Cardiology
Heart & circulation clinical trials
Heart disease, blood pressure, and disorders of the blood vessels and circulation. We’re tracking 9,609 recruiting studies in this area right now.
By phase
- Not applicable7,632
- Phase 4472
- Phase 2469
- Phase 3439
- Phase 1350
- Phase 1/Phase 2160
- Phase 2/Phase 387
Top conditions
- Stroke797
- Heart Failure534
- Hypertension388
- Cardiovascular Diseases373
- Coronary Artery Disease363
- Multiple Myeloma327
- Atrial Fibrillation259
- Ischemic Stroke190
- Atrial Fibrillation (AF)154
- Acute Ischemic Stroke139
- Pulmonary Hypertension104
- Myocardial Infarction97
- Congenital Heart Disease84
- Peripheral Arterial Disease79
- Stroke, Ischemic78
- Aortic Valve Stenosis76
- Obesity74
- Acute Coronary Syndrome73
Leading sponsors
- Mayo Clinic93
- Assistance Publique - Hôpitaux de Paris88
- National Taiwan University Hospital68
- China National Center for Cardiovascular Diseases60
- Second Affiliated Hospital, Zhejiang University, School of Medicine58
- Beijing Tiantan Hospital53
- Insel Gruppe AG, University Hospital Bern49
- Massachusetts General Hospital49
- Yonsei University48
- Johns Hopkins University45
Where studies are running
- California453
- Alabama196
- Arizona181
- Massachusetts173
- New York168
- Florida140
- Texas122
- Maryland118
- Minnesota117
- Illinois112
Recruiting studies9,609 total
- NCT04968509RecruitingPhase 3
PCSK9 shots for calcified aortic valve narrowing
This study tests whether adding PCSK9 inhibitor injections (to statin treatment) can slow or improve calcific aortic valve stenosis, a condition where the heart’s aortic valve becomes stiff and narrowed. It’s aimed at adults with mild-to-moderate disease or certain people with severe disease but no symptoms.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06208007Recruiting
Predicting heart failure with stiff arteries
This study looks at whether stiffer arteries can help predict a type of heart failure where the heart doesn't relax properly (HFpEF). It's for people who have risk factors like high blood pressure, diabetes, or being older, and who may have early signs of heart trouble.
Göttingen, Lower SaxonyAges 18 years+ - NCT04061512RecruitingPhase 2/Phase 3
Rituximab plus ibrutinib versus standard steroids plus rituximab
This trial compares two starting treatment plans for Waldenström’s macroglobulinaemia, testing whether one works better or causes fewer problems. It studies rituximab plus ibrutinib versus a standard mix of rituximab, cyclophosphamide, and dexamethasone (steroids).
BathAges 18 years+ - NCT03003299Recruiting
Valve replacement for failing aortic bioprosthetic valves
This trial studies a new “valve-in-valve” procedure to treat a failing aortic bioprosthetic valve. It may help people improve blood flow through the heart valve and reduce valve-related problems.
Phoenix, ArizonaAges Any age - NCT04558723Recruiting
MRI-guided heart defibrillator placement for non-ischemic weakened hearts
This study looks at whether using a heart MRI (CMR) to guide where to place an implanted defibrillator (ICD) improves outcomes for people with a weakened heart muscle caused by non-ischemic dilated cardiomyopathy. It’s for adults who have low pumping strength and evidence of heart scarring on MRI.
Lübeck, Schleswig-HolsteinAges 18 years+ - NCT02355457Recruiting
Blood marker study in new heart attack symptoms
This study looks at blood “biomarkers” (signals in blood tests) in people who arrive with symptoms that could be a heart attack. It may help doctors spot and manage acute heart problems sooner and more accurately.
HamburgAges 18 years+ - NCT05442970Recruiting
Study to assess risk of atrial fibrillation
This study looks at how to better judge a person’s risk of developing atrial fibrillation, a type of irregular heartbeat. You may help researchers by completing interviews and assessments that guide future risk estimates.
HamburgAges 18–85 - NCT05204212Recruiting
Heart procedure to close an atrial clot risk pouch in kidney failure
This trial tests a heart procedure that closes a part of the heart called the left atrial appendage to help prevent stroke in people with an irregular heartbeat (atrial fibrillation) and very advanced kidney disease. It’s mainly for patients who can take the needed blood-thinner medicines and who do not already have a clot in that pouch.
Lübeck, Schleswig-HolsteinAges 18 years+ - NCT06048796Recruiting
Early stopping of sedation after cardiac arrest with normal EEG
This study is testing whether it is safe to stop sedation and temperature management early in cardiac arrest patients who have a normal-looking brain wave test (EEG). If you qualify, you would stop sedation sooner than usual, which may help you wake up faster.
