Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,749 recruiting studies in this area right now.
By phase
- Not applicable3,095
- Phase 4251
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University32
- Tanta University30
- Foundation University Islamabad27
- Mayo Clinic26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California158
- New York80
- Massachusetts68
- Florida65
- Texas52
- Ohio48
- Maryland42
- Minnesota41
- North Carolina38
- Illinois37
Recruiting studies3,748 total
- NCT06891690Recruiting
Brain stimulation for neurological and gynecological conditions
This trial tests whether a gentle brain stimulation technique called tDCS can help people with neurological problems (like weakness in arms or legs) or certain gynecological conditions (like endometriosis or painful periods) who are not using other treatments. It aims to see if tDCS can improve symptoms.
PoznanAges 18–90 - NCT06892743Recruiting
Comparing two pain blocks for kidney removal surgery
This trial compares two ultrasound-guided nerve blocks to see which one provides better pain relief for patients undergoing open kidney removal (nephrectomy). If you have kidney cancer and are scheduled for this surgery, you may be able to join.
Maadi, Cairo GovernorateAges 18–70 - NCT06893822Recruiting
Griffonia simplicifolia for pain in healthy volunteers
This trial tests if a natural supplement called Griffonia simplicifolia can change how your body processes pain. It is looking for healthy people to take part.
GrazAges 18–99 - NCT06894355Recruiting
Hydrotherapy for athletes with long-term back pain
This trial tests whether group hydrotherapy (water-based exercise) can help athletes with long-term low back pain. It may be a good fit if you are an active athlete, have had back pain for at least 3 months, and train frequently.
NetanyaAges 18 years+ - NCT06896994Recruiting
Study of esketamine plus pregabalin and duloxetine for shingles nerve pain
This trial tests whether adding esketamine to two standard pain medicines (pregabalin and duloxetine) can better treat nerve pain from shingles that persists for months. It's for people whose pain hasn't improved enough with pregabalin alone.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06903819RecruitingPhase 4
Ketamine for pain and mental health after orthopedic injury
This trial tests if ketamine can reduce pain, opioid use, and improve mental health in adults recovering from serious orthopedic injuries. It may help those with high injury severity scores.
Lubbock, TexasAges 18–65 - NCT06903962Recruiting
Mind-body program for chronic arm or hand pain
This trial tests whether a mind-body program can help people with long-term pain in their upper arm, forearm, or hand that is not caused by a clear physical injury. It focuses on retraining how your brain responds to pain triggers.
Boston, MassachusettsAges 18–60 - NCT06905340Recruiting
Pain-guided opioid use during surgery with regional anesthesia
This trial uses a special monitor (NOL index) to help doctors give just the right amount of pain medicine during surgery. It is for people having trauma or orthopedic surgery who are also getting regional anesthesia.
HamburgAges 18 years+ - NCT06906107Recruiting
Neck pain study: testing a personalized treatment approach
This study is testing a method to see which neck pain patients benefit most from manual therapy and exercise. You may be eligible if you have neck pain (with or without arm symptoms) and have not had recent whiplash, neck surgery, or certain other conditions.
Rochester, MinnesotaAges 18–70 - NCT06906211Recruiting
Ultrasound for chronic back pain in veterans
This trial tests if a gentle ultrasound treatment to a specific part of the brain can help veterans with chronic back pain. It aims to see if targeting the insula can reduce pain that spreads to other areas of the body.
Washington D.C., District of ColumbiaAges 21–75 - NCT06907810Recruiting
Study of fat molecules in long-term breast surgery pain
This trial looks at how certain natural fat molecules in your body might relate to long-term pain after breast cancer surgery. It could help doctors better understand and treat chronic pain in the future.
Brussels, Brussels CapitalAges 18 years+ - NCT06908486Recruiting
Cognitive training for pain in type 2 diabetes
This study tests a computer-based training program that may help people with type 2 diabetes and ongoing pain think about pain in a less negative way. You can do it from home on your computer over 3 months.
Camperdown, New South WalesAges 18 years+ - NCT06908564Recruiting
Game-based balance rehab after hip replacement
This study tests a fun, game-based balance exercise program for people recovering from their first hip replacement. It may help you improve your balance and recover faster.
Rome, ItalyAges 18–85 - NCT06909851Recruiting
Comparing nerve blocks for pain after knee arthroscopy
This study compares two different types of nerve blocks to see which provides better pain relief after arthroscopic knee surgery. You will receive one of the blocks after your surgery, and your pain levels will be tracked.
IstanbulAges 18–72 - NCT06910644Recruiting
Pain relief after mastectomy: dexmedetomidine vs lidocaine
This trial tests whether adding dexmedetomidine or lidocaine to anesthesia during mastectomy helps reduce long-term pain after surgery. It's for women with breast cancer undergoing mastectomy with lymph node removal.
CairoAges 18–75 - NCT06912334Recruiting
Vagus nerve stimulation for fibromyalgia pain relief
This trial tests a device that uses gentle electrical pulses on the ear to stimulate the vagus nerve, which may help reduce fibromyalgia pain and sensitivity. You will not know if you are receiving the real stimulation or a placebo to ensure unbiased results.
Athens, GreeceAges 18–79 - NCT06912386Recruiting
Ear device for period pain relief study
This trial tests a device that gently stimulates a nerve in your ear to see if it eases menstrual cramps. It may offer a drug-free option for managing period pain.
Chengdu, SichuanAges 18–45 - NCT06913270Recruiting
Virtual reality for pain during burn dressing changes
This study tests whether using virtual reality (VR) during dressing changes can help reduce pain and anxiety for adults with burn injuries. If you have moderate to severe pain during dressing changes, this approach might offer extra comfort without extra medication.
CairoAges 18–65 - NCT06913868Recruiting
Comparing two types of physical therapy for fibromyalgia pain
This study compares a standard physical therapy approach with one based on group consensus to see which works better for fibromyalgia pain. It may help find a more personalized treatment for your condition.
CairoAges 18–65 - NCT06914557RecruitingPhase 2
Scrambler therapy plus duloxetine for chemo nerve pain
This study tests whether adding a non-invasive device called Scrambler Therapy to the usual nerve pain medicine (duloxetine) can better relieve chemotherapy-induced nerve pain. It is for people with cancer who still have significant nerve pain despite taking duloxetine.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06914960Recruiting
Ultrasound-guided nerve radiofrequency for knee pain
This trial tests a treatment that uses radio waves to reduce pain signals from the nerves around the knee. It might help if you have long-lasting knee pain from osteoarthritis and find certain movements very painful.
Ankara, AnkaraAges 30–75 - NCT06915558Recruiting
Reducing inflammation in weight loss surgery
This trial tests a method to control inflammation during bariatric surgery. It may help patients recover better and have fewer complications.
Barcelona, BarcelonaAges 18–65 - NCT06915662RecruitingPhase 2
A nerve cap for pain after finger amputation
This trial tests a small nerve cap, called Tulavi Allay, placed on the end of a cut nerve during finger amputation surgery. The cap is meant to reduce pain and protect the nerve ending. It is for people who have lost one or more fingers in an accident.
Boston, MassachusettsAges 22 years+ - NCT06917300Recruiting
Virtual reality to reduce pain and anxiety before spine surgery
This trial tests if using virtual reality before surgery can help reduce pain and anxiety in people having elective spine surgery. If you're scheduled for spine surgery and speak Polish, you may be able to participate.
Lodz, Łódź VoivodeshipAges 25–70
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,749 recruiting pain medicine studies from the U.S. registry right now, out of 6,811 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.