Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 1,962 recruiting studies in this area right now.
By phase
- Not applicable1,543
- Phase 2144
- Phase 385
- Phase 182
- Phase 460
- Phase 1/Phase 235
- Phase 2/Phase 313
Top conditions
- Periodontitis103
- Nasopharyngeal Carcinoma74
- Periodontal Diseases50
- Dental Caries46
- Gingivitis35
- Head and Neck Cancer35
- Oral Cancer32
- Periodontal Disease29
- Dental Implant28
- Gingival Recession25
- Alveolar Bone Loss24
- Nasopharyngeal Carcinoma (NPC)24
- Sjogren's Syndrome24
- Tooth Loss24
- Temporomandibular Disorders (TMD)22
- Oropharynx Cancer21
- Peri-Implantitis21
- Temporomandibular Joint Disorders20
Leading sponsors
- Cairo University77
- Sun Yat-sen University50
- Mansoura University25
- Ain Shams University24
- Postgraduate Institute of Dental Sciences Rohtak24
- Tanta University24
- Al-Azhar University23
- Universidad Complutense de Madrid16
- University of Baghdad16
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California44
- Texas26
- Florida21
- Maryland21
- Massachusetts21
- New York19
- Pennsylvania19
- Ohio18
- Alabama17
- Michigan15
Recruiting studies1,962 total
- NCT05973656Recruiting
Study how alcohol affects the risk of mouth cancer
This study looks at how a breakdown product from alcohol (acetaldehyde) may play a role in oral (mouth) cancer. It may help researchers understand who is more affected by alcohol and why.
Minneapolis, MinnesotaAges 18–45 - NCT05964933Enrolling by invitation
Pulpotomy vs root canal for painful nerve inflammation
This trial compares two treatments for a tooth nerve that is very inflamed and causing lingering pain: a pulpotomy versus a full root canal. It may help you choose the approach that best relieves symptoms and supports healing for the right kind of tooth.
SingaporeAges 12 years+ - NCT05964387Recruiting
Silver fluoride treatment and local numbing for tooth cavities
This study tests whether applying silver diamine fluoride (a cavity-stopping liquid) changes how well local numbing works during dental treatment for certain tooth defects. It may help determine the safest and most comfortable way to treat weak, cavity-prone molars in children.
Ann Arbor, MichiganAges 6–11 - NCT05943782Enrolling by invitation
Digital onlay fillings made two ways for back teeth
This trial compares two digital manufacturing methods to make ceramic onlay fillings for back (molar) teeth—one method that removes material and one that builds it up. It may help you learn which approach makes more comfortable, effective onlays for teeth needing repair.
CairoAges 18–50 - NCT05941741RecruitingPhase 3
Tested low-dose radiation plus cadonilimab for nasopharyngeal cancer
This Phase 3 trial studies whether adding low-dose radiation to cadonilimab (an immune therapy) can improve outcomes for people newly diagnosed with a specific type and stage of nasopharyngeal cancer. If you’re eligible, it may offer a new treatment approach and helps researchers confirm whether it works best.
Guangzhou, GuangdongAges 18–70 - NCT05932017Enrolling by invitation
Compare two ways to see during gum surgery
This trial compares two tools surgeons use to see during gum (periodontal) surgery: magnifying loupes versus a videoscope. It may help improve how the procedure is done for people with more severe gum disease.
Dallas, TexasAges 18 years+ - NCT05907239Recruiting
Shock wave therapy for jaw muscle pain
This trial tests whether focused shock wave treatment can reduce chronic jaw pain caused by jaw muscle problems. You might qualify if you have moderate to severe temporomandibular (jaw) pain for at least 3 months.
São Paulo, São PauloAges 18 years+ - NCT05880797Recruiting
Study of throat cancer profiles using multiple tests
This trial studies oropharyngeal (throat) cancer, including certain HPV-related cancers of unknown starting point, using several ways to measure tumor features. The goal is to better understand these cancers and possibly guide future care.
Palo Alto, CaliforniaAges 18 years+ - NCT05902026Enrolling by invitation
Questionnaire study for jaw-related headache and pain impact
This study tests a biopsychosocial questionnaire (a survey about thoughts, daily life, and pain) for people with jaw-related headaches from temporomandibular disorder (TMD). It may help researchers better understand what influences headache severity and how to support treatment planning.
Gaziantep, Hasan Kalyoncu UniversityAges 18–60 - NCT05894083RecruitingPhase 2
PET-Scan Tailored De-escalation for p16+ throat cancer
This trial tests a treatment plan that may lower (de-escalate) therapy intensity for certain p16+ or HPV-positive throat cancers. It uses PET scan results and tumor features to try to keep cancer control while reducing side effects.
