Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,578 recruiting studies in this area right now.
By phase
- Not applicable2,954
- Phase 4240
- Phase 2129
- Phase 3103
- Phase 193
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University59
- Beijing Tiantan Hospital34
- Tanta University33
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University21
Where studies are running
- California151
- New York79
- Massachusetts65
- Florida64
- Texas50
- North Carolina41
- Illinois40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,578 total
- NCT06873113Recruiting
Blood flow therapy for shoulder pain
This study tests a new type of physical therapy that uses a blood pressure cuff to gently limit blood flow to the arm during exercise. It may help people with shoulder pain from subacromial impingement (a common cause of shoulder pain) regain function.
Gainesville, FloridaAges 18–50 - NCT06076889Recruiting
Online pain relief program for Canadian youth with chronic pain
This trial tests a virtual program called Power Over Pain Portal, designed to help Canadian youth with chronic pain manage their symptoms from home. It offers step-by-step support through a smartphone or computer over two months.
Toronto, OntarioAges 12–18 - NCT06860867Recruiting
Nucleus replacement for single-level discogenic low back pain
This trial tests a new device called PerQdisc for people with chronic low back pain from a single damaged disc in the lower spine. The goal is to see if the device can safely replace the inner gel of the disc without major surgery.
Glendale, ArizonaAges 22–70 - NCT06859021Recruiting
Checking chest pain callers with a new priority score
This study tests whether a simple scoring tool can help emergency dispatchers decide how fast to respond to people calling about chest pain. If you call emergency services with chest pain, this could help make sure you get the right help quickly.
AngersAges 18 years+ - NCT06863688Enrolling by invitation
Ankle fracture surgery with tourniquet study
This trial compares tourniquet use during ankle fracture surgery. It looks at outcomes for patients with a simple (closed) ankle fracture caused by a ground-level fall who are having metal plates and screws placed.
Iowa City, IowaAges 18–65 - NCT06861920RecruitingPhase 4
NSAID use for painful periods to prevent chronic pelvic pain
This study tests whether using NSAIDs (like naproxen) for painful periods can help prevent chronic pelvic pain later on. It's for people with regular, painful periods who are otherwise healthy.
Evanston, IllinoisAges 18–35 - NCT06859723RecruitingPhase 1
Effects of high potency cannabis on daily users
This study tests how high potency cannabis affects mood, thinking, and pain sensitivity in people who smoke cannabis almost every day. It will help researchers understand both immediate and long-lasting effects.
Los Angeles, CaliforniaAges 21–55 - NCT06862609Recruiting
Pain relief block for inguinal hernia surgery
This study tests a nerve block called QIPB to reduce pain after laparoscopic inguinal hernia repair. It is for adults having planned surgery on one side under general anesthesia.
KonyaAges 18–65 - NCT06865378Enrolling by invitation
Breathing gas and nausea after hysterectomy study
This study looks at whether levels of carbon dioxide in your breath and blood flow measurements during surgery can help predict nausea, vomiting, or pain after a hysterectomy. It may help doctors better manage your recovery.
IstanbulAges 20–65 - NCT06866054Recruiting
A block for shoulder surgery pain relief
This trial tests a nerve block to reduce pain after arthroscopic shoulder surgery. It might help you have less pain and recovery time after the procedure.
Istanbul, BagcilarAges 18–75 - NCT06864780Recruiting
Posture exercises for forward head posture in device users
This trial tests if posture correction exercises can help fix forward head posture caused by heavy smartphone or laptop use. It is for people who spend at least 2-3 hours daily on their devices and have not had treatment for this condition before.
Malakand, KpkAges 18–40 - NCT06864234RecruitingPhase 4
Beta-blockers for chest pain without blocked arteries
This trial tests if beta-blocker medication improves blood flow and reduces resistance in the tiny blood vessels of the heart in people who have chest pain but no major blockages in their arteries.
