Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,578 recruiting studies in this area right now.
By phase
- Not applicable2,954
- Phase 4240
- Phase 2129
- Phase 3103
- Phase 193
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University59
- Beijing Tiantan Hospital34
- Tanta University33
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University21
Where studies are running
- California151
- New York79
- Massachusetts65
- Florida64
- Texas50
- North Carolina41
- Illinois40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,578 total
- NCT06892743Recruiting
Comparing two pain blocks for kidney removal surgery
This trial compares two ultrasound-guided nerve blocks to see which one provides better pain relief for patients undergoing open kidney removal (nephrectomy). If you have kidney cancer and are scheduled for this surgery, you may be able to join.
Maadi, Cairo GovernorateAges 18–70 - NCT06895564Recruiting
Proton radiation for hard-to-treat spine tumors
This trial tests a special type of proton radiation for people whose spine cancer has spread from another part of the body and cannot be treated effectively with standard X-ray radiation. The goal is to see if proton radiation can safely deliver a high dose of radiation to the tumor.
Baltimore, MarylandAges 18 years+ - NCT06897007Recruiting
Ciprofol dosage in patients with insomnia under anesthesia
This study looks at how the sedative drug ciprofol works differently in people with insomnia compared to those who sleep well. It aims to help doctors give the right dose for your type of surgery.
Beijing, Beijing MunicipalityAges 18–64 - NCT06892977Enrolling by invitation
Stress and pain interaction study
This study looks at how stress affects pain sensitivity and how the brain processes pain. It uses MRI scans to see brain activity while participants experience mild pain, which may help improve pain treatments.
GhentAges 18–55 - NCT06891625Recruiting
Movement performance in people with chronic back pain
This study looks at how people with long-term back pain move. It aims to understand movement patterns in chronic back pain, which could help design better treatments.
HuddingeAges 18 years+ - NCT06640231Recruiting
Sealer activation for reducing pain after root canal
This trial tests if activating a sealer inside a tooth after root canal can reduce pain in the days after treatment. It may help people with a painful lower molar that still has a live nerve.
Cairo, New CairoAges 18–40 - NCT06879860Enrolling by invitation
Comparing stitch vs no stitch for groin hernia repair
This study compares two ways to fix a mesh during groin hernia surgery: 3D patch with one stitch versus no stitches at all. It aims to see which method leads to less long-term pain and fewer hernias coming back. If you have a first-time, moderately large groin hernia, you may qualify.
Nanchong, SichuanAges 18–80 - NCT06886633Enrolling by invitation
Breathing exercise and cold pack for wound cleaning pain
This study tests whether a simple breathing exercise and a cold pack can help reduce pain and anxiety while a wound is being cleaned (called sharp debridement). If you are having a wound cleaned and feel anxious about it, this may be a way to feel more comfortable.
Gaziantep, GaziantepAges Any age - NCT06880484Enrolling by invitation
Far-infrared socks for diabetic nerve pain
This study tests whether special far-infrared socks can help relieve nerve pain and improve nerve function in people with diabetic nerve damage. If you have mild to moderate nerve pain and live in Kayseri, you may be able to join.
Talas, KayseriAges 19 years+ - NCT06882733Recruiting
TENS therapy for leg blood flow in healthy adults
This trial tests whether a gentle electrical stimulation (TENS) applied to the leg muscles and nerve clusters can improve blood flow behind the knee. It looks at immediate effects and might help understand better ways to support circulation.
Kaohsiung City, TaiwanAges 18 years+ - NCT06886815Recruiting
Nerve block for Achilles tendon repair surgery
This trial tests if a nerve block in the back of the knee improves pain control after surgery to repair a torn Achilles tendon. It may help you recover more comfortably as a day surgery patient.
Toronto, OntarioAges 18–65 - NCT06889389Recruiting
Education and exercise for neck pain relief
This study tests if combining education with exercise can reduce pain and improve function for people with non-specific neck pain (pain not caused by a specific injury or disease). Participants will learn about their condition and do guided exercises.
Elche, AlicanteAges 18–65 - NCT06888895Recruiting
Stretching for tight hamstrings in low back pain
This study compares two types of hamstring stretching techniques (passive vs. active-passive) to see which one improves flexibility more in people with chronic low back pain. It may help you if your hamstrings feel tight and your pain has lasted at least 3 months.
Cébazat, FranceAges 18–65 - NCT06880497Recruiting
Comparing knee sounds after two types of knee replacement
This study compares how much noise the knee makes (and how it feels to the patient) after two different kinds of total knee replacement surgery. It aims to help patients know what to expect after surgery.
AuxerreAges 18 years+ - NCT06884332Recruiting
Spinal radiation for bone pain from cancer
This trial tests a specific type of radiation therapy for bone pain caused by cancer that has spread to the spine. It aims to improve pain relief and quality of life.
Brest, BrestAges 18 years+ - NCT06129890Recruiting
Brain stimulation for nerve pain and depression
This trial tests whether a noninvasive brain stimulation technique (rTMS) can help people with long-term nerve pain who also have depression. It aims to see if this treatment can reduce pain and improve mood.
Saint-EtienneAges 18–85 - NCT06726239Recruiting
Relaxation exercises before getting up after heart bypass
This study tests whether doing gentle relaxation exercises before getting out of bed can help reduce pain, anxiety, and stress after heart bypass surgery. It may make recovery more comfortable.
Istanbul, IstanbulAges 35–65 - NCT06848218Recruiting
Music therapy during non-invasive breathing support for children
This study tests if music therapy can help children who are receiving breathing support (non-invasive ventilation) in the pediatric intensive care unit. It aims to reduce stress and discomfort during treatment.
MontpellierAges Up to 17 years - NCT06873386Recruiting
Electrical stimulation for glute weakness after back pain
This study tests a non-surgical treatment using a small needle to send gentle electrical pulses to the glute (buttock) muscles. It is for people who have had low back pain in the past and now have weak glute muscles.
Sabadell, BarcelonaAges 18 years+ - NCT06873113Recruiting
Blood flow therapy for shoulder pain
This study tests a new type of physical therapy that uses a blood pressure cuff to gently limit blood flow to the arm during exercise. It may help people with shoulder pain from subacromial impingement (a common cause of shoulder pain) regain function.
Gainesville, FloridaAges 18–50 - NCT06869967Recruiting
Pain Control After Ear Surgery (Mastoidectomy)
This study tests a pain-blocking injection to reduce pain after a specific type of ear surgery (mastoidectomy). It may help you feel less pain after your operation.
IstanbulAges 18 years+ - NCT06870162Recruiting
Pain disengagement training: a writing study for chronic pain
This study tests a writing-based program to help people with chronic pain learn to disengage from pain-related thoughts. It aims to reduce pain catastrophizing and improve daily function.
Boston, MassachusettsAges 18 years+ - NCT06874452RecruitingPhase 4
Anti-anxiety pill for second cataract surgery
This study tests if giving the anti-anxiety pill alprazolam (XANAX) before your second cataract surgery helps reduce anxiety and improve satisfaction with the procedure.
TaipeiAges 18–80 - NCT06878014RecruitingPhase 4
Morphine for pain relief after hip replacement surgery
This trial tests different doses of morphine given during spinal anesthesia to find the safest and most effective way to control pain after hip replacement surgery. If you are having a total hip replacement, you may be able to join.
Sosnowiec, Silesian VoivodeshipAges 18–75
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,578 recruiting pain medicine studies from the U.S. registry right now, out of 6,493 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.