Ann Arbor, MichiganAges 18 years+ - NCT05899933Recruiting
Compare two surgical treatments for peri-implantitis
This study compares two different surgical approaches to treat peri-implantitis, an infection/inflammation around dental implants. You may be enrolled because you have a qualifying implant and meet health and medication requirements.
AthensAges 18–80 - NCT05888935Recruiting
AI checks for tooth root infections on dental X-rays
This study tests an artificial intelligence tool to detect small infections around tooth roots using routine panoramic dental X-rays. You might benefit if your scans are used to more accurately spot these problems compared with standard reading.
MetzAges 18 years+ - NCT05884320RecruitingPhase 2
Sacituzumab govitecan for advanced salivary gland cancers
This Phase 2 trial tests sacituzumab govitecan, an anti-cancer medicine, in people with recurrent or metastatic (coming back or spread) secretory gland cancers or related salivary gland cancers. It aims to see how well the treatment can shrink tumors and control disease when surgery or radiation is not a cure.
Houston, TexasAges 18 years+ - NCT05908682Recruiting
Study of ibrexafungerp safety during pregnancy
This study looks at what happens when ibrexafungerp is taken during pregnancy, including outcomes for the baby. You may join if you were exposed to this medicine during pregnancy (or very close to conception) and you agree to share information and complete study follow-up.
New Delhi, Vasant ViharAges birth+ - NCT05859997Enrolling by invitation
CAR-T cell therapy for active autoimmune disease flare-ups
This study tests an immune-cell treatment (CAR-T, called BRL-301) in people with certain autoimmune diseases that are active and hard to control. It may help your immune system calm down if standard treatments have not worked or your disease has returned.
Shanghai, Shanghai MunicipalityAges 18–65 - NCT05858411Recruiting
Biologic gum treatments added to non-surgical cleaning
This trial studies whether adding a biologic medicine to standard non-surgical gum (periodontal) treatment can improve deep gum pockets in certain bone defects. It may help people whose gum disease has specific “intrabony” defects, but you must meet several health and medication rules.
TiranaAges 18 years+ - NCT05876169Enrolling by invitation
Study how jaw surgery changes neck and jaw movement
This study looks at how orthognathic (jaw alignment) surgery affects how your jaw and neck muscles move. It may help doctors better understand recovery and movement changes after surgery.
UmeåAges 16–50 - NCT05851248Recruiting
Gum graft treatment for a single lower front tooth
This trial studies a “free mucogingival graft,” a surgical gum tissue transplant, to cover exposed root (recession) in a specific area of the lower front teeth. If you have a deep recession in a healthy mouth with low gum bleeding, you may be able to try this approach and help researchers learn how well it works.
Murcia, MurciaAges 18 years+ - NCT05865028RecruitingPhase 2
Test drug APG-157 for abnormal mouth tissue
This Phase 2 trial studies whether APG-157 can safely improve abnormal cells in the mouth (dysplasia) or early cancer-like changes (carcinoma in situ). You may be eligible if you have a visible, biopsy-proven lesion and can take oral medication while meeting blood and health requirements.
Miami, FloridaAges 18 years+ - NCT05853692Recruiting
Preventing mouth sores during head and neck radiation
This trial tests a gel called “Gel X” to help prevent painful mouth sores (oral mucositis) in people receiving radiation for head and neck cancer. It may help you stay more comfortable and maintain eating and speaking during treatment.
Roma, ItalyAges 18 years+ - NCT05851963Recruiting
Toothbrushing help for teens with fixed braces
This study looks at whether using specific toothbrushes in daily life can improve dental gum and tooth health for teens with fixed braces. It may help by testing simple at-home brushing routines that could reduce gum problems during orthodontic treatment.
NancyAges 11–15 - NCT05738096RecruitingEarly Phase 1
Testing nerve recordings to improve facial pain rhizotomy
This study looks at special nerve testing (nerve recordings) in adults who are scheduled for a procedure called percutaneous rhizotomy for facial pain. The goal is to see whether these recordings can help improve how the procedure works and affects pain.
Minneapolis, MinnesotaAges 18 years+ - NCT05813236Recruiting
Compare two suture types for gum surgery healing
This trial compares two different types of stitches (suture materials) to see which one works better after gum (periodontal) surgery. It may help by improving comfort and healing in people needing resective periodontal surgery.
Sant Cugat del Vallès, CataloniaAges 18 years+ - NCT05819697Recruiting
Helping burning mouth symptoms with improved memory recall
This trial looks at ways to reduce how much people with burning mouth syndrome struggle to recall information during the study. If you qualify, you may be asked to complete study tasks and share saliva to support the research.
Philadelphia, PennsylvaniaAges 18 years+
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 1,962 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,756 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.