Cardiology
Heart & circulation clinical trials
Heart disease, blood pressure, and disorders of the blood vessels and circulation. We’re tracking 9,989 recruiting studies in this area right now.
By phase
- Not applicable7,969
- Phase 2481
- Phase 4481
- Phase 3447
- Phase 1361
- Phase 1/Phase 2163
- Phase 2/Phase 387
Top conditions
- Stroke845
- Heart Failure564
- Hypertension400
- Cardiovascular Diseases389
- Coronary Artery Disease370
- Multiple Myeloma332
- Atrial Fibrillation267
- Ischemic Stroke200
- Atrial Fibrillation (AF)141
- Acute Ischemic Stroke139
- Pulmonary Hypertension100
- Myocardial Infarction99
- Congenital Heart Disease86
- Stroke, Ischemic85
- Peripheral Arterial Disease83
- Acute Coronary Syndrome82
- Obesity80
- Aortic Valve Stenosis79
Leading sponsors
- Mayo Clinic94
- Assistance Publique - Hôpitaux de Paris91
- National Taiwan University Hospital74
- China National Center for Cardiovascular Diseases59
- Beijing Tiantan Hospital52
- Riphah International University51
- Second Affiliated Hospital, School of Medicine, Zhejiang University51
- Massachusetts General Hospital50
- Insel Gruppe AG, University Hospital Bern49
- Johns Hopkins University47
Where studies are running
- California466
- Alabama197
- Massachusetts182
- Arizona173
- New York162
- Florida144
- Maryland120
- Minnesota120
- Illinois119
- Texas118
Recruiting studies9,986 total
- NCT05719454Recruiting
Pacemaker-based nerve therapy for high blood pressure
This study tests a new pacemaker programming method (nerve therapy) to help lower blood pressure. It may be an option if you need a dual-chamber pacemaker and your blood pressure stays high despite medicine.
PragueAges 18 years+ - NCT05719545Recruiting
Study of people getting a heart procedure through the skin
This study follows people who have an acute heart problem and need a heart procedure done through the skin. It may help researchers better understand care for people in this urgent situation.
Jinan, ShandongAges 18–85 - NCT05721170RecruitingPhase 4
Beta blockers after TAVI in high-risk adults with valve narrowing
This study tests whether stopping beta blockers after TAVI is safe and effective compared with continuing them. It may help clarify the best medication plan after valve replacement for people at higher surgical risk.
NicosiaAges 18 years+ - NCT05720936Recruiting
Nerve block treatment for dangerous heart rhythm episodes
This trial looks at a procedure called a stellate ganglion block to calm dangerous, repeated heart rhythm attacks that haven’t improved with standard medicines. It may help reduce how often and how long these episodes last while you’re in the hospital.
Alessandria, ALAges Any age - NCT05721781Recruiting
Reducing infection risk after gum and tooth issues
This study looks at ways to lower the risk of infective endocarditis, a serious heart infection that can happen after certain bacteria enter the bloodstream from the mouth. You may be asked to pause routine dental cleanings for a period while they track dental health and infection risk.
Boston, MassachusettsAges 18 years+ - NCT05722418RecruitingPhase 1
CRISPR-edited CAR-T for harder-to-treat myeloma
This Phase 1 study tests a lab-made immune cell therapy (CAR-T) made from a donor, with a CRISPR edit, for multiple myeloma that has come back or not responded to treatment. It aims to find the safest way to give the treatment and see how well it can control the cancer.
Birmingham, AlabamaAges 18 years+ - NCT05722405RecruitingPhase 4
Ixazomib plus lenalidomide compared to ixazomib alone for myeloma maintenance
This trial studies whether adding low-dose lenalidomide to ixazomib can help keep high-risk multiple myeloma from coming back after initial treatment. It may help prolong the time before the disease worsens, while also checking side effects.
Hangzhou, ZhejiangAges 18–80 - NCT05724121Recruiting
Study heart rhythm changes during BTK or venetoclax treatment
This observational study tracks how your heart rhythm (heartbeat pattern) changes while you take a BTK inhibitor or venetoclax. It may help doctors better understand heart rhythm risks in people receiving these cancer-related medicines.
Bethesda, MarylandAges 18–110 - NCT05724173Recruiting
Test of a brain-to-computer device for ALS hand paralysis
This study checks whether a brain-computer interface (a BrainGate2 system) is safe and workable for people with ALS. If you qualify, you may be asked to try the device and complete study tasks to help researchers learn how well it can support communication or control.
Stanford, CaliforniaAges 18–80 - NCT05724823Recruiting
Online seated exercise program for people after stroke
This study tests a virtual (online) exercise program done mostly while seated to help people with long-term stroke challenges move more easily and safely. You may be eligible if you can use a walking aid, can stand up from a chair, and can do about 60 minutes of exercise while using a computer or tablet.