Arnhem, GelderlandAges 18 years+ - NCT04475289Recruiting
Registry tracking test results for coronary artery anomalies
This study follows adults who have a coronary artery anomaly and are getting a medically needed heart test at the study hospital. Researchers collect information from those tests to better understand outcomes and what different findings mean.
BernAges 18 years+ - NCT06411392Recruiting
Radiation therapy for difficult-to-control fast heart rhythm
This study tests a form of focused radiation (SBRT) to treat a dangerous fast heart rhythm called ventricular tachycardia (VT) when medicines and other procedures haven't worked. It may help reduce the number of VT episodes and improve your quality of life.
GrazAges 18 years+ - NCT06393478Recruiting
Southeastern Europe Microcirculation Registry
This study is collecting information about how well the tiny blood vessels in the heart work in people with chest pain. It helps doctors learn more about microcirculation problems and may lead to better treatments.
RijekaAges 18 years+ - NCT04217421RecruitingPhase 3
Allopurinol for newborns needing heart surgery with bypass
This trial tests whether the medicine allopurinol can protect the brain and heart in newborns with serious congenital heart disease who need heart surgery soon after birth. It may help reduce injury during and around surgery that uses a heart-lung machine (cardiopulmonary bypass).
GroningenAges Up to 1 month - NCT04868578Recruiting
Vitamin PPI supplements for ectopic calcification in PXE
This trial studies whether taking PPI-type supplements can slow or reduce unwanted calcification in people with PXE. It’s meant to help manage disease changes caused by abnormal calcium deposits, based on your medical testing.
AngersAges 18–65 - NCT05479669Recruiting
Testing detailed heart scans in people with heart failure symptoms
This study looks at whether doing very detailed heart testing helps understand and guide care for people with heart failure with preserved pumping strength. You may be eligible if you’re an adult with specific symptom levels, recent heart-failure-related visits, and matching scan and blood test results.
GroningenAges 18 years+ - NCT06416761Recruiting
Genetics and kidney disease progression study
This study looks at how genetics affect the progression of kidney diseases. Joining may help researchers understand your condition better and find better treatments.
MilanAges 18 years+ - NCT06417502Recruiting
China pediatric rheumatic disease registry study
This study collects information from children with rheumatic and immune system diseases in China to better understand these conditions. By participating, you help researchers learn more about how to diagnose and treat these diseases.
Beijing, Beijing MunicipalityAges Up to 18 years - NCT06369818Recruiting
Heart output measurement in shock patients on life support
This study tests if a new way of measuring heart function (using sound waves and breath analysis) works well in patients who are in severe heart failure and need a heart-lung machine. It might help doctors better monitor patients after heart surgery.
MünsterAges 18 years+ - NCT07851493Recruiting
Exercise assessment before chemotherapy for multiple myeloma
This study looks at how exercise affects the body before you start chemotherapy for multiple myeloma. It aims to understand your fitness level to help tailor treatment support.
Munich, BavariaAges 18–99 - NCT07852936Recruiting
Group therapy for emotional recovery after brain injury
This study tests a group-based talk therapy program designed to help people with acquired brain injury express and process emotions, aiming to improve mental health and coping after injury.
UppsalaAges 18 years+ - NCT07851779RecruitingPhase 4
Stopping heart failure drugs after excellent response to cardiac resynchronization therapy
This trial studies whether patients with non-ischemic cardiomyopathy who have responded extremely well to a special pacemaker (CRT) can safely stop their heart failure medications. It aims to see if their heart function stays stable without these drugs.
L'Hospitalet de Llobregat, BarcelonaAges 18 years+ - NCT07852221Recruiting
Pace and ablate for atrial fibrillation
This study looks at how well a treatment called 'pace and ablate' works for people with atrial fibrillation. It involves using a pacemaker or similar device to control the heart rate, and it aims to see who benefits most and how they do over time.
ZabrzeAges 18 years+ - NCT07853261Recruiting
Balloon inflation study for coronary stent placement
This trial tests a special way of inflating a balloon after placing a stent in a blocked heart artery. It aims to improve how well the stent expands, which may help keep the artery open.
Changchun, JilinAges 18 years+ - NCT07851350Recruiting
Preparing for major surgery with a personalized fitness plan
This study offers a program to help you get physically and mentally ready for major surgery. It tests whether a personalized preparation plan improves recovery and reduces complications.
Varese, VAAges 18 years+
Common questions
- How many heart & circulation clinical trials are recruiting?
- Clin2 is tracking 9,609 recruiting cardiology studies from the U.S. registry right now, out of 14,617 we cover in this area in total.
- What does “Heart & circulation” cover here?
- Heart disease, blood pressure, and disorders of the blood vessels and circulation. We group each study into heart & circulation based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a heart & circulation trial near me?
- Use the search to filter heart & circulation studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
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- Pain
- Injuries & trauma
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.