Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,578 recruiting studies in this area right now.
By phase
- Not applicable2,954
- Phase 4240
- Phase 2129
- Phase 3103
- Phase 193
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University59
- Beijing Tiantan Hospital34
- Tanta University33
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University21
Where studies are running
- California151
- New York79
- Massachusetts65
- Florida64
- Texas50
- North Carolina41
- Illinois40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,578 total
- NCT06850740Enrolling by invitation
Spinal ondansetron for hernia repair pain relief
This trial tests if adding ondansetron to standard spinal anesthesia during hernia surgery can provide better pain relief. It may help you need less pain medicine after the procedure.
IsmailiaAges 18–60 - NCT06851533Recruiting
Pain relief methods for lumbar microsurgery recovery
This trial compares two different types of nerve blocks to see which one reduces the need for strong pain medicine after lumbar microsurgery. It may help patients have better pain control and fewer side effects from opioids.
IstanbulAges 18–80 - NCT06854913Enrolling by invitation
Shoulder Surgery and Sleep in Workers
This study looks at how shoulder surgery affects the sleep of people who do physical work. If you are having shoulder surgery, researchers want to see if your sleep changes after the operation.
Rome, ItalyAges 18 years+ - NCT06854302Enrolling by invitation
Studying chest pain after successful heart stent procedure
This study looks at why some people still have chest pain (angina) even after a successful heart stent procedure (PCI). You will have a heart MRI (stress CMR) before the stent procedure, and doctors will measure blood flow in your heart arteries during and after the procedure.
Cambridge, CambridgeshireAges 18 years+ - NCT06854991Enrolling by invitation
Virtual reality for managing pain in healthy kids
This study tests if virtual reality can help distract children and teenagers from the feeling of pain. It could show that VR is a helpful tool for managing pain without medicine.
Columbus, OhioAges 6–17 - NCT06848023Enrolling by invitation
Shoulder replacement vs tendon repair in older adults
This study compares how well two different shoulder surgeries—reverse total shoulder replacement and rotator cuff repair—work for people 60 and older, at least one year after the operation. If you meet the age and surgery requirements, your results could help doctors decide which procedure is better for older adults.
Germantown, TennesseeAges 60–95 - NCT06847360Recruiting
Home-based ear stimulation for IBS pain
This trial tests a gentle, non-invasive ear stimulation device (taVNS) used at home to reduce pain from Irritable Bowel Syndrome (IBS). It might help if you have moderate pain most days.
New Haven, ConnecticutAges 18–29 - NCT06853431RecruitingPhase 4
Pre-surgery calming medicine for children ages 1 to 6
This study tests a combination of two medicines (dexmedetomidine and esketamine) given as a nasal spray to help children relax before surgery. The goal is to find the best dose that works well with the least side effects.
Wenzhou, ZhejiangAges 1–6 - NCT06848166Recruiting
Artery blockage treatment for chronic migraine
This trial tests a procedure that blocks a blood vessel in the head to see if it reduces chronic migraine pain. It might help people who have not found relief from other treatments.
Bishkek, BishkekAges 21–70 - NCT05830279Recruiting
Personalized drug choices to better manage cancer treatment side effects
This trial tests a personalized approach to selecting drugs during cancer treatment. The goal is to improve how well your prescribed medicines work for symptoms and side effects while keeping you safe.
London, OntarioAges 18 years+ - NCT05382962Recruiting
Using an app to help teens cope with post-surgery pain
This trial tests whether a phone app (iCanCope) can help teens better manage pain after surgery for scoliosis or certain chest conditions (pectus carinatum/excavatum). If you’re having one of these surgeries soon, the app may help with coping and day-to-day comfort after the operation.
Boston, MassachusettsAges 12–18 - NCT06841276Recruiting
Digital tool for chronic pain relief study
This study tests a smartphone device called QoLibri that helps manage long-term pain. You use it at home for a few weeks to see if it reduces pain and improves daily life.
