Cardiology
Heart & circulation clinical trials
Heart disease, blood pressure, and disorders of the blood vessels and circulation. We’re tracking 9,973 recruiting studies in this area right now.
By phase
- Not applicable7,957
- Phase 2481
- Phase 4480
- Phase 3447
- Phase 1360
- Phase 1/Phase 2162
- Phase 2/Phase 386
Top conditions
- Stroke843
- Heart Failure565
- Hypertension399
- Cardiovascular Diseases390
- Coronary Artery Disease373
- Multiple Myeloma333
- Atrial Fibrillation268
- Ischemic Stroke200
- Atrial Fibrillation (AF)140
- Acute Ischemic Stroke138
- Myocardial Infarction101
- Pulmonary Hypertension100
- Stroke, Ischemic86
- Congenital Heart Disease85
- Peripheral Arterial Disease83
- Acute Coronary Syndrome82
- Obesity80
- Aortic Valve Stenosis79
Leading sponsors
- Mayo Clinic94
- Assistance Publique - Hôpitaux de Paris91
- National Taiwan University Hospital74
- China National Center for Cardiovascular Diseases59
- Beijing Tiantan Hospital52
- Riphah International University51
- Second Affiliated Hospital, School of Medicine, Zhejiang University51
- Massachusetts General Hospital50
- Insel Gruppe AG, University Hospital Bern49
- Johns Hopkins University47
Where studies are running
- California461
- Alabama197
- Massachusetts183
- Arizona173
- New York161
- Florida145
- Maryland120
- Minnesota120
- Illinois119
- Texas118
Recruiting studies9,970 total
- NCT05068674RecruitingPhase 1
Stem cell heart muscle therapy for weak heart after prior heart attack
This Phase 1 study tests a treatment made from stem cells to grow heart muscle cells (“cardiomyocytes”) for people with long-lasting (chronic) heart weakness after a prior heart attack. It aims to see if the therapy can improve heart function and is safe in carefully selected patients.
Palo Alto, CaliforniaAges 21–80 - NCT04734756Enrolling by invitation
Dragonfly device study for leaking mitral valve in high-risk patients
This trial tests the safety and effectiveness of a heart procedure that repairs a leaking mitral valve through thin tubes, using the Dragonfly system. It’s for people who have significant mitral valve leak symptoms but are considered high risk for open-heart surgery.
Hangzhou, ZhejiangAges 18 years+ - NCT05076019Recruiting
Atorvastatin during heart valve surgery for patients over 60
This trial studies whether taking atorvastatin (a cholesterol medicine) around the time of surgical aortic valve replacement can improve outcomes. It is mainly for people who have not taken similar medicines recently and do not have certain heart rhythm or liver/kidney problems.
OdenseAges 60–95 - NCT05011149RecruitingPhase 3
Medicine for early treatment of a leaking heart vessel
This trial studies whether giving medicine soon can help preterm babies with a patent ductus arteriosus (a temporary leaking blood vessel in the heart). It aims to see if early treatment improves outcomes for very early gestational age infants.
Orange, CaliforniaAges Up to 3 days - NCT04959838Recruiting
Study of job stress in eye doctors and trainees
This study looks at job stress among ophthalmologists (eye doctors) and ophthalmology residents. It may help improve working conditions and support for people in eye care.
Clermont-FerrandAges 18–65 - NCT04707872Recruiting
Study of a blood test after heart transplant
This study checks whether a special blood test can help detect heart transplant rejection or problems by comparing it to biopsy results. It may help your care team monitor your transplant with less guesswork.
Little Rock, ArkansasAges Any age - NCT04954404Recruiting
Mitral valve procedure registry for Chinese patients in one center
This study is a registry (a way to track real-world outcomes) for people with mitral valve disease who receive a mitral valve procedure. It helps doctors understand how well these procedures work and what complications happen in patients like you.
Hangzhou, ZhejiangAges 18 years+ - NCT05073419Recruiting
Test for heart rhythm issues after a heart attack
This trial checks how well a small heart monitor device can detect abnormal heart rhythms after a recent heart attack. It may help doctors catch rhythm problems early, which could improve follow-up care after discharge.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT04770012RecruitingPhase 3
Aspirin or clopidogrel after heart transplant
This study tests antiplatelet medicines (like aspirin or clopidogrel) in people who have had a heart transplant. The goal is to see if these medicines can safely help prevent blood-related complications after transplant.
Vancouver, British ColumbiaAges 18 years+ - NCT05204212Recruiting
Heart procedure to close an atrial clot risk pouch in kidney failure
This trial tests a heart procedure that closes a part of the heart called the left atrial appendage to help prevent stroke in people with an irregular heartbeat (atrial fibrillation) and very advanced kidney disease. It’s mainly for patients who can take the needed blood-thinner medicines and who do not already have a clot in that pouch.
