Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,749 recruiting studies in this area right now.
By phase
- Not applicable3,095
- Phase 4251
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University32
- Tanta University30
- Foundation University Islamabad27
- Mayo Clinic26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California158
- New York80
- Massachusetts68
- Florida65
- Texas52
- Ohio48
- Maryland42
- Minnesota41
- North Carolina38
- Illinois37
Recruiting studies3,748 total
- NCT06938568Recruiting
Personalized back training for low back pain
This study tests a personalized back exercise program for people with long-lasting low back pain that limits their daily activities. The goal is to see if it helps improve physical function and reduce pain.
Lucerne, Canton of LucerneAges 18–65 - NCT06939257Recruiting
Hormone therapy and pain in gender diverse adults
This study looks at how gender-affirming hormone therapy affects pain in gender diverse (GM) adults. It may help understand whether these hormones change how you feel pain.
Kansas City, KansasAges 18–50 - NCT06940986Recruiting
Holistic pain self-management for military health system patients
This trial tests a holistic pain self-management program for people with long-term muscle or bone pain. It aims to help you take control of your pain through education and support, without relying only on medications.
Fairbanks, AlaskaAges 18 years+ - NCT06941298Recruiting
Cannabis and depression study for teens and young adults
This study looks at how cannabis affects the brain and mood in teens and young adults. It compares people who use cannabis, people with depression who don't use cannabis, and healthy volunteers to understand links between cannabis use and mental health.
Miami, FloridaAges 14–20 - NCT06943898Recruiting
Core and Breathing Exercises for Chronic Low Back Pain
This study tests if core and breathing exercises can improve balance and body awareness in people with chronic low back pain. The exercises are gentle and focus on strengthening the muscles that support your spine.
Sivas, MerkezAges 18–65 - NCT06946290Recruiting
Nerve block for pain relief after heart surgery
This study tests a nerve block, called an intertransverse process block, to see if it helps people feel better and recover faster after heart surgery. The block is given during surgery to reduce pain.
Hong KongAges 18 years+ - NCT06946940RecruitingPhase 2
Cannabis oil for fibromyalgia pain
This trial tests whether cannabis oil can help people with fibromyalgia who still have pain despite trying other treatments. Participants will receive cannabis oil, and researchers will look for biological markers that predict who responds best.
HaifaAges 30 years+ - NCT06947122Recruiting
Mindfulness app for opioid use and chronic pain
This trial tests a mindfulness-based app (Mindful Journey) to help people with both opioid use disorder and chronic pain. You'll use the app daily for a short time to see if it reduces pain and supports your recovery.
Phoenix, ArizonaAges 18 years+ - NCT06948500Recruiting
Virtual reality exercise program for fibromyalgia pain
This study tests whether a virtual reality exercise program that changes how you see your own movements can help reduce pain and improve function in people with fibromyalgia. You would do the exercises at home using a headset, and researchers will check if this approach works better than standard exercise.
Valencia, Valencia-valènciaAges 18–80 - NCT06949826RecruitingPhase 4
Buprenorphine for pain after ankle fracture surgery
This trial tests if buprenorphine, a non-opioid pain medicine, works well for people who have not used opioids before. After ankle fracture surgery, you would get buprenorphine instead of stronger opioids to see if it controls pain just as well with fewer side effects.
St Louis, MissouriAges 18 years+ - NCT06955117Recruiting
McKenzie vs manual therapy for low back pain
This study compares two physical therapy methods to see which works better for low back pain that has lasted more than 4 weeks. It could help you find a more effective treatment without surgery or strong medication.
Malakand, KPKAges 35–45 - NCT06956664Recruiting
Exercise after steroid injection for herniated disc
This study tests whether adding a structured exercise program after a steroid injection for a herniated disc in the lower back helps reduce pain and improve function better than the injection alone. You may be eligible if you recently had the injection but still have significant pain.
ÇankırıAges 18–70 - NCT06957158Recruiting
How calcium levels affect pain after abdominal surgery
This study looks at whether calcium levels in your blood can affect how much pain you feel after abdominal surgery. It may help doctors manage pain better after surgery in the future.
Chongqing, Chongqing MunicipalityAges 18–70 - NCT06957743Recruiting
Meditation and hypnosis for older adults with chronic pain
This study tests whether mindfulness meditation or self-hypnosis can help older adults manage chronic pain. You'll attend training sessions and have brain scans (EEG and MRI) to see how these techniques affect pain.
Seattle, WashingtonAges 60 years+ - NCT06959004Recruiting
Does substance P trigger migraine attacks without aura?
This study tests whether a substance called substance P can cause migraine attacks in people who have migraine without aura. Results may help understand new ways to prevent or treat migraine.
Glostrup MunicipalityAges 18–65 - NCT06959056Recruiting
Cooling therapy for pain after double lung transplant
This test uses a special cooling treatment called cryo-analgesia to see if it helps reduce pain and speed up recovery after a double lung transplant. It is only for people with end-stage COPD getting a transplant at UZ Leuven.
Leuven, Vlaams-BrabantAges 18 years+ - NCT06959147RecruitingPhase 4
Study for nerve pain after shingles using radiofrequency and a numbing shot
This trial tests a two-step procedure for treating nerve pain after shingles (called postherpetic neuralgia). First, a special type of radiofrequency treatment is applied to block the pain signals. Then, a long-lasting numbing medicine is injected under the skin to help keep the pain away. It is for people aged 40 to 85 who have not gotten enough relief from standard medicines.
Zunyi, GuizhouAges 40–85 - NCT06960018Recruiting
Ennovate minimally invasive spinal screw placement study
This study tests a new, less invasive method for placing screws in the cervical spine (upper back and neck). It is designed for patients who need spinal stabilization after injury or degeneration.
AachenAges 18 years+ - NCT06960317Recruiting
Numbing injection for IUD placement pain
This study tests whether a numbing injection (lidocaine) in the cervix can reduce pain during IUD placement. It's for women who have never had a vaginal birth and are getting their first IUD.
La Jolla, CaliforniaAges 18–50 - NCT06961396Recruiting
Virtual reality for period pain relief
This trial tests if using virtual reality can help reduce pain during menstruation in young women with primary dysmenorrhea (painful periods not caused by another condition). It may offer a drug-free option for managing period discomfort.
IsmailiaAges 13–20 - NCT06962306RecruitingPhase 4
Pain relief study for children having cleft palate surgery
This trial tests different ways to manage pain after cleft palate repair in young children. The goal is to find which approach works best to lower pain and improve recovery.
Durham, North CarolinaAges 6 months–4 years - NCT06962475Recruiting
Custom foot orthotics for chronic forefoot pain
This trial tests if custom foot orthotics (shoe inserts) can reduce chronic pain under the ball of the foot. If you have had forefoot pain for at least 3 months and can walk without a cane or walker, you may be able to join.
Trois-Rivières, QuebecAges 18 years+ - NCT06963658Recruiting
Isometric Exercise and Pain Sensitivity in Chronic Low Back Pain
This study tests whether a simple, still (isometric) exercise can reduce how sensitive you are to pain. It is for adults with long-term low back pain who can safely do physical therapy exercises.
Bisha, 'Asir RegionAges 18 years+ - NCT06964243Recruiting
Brain stimulation for nerve pain relief
This trial tests if mild magnetic pulses to the brain area controlling movement can safely reduce nerve pain from damaged peripheral nerves.
Créteil, Île-de-France RegionAges 18–80
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,749 recruiting pain medicine studies from the U.S. registry right now, out of 6,811 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.