Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 1,962 recruiting studies in this area right now.
By phase
- Not applicable1,543
- Phase 2144
- Phase 385
- Phase 182
- Phase 460
- Phase 1/Phase 235
- Phase 2/Phase 313
Top conditions
- Periodontitis103
- Nasopharyngeal Carcinoma74
- Periodontal Diseases50
- Dental Caries46
- Gingivitis35
- Head and Neck Cancer35
- Oral Cancer32
- Periodontal Disease29
- Dental Implant28
- Gingival Recession25
- Alveolar Bone Loss24
- Nasopharyngeal Carcinoma (NPC)24
- Sjogren's Syndrome24
- Tooth Loss24
- Temporomandibular Disorders (TMD)22
- Oropharynx Cancer21
- Peri-Implantitis21
- Temporomandibular Joint Disorders20
Leading sponsors
- Cairo University77
- Sun Yat-sen University50
- Mansoura University25
- Ain Shams University24
- Postgraduate Institute of Dental Sciences Rohtak24
- Tanta University24
- Al-Azhar University23
- Universidad Complutense de Madrid16
- University of Baghdad16
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California44
- Texas26
- Florida21
- Maryland21
- Massachusetts21
- New York19
- Pennsylvania19
- Ohio18
- Alabama17
- Michigan15
Recruiting studies1,962 total
- NCT06070558Recruiting
Study of normal and abnormal jaw joint motion using real-time MRI
This study uses real-time MRI to take detailed images of your jaw joint (the temporomandibular joint) to better understand its normal and painful variations. It may help if you have jaw pain or clicking, but you don't need to have a problem to join.
NancyAges 18 years+ - NCT06077513Enrolling by invitation
Comparing two mesh frames for jawbone grafting
This trial tests two different metal mesh frames used to rebuild bone in the jaw before placing a dental implant. If you need a bone graft for a missing tooth, this study may help find the best option for you.
Boston, MassachusettsAges 18–80 - NCT06075134Recruiting
EMG-guided vs. standard Botox for gummy smile treatment
This trial compares two ways of giving Botox for a gummy smile: one using a machine that measures muscle activity (EMG‑guided) and the usual method. The goal is to see which approach works better.
CairoAges 18–50 - NCT06072495Recruiting
Understanding Why Some Cleft Palate Repair Patients Have Ongoing Speech Issues
This study uses special MRI scans to help doctors understand why some children who had cleft palate surgery still have difficulty with certain speech sounds. By looking at how the muscles in the back of the throat work, researchers hope to improve future surgical techniques and speech outcomes.
AmiensAges 7–12 - NCT06073704Recruiting
Light therapy for gum disease in people with obesity
This study tests whether adding a special light-activated cleaning (antimicrobial photodynamic therapy) to standard gum disease treatment can help people with obesity who have gum disease. It aims to see if this extra step improves gum health more than standard treatment alone.
Bauru, São PauloAges 18–70 - NCT06063876Enrolling by invitation
Gum health study for treated dental implants
This study looks at how gums react to plaque buildup around dental implants that were previously treated for infection. It may help understand if one treatment method leads to healthier gums.
Pittsburgh, PennsylvaniaAges 18–80 - NCT06059261RecruitingPhase 2
Envafolimab plus chemoradiation and endostatin for advanced nasopharyngeal cancer
This trial tests a combination of a new immunotherapy (envafolimab) with standard chemoradiation and a drug that blocks blood vessel growth (endostatin) for people with advanced nasopharyngeal cancer that hasn't been treated before. The goal is to see if this combination works better than the usual treatment.
Chongqing, Chongqing MunicipalityAges 18–65 - NCT04422847Recruiting
3D printed tools to help anesthesia for children with cleft face
This study uses computer planning and 3D printed models to help the anesthesia team manage breathing and airway safety during a child’s cleft-related surgery. It may improve planning and safety by matching the anesthesia plan to your child’s anatomy.
Brno, Jihomoravská KrajAges Up to 2 years - NCT06038487Recruiting
Early vs. standard timing for upper jaw implant dentures
This trial compares placing implants in the upper jaw immediately versus waiting for healing, to see which approach works better for people who already wear full dentures. You may qualify if you have no upper teeth and your jawbone is healthy enough for implants without extra bone grafts.
Cleveland, OhioAges 21 years+ - NCT06050655Enrolling by invitation
Lingual aligners for adults: how well do they work?
