Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,749 recruiting studies in this area right now.
By phase
- Not applicable3,095
- Phase 4251
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University32
- Tanta University30
- Foundation University Islamabad27
- Mayo Clinic26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California158
- New York80
- Massachusetts68
- Florida65
- Texas52
- Ohio48
- Maryland42
- Minnesota41
- North Carolina38
- Illinois37
Recruiting studies3,748 total
- NCT06966245RecruitingPhase 3
Oil for severe breast pain in premenopausal women
This trial tests whether an oil applied to the breast can reduce severe breast pain in premenopausal women. If you have had breast pain for at least six months and it is not caused by the chest wall, this study may be a good fit.
GuangzhouAges 18–60 - NCT06968065Recruiting
Pain control after minimally invasive heart surgery: nerve block vs wound injection
This study compares two ways to manage pain after minimally invasive heart surgery: a nerve block injection near the ribs or injecting numbing medicine into the wound. The goal is to find which method works better for reducing pain and your need for painkillers.
IstanbulAges 18–75 - NCT06968689Recruiting
Brain activity study for experimental and chronic pain
This study uses MRI and EEG to look at brain connections involved in pain. It may help us understand how the brain processes pain and could lead to better treatments.
Houston, TexasAges 18–60 - NCT06968871Recruiting
Gentler Pap test for cervical cancer screening
This trial tests a new, gentler Pap test to see if it makes screening more comfortable and easier for women. If you're a woman 25 or older and not pregnant or on your period, you might be able to join.
DouliuAges 25 years+ - NCT06969105Recruiting
Music for comfort during labor and delivery
This study tests whether listening to music during labor can help reduce pain and anxiety. Researchers will compare outcomes for laboring women who listen to music versus those who do not.
Boston, MassachusettsAges 18 years+ - NCT06969417Recruiting
Comparing two medications for shingles nerve pain
This trial compares two medications (pregabalin and lacosamide) to find out which works better for relieving nerve pain that continues after shingles. If you have this persistent pain and are not already on painkillers, you may be able to join.
Kharan, Punjab ProvinceAges 18–50 - NCT06969456Recruiting
Exercise and nerve stimulation for chronic back pain
This study looks at whether combining exercise with a type of nerve stimulation (called neuromodulation) can help people with long-term spinal pain that has nerve involvement. It may be an option if you have had pain for at least 6 months and it is severe.
Valencia, ValenciaAges 18–70 - NCT06970028Recruiting
Sensation study in ADPKD patients
This study looks at how people with ADPKD (a kidney condition that causes cysts) sense touch and temperature on their skin. It will compare their results with those of healthy volunteers to better understand the condition and help future treatments.
LeuvenAges 12 years+ - NCT06971016Recruiting
Mobilization and balance exercises for knee osteoarthritis
This study tests whether a special hands-on technique (Mulligan mobilization) combined with balance exercises can help people with knee osteoarthritis feel better and move easier. It's for people with mild to moderate knee OA who can walk without help.
Karachi, SindhAges 40 years+ - NCT06973837Recruiting
Brain study on chronic back pain and insomnia
This study looks at how the brain works in people with chronic low back pain and/or chronic insomnia. It compares these groups to healthy volunteers using MRI and pain tests.
LeuvenAges 18–60 - NCT06974552Recruiting
Support surfaces during robotic pelvic surgery
This trial compares different support surfaces for patients having robotic surgery in the lower pelvic area while in a steep head-down position. It aims to see which surface helps prevent skin injuries.
Istanbul, AtaşehirAges Any age - NCT06974773Recruiting
Electrical stimulation for endometriosis pain flare-ups
This trial tests a remote electrical stimulation device to reduce endometriosis pain flare-ups. It may help if you have regular or irregular periods with pelvic pain and own a smartphone.
San Francisco, CaliforniaAges 22–45 - NCT06975761RecruitingPhase 2
Comparing two root canal fillings for pain
This study compares two types of root canal filling materials to see which one is better at reducing pain after the procedure. If you have a painful lower back tooth that needs a root canal and you are a healthy man aged 20-40, you may be able to join.
Rawalpindi, Punjab ProvinceAges 20–40 - NCT06976320Recruiting
Nerve block for gallbladder surgery pain
This trial tests a nerve block injection in the abdominal wall to reduce pain after gallbladder removal surgery. It may help patients recover more comfortably.
IstanbulAges 18–80 - NCT06976632Recruiting
Helping ease vaccine pain for pregnant women
This study tests two simple methods (a skin tap and a cold spray) to see if they can reduce pain and stress during a tetanus vaccine shot in pregnant women.
Manisa, Uncubozköy/YunusemreAges 18–42 - NCT06977100Recruiting
Journaling study for jaw pain with other chronic pain conditions
This study tests if a journaling program can help people with jaw pain and at least one other chronic pain condition (like fibromyalgia, IBS, or migraines). You will write about your thoughts and feelings to see if it reduces pain and improves well-being.
Gainesville, FloridaAges 18–80 - NCT06977321Recruiting
Taping vs mud therapy for carpal tunnel syndrome
This study tests whether taping therapy (kinesiotaping) or a mud pack treatment (peloidotherapy) can help reduce pain and improve function for people with mild to moderate carpal tunnel syndrome. It may be an option if you want non-surgical, drug-free relief.
KonyaAges 1.5 years–5.4 years - NCT06978166Recruiting
Digital therapy for chronic pain and mood
This study tests a smartphone app that gives you personalized tips and exercises to help manage chronic pain along with depression or anxiety. It is designed for adults ages 45 and older and aims to see if these digital check-ins can improve how you feel day to day.
St Louis, MissouriAges 45 years+ - NCT06978127Recruiting
Tech help for dialysis patients to feel better
This study tests a program that uses technology to help people on dialysis feel better and take a more active role in their care. It may help you if you are on dialysis and want extra support.
Albuquerque, New MexicoAges 18 years+ - NCT06978179Recruiting
Nerve blocks for pain after lower belly surgery
This trial compares two types of nerve blocks (QL block vs TAP block) to see which one provides better pain relief after lower abdominal surgery. If you are having this surgery, you may be able to join and receive one of these blocks to help manage your pain.
SohagAges 18–65 - NCT06978816Recruiting
Ear pressure points plus pain meds for kidney stone relief
This study tests whether pressing specific points on the ear, along with pain medicine, can relieve kidney stone pain faster than pain medicine alone. It's designed for people with confirmed kidney stones and moderate to severe pain who haven't taken pain relievers recently.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06980090Recruiting
How doctors' expectations affect their emotions
This study looks at how expecting to feel pain can change how doctors react emotionally. It uses brain scans (MRI) and mild electrical stimulation (tTIS) to understand these effects.
Hanover, New HampshireAges 18–55 - NCT06981312Recruiting
Internet therapy for teens with chronic pain
This study tests two online treatments for teenagers with chronic pain: Acceptance and Commitment Therapy (ACT) and pain education. It aims to see if these programs help reduce pain and improve daily life, and parents join a separate support program.
VallentunaAges 13–19 - NCT06982625Recruiting
Numbing injection after hip replacement for pain relief
This trial tests whether an injection of numbing medicine near the hip can help control pain after a hip replacement surgery. It may be an option for people who have significant pain after their operation.
ParisAges 18 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,749 recruiting pain medicine studies from the U.S. registry right now, out of 6,811 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.