Cardiology
Heart & circulation clinical trials
Heart disease, blood pressure, and disorders of the blood vessels and circulation. We’re tracking 9,973 recruiting studies in this area right now.
By phase
- Not applicable7,957
- Phase 2481
- Phase 4480
- Phase 3447
- Phase 1360
- Phase 1/Phase 2162
- Phase 2/Phase 386
Top conditions
- Stroke843
- Heart Failure565
- Hypertension399
- Cardiovascular Diseases390
- Coronary Artery Disease373
- Multiple Myeloma333
- Atrial Fibrillation268
- Ischemic Stroke200
- Atrial Fibrillation (AF)140
- Acute Ischemic Stroke138
- Myocardial Infarction101
- Pulmonary Hypertension100
- Stroke, Ischemic86
- Congenital Heart Disease85
- Peripheral Arterial Disease83
- Acute Coronary Syndrome82
- Obesity80
- Aortic Valve Stenosis79
Leading sponsors
- Mayo Clinic94
- Assistance Publique - Hôpitaux de Paris91
- National Taiwan University Hospital74
- China National Center for Cardiovascular Diseases59
- Beijing Tiantan Hospital52
- Riphah International University51
- Second Affiliated Hospital, School of Medicine, Zhejiang University51
- Massachusetts General Hospital50
- Insel Gruppe AG, University Hospital Bern49
- Johns Hopkins University47
Where studies are running
- California461
- Alabama197
- Massachusetts183
- Arizona173
- New York161
- Florida145
- Maryland120
- Minnesota120
- Illinois119
- Texas118
Recruiting studies9,970 total
- NCT05185141Recruiting
Carotid ultrasound test to guide fluid during major abdominal surgery
This study uses a non-invasive ultrasound scan of the neck (carotid Doppler) to help predict whether you’ll benefit from extra IV fluids during major abdominal surgery. It aims to improve fluid management without placing extra invasive monitoring unless already planned.
Mainz, Rhineland-PalatinateAges 18–80 - NCT04736667Recruiting
Screening survey for mitral valve treatment planning
This study is for people who did not pass an initial screening for a specific mitral valve procedure called TMVI. It may help the team understand screening results and improve how patients are assessed for the right next steps.
Phoenix, ArizonaAges 18 years+ - NCT05050799Recruiting
Testing a new device to place central lines in harder cases
This study tracks how well a new device (the Surfacer System) works when standard methods can’t place a central venous line (a larger tube into a major vein). It may help people who need a long-term access line but have blocked veins where usual procedures don’t work.
Tucson, ArizonaAges 18 years+ - NCT05206955RecruitingPhase 3
Tadalafil versus placebo for Fontan circulation problems
This study tests whether tadalafil (a daily pill) can improve blood flow and protect organs in adults who have had Fontan surgery. Participants will either receive tadalafil or a placebo, and they will be monitored during a planned heart catheter procedure.
Rochester, MinnesotaAges 18 years+ - NCT05531474Recruiting
Bariatric surgery to lower future heart and stroke events
This trial looks at whether weight-loss surgery can reduce the chances of heart attack, stroke, or other serious heart problems in people at higher heart risk. You might be offered surgery and followed over time to see if cardiovascular events are reduced.
Hamilton, OntarioAges 18 years+ - NCT05072119Recruiting
Hospital registry to track heart device outcomes
This study keeps a secure record of people who receive a pacemaker, ICD, or implantable loop recorder, to understand how these devices perform over time. If you join, your care team will track your follow-up visits for at least 12 months.
Naples, NapoliAges 14 years+ - NCT04890821Recruiting
Percutaneous ring repair for leaking tricuspid valve
This early study tests a minimally invasive device that helps tighten (repair) the tricuspid valve ring to reduce severe leaking. It may help people who still have symptoms from right-sided heart failure even after taking the best available medicines.
Hackensack, New JerseyAges 18 years+ - NCT04921501Recruiting
Testing a detailed heart tracing to evaluate rhythm risks
This study checks a more detailed kind of heart recording (ECG) using many small sensors to better measure electrical rhythm problems. It may help doctors refine how they assess risk in people with serious or suspected dangerous heart rhythm issues.
Clermont-FerrandAges 14 years+ - NCT04704947RecruitingPhase 3
Beta blockers and fracture risk in osteoporosis
This study tests whether using beta blocker blood pressure medicines affects the risk of fractures in people with osteoporosis. It may help doctors understand which medication choices lower fracture risk.
TantaAges 50 years+ - NCT05028777Recruiting
People with a heart clot who can join a hospital record study
This study looks at people age 18+ who were found to have a blood clot in the left side of the heart (left ventricular thrombus) on scans between 2013 and 2020. It will compare how different blood-thinner medicines were used and what outcomes occurred.
