruiting
Fontan stent study for liver stiffness and exercise
This study looks at whether placing a stent in the Fontan blood vessel can improve liver health and exercise ability in teenagers and young adults. If you are between 12 and 21 years old and need a stent in your Fontan pathway, you may be able to join.
Los Angeles, CaliforniaAges 12–21 - NCT07065747Recruiting
Understanding inflammation in uveitis using advanced eye imaging
This study uses a special eye scan (OCT) to measure and classify inflammatory cells inside the eye. It aims to better understand different types of uveitis and improve diagnosis and treatment.
Portland, OregonAges 5–85 - NCT07066046Recruiting
AI-assisted colonoscopy for finding colorectal lesions
This trial tests whether artificial intelligence can help doctors better detect and classify growths in the colon during a colonoscopy. You may benefit from potentially more accurate results.
São Paulo, São PauloAges 18 years+ - NCT06889480Recruiting
Deep brain stimulation for severe Tourette syndrome
This trial tests a surgical procedure using deep brain stimulation to treat severe Tourette syndrome that hasn't improved with other treatments. It may help reduce tics by targeting specific areas in the brain.
Beijing, Beijing MunicipalityAges 18–60 - NCT06984445Recruiting
Cord Blood Protein in Anemia Transfusion Study
This study measures a protein (S100B) in cord blood from babies who had or did not need a blood transfusion in the womb for hemolytic disease. It looks for possible markers of brain health.
WarsawAges 18 years+ - NCT06087367Recruiting
Database study of KCNH2 gene variants
This study is building a database to better understand how different changes in the KCNH2 gene affect health. It may help doctors make more accurate diagnoses and predictions for people with this gene variant.
Nantes, Loire-atlantiqueAges Any age - NCT07057284Enrolling by invitation
Dentofacial effects of proton therapy for childhood head and neck cancer
This study looks at how proton beam therapy (a precise type of radiation) affects the teeth and face in children and teens who had head or neck cancer. The goal is to understand these long-term effects and help improve future care.
ManchesterAges 2–32 - NCT07056569Recruiting
Testing a dermatitis cream for adults and children with eczema
This study tests a medical cream for people with atopic or contact dermatitis (eczema). It aims to see how well the cream works and if it is safe for both adults and children over 6 months old.
MilanAges 6 months–65 years - NCT07058662RecruitingPhase 1/Phase 2
Gene therapy study for Duchenne muscular dystrophy in boys 4-8
This study tests a new gene therapy called BBM-D101 for boys with Duchenne muscular dystrophy. The goal is to see if it is safe and can help improve muscle function. It is for boys aged 4 to 8 who can still walk.
Beijing, Beijing MunicipalityAges 4–9 - NCT07063251RecruitingEarly Phase 1
Gene therapy safety study for Stargardt disease in teens
This study tests a new gene therapy called HG005 for Stargardt disease in young people aged 6 to 17. It aims to see if the treatment is safe and tolerable, and how well it works.
ShanghaiAges 6–17 - NCT07062588RecruitingPhase 2
AGA2115 for osteogenesis imperfecta in adults with COL1A1/COL1A2 variations
This trial tests a new drug called AGA2115 for people with osteogenesis imperfecta (also known as brittle bone disease) who have a confirmed genetic change in the COL1A1 or COL1A2 genes. The study aims to see if the drug can help strengthen bones and reduce fracture risk.
Phoenix, ArizonaAges 18–75 - NCT07064122RecruitingPhase 1
Study of an IRAK4 blocker for blood cancers
This trial tests a new drug called AZD2962 for people with certain blood cancers (MDS or CMML) that have come back or not responded to treatment. The drug blocks a protein called IRAK4, which may help stop cancer growth.
Miami, FloridaAges 18–110 - NCT06988189Recruiting
Finding hidden heart rhythm problems in adults
This study looks for hidden heart rhythm problems in adults. It involves simple tests to find conditions that might otherwise go unnoticed.
LondonAges 18–100 - NCT07059689Recruiting
Comparing breathing support after heart surgery in children
This trial compares two types of breathing support (high-flow nasal cannula vs. non-invasive ventilation) in children who have recently had heart surgery and are at high risk of having trouble breathing after their breathing tube is removed. The goal is to see which method works better to help them breathe on their own.
Jakarta, DKI JakartaAges Up to 18 years - NCT07062497RecruitingPhase 2/Phase 3
Clonidine in nerve block for umbilical hernia repair
This trial tests if adding clonidine to a numbing injection (nerve block) improves pain control after outpatient umbilical hernia repair. It aims to reduce the need for pain medicines and enhance recovery.
Rio de Janeiro, Rio de JaneiroAges 18–65 - NCT07061509Recruiting
Exercise habits and health risks in gym goers
This study looks at how exercise habits can become unhealthy and what health risks might come with too much exercise. It may help you understand if your workout routine is balanced and safe.
Istanbul, ÜsküdarAges 18–85 - NCT07056738Enrolling by invitation
Ganglion Cell Loss Study in Retinitis Pigmentosa
This study looks at whether a type of retinal cell (ganglion cells) degenerates in people with retinitis pigmentosa. The goal is to learn more about the progression of the disease over time.
GöttingenAges 18 years+ - NCT07064174Recruiting
Sickle cell kidney research study
This study collects kidney tissue samples from people with sickle cell disease and healthy volunteers to better understand how sickle cell affects the kidneys. If you have sickle cell disease or a related blood disorder, you may help researchers find new ways to protect kidney function.
Dallas, TexasAges 18–65 - NCT07062757Enrolling by invitation
Massage and melatonin for jaw surgery recovery
This study tests whether combining gentle lymphatic drainage massage with melatonin can reduce pain and swelling after jaw surgery. If you are scheduled for jaw surgery for the first time and are otherwise healthy, you may be able to join.
Istanbul, FatihAges 16–55 - NCT06636240Recruiting
Mulberry for eczema in children
This study tests whether mulberry extract could help improve eczema symptoms in children. It is a small, early trial to see if this natural prebiotic is safe and helpful.
New Taipei City, TaiwanAges 6–17 - NCT07051902Recruiting
Microbiome and Atopy in Mali
This study is looking at how the natural bacteria on our skin and in our gut relate to eczema and asthma in people living in Mali. It will compare people with these conditions to healthy volunteers to learn more about what might cause them.
BamakoAges 3 years+ - NCT07046806RecruitingPhase 1/Phase 2
Oral deucrictibant for hereditary angioedema attacks
This trial tests an oral medication called deucrictibant to prevent and treat swelling attacks in people with hereditary angioedema. It may help reduce the number and severity of attacks.
Wheaton, MarylandAges 18–75 - NCT06989216Recruiting
Skin imaging study for adults
This trial uses advanced imaging to take detailed pictures of your skin. It may help doctors better understand and diagnose skin conditions.
StockholmAges 18 years+ - NCT05004129RecruitingPhase 2/Phase 3
Tideglusib for genetic childhood myotonic dystrophy
This trial studies how safe and effective tideglusib is for children and young adults with congenital or childhood-onset myotonic dystrophy type 1 (DM1). It may help researchers learn whether the medicine improves symptoms while tracking side effects closely.
Little Rock, ArkansasAges 6–45
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,762 recruiting medical genetics studies from the U.S. registry right now, out of 5,482 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.