Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 2,053 recruiting studies in this area right now.
By phase
- Not applicable1,631
- Phase 2148
- Phase 183
- Phase 381
- Phase 458
- Phase 1/Phase 236
- Phase 2/Phase 316
Top conditions
- Periodontitis108
- Nasopharyngeal Carcinoma79
- Periodontal Diseases57
- Dental Caries49
- Gingivitis35
- Head and Neck Cancer35
- Oral Cancer35
- Dental Implant30
- Sjogren's Syndrome29
- Gingival Recession27
- Periodontal Disease27
- Alveolar Bone Loss23
- Nasopharyngeal Carcinoma (NPC)23
- Peri-Implantitis23
- Tooth Loss22
- Oropharynx Cancer21
- Temporomandibular Disorders (TMD)21
- Trigeminal Neuralgia21
Leading sponsors
- Cairo University91
- Sun Yat-sen University53
- Ain Shams University30
- Mansoura University30
- Postgraduate Institute of Dental Sciences Rohtak24
- Al-Azhar University23
- Tanta University23
- University of Baghdad19
- Universidad Complutense de Madrid18
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California40
- Texas27
- Massachusetts22
- Ohio22
- Pennsylvania22
- New York20
- Maryland19
- Florida18
- Alabama16
- Michigan15
Recruiting studies2,053 total
- NCT02880891Recruiting
Splinting vs not splinting dental crowns on implants
This trial compares two ways of connecting single dental crowns (splinted vs not splinted) on dental implants. It looks at how well the gums and bone stay stable around the implants over time, after the crowns are put in.
Beijing, Beijing MunicipalityAges 20 years+ - NCT02814149Recruiting
Compare early vs delayed dental implant placement
This trial studies whether placing a dental implant right away or after a delay leads to better appearance and healing. It looks at cosmetic results and X-ray findings, and is for people missing one front upper tooth.
Guangzhou, GuangdongAges 18–80 - NCT02584270Recruiting
Speech training with a mouth prosthesis for early tongue cancer
This trial tests a speech-rehabilitation program using a custom mouth prosthesis for people newly diagnosed with early tongue cancer (T1 or T2). It may help improve speech as you go through cancer treatment.
Ann Arbor, MichiganAges 18 years+ - NCT02290145RecruitingPhase 2
Study of Cyclin D1–targeted chemotherapy before oral cancer surgery
This Phase 2 trial tests a chemotherapy plan given first (before surgery) for people with oral squamous cell carcinoma that has specific cancer markers and lymph node involvement. It aims to shrink or control the cancer so treatment after may work better.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT02910323Recruiting
Study for cluster headaches and trigeminal nerve pain
This study looks at people with certain severe headache disorders (cluster-type headaches or SUNCT/SUNA) or trigeminal neuralgia (sharp facial nerve pain). Researchers want to better understand these conditions and see how study testing/record review may help care.
Houston, TexasAges 18 years+ - NCT02327884Recruiting
Study saliva and related diseases to learn health patterns
This study looks at diseases that involve the salivary (saliva) glands, and may also include people with active hepatitis, oral cancer, or healthy adults. Researchers collect blood, urine, saliva, and sometimes tissue to better understand what’s happening and how these conditions relate to saliva and oral health.
Bethesda, MarylandAges 4–100 - NCT02639312Recruiting
Study of how craniofacial differences develop over time
This study follows children and adults with craniofacial (head/face) differences to learn how their growth changes over time. It also enrolls unaffected family members and healthy volunteers to compare what is “typical,” using scans and optional genetic testing.
Bethesda, MarylandAges 2–100 - NCT03003052Recruiting
Study of dental care ideas for implant patients
This study looks at how dental care is understood and delivered for people getting specialist dental treatment, often dental implants. You may be invited if you’re a patient at The Campbell Clinic and you can understand and consent to the study information.
NottinghamAges 18 years+ - NCT03215719RecruitingPhase 2
De-escalating treatment for HPV-positive throat cancer with low-risk signals
This Phase 2 trial tests whether people with HPV-positive oropharyngeal (throat) cancer who look “lower risk” can safely receive less intensive treatment. It uses HPV blood test results and cancer staging scans to guide whether treatment can be de-escalated.
New York, New YorkAges 18 years+ - NCT07124520Recruiting
Lingual strength training after tongue cancer surgery
This study tests if using a device to exercise your tongue after partial tongue removal helps you recover tongue strength and function better than standard care. It is for people having their first surgery for oral tongue cancer.