BernAges 18 years+ - NCT05152888RecruitingPhase 4
Testing a cholesterol drug to improve heart blood flow on scans
This trial studies whether lowering LDL (“bad cholesterol”) with a PCSK-9 inhibitor (evolocumab) improves blood flow to the heart, measured by special PET scans. It’s for people over a certain age who have stable coronary artery disease and a higher risk of heart problems.
Boston, MassachusettsAges 50–90 - NCT04957719Enrolling by invitationPhase 3
Testing selatogrel to prevent problems after a recent heart attack
This trial tests selatogrel to see if it can better prevent harmful heart and blood-clot outcomes after a recent heart attack. You may be considered if you had a heart attack in the past 4 weeks and have higher-risk heart artery disease.
Alexander City, AlabamaAges 18 years+ - NCT05732077Recruiting
Stent decisions for kidney artery narrowing in hard-to-control blood pressure
This trial studies whether using a pressure-based test called fractional flow reserve (FFR) helps doctors choose the right kidney artery stent for people with narrowing of kidney arteries and high blood pressure. It may help improve blood pressure control while avoiding unnecessary procedures.
Beijing, Beijing MunicipalityAges 18 years+ - NCT03775577Recruiting
Exercise testing study for people with heart failure
This study looks at exercise intolerance in heart failure, using heart and lung tests to understand how symptoms affect activity. It may help researchers better identify what limits exercise and how heart failure impacts quality of life.
Baltimore, MarylandAges 21 years+ - NCT03770312RecruitingPhase 4
Testing low/moderate statin use to prevent heart problems in older adults
This study looks at whether taking a low- to moderate-dose statin can prevent first-time heart and stroke problems in people age 70 and older. It may help you lower “bad cholesterol” (LDL) and see if that leads to fewer heart events over time.
SeoulAges 70 years+ - NCT04487314Recruiting
Study of chronic vein disease over time
This study follows people (and certain close family members) to document how chronic vein problems develop and change over time. You would get yearly checkups and ultrasound scans to track the natural course of the condition.
Saint PetersburgAges 10 years+ - NCT05310461Recruiting
Early or delayed valve surgery for mixed heart valve disease
This study compares doing aortic valve replacement sooner versus waiting, in people with moderate aortic valve narrowing plus at least moderate leakage in the mitral valve. It aims to see which timing improves heart symptoms and outcomes while keeping treatment safe.
BernAges 18 years+ - NCT04253301Recruiting
Testing a vein valve device for chronic venous valve leak
This study tests whether an implanted “vein valve” system can improve blood flow in people with painful chronic venous valve leakage in the thigh/knee veins. It also checks if the procedure and follow-up are safe and workable, especially with blood-thinner medicines before and after.
Nedlands, Western AustraliaAges 18 years+ - NCT05390892RecruitingPhase 4
Preventing kidney and heart damage in type 2 diabetes
This study tests whether diabetes medicines can help prevent worsening heart and kidney problems in people with type 2 diabetes. You’ll be assigned by chance to one of these medicine types, and your other care will be adjusted for safety.
Huntsville, AlabamaAges 40–80 - NCT04393181Recruiting
Study how donor heart function affects transplant outcomes
This study looks at how well donor hearts work and how that affects outcomes after heart transplantation. It may help transplant teams choose and use donor hearts more effectively.
Gothenburg, Västra Götaland CountyAges 18 years+ - NCT05511792Recruiting
Smaller valve size approach versus standard valve size in TAVR
This trial compares a “smaller valve sizing” approach versus the usual sizing method during TAVR (a catheter-based valve replacement) for people with bicuspid aortic stenosis. The study aims to see which method improves safety and outcomes for the right valve fit.
Fuzhou, FujianAges 60 years+ - NCT04240366Recruiting
Extra left atrial appendage treatment during AF ablation
This trial tests whether adding treatment to the left atrial appendage during a standard catheter ablation helps people with persistent atrial fibrillation (AF). It may improve how well AF is controlled, but you must meet specific heart rhythm and heart scan measurements to join.
Hamburg, Free and Hanseatic City of HamburgAges 18 years+ - NCT04441203Recruiting
Virtual clinic for managing heart failure at home
This trial tests a virtual “heart failure clinic” and home heart monitoring to help people manage symptoms and outcomes. It may help by catching problems earlier and guiding safer self-care between doctor visits.
Montreal, QuebecAges 18 years+ - NCT04027777Recruiting
Study of a wearable blood pressure device in adults
This observational study tests how well a wearable device (the Aktiia bracelet) measures blood pressure by comparing it to standard listening checks. It may help people understand how accurate home-style blood pressure readings can be in different health situations.
LausanneAges 21–85
Common questions
- How many heart & circulation clinical trials are recruiting?
- Clin2 is tracking 9,973 recruiting cardiology studies from the U.S. registry right now, out of 15,205 we cover in this area in total.
- What does “Heart & circulation” cover here?
- Heart disease, blood pressure, and disorders of the blood vessels and circulation. We group each study into heart & circulation based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a heart & circulation trial near me?
- Use the search to filter heart & circulation studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.