Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 2,053 recruiting studies in this area right now.
By phase
- Not applicable1,631
- Phase 2148
- Phase 183
- Phase 381
- Phase 458
- Phase 1/Phase 236
- Phase 2/Phase 316
Top conditions
- Periodontitis108
- Nasopharyngeal Carcinoma79
- Periodontal Diseases57
- Dental Caries49
- Gingivitis35
- Head and Neck Cancer35
- Oral Cancer35
- Dental Implant30
- Sjogren's Syndrome29
- Gingival Recession27
- Periodontal Disease27
- Alveolar Bone Loss23
- Nasopharyngeal Carcinoma (NPC)23
- Peri-Implantitis23
- Tooth Loss22
- Oropharynx Cancer21
- Temporomandibular Disorders (TMD)21
- Trigeminal Neuralgia21
Leading sponsors
- Cairo University91
- Sun Yat-sen University53
- Ain Shams University30
- Mansoura University30
- Postgraduate Institute of Dental Sciences Rohtak24
- Al-Azhar University23
- Tanta University23
- University of Baghdad19
- Universidad Complutense de Madrid18
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California40
- Texas27
- Massachusetts22
- Ohio22
- Pennsylvania22
- New York20
- Maryland19
- Florida18
- Alabama16
- Michigan15
Recruiting studies2,053 total
- NCT07412314Recruiting
Proton Therapy for Recurrent Nasopharyngeal Cancer
This trial uses proton therapy (a precise type of radiation) to treat people whose nasopharyngeal cancer has come back. It aims to see if this treatment can help control the cancer while limiting side effects.
Guangzhou, GuangdongAges 18 years+ - NCT07413341RecruitingPhase 1
Study of new drug TI-0032-III for hard-to-treat autoimmune diseases
This early-phase trial tests a new drug called TI-0032-III for people with several autoimmune diseases that haven't gotten better with standard treatments. It aims to see if the drug can safely reduce disease activity and offer a new option for people who have few choices left.
Shanghai, Shanghai MunicipalityAges 18–65 - NCT07414173RecruitingPhase 4
Mouthrinse for plaque and gum health
This study tests whether a special antimicrobial mouthrinse can reduce plaque buildup and improve gum health over 6 months. If you have early gum disease (gingivitis) and are generally healthy, this trial may be a good fit.
SchenefeldAges 18–70 - NCT07414498Recruiting
Bacteria in gum surgery for implant and tooth infections
This study looks at the bacteria living in deep gum pockets around implants or teeth during different types of gum surgery. It may help determine which surgical approach is best for your kind of gum infection.
Münster, North Rhine-WestphaliaAges 18–80 - NCT07415733Recruiting
Gum health toothpaste study for people with bleeding gums
This trial tests a toothpaste designed to improve gum health in people who have gingival problems like bleeding gums. It aims to see if the toothpaste can reduce gum bleeding and improve overall gum condition.
Jakarta PusatAges 18 years+ - NCT07419269Recruiting
Comparing donor vs. patient bone grafts for jawbone repair
This trial tests whether donated (allogenic) bone blocks work as well as your own bone to rebuild the jaw so dental implants can be placed. It's for people missing 1-4 teeth where the bone ridge is too thin.
Graz, StyriaAges 18 years+ - NCT07420777Recruiting
3D-printed aligners for treating an open bite
This study tests whether new 3D-printed shape-memory aligners can effectively fix a mild-to-moderate open bite (when front teeth don't touch when you bite down). It may be a good option if you are between 18 and 35, generally healthy, and have a mild open bite with fairly straight teeth.
Erbil, Erbil GovernorateAges 18–35 - NCT07421960Recruiting
Periodontitis and sleep quality study
This study looks at how gum disease (periodontitis) might be related to sleep quality. It compares people with healthy gums to those with gum disease.
Istanbul, IstanbulAges 18–65 - NCT07424716Recruiting
Bone healing with platelet-rich fibrin after cyst removal
This trial tests whether a natural blood concentrate (PRF) helps jawbone heal better after removing a dental cyst. It may improve recovery and reduce the need for additional bone grafting.
Sanaa, Sanaa GovernorateAges 18–80 - NCT07424742Recruiting
Toothless upper jaw implant study without bone grafts
This trial tests a way to place dental implants in the upper jaw where bone is thin (4-6 mm height) without needing a bone graft. It uses special self-tapping implants to lift the sinus floor gently through the implant site.