Basking Ridge, New JerseyAges 18 years+ - NCT07671651Recruiting
Ozone therapy for early tooth decay in children
This trial tests whether ozone therapy can help reverse the earliest stages of tooth decay (white spots on teeth) in children. Children aged 6–12 with small, non-cavity spots may benefit from this treatment instead of traditional fillings.
Istanbul, MaltepeAges 6–14 - NCT07676695Recruiting
Jaw Device and Sound Waves for Class II Malocclusion
This trial tests a special jaw repositioning device (Twin-Block) combined with low-intensity sound waves (LIPUS) to help treat a class II malocclusion (when the lower jaw is set back) in children and teens. It aims to improve jaw alignment and joint outcomes.
CairoAges 10 months–1.2 years - NCT03083405Enrolling by invitation
Study of tooth grinding during sleep
This study is for adults who have been diagnosed with sleep bruxism (tooth grinding during sleep). Researchers want to understand it better using sleep testing, and it may help refine how this condition is evaluated.
WroclawAges 18–70 - NCT02422875Enrolling by invitation
Study of immune markers in autoimmune disease and lupus
This study looks at blood and immune cell markers (autoantibodies and immune cell “signatures”) to better understand autoimmune conditions, including lupus. It may help researchers identify which markers are linked to disease and how immune cells respond after vaccination.
Atlanta, GeorgiaAges 18 years+ - NCT02702869Enrolling by invitation
Study of improving care for common facial clefts
This trial is part of a quality-improvement and research program for people with typical facial clefts. It aims to help improve how care is organized and measured across treatment centers, which may benefit future patients and help your team deliver coordinated care.
Gainesville, FloridaAges 1 day–22 years - NCT07399197Recruiting
Tracking tooth movement after pulling in upper canine
This trial uses 3D imaging to measure bone and root changes when pulling an upper canine that sticks out toward the cheek into its proper position. It may help doctors understand how to treat this condition better.
Sanaa, Sana'aAges 12 years+ - NCT07400328RecruitingPhase 2
Stem cell injection to prevent severe mouth sores in transplant
This trial is testing a single injection called Amimestrocel to prevent severe mouth sores in people getting a stem cell transplant. The study is for adults who are receiving high-dose conditioning with total body irradiation or melphalan, which often cause painful mouth inflammation.
Suzhu, JiangsuAges 18–65 - NCT07401641Recruiting
Pain control study for oral cancer surgery
This study tests two different pain medicines (dezocine or nalbuphine) combined with sufentanil to see which helps better control pain after oral cancer surgery with free flap reconstruction. It also looks at side effects and how well the transplanted tissue survives.
Guangzhou, GuangdongAges 18–70 - NCT07403006Recruiting
Comparing two gum recession treatments for better results
This trial looks at two ways to clean the tooth root before a common gum graft procedure. One method uses a special powder and water spray, the other uses hand tools. The goal is to see if one leads to better gum coverage.
Warsaw, MazowszeAges 18–60 - NCT07405905Recruiting
Comparing mini implant placements for fixing upper teeth overbite
This study tests two ways of placing small temporary anchors (mini implants) in the jaw to help pull upper front teeth back into a better position. It is for patients who have finished growing and have a Class II overbite, to see which anchor location works best.
Rohtak, HaryanaAges 18–30 - NCT07406867Recruiting
Can photos and bitewings detect gum disease?
This study tests whether photos, X-rays, and other non-invasive methods can identify gum disease as accurately as a clinical exam. It may help patients avoid needles or probing.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07409558Recruiting
3D scan study for gum improvement after surgery
This study uses 3D digital scans to measure gum tissue changes after a gum grafting procedure. It may be helpful for people with receding gums on their lower front teeth.
Kahramanmaraş, KahramanmaraşAges 18 years+ - NCT07409571Recruiting
Gum graft healing after surgery on the palate
This study is testing how well the roof of your mouth heals after a gum graft procedure. It aims to find better ways to help this area heal faster and more comfortably.
Kahramanmaraş, KahramanmaraşAges 18 years+ - NCT07410351Recruiting
Periodontal risk self-assessment for Saudi adults
This trial is creating a simple online tool to help you assess your risk for gum disease. If you join, you will answer a questionnaire and have a quick gum check at the same visit.
Abhā, 'Asir RegionAges 18 years+
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 2,053 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,969 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
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- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.