Lübeck, Schleswig-HolsteinAges 18 years+ - NCT05257954Recruiting
Testing frailty in people getting a left atrial appendage closure
This study looks at frailty (how strong or vulnerable a person is) in adults who are having a left atrial appendage closure procedure through a catheter. The goal is to understand which patients may be more vulnerable during or after the procedure.
Québec, QuebecAges 18 years+ - NCT04723888Recruiting
Supplements to slow aneurysm growth and prevent rupture
This trial studies whether alpha-ketoglutarate, a supplement, can slow the growth of an abdominal aortic aneurysm and reduce the risk of rupture. It may help people whose aneurysm size is in a specific range by tracking changes over time and watching for safety.
ShanghaiAges 50 years+ - NCT05257161Recruiting
Carotid stent study comparing two stent positions using brain MRI
This study looks at how well a carotid artery stent works soon after the procedure, using special MRI pictures of the brain. It compares outcomes between stent placement closer to the top versus closer to the bottom of the narrowed area, to see which approach is safer for early brain effects.
NovosibirskAges 45–80 - NCT05392764RecruitingPhase 3
SGLT2 medicine for high-risk people after sudden worsening heart failure
This Phase 3 trial tests whether starting an SGLT2 inhibitor early in the hospital can improve outcomes for people at high risk after acute (sudden) heart failure. If you qualify, you would be randomized to receive the study medicine or standard care, started within 12 hours of admission.
Anjo, Aichi-kenAges 20 years+ - NCT05214365Recruiting
Pacing study to help people with heart block avoid stronger harm
This study looks at a heart pacing approach to prevent damage to the heart muscle that can sometimes happen after a pacemaker is placed for atrioventricular (heart rhythm) block. It may help some people avoid worsening heart function over time.
BarcelonaAges 18–100 - NCT05106062Recruiting
Remote heart monitoring program for defibrillator patients
This trial studies whether using a remote monitoring device for people with certain heart devices improves outcomes and is worth the effort/cost. It looks at results for different patient groups and needs people to actively use the monitoring system.
SeoulAges 19–80 - NCT06748924Recruiting
Chronic coronary syndrome snapshot study
This study looks at how well doctors follow standard guidelines when treating people with chronic coronary syndrome (a type of long-term heart disease). It may help doctors improve care for patients with chest pain, heart disease, or related conditions.
YerevanAges 18 years+ - NCT05256745RecruitingPhase 1/Phase 2
A medicine to protect the heart during breast cancer chemotherapy
This early-phase study tests azeliragon to lower the risk of chemotherapy-related heart damage in women with early-stage breast cancer. Participants get their planned standard chemotherapy, plus the study medicine, and are monitored for safety and heart health.
Washington D.C., District of ColumbiaAges 18 years+ - NCT05251324Recruiting
Study effects of hot flushes on heart and blood pressure
This study looks at how hot flushes (also called hot flashes) may affect heart function and blood pressure in postmenopausal people. You may be able to take part if you are not currently using hormone therapy or can stop it for the study.
Minneapolis, MinnesotaAges 40–70 - NCT04678258Recruiting
Study without x-ray guidance for treating atrial flutter
This trial tests a way to do a heart procedure for “atrial flutter” with less or no x-ray use. It may help reduce radiation exposure while still aiming to cure the abnormal rhythm.
Fürth, BavariaAges 18 years+ - NCT04913805RecruitingPhase 2
Study for HFpEF using heart pressure and energy signals
This Phase 2 study tests how matching heart “filling pressure” and heart muscle “energy use” may improve understanding or treatment of HFpEF, a type of heart failure with preserved pumping strength. You may be asked to have heart scans/tests and follow a study plan if your symptoms and test results fit.
Philadelphia, PennsylvaniaAges 18 years+ - NCT04795193Enrolling by invitation
Minithoracotomy vs open surgery for multiple blocked heart arteries
This trial compares two types of bypass surgery for people with multiple blocked heart arteries, to see which one better improves quality of life and how well the bypasses stay open. You may be assigned based on your preferences, and the study also tracks heart scan and follow-up results.
Beijing, Beijing MunicipalityAges 25–85 - NCT05625997Recruiting
Test shockwave and drug-coated balloon for blocked arteries
This study tests a device approach called Shockwave IVL followed by a drug-coated balloon to treat hard, calcified coronary (heart) artery blockages. It may help improve how well the artery stays open after treatment.
São PauloAges 18 years+ - NCT05334888Recruiting
Study how sex and gut bacteria relate to heart risk
This study follows people over time to understand how sex-related factors and gut bacteria may affect heart and blood-vessel risk. It may help researchers identify who could benefit from earlier prevention, based on personal risk patterns.
BerlinAges 18–50
Common questions
- How many heart & circulation clinical trials are recruiting?
- Clin2 is tracking 9,973 recruiting cardiology studies from the U.S. registry right now, out of 15,205 we cover in this area in total.
- What does “Heart & circulation” cover here?
- Heart disease, blood pressure, and disorders of the blood vessels and circulation. We group each study into heart & circulation based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a heart & circulation trial near me?
- Use the search to filter heart & circulation studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.