Cardiology
Heart & circulation clinical trials
Heart disease, blood pressure, and disorders of the blood vessels and circulation. We’re tracking 9,989 recruiting studies in this area right now.
By phase
- Not applicable7,969
- Phase 2481
- Phase 4481
- Phase 3447
- Phase 1361
- Phase 1/Phase 2163
- Phase 2/Phase 387
Top conditions
- Stroke845
- Heart Failure564
- Hypertension400
- Cardiovascular Diseases389
- Coronary Artery Disease370
- Multiple Myeloma332
- Atrial Fibrillation267
- Ischemic Stroke200
- Atrial Fibrillation (AF)141
- Acute Ischemic Stroke139
- Pulmonary Hypertension100
- Myocardial Infarction99
- Congenital Heart Disease86
- Stroke, Ischemic85
- Peripheral Arterial Disease83
- Acute Coronary Syndrome82
- Obesity80
- Aortic Valve Stenosis79
Leading sponsors
- Mayo Clinic94
- Assistance Publique - Hôpitaux de Paris91
- National Taiwan University Hospital74
- China National Center for Cardiovascular Diseases59
- Beijing Tiantan Hospital52
- Riphah International University51
- Second Affiliated Hospital, School of Medicine, Zhejiang University51
- Massachusetts General Hospital50
- Insel Gruppe AG, University Hospital Bern49
- Johns Hopkins University47
Where studies are running
- California466
- Alabama197
- Massachusetts182
- Arizona173
- New York162
- Florida144
- Maryland120
- Minnesota120
- Illinois119
- Texas118
Recruiting studies9,986 total
- NCT05706831Recruiting
Music and gentle brain stimulation after neurological injury
This trial tests whether combining music with gentle electrical brain stimulation can improve symptoms after a neurologic event, such as language and attention problems. It’s meant for adults who are living with effects of stroke and certain levels of reduced awareness.
Bari, BaAges 18 years+ - NCT05707871RecruitingEarly Phase 1
Testing how low-nicotine cigarettes affect heart measurements
This early study checks whether very low-nicotine cigarettes change heart-related measurements during a lab visit. It may help researchers understand how lowering nicotine could affect cardiovascular (heart and blood vessel) function.
Winston-Salem, North CarolinaAges 21 years+ - NCT05708859RecruitingPhase 4
Tirzepatide to slow plaque buildup in coronary arteries
This trial studies tirzepatide to see if it can slow the progression of coronary artery plaque in people with type 2 diabetes. It uses special heart CT scans to track changes over time.
Torrance, CaliforniaAges 40–80 - NCT05708807Recruiting
Follow-up study of recovery after first-time stroke in Gothenburg
This study tracks how people recover after their first-ever stroke (either blocked artery stroke or bleeding in the brain). It may help doctors better understand recovery patterns and what support could work best over time.
GothenburgAges 18 years+ - NCT05709132Recruiting
Peer mentorship program for teens living with heart failure
This program matches teens (ages 12–17) with a trained young adult mentor to exchange supportive check-ins by text or phone over about 15 weeks. It aims to help teen patients better manage their heart condition and feel supported through their care.
Toronto, OntarioAges 12–30 - NCT05709314RecruitingPhase 2
AMDX-2011P for cerebral amyloid angiopathy (CAA
This Phase 2 study tests AMDX-2011P to see if it can help people with cerebral amyloid angiopathy (CAA), a condition where abnormal protein affects blood vessels in the brain. You may be able to join if you have confirmed or likely CAA and a recent brain MRI showing changes from CAA.
Phoenix, ArizonaAges 18 years+ - NCT05709470Recruiting
Mental health support study for children with heart defects
This study looks at mental health in children and teens (age 5–17) who were born with a heart defect. It may help researchers understand what support is needed and how best to measure mental well-being.
CopenhagenAges 5–17 - NCT05710692RecruitingPhase 2/Phase 3
Study drug PRX-102 for Fabry disease in Japanese patients
This trial tests whether PRX-102 is safe and effective for treating Fabry disease in Japanese participants. It also measures how the drug moves through the body and affects body systems, to see if it helps your symptoms and organ function.
Chikushino-shi, FukuokaAges 13–70 - NCT05709626RecruitingPhase 4
Testing prasugrel alone after stent placement for heart attack
This study checks whether taking prasugrel by itself, after you get a drug-eluting stent for a heart attack (STEMI), can work as well as the standard approach. It may help prevent blood clots in the stent, but it requires specific blood-thinner plans for 12 months.
Sayama, OsakaAges 18 years+ - NCT05710705Recruiting
Bioimpedance monitoring in belly-flap breast reconstruction
This study tests a method called bioimpedance to monitor blood flow in the transplanted belly tissue during breast reconstruction surgery. It may help doctors know when the blood supply is stable, which could lead to safer recovery.
AmiensAges 18 years+ - NCT05711186Recruiting
Shared decision support for aortic valve procedures
This trial tests a structured, team-guided conversation to help you choose between two common valve procedures: SAVR (surgery) or TAVR (a less invasive procedure done through the groin). It may help you make a choice that fits your health goals and preferences.