Sanaa, Sanaa GovernorateAges 18–80 - NCT07424846RecruitingPhase 2/Phase 3
Xylitol gum to prevent gum disease and early birth
This trial tests if chewing xylitol gum during pregnancy can reduce gum disease and preterm birth. You would chew gum after meals and attend dental visits and follow-ups.
LilongweAges Any age - NCT07430670Recruiting
Gum healing with oral and tissue care after recession surgery
This study tests a special oral product and skin care along with gum surgery for people with gum recession on a lower front tooth. It looks at whether the product helps the healing process after adding a small piece of gum tissue.
Madrid, MadridAges 18 years+ - NCT07433725Recruiting
Comparing 3D-printed vs. standard splints for teeth grinding and jaw pain
This trial compares a new 3D-printed splint with a standard acrylic splint for treating teeth grinding (bruxism) and jaw joint problems. Participants wear the splint at night for 3 months to see which type works better.
AnkaraAges 18–25 - NCT07436039Recruiting
Toothpaste for sensitivity and color improvement in MIH
This study tests a new toothpaste containing nano-hydroxyapatite, a substance that mimics natural enamel, to see if it can help reduce sensitivity and improve the color of teeth affected by Molar-Incisor Hypomineralization (MIH)—a condition where first molars and sometimes front teeth have white, yellow, or brown spots. It is for children aged 6 to 12 who have these spots on at least one permanent molar or baby molar.
JeddahAges 6–12 - NCT07436650Recruiting
Laser therapy for mouth sores in children having a bone marrow transplant
This study tests whether a special kind of laser therapy (called high-level laser therapy) can help heal severe mouth sores in children who are having a bone marrow transplant. If your child has painful mouth sores from the transplant, this treatment might reduce pain and speed healing.
Cairo, Cairo GovernorateAges Up to 18 years - NCT07437417Recruiting
Recession coverage with a new gum graft material
This study tests a new volume-stable gum graft material to cover exposed tooth roots caused by receding gums. It is for healthy patients seeking treatment for gum recession on front teeth.
BernAges 18 years+ - NCT07439614Recruiting
Comparing two ways to clean a dead nerve during a root canal
This trial compares two different ways to clean a molar tooth during a root canal when the nerve is dead. The goal is to find which method is better at removing infection without causing discomfort.
Buffalo, New YorkAges 18–70 - NCT07439679Recruiting
Anxiety Before Double Jaw Surgery and Your Recovery
This trial studies how anxiety before double jaw surgery affects your body during surgery and your recovery (pain, swelling, and ability to open your mouth). Researchers will use a simple anxiety questionnaire to see if feeling anxious changes your surgical experience.
IstanbulAges 18 years+ - NCT07443410Recruiting
Probiotics for gum disease treatment
This trial tests whether taking pre- and probiotics alongside non-surgical gum treatment improves healing and reduces harmful bacteria. It may help people with advanced gum disease (stage III or IV periodontitis).
Heidelberg, Baden-WurttembergAges 18 years+ - NCT07443917Recruiting
Study of Treponema Parvum in gum disease patients
This study looks for a specific bacteria called Treponema Parvum in the gums of people with periodontitis (severe gum disease). It aims to understand if this bacteria is linked to gum disease and could help improve future treatments.
BaghdadAges 30 years+ - NCT07445516Recruiting
Bite adjustment for TMD: long-term follow-up
This trial follows up with people who previously had a dental bite adjustment (occlusal equilibration) for TMD (jaw or face muscle/joint pain). It compares their long-term results with a group that received a 'sham' (fake) procedure.
Santiago de Compostela, A CoruñaAges 18–85 - NCT07445555Recruiting
Gum Recession Study: Braces vs. No Braces
This study looks at gum recession (when gums pull away from teeth) in adults, comparing those who had braces in the past to those who did not. It aims to understand if orthodontic treatment affects gum health.
LeuvenAges 18 years+ - NCT07446127Recruiting
Adding Laser to Gum Disease Treatment
This trial tests adding a special laser (diode laser) to standard deep cleaning for gum disease. The goal is to see if the laser helps reduce infection and improve healing better than cleaning alone.
Afula, NorthAges 18 years+ - NCT07448571Recruiting
Testing i-PRF for better root canal retreatment healing
This study tests whether using a special platelet-rich concentrate (i-PRF) during a root canal retreatment can help heal infection at the tip of the root better than standard retreatment alone. It is for adults with a previously treated upper front tooth that now shows signs of infection on X-ray.
IstanbulAges 18–50
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 2,053 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,969 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
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- Genetic & congenital
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- Pain
- Injuries & trauma
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.