Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,578 recruiting studies in this area right now.
By phase
- Not applicable2,954
- Phase 4240
- Phase 2129
- Phase 3103
- Phase 193
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University59
- Beijing Tiantan Hospital34
- Tanta University33
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University21
Where studies are running
- California151
- New York79
- Massachusetts65
- Florida64
- Texas50
- North Carolina41
- Illinois40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,578 total
- NCT06833372Recruiting
Shock wave therapy for knee arthritis
This trial tests if shock wave treatment can reduce knee pain from osteoarthritis. It may help people with moderate knee arthritis who haven't had recent physical therapy or joint injections.
BariAges 45–80 - NCT06830655Enrolling by invitation
Climbing performance and body factors study
This study looks at how mobility, balance, and fatigue affect climbing performance. If you are a healthy climber, you may help researchers understand what makes a better climber.
Gdansk, GdańskAges 15–45 - NCT06828159Recruiting
Can wild blueberries improve joint health?
This study tests whether eating wild blueberries can improve joint health in people with arthritis. You would eat blueberries or a placebo daily for several weeks to see if they help with pain and stiffness.
Oklahoma City, OklahomaAges 40–75 - NCT06834685Recruiting
Laser therapy for nerve pain after chemotherapy
This study tests a special laser treatment (photobiomodulation) to reduce nerve pain caused by chemotherapy in cancer patients. If you have had nerve pain for at least 3 months after chemo and can attend twice-weekly sessions, this may help ease your pain.
Mougins, Alpes MaritimesAges 18 years+ - NCT06827730Recruiting
Ultrasound for chest or belly pain in the ER
This study uses a quick bedside ultrasound (called PoCUS) to help doctors diagnose chest or belly pain in the emergency room. If you join, you'll get this ultrasound early in your visit to see if it helps find the cause of your pain faster and more accurately.
BrusselsAges 18 years+ - NCT06835582Enrolling by invitation
Checking Methadone and Its Breakdown Levels
This study is checking the levels of methadone and its breakdown products in your blood. It helps make sure the medication is working safely for conditions like opioid use disorder or chronic pain.
Lemon Grove, CaliforniaAges 18–70 - NCT06828185Recruiting
Comparing two surgery methods for testicular cancer
This trial compares two ways of doing surgery (radical orchiectomy) for testicular cancer. One method is the standard approach and the other spares a layer of muscle tissue. The study looks at patient experiences and recovery.
Loma Linda, CaliforniaAges 18 years+ - NCT06829030Enrolling by invitationPhase 1/Phase 2
Comparing two injections for low back pain relief
This trial compares two types of injections—one standard anti-inflammatory drug and one simple sugar water solution—to see which works better for treating low back pain in an emergency setting. If you are an adult between 18 and 55 with isolated low back pain, this study may help find a more effective pain treatment.
AksarayAges 18–55 - NCT06655675Recruiting
Blood flow changes after epidural pain relief in labor
This study looks at how a type of labor pain relief (combined spinal-epidural) affects blood flow in the mother and baby's main arteries. It may help doctors understand if this common pain relief method is safe for all labors.
Toronto, OntarioAges 18–50 - NCT06206148Recruiting
Comparing ways to record pain after surgery
This study compares different methods of recording pain after surgery to see which is easiest and most accurate. If you have surgery and can use a smartphone or a button, you may be able to help.
San Francisco, CaliforniaAges 18 years+ - NCT05378841Recruiting
Surgery to reduce pain in finger osteoarthritis
This trial tests whether surgical “nerve disconnection” (joint denervation) can reduce pain from osteoarthritis in a finger joint. It focuses on people who have ongoing finger pain despite usual treatments for at least 3 months.
ParisAges 18 years+ - NCT06821516Recruiting
Comparing two nerve blocks for hip replacement pain
This study compares two different nerve block techniques to manage pain after a total hip replacement. The goal is to find out which method provides better pain relief and recovery.
Istanbul, Türki̇yeAges 18 years+ - NCT06817330Recruiting
Music therapy after ECT for depression
This trial tests if listening to music after electroconvulsive therapy (ECT) helps reduce confusion or agitation. It may help people being treated for depression feel calmer after their procedure.
RotterdamAges 18 years+ - NCT06820190Recruiting
Numbing injection for pain after scoliosis fusion surgery
This trial is testing a new type of numbing injection near the spine to see how well it controls pain after scoliosis surgery. If you are having a posterior spinal fusion for idiopathic scoliosis, you may be able to join and receive the injection plus patient-controlled pain medicine.
Tanta, El-GharbiaAges 18 years+ - NCT06819696Recruiting
Comparing two ACL reconstruction surgery methods
This trial compares two ways of doing anterior cruciate ligament (ACL) reconstruction surgery: using a tourniquet to control bleeding, or using a special sheath that allows fluid to flow in and out. The goal is to see which method works better during surgery.
Reims, MarneAges 18 years+ - NCT06818396Recruiting
Pain relief for hip surgery: comparing two methods
This study compares two ways to manage pain during hip surgery: a nerve block in the groin area versus a spinal medication. The goal is to find which approach offers better pain control with fewer side effects.
CairoAges 21 years+ - NCT06823206Recruiting
Movement training for shoulder pain from rotator cuff issues
This trial tests whether learning movement techniques combined with sensorimotor training (exercises that improve how your brain controls your shoulder) can help reduce chronic shoulder pain caused by rotator cuff problems. It may be a good fit if you have had shoulder pain for over three months with changes seen on MRI or ultrasound.
Hong KongAges 50 years+ - NCT06823349RecruitingPhase 4
Pain relief study for normal labor
This trial compares a single injection of pain medicine into the spinal fluid to other methods during normal labor. It aims to see how well it works for women in active labor with a single, full-term baby in head-down position.
AswānAges Any age - NCT06822764Enrolling by invitation
Thinking about pain intensity
This study looks at how people think about and rate their own pain. You may be able to join if you have had muscle or bone pain for at least 3 months, in more than one area, and that pain varies in intensity.
Columbia, MissouriAges 18 years+ - NCT06818175Recruiting
Study of back muscle tissue and treatment for low back pain
This study looks at the tissue in your lower back using ultrasound and physical exams. It tests a treatment to see if it helps people with new or long-term low back pain, and also compares results to people without pain.
Blacksburg, VirginiaAges 18–50 - NCT06825390Recruiting
Ear stimulation and brain imaging for chronic low back pain
This study tests if a non-invasive ear stimulation technique can change brain activity linked to chronic low back pain. You would have a brain scan before and after the treatment to see how your brain responds.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT06817837Enrolling by invitation
Can hypnosis help adults with brain injury?
This study tests if hypnosis can help adults with stroke or traumatic brain injury who have symptoms like anxiety, trouble sleeping, pain, or behavior issues. Researchers want to see if it's a feasible and useful addition to usual care.
Tinlot, LiègeAges 18 years+ - NCT06821607Recruiting
Telerehab for chronic low back pain
This study tests if online rehabilitation therapy can help people with ongoing low back pain. You would connect with a specialist from home.
Baltimore, MarylandAges 18–64 - NCT06820528Recruiting
Thumb arthritis surgery: is in-clinic therapy needed?
This trial compares recovery after thumb joint surgery with or without in-clinic physical therapy. It aims to see if patients can recover just as well with home exercises alone, which could reduce travel and costs.
Columbia, MissouriAges 18 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,578 recruiting pain medicine studies from the U.S. registry right now, out of 6,493 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.