BernAges 70 years+ - NCT05711173Recruiting
Study blood clot triggers and immune cell changes in clot patients
This study looks at how certain blood cell changes and immune system activity may relate to blood clots in specific veins or lungs. It may help researchers understand why clots happen “without a clear cause” and how to better predict risk.
BordeauxAges 6–50 - NCT05711849RecruitingPhase 2
Stem cell treatment for long-lasting chest pain not helped by meds
This Phase 2 trial tests whether stem cells placed into the heart artery can safely reduce symptoms in people with “refractory” angina (chest pain) despite maximum heart-healthy medication. You may qualify if your chest pain is limiting your activity and other heart procedures (stents/bypass) aren’t possible or are too risky.
London, EnglandAges 18 years+ - NCT05712824Recruiting
Device to measure left-heart pressure in advanced heart failure
This trial tests a wirelessly implanted device that measures pressure in the left upper heart chamber (left atrial pressure) in people with advanced heart failure. By tracking that pressure, researchers hope to better understand disease status and guide care.
Tbilisi, GeorgiaAges 22–88 - NCT05712395Recruiting
Pain-free exercise program for people with leg artery disease
This trial tests a new kind of exercise that is meant to be non-ischemic (not reduce blood flow) and pain-free, to see if it helps people with peripheral artery disease (PAD) who get leg pain when walking. You may be eligible if you have PAD confirmed by specific treadmill and blood-pressure measurements and meet the exercise and health safety requirements.
Oklahoma City, OklahomaAges 40 years+ - NCT05713734Recruiting
Study of unexplained bleeding blood tests in adults
This Swiss study looks at people with unexplained bleeding by using a standardized bleeding score and taking a blood sample. It may help researchers better understand possible bleeding causes even when the reason isn’t clear yet.
BellinzonaAges 16–65 - NCT05713630RecruitingPhase 3
Tranexamic acid for symptomatic subdural blood clots
This trial studies whether tranexamic acid (a medicine that helps slow blood breakdown) can improve outcomes for people with symptomatic subdural hematoma—blood collecting between the brain and its outer covering. You may be able to join if you’re older, have bleeding seen on CT, symptoms linked to the bleed, and meet several safety and timing rules.
Toronto, OntarioAges 45 years+ - NCT05714319Recruiting
Testing acetylcholine during heart artery checks for INOCA/MINOCA
This trial studies what acetylcholine testing during a coronary angiogram (CAG) can show in people with INOCA or MINOCA. It may help doctors better understand certain “spasm” or blood-vessel function problems that can cause chest pain or heart-attack-like symptoms without a blocked artery.
RomeAges 18 years+ - NCT05715710Recruiting
MRI and brain vein pattern study for memory and thinking problems
This study looks at whether certain deep brain veins seen on MRI are linked to thinking and memory problems in people with small-vessel brain disease. It compares brain scan findings with cognitive (thinking) testing to better understand what may drive cognitive dysfunction.
Zigong, SichuanAges 50–85 - NCT05715203Recruiting
Study of how stiff the aorta is in inherited aortic conditions
This study looks at how “stiff” the aorta (the body’s main artery) is in people with inherited aortic conditions. It may help researchers better understand the condition and how it progresses over time.
San Donato Milanese, LombardyAges Any age - NCT05717725RecruitingPhase 3
Pulsed heart ablation vs fake procedure for irregular heartbeat
This trial tests whether pulsed-field ablation (a targeted treatment meant to stop abnormal heart signals) works better than a sham, or “placebo,” ablation. It is for certain people with atrial fibrillation (AF) to see if symptoms and heart rhythm outcomes improve.
PragueAges 18 years+ - NCT05718128RecruitingPhase 4
Study of taking heart muscle samples from the inside
This trial studies patients who need an endocardial myocardial biopsy, meaning a small heart muscle sample taken from inside the heart. It’s meant for people with heart problems whose cause is not clearly known and may help doctors learn more about what’s going on.
Hangzhou, ZhejiangAges 18–80 - NCT05718622Recruiting
EECP for people with stable first stroke and blocked artery
This study looks at whether EECP (a non-surgical therapy that helps blood flow) improves outcomes in people who recently had their first ischemic stroke and have a narrowed or blocked artery. It also aims to predict who may benefit most based on health data.
Xi'an, ShaanxiAges 18–80 - NCT05719415Recruiting
Testing balloon treatment effects on lung blood-vessel surface area
This study looks at how a procedure called balloon pulmonary angioplasty changes measurements in lung blood vessels in people with chronic thromboembolic pulmonary hypertension. It may help doctors understand what changes the treatment makes and why.
Montreal, QuebecAges 18–75
Common questions
- How many heart & circulation clinical trials are recruiting?
- Clin2 is tracking 9,989 recruiting cardiology studies from the U.S. registry right now, out of 15,300 we cover in this area in total.
- What does “Heart & circulation” cover here?
- Heart disease, blood pressure, and disorders of the blood vessels and circulation. We group each study into heart & circulation based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a heart & circulation trial near me?
- Use the search to filter heart & circulation studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
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- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
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- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.