Aalst, FlandersAges 18 years+ - NCT06859710RecruitingPhase 1
THC and CBD as a harm reduction strategy
This study looks at whether different types of cannabis (containing THC and/or CBD) might help people who use cannabis regularly reduce potential harms. You will be asked to take cannabis in a controlled setting and complete tasks and questionnaires.
Los Angeles, CaliforniaAges 21–55 - NCT06859801Recruiting
Bone pain study combining ablation and radiation
This study looks at combining two treatments for painful bone tumors that have spread from other cancers. It tests if using both treatments together provides better pain relief than either alone.
San Diego, CaliforniaAges 21 years+ - NCT05141591Recruiting
Anxiety before ENT surgery and opioid use after surgery
This trial looks at whether people’s anxiety before ear, nose, and throat (ENT) surgery affects how much pain medicine (opioids) they need after surgery. It may help doctors better plan pain control based on anxiety level and possibly gender-related patterns.
Vienna, State of ViennaAges 18 years+ - NCT05738278Recruiting
Care changes guided by heart rate in non-speaking autistic people
This study tests whether using a person’s heart rate to guide care can improve day-to-day support for autistic people who do not communicate verbally. It’s aimed at people who live in a care home or attend a staffed day program most days of the week.
OsloAges 5–70 - NCT06619197Recruiting
Reflexology in Sickle Cell Disease Study
This study tests if foot reflexology, a gentle pressure technique on your feet, can help relieve pain from a sickle cell crisis while in the hospital. It is only for children and teens under 18.
BronAges Up to 18 years - NCT05894772Recruiting
Virtual portal program for youth waiting for chronic pain care
This study tests a virtual “stepped care” portal (a website/app) to help young people manage chronic pain while they’re waiting to start specialized care. It aims to see whether the portal improves support and outcomes during the wait time.
Halifax, Nova ScotiaAges 12–18 - NCT06856733Recruiting
Better opioid management for long-term non-cancer pain
This study tests a new way to help people who have been taking opioids for chronic pain (not caused by cancer) for at least 90 days. The goal is to improve treatment and reduce risks, such as developing tolerance or side effects, while still managing pain effectively.
Gävle, Gävleborg CountyAges 18–70 - NCT06857344Recruiting
Smart anesthesia system for painless endoscopy
This trial tests a computer system that controls anesthesia during routine painless gastrointestinal endoscopy. The system learns from past procedures to keep you safely asleep while the doctor examines your digestive tract.
Anxi, FujianAges 18–65 - NCT06847360Recruiting
Home-based ear stimulation for IBS pain
This trial tests a gentle, non-invasive ear stimulation device (taVNS) used at home to reduce pain from Irritable Bowel Syndrome (IBS). It might help if you have moderate pain most days.
New Haven, ConnecticutAges 18–29 - NCT06854913Enrolling by invitation
Shoulder Surgery and Sleep in Workers
This study looks at how shoulder surgery affects the sleep of people who do physical work. If you are having shoulder surgery, researchers want to see if your sleep changes after the operation.
Rome, ItalyAges 18 years+ - NCT06849466Enrolling by invitationPhase 4
Perioperative dexmedetomidine for chronic pain after lung surgery
This study tests whether giving the medication dexmedetomidine during and after surgery can prevent long-term pain after a thoracoscopic lung resection. If you are scheduled for this type of lung surgery, you may be able to join and help see if this drug makes recovery less painful over time.
Beijing, Beijing MunicipalityAges 18–80 - NCT06853431RecruitingPhase 4
Pre-surgery calming medicine for children ages 1 to 6
This study tests a combination of two medicines (dexmedetomidine and esketamine) given as a nasal spray to help children relax before surgery. The goal is to find the best dose that works well with the least side effects.
Wenzhou, ZhejiangAges 1–6
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,578 recruiting pain medicine studies from the U.S. registry right now, out of 6,493 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.