Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,749 recruiting studies in this area right now.
By phase
- Not applicable3,095
- Phase 4251
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University32
- Tanta University30
- Foundation University Islamabad27
- Mayo Clinic26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California158
- New York80
- Massachusetts68
- Florida65
- Texas52
- Ohio48
- Maryland42
- Minnesota41
- North Carolina38
- Illinois37
Recruiting studies3,748 total
- NCT06917651RecruitingPhase 3
Study of a new pain medicine for arm or leg injuries in the ER
This trial tests a fast-acting pain pill (sufentanil) placed under the tongue for people with moderate to severe pain from a single arm or leg injury. It aims to see if it works well in the emergency room.
FranceAges 18 years+ - NCT06918470Recruiting
Do noise cancelling headphones help with pain after surgery?
This study tests whether wearing noise cancelling headphones after gynecologic laparoscopy can reduce pain. If you are a woman having this surgery, you may be able to participate.
Wuhan, HubeiAges 18–55 - NCT06918535Recruiting
Relaxation vs muscle technique for neck pain in computer users
This study compares two therapies for neck pain in people who use computers for long hours. The goal is to see which method better reduces pain and stiffness from tight neck muscles.
Karachi, SindhAges 20–45 - NCT06920459Recruiting
Zimmer Biomet Shoulder Replacement Study
This study is testing a shoulder replacement system made by Zimmer Biomet to see how well it works for people with severe shoulder problems, like arthritis or fractures. If you qualify, you would receive the implant and be asked to come back for regular checkups to track your recovery.
PforzheimAges 20 years+ - NCT06921174RecruitingPhase 2
Pelvic pain relief after childbirth: massage vs device
This study compares two non-surgical therapies for postpartum perineal pain: traditional perineal massage versus a small silicone device used inside the vagina. If you have persistent pain after a vaginal birth and have not tried other treatments yet, this trial may help you find relief.
Murcia, MurciaAges 18 years+ - NCT06921694Recruiting
Exercise program for lower back pain
This trial tests a combined exercise program with stretching, strength, and aerobic exercises to help relieve chronic lower back pain. It looks at whether specific movements can reduce pain and improve daily function.
Nottingham, NottsAges 18–45 - NCT06924671Recruiting
GLA:D Back Canada program for chronic low back pain
This study tests a program called GLA:D Back Canada, which is designed to help people with long-lasting low back pain. It focuses on exercises and education to improve your back health and daily function.
Edmonton, AlbertaAges 18 years+ - NCT06927531Recruiting
Pilates ball and massage for reducing labor pain
This study tests whether using a Pilates ball and sacral massage during labor can help reduce pain, shorten delivery time, and improve your birth experience. It is for first-time mothers with a full-term, low-risk pregnancy.
Şehitkamil, Gazi̇antepAges 18–35 - NCT06927804Recruiting
Virtual reality for comfort during port placement
This trial tests whether using virtual reality (a headset showing calming images) can help patients feel more comfortable and less distressed while having a small device (a port) inserted under the skin for chemotherapy or other cancer treatments.
Ostrava, Moravian-Silesian RegionAges 18 years+ - NCT06928597Recruiting
GPR therapy for chronic low back pain
This study tests a physical therapy method called Global Postural Re-education (GPR) for people with long-term low back pain that is not caused by a specific disease. It aims to see if GPR can help reduce pain and improve function.
Salvador, Estado de BahiaAges 18–55 - NCT06928740Recruiting
Music app vs. gas for anxiety during back injection
This trial tests whether listening to a digital music app can reduce anxiety as well as a standard gas (laughing gas) does in people getting a CT-guided back injection for low back pain.
NîmesAges 18 years+ - NCT06929598Recruiting
Shiatsu for chronic pain in children and teens
This study tests whether Shiatsu—a gentle, hands-on therapy—can help reduce chronic, non-inflammatory pain in children and adolescents. If you or your child have had long-term pain without inflammation and are already being seen at a specific pain clinic in Tel Aviv, this trial might be a good fit.
Tel Aviv, Tel AvivAges 10–18 - NCT06930703RecruitingPhase 1/Phase 2
CBD for sickle cell pain
This trial tests if cannabidiol (CBD) can help reduce pain interference in adults with sickle cell disease. You will take CBD daily for 4 weeks and report your pain levels.
Manhattan, New YorkAges 18 years+ - NCT06932406Recruiting
Personality and self-help for jaw pain
This study tests whether a self-management program for jaw and face pain works differently in people with different personalities. You will learn techniques to manage your pain at home.
Valencia, ValenciaAges 18–65 - NCT06932432Recruiting
Psychological support study for young adults with chronic pain
This study tests a new approach to psychological support for young adults (ages 18-25) with chronic pain that started in childhood. It uses daily surveys on your smartphone to adjust support based on what you need day to day.
Seattle, WashingtonAges 18–25 - NCT06932835Recruiting
Pain relief after gallbladder surgery: TAP vs. M-TAPA block
This trial compares two types of nerve blocks (TAP and M-TAPA) to see which one provides better pain relief after planned laparoscopic gallbladder removal. Both blocks are injections of numbing medicine around your abdomen to help control pain after surgery.
Yenimahalle, AnkaraAges 18–65 - NCT06932887RecruitingPhase 3
Walking to reduce arthritis pain
This study tests a walking program to help reduce pain from osteoarthritis. It is designed for people with arthritis in their hips, knees, feet, or spine.
Salt Lake City, UtahAges 45 years+ - NCT06933303Recruiting
Distraction for pain in children with burns
This trial tests if using a kaleidoscope can help distract children aged 7-12 from pain during burn dressing changes, in a setting where pain medicine is not usually given. The goal is to see if this simple tool can reduce pain without extra medication.
Empangeni, KwaZulu-NatalAges 7–12 - NCT06933498Recruiting
Nerve block for less pain meds in back surgery
This trial tests whether a nerve block (called an erector spinae plane block) given before surgery can reduce the amount of pain medicine and anesthesia needed during lumbar disc surgery. It may help people have less pain and fewer side effects.
AnkaraAges 18–75 - NCT06933680Recruiting
Nerve block for jaw surgery pain relief
This trial tests whether a nerve block behind the nose can reduce pain after double-jaw surgery. It may help patients who are having this surgery and want better pain control.
Istanbul, FatihAges 18–45 - NCT06934421Recruiting
A new approach for knee radiofrequency ablation
This trial tests a revised method for radiofrequency ablation to treat chronic knee pain from severe osteoarthritis (KL grade III or IV). It aims to see if the procedure can help patients who haven't gotten relief from standard treatments like physical therapy, painkillers, and steroid injections.
FaroAges 18 years+ - NCT06935708RecruitingPhase 4
Comparing morphine to epidural pain relief for colon surgery
This study compares two pain relief methods—morphine given through a spinal needle versus pain medicine delivered through a tiny tube in the back—after colorectal cancer surgery. It aims to see which approach works better for controlling pain.
SplitAges 18–80 - NCT06936995Recruiting
Comparing pain relief methods for ACL surgery recovery
This trial tests two ways to manage pain after ACL reconstruction: a combination of medications (multimodal analgesia) versus a nerve block in the thigh (femoral block). The goal is to see which approach provides better pain control and recovery.
AnkaraAges 18–65 - NCT06937853Recruiting
Genes and painkiller response for tooth pain
This trial tests whether your genes affect how well a common painkiller (NSAID) works for tooth pain after a root canal procedure. It may help find the best pain relief for you.
Erzurum, ErzurumAges 18–65
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,749 recruiting pain medicine studies from the U.S. registry right now, out of 6,811 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.