Vancouver, British ColumbiaAges 18 years+ - NCT05725499Recruiting
Check if skin stimulation lowers blood pressure drops after spinal injury
This study tests a skin “stimulation” treatment to see if it helps stabilize blood pressure in people with spinal cord injury who get low blood pressure when sitting up. If you often have dizziness, faintness, or low readings after changing positions, this trial may help find safer ways to manage it.
West Orange, New JerseyAges 18–75 - NCT05726916RecruitingPhase 3
Eculizumab for severe kidney and blood clotting emergencies in adults
This trial studies eculizumab, a targeted blood-clotting and immune system medicine, for adults hospitalized with hypertensive emergency–associated hemolytic uremic syndrome (a serious condition affecting kidneys and blood). It aims to see whether the drug can improve outcomes after this life-threatening event.
ParisAges 18 years+ - NCT05727111Recruiting
Home therapy program for people with long-term stroke
This trial tests a structured therapy program done at home to help with movement after chronic stroke. It may help if you have lasting arm/hand problems and can follow simple instructions with a caregiver’s daily support.
BrusselsAges 18–100 - NCT05727930Recruiting
Early walking rehab trial after stroke using treadmill training
This trial studies a more intensive, early walking exercise program after a stroke. It may help improve walking speed, balance, and the ability to move safely with less support.
Indianapolis, IndianaAges 18–85 - NCT05728359Recruiting
Genetic study of outcomes in cardiogenic shock
This study looks at whether a person’s genetic information (genomics) can help predict outcomes in cardiogenic shock. You may be asked to give consent and provide information during a serious heart-related emergency, usually soon after symptoms start.
LondonAges 18–80 - NCT05728229Recruiting
Nutrition program for fatigue after stroke
This study looks at whether a nutrition approach can reduce fatigue in people after a stroke. It will compare the effects of diet-related support during recovery, aiming to help you feel less tired and more active.
Roma, RMAges 55 years+ - NCT05728333RecruitingPhase 2/Phase 3
Tirofiban or alteplase before clot removal in stroke
This trial tests whether giving either tirofiban or alteplase through a vein before a mechanical clot-removal procedure works better for an acute ischemic stroke. It may help improve how well blood flow returns and how much recovery patients can have after treatment.
Hangzhou, ZhejiangAges 18 years+ - NCT05728840Recruiting
Virtual reality exercises for new attention problems after brain injury
This study tests whether virtual reality (computer-generated) exercises can improve attention after a recent brain injury, most often stroke. You may be eligible if your brain injury happened within the last month and testing shows measurable attention difficulties.
LausanneAges 18 years+ - NCT05728580Recruiting
Study of PCI results at Beijing Friendship Hospital
This trial is for adults who already had a PCI procedure for coronary heart disease and had a successful result. The study looks at how PCI was done in practice and may help improve future treatment and follow-up.
Beijing, Beijing MunicipalityAges 18 years+ - NCT05730036RecruitingPhase 3
Linvoseltamab vs standard treatment for relapsed myeloma
This trial compares linvoseltamab against a standard combination (elotuzumab + pomalidomide + dexamethasone) in adults with multiple myeloma that has returned or not responded. It aims to find out whether linvoseltamab works better and is safe for people who have already had some myeloma treatments.
Los Angeles, CaliforniaAges 18 years+ - NCT05731687Recruiting
Balloon or two-stent approach for clogged bifurcation arteries
This trial compares two ways to open a specific type of heart blockage that involves both a main artery and a side branch. It tests whether using a drug-coated balloon (“hybrid strategy”) works as well as using a planned two-stent approach (“stepwise provisional strategy”).
Eindhoven, North BrabantAges 18 years+ - NCT05731830Recruiting
Study how air pollution relates to Takotsubo heart episodes
This study looks at whether levels of air pollution are linked to Takotsubo syndrome (a temporary heart condition). It may help doctors understand what environmental factors could affect episodes and timing.
RomeAges 18 years+ - NCT05732051RecruitingPhase 2
Nicotinamide riboside to protect the heart during breast cancer chemo
This trial tests whether nicotinamide riboside can help prevent heart problems caused by a common breast-cancer chemotherapy (anthracyclines). If you’re eligible, you’ll be followed to see how your heart is doing during treatment.
Lørenskog, AkershusAges 18 years+ - NCT05731986Recruiting
Skin nerve stimulation to raise blood pressure after spinal injury
This study tests whether a device that delivers mild electrical stimulation through the skin can improve low blood pressure after an acute spinal cord injury. It may help reduce episodes of dizziness or faint-feeling caused by blood pressure dropping when you sit up.
West Orange, New JerseyAges 18–75
Common questions
- How many heart & circulation clinical trials are recruiting?
- Clin2 is tracking 9,989 recruiting cardiology studies from the U.S. registry right now, out of 15,300 we cover in this area in total.
- What does “Heart & circulation” cover here?
- Heart disease, blood pressure, and disorders of the blood vessels and circulation. We group each study into heart & circulation based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a heart & circulation trial near me?
- Use the search to filter heart & circulation studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.