Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,749 recruiting studies in this area right now.
By phase
- Not applicable3,095
- Phase 4251
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University32
- Tanta University30
- Foundation University Islamabad27
- Mayo Clinic26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California158
- New York80
- Massachusetts68
- Florida65
- Texas52
- Ohio48
- Maryland42
- Minnesota41
- North Carolina38
- Illinois37
Recruiting studies3,748 total
- NCT07060495RecruitingPhase 3
RADA16 gel for pain after adult tonsillectomy
This trial tests a new gel (RADA16) placed on the tonsil area after surgery to see if it helps reduce pain and speed healing. It is for adults having a standard tonsillectomy.
Livingston, New JerseyAges 18 years+ - NCT07061847RecruitingPhase 2
Lidocaine infusion for severe chronic migraines
This trial tests if a lidocaine infusion into an artery in the head can reduce severe chronic daily headaches. It is for people who have tried multiple treatments without enough relief.
Great Neck, New YorkAges 18–75 - NCT07062497RecruitingPhase 2/Phase 3
Clonidine in nerve block for umbilical hernia repair
This trial tests if adding clonidine to a numbing injection (nerve block) improves pain control after outpatient umbilical hernia repair. It aims to reduce the need for pain medicines and enhance recovery.
Rio de Janeiro, Rio de JaneiroAges 18–65 - NCT07063147Recruiting
Heart ultrasound for stable chest pain management
This study uses a heart ultrasound (TTE) to help doctors better manage stable chest pain. If you have chest pain that may be from a blocked artery but haven't had a heart attack or heart procedures before, this trial could help improve your care.
TianjinAges 18 years+ - NCT07063394Recruiting
Virtual reality to reduce opioid use after heart or lung surgery
This trial tests if using virtual reality after heart or chest surgery can help reduce the amount of strong painkillers (opioids) patients need. It may offer a non-drug way to manage pain and speed up recovery.
São Paulo, São PauloAges 16–40 - NCT07064434Recruiting
Nerve block for safer blood pressure control during hip replacement
This trial tests a type of nerve block (sacral canal block) to help manage blood pressure during hip replacement surgery. It aims to see if it can safely lower blood pressure on purpose, which may reduce bleeding and improve recovery.
Yinchuan, NingxiaAges 45 years+ - NCT07067619Recruiting
Pain acceptance training for emotional and physical distress
This trial tests a training program to help people accept chronic pain and emotional distress. It looks at how thinking patterns might help or hinder progress.
HaifaAges 18–70 - NCT07069179Recruiting
Choose to Move replacement study for older adults
This study tests a program called Choose to Move Replacement Ready (CTM-RR) designed for older adults. It looks at how well activity coaches and healthcare referral partners can help people get active.
Vancouver, British ColumbiaAges 50 years+ - NCT07070401Recruiting
VR for kidney stone pain in the ER
This trial tests whether using a virtual reality headset can help reduce pain in people coming to the emergency room with kidney stone pain. If you have had kidney stones before and are in significant pain, this might be a way to feel better without relying only on medication.
Toms River, New JerseyAges 18 years+ - NCT07070986Recruiting
Skin stimulation for anxiety before heart surgery
This trial tests whether a gentle skin stimulation device can lower anxiety and improve heart rate balance in people waiting for heart surgery.
BronAges 18 years+ - NCT07071506Recruiting
New tools to track migraine prevention
This study tests new ways to monitor how well preventive migraine treatments are working. It is for people with chronic migraine who may be starting or already using preventive medications.
Aarhus C, DenmarkAges 18–65 - NCT07072091Recruiting
Whole-body vs shoulder physiotherapy for volleyball players
This trial compares two physiotherapy approaches for volleyball players: one focusing only on the shoulder, and another looking at the whole body. It aims to find which method helps prevent or reduce shoulder problems.
Trieste, TriesteAges 17–30 - NCT07072468RecruitingPhase 2
Test of a gel for nerve pain after chemotherapy
This study tests a new gel (VMD-3866) applied to the skin to treat moderate nerve pain, numbness, or tingling caused by previous chemotherapy. It aims to see if the gel can safely reduce pain for people whose symptoms have been stable for at least 8 weeks.
London, UKAges 18–80 - NCT07072702Recruiting
Online program to reduce unfairness feelings after work injury
This study tests an online program to help people who feel a strong sense of unfairness after a work-related back or neck injury. It aims to see if the program is helpful and practical for people early in their recovery.
Montreal, QuebecAges 25–65 - NCT07073027Recruiting
How digital media affects kids' healthcare experiences
This study looks at how using digital media (like videos or apps) before or during a hospital procedure affects kids' experiences. If you have a smartphone and a procedure coming up, you may be able to join.
Vancouver, British ColumbiaAges 5–23 - NCT07073209Recruiting
Nerve blocks for hip fracture pain relief
This trial compares two types of nerve blocks (one near the hip bone, one in the thigh) to see which provides better pain relief for people with a hip fracture. If you qualify, you would receive one of these blocks as part of your standard care.
Manhattan, New YorkAges 18 years+ - NCT07073846RecruitingPhase 4
Lidocaine and dexmedetomidine for pain after weight-loss surgery
This study tests whether adding two medicines (lidocaine and dexmedetomidine) to your anesthesia during weight-loss surgery can reduce pain, swelling, and stress on the body. It might help you have a smoother recovery.
Mexico City, Mexico CityAges 18–60 - NCT07075055Recruiting
New bioceramic medication for infected front teeth
This trial tests a new bioceramic medication placed inside the root canal of infected front teeth to see if it improves healing. It is for adults with mature front teeth and an infection around the root tip, who are otherwise healthy.
MinyaAges 18–40 - NCT07078682Recruiting
Study of two supplements for uterine fibroid symptoms
This trial tests two supplements (Elix Cycle Balance and Elix Daily Harmony) to see if they can reduce pain and other symptoms caused by uterine fibroids. It is for women who have regular but painful periods and want to try a non-medicine option.
Las Vegas, NevadaAges 20–45 - NCT07080788Recruiting
Native American Pain Risk Study: Smoking Cessation
This study looks at how quitting smoking affects pain in Native American adults. Eligible participants are daily smokers who own a smartphone and do not have heart problems or chronic pain.
Tulsa, OklahomaAges 18 years+ - NCT07080892Recruiting
Comparing two ways to give a knee nerve block for pain after knee replacement
This study compares two different ways of giving a nerve block (called iPACK) to see which works better for pain after total knee replacement. The goal is to find the best spot for the injection to help you feel more comfortable after surgery.
BratislavaAges 18–80 - NCT07081048Recruiting
Reducing newborn pain during a heel stick blood test
This study tests two pain-relief methods during a heel stick blood draw in full-term newborns. The goal is to find which method helps babies feel less pain and stay more comfortable.
MersinAges 1 day–1 month - NCT07081373Recruiting
Repeat dose of liposomal bupivacaine for pain after anal fistula surgery
This trial tests if a repeat dose of liposomal bupivacaine (a long-acting numbing medicine) helps reduce pain after surgery for anal fistula. It may be a good option if you are having this surgery and want better pain control.
Guangzhou, GuangdongAges 18–60 - NCT07084714Recruiting
Can moderate exercise help with period symptoms?
This trial tests whether moderate aerobic exercise can help manage menstrual cycle symptoms in people who are not very active. You would exercise for a few weeks while tracking your symptoms to see if exercise makes a difference.
Colorado Springs, ColoradoAges 18–40
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,749 recruiting pain medicine studies from the U.S. registry right now, out of 6,811 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.