This trial tests whether lingual aligners (braces placed on the inside of your teeth) are effective for straightening teeth in adults. If you are an adult planning to get orthodontic treatment, this study may be for you.
Geneva, Canton of GenevaAges 18 years+ - NCT06047236Recruiting
Immune markers in salivary gland cancer
This study looks at immune cells and substances in blood, saliva, and stool from people with salivary gland cancer. The goal is to find markers that could help predict how the disease behaves.
Erlangen, BavariaAges 18 years+ - NCT06037161Recruiting
Comparing two gum coverage methods for a lower front tooth
This trial compares two ways to cover a receded gum on a single lower front tooth. It tests which method works better for people with mild to moderate gum recession.
Cleveland, OhioAges 18 years+ - NCT06024395Recruiting
Helping people overcome fear of the dentist
This trial tests a step-by-step approach to help people who are afraid of the dentist. It uses a smartphone or tablet to guide you through relaxation and coping skills.
New York, New YorkAges 13–99 - NCT06006429Recruiting
Using a scanner to check teeth and gums
This study tests if a special intraoral scanner can help dentists find gum problems and tooth issues. If you have receding gums, you may be able to join.
ReimsAges 18 years+ - NCT06017895Recruiting
Doxepin rinse for severe swallowing pain during throat radiation
This trial tests a medicated mouth rinse (doxepin) to ease severe pain when swallowing, caused by radiation therapy for nasopharyngeal cancer. It aims to help patients who are currently receiving radiation and have mouth or throat sores.
Guangzhou, GuangdongAges 18 years+ - NCT06012071Recruiting
Zirconia implants for a missing upper premolar
This trial tests two types of zirconia (ceramic) dental implants for replacing a single missing upper premolar. It aims to see which implant platform works best for long-term stability.
LjubljanaAges 25 years+ - NCT06023550Recruiting
Complicated Ear, Nose, and Throat Infections Study
This study looks at patients with complicated infections of the ear, nose, throat, or neck that are treated at a specific hospital in Slovenia. The goal is to learn more about these infections and how they are managed.
Ljubljana, LjubljanaAges Any age - NCT06017817Recruiting
Light therapy for implant gum disease
This study tests a special light-activated treatment (antibacterial photodynamic therapy) to fight infection around dental implants. It may be an option for people with moderate to severe implant-related gum disease who are not smokers and do not have diabetes.
StockholmAges 18–85 - NCT05269472Recruiting
Study of nerve signals during facial pain procedures
This study measures nerve activity (electrical signals in nerves) in people who have trigeminal neuralgia and are getting a common facial pain procedure. It may help researchers better understand the condition and improve future treatments.
Minneapolis, MinnesotaAges 18 years+ - NCT05983432RecruitingPhase 1
Study of BL-B01D1 for advanced lung and other solid tumors
This trial tests an experimental drug called BL-B01D1 for people with several types of advanced solid tumors, especially non-small cell lung cancer and breast cancer. It's designed for those whose cancer has continued to grow after standard treatments.
Beverly Hills, CaliforniaAges 18 years+ - NCT05989750Recruiting
Air-Polishing Teeth Cleaner During Braces Treatment
This study tests a special air-polishing cleaning method using erythritol (a gentle powder) during braces treatment. It may help keep teeth and gums healthier while you have braces.
Geneva, Canton of GenevaAges 12–16 - NCT05945225Enrolling by invitation
Oral care during pregnancy to reduce gum inflammation
This study looks at how a specific oral care approach during pregnancy may lower gum inflammation. It mainly enrolls pregnant people in mid-pregnancy and checks gum health over time.
NancyAges 18–40 - NCT05964387Recruiting
Silver fluoride treatment and local numbing for tooth cavities
This study tests whether applying silver diamine fluoride (a cavity-stopping liquid) changes how well local numbing works during dental treatment for certain tooth defects. It may help determine the safest and most comfortable way to treat weak, cavity-prone molars in children.
Ann Arbor, MichiganAges 6–11 - NCT05964933Enrolling by invitation
Pulpotomy vs root canal for painful nerve inflammation
This trial compares two treatments for a tooth nerve that is very inflamed and causing lingering pain: a pulpotomy versus a full root canal. It may help you choose the approach that best relieves symptoms and supports healing for the right kind of tooth.
SingaporeAges 12 years+
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 1,962 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,756 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
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- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.