NaillouxAges 18 years+ - NCT06840262Recruiting
Nerve surgery for pain after cancer amputation
This study tests two surgical techniques—target muscle re-innervation and regenerative peripheral nerve interfaces—alone or together, to help reduce pain felt in the remaining limb or the missing limb (phantom pain) after amputation for cancer. The goal is to find the best way to manage pain and improve quality of life.
Houston, TexasAges 18 years+ - NCT06837909Recruiting
Nerve block vs wound injection for breathing after kidney donation
This study compares two ways to manage pain after laparoscopic kidney donation surgery: a nerve block (injection near the belly muscles) versus injecting numbing medicine directly into the surgical wound. The goal is to see which method helps you breathe better after surgery.
Petah TikvaAges 18 years+ - NCT06844838Recruiting
Faster, Safer Awakening After Brain Surgery
This study tests a new way of giving anesthesia during elective brain surgery to help you wake up faster and safer. It uses a special monitor to guide the amount of medication so you can recover more quickly.
MilanAges 18 years+ - NCT06838039Recruiting
A second nerve block for less pain after lung surgery
This study tests whether adding a second nerve block (serratus anterior block) within 24 hours after a lung surgery (VATS) can reduce pain better than the standard nerve block alone. It aims to help patients control pain with fewer strong painkillers.
HebronAges 18–70 - NCT06837857RecruitingPhase 2
Opioid pain relief study for older adults with chronic pain
This study tests whether a carefully managed prescription opioid can safely help older adults with long-term pain that hasn't been relieved by other pain medicines. The goal is to see if it improves pain without harming memory or brain health.
Rochester, MinnesotaAges 65 years+ - NCT04085406Recruiting
Deep brain stimulation for hard-to-treat low back pain
This trial studies deep brain stimulation (DBS) to reduce severe low back pain that hasn’t improved after many standard treatments and procedures. It may help people whose pain is long-lasting and not fixable with another surgery.
Los Angeles, CaliforniaAges 40–75 - NCT05427058Recruiting
Nerve blocks to treat hard-to-control cancer pelvic pain
This trial tests two types of pain-relieving nerve blocks for people with severe cancer pain in the pelvis or perineum that has not improved enough with standard stepwise pain medicines. It may help reduce pain and lessen bothersome side effects from pain pills.
Malang, East JavaAges 18 years+ - NCT06615349Recruiting
Digital monitoring for palliative care patients
This trial tests whether using a smartphone app to track your symptoms and health data can improve care and quality of life for people with serious illnesses who are receiving palliative care.
Zurich, Canton of ZurichAges 18 years+ - NCT06827262Recruiting
A procedure for vertebrogenic back pain relief
This trial tests a minimally invasive procedure that uses a special device to target and treat nerve-related back pain coming from the vertebrae (the bones in your spine). It may offer lasting relief without more major surgery.
Flagstaff, ArizonaAges 18 years+ - NCT01838148Recruiting
Tests heart signals to detect reduced blood flow during exercise
This study looks at specific blood-flow and heart-rhythm signals during an exercise test to find signs of reduced blood flow to the heart. It may help doctors spot heart problems sooner and decide who needs more care.
BaselAges 18 years+ - NCT06828159Recruiting
Can wild blueberries improve joint health?
This study tests whether eating wild blueberries can improve joint health in people with arthritis. You would eat blueberries or a placebo daily for several weeks to see if they help with pain and stiffness.
Oklahoma City, OklahomaAges 40–75 - NCT06834724Recruiting
CPAP for sleep apnea and chronic pain
This study looks at whether CPAP treatment improves pain and daily life in people who have both sleep apnea and chronic pain. It tests if starting CPAP for the first time can help these symptoms.
BrusselsAges 18 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,578 recruiting pain medicine studies from the U.S. registry right now, out of 6,493 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.