Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,580 recruiting studies in this area right now.
By phase
- Not applicable2,955
- Phase 4240
- Phase 2129
- Phase 3103
- Phase 194
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University61
- Beijing Tiantan Hospital34
- Tanta University34
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University21
Where studies are running
- California151
- New York79
- Florida65
- Massachusetts65
- Texas51
- Illinois40
- North Carolina40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,580 total
- NCT06708000Enrolling by invitationPhase 3
Personalized testing for new chest pain
This trial compares a personalized evaluation approach to standard care for people with new chest pain who might have heart disease. It aims to see if tailoring tests can improve diagnosis and outcomes.
HerningAges 30–75 - NCT06716294Recruiting
Radiofrequency ablation and stabilization for spine tumors
This trial tests a treatment that uses heat to destroy active spine tumors from cancer that has spread, followed by stabilizing the bone. It aims to see if the treatment works by using a special scan (PET-CT) to confirm the results.
Athens, AthensAges 18–90 - NCT06709391Recruiting
Spinal fusion vs. no surgery for chronic low back pain
This trial tests whether a spinal fusion surgery is better than staying with non-surgical treatments for people with long-term, severe low back pain from worn-out discs in the lower spine. It aims to find out which approach offers better pain relief and quality of life.
GothenburgAges 25–65 - NCT06705751Recruiting
Faster diagnosis of abnormal coronary artery origin
This study tests a new, faster way to diagnose an uncommon heart condition where one of the main arteries (the coronary artery) starts from the wrong place on the aorta. The goal is to help doctors find and treat it sooner.
San Donato Milanese, ItaliaAges 6 years+ - NCT06703671Recruiting
Acupuncture for disc-related low back pain
This trial tests whether electroacupuncture (a type of acupuncture with mild electric pulses) can help people with low back pain caused by a damaged disc. If you have had back pain for at least a month and have not had certain other treatments recently, you may be eligible.
Beijing, Beijing MunicipalityAges 18–70 - NCT06699745Enrolling by invitation
Music vs. white noise for kids during endoscopy
This study compares playing music or white noise during a child's first endoscopy to see which helps them feel more comfortable. It might help your child relax during the procedure.
Istanbul, AvcilarAges 6–12 - NCT06702189Recruiting
EXOPULSE Mollii Suit for low back pain
This trial tests a special suit (EXOPULSE Mollii) to see if it helps relieve low back pain. It may be an option if you've had back pain for at least 3 months and are not planning surgery.
Créteil, VAL DE MarneAges 18–75 - NCT06704061Recruiting
Online yoga vs ACT for chronic pain in veterans
This study compares online yoga with Acceptance and Commitment Therapy (ACT), a type of talk therapy, to see which helps veterans better manage long-lasting muscle or bone pain. You can join from home through the internet.
Palo Alto, CaliforniaAges 18 years+ - NCT06332560Recruiting
Endometriosis pain and lifestyle
This study looks at how diet and lifestyle changes, including cognitive behavioral therapy (a type of talk therapy), might help reduce pain from endometriosis. You would follow a special diet and attend therapy sessions while researchers track your symptoms.
's-HertogenboschAges 17 years+ - NCT06685575Enrolling by invitation
Comparing two types of back surgery for leg pain
This trial compares a newer, less invasive surgery (endoscopic foraminotomy) to a traditional back surgery for people with leg pain caused by a narrowed spine canal. The goal is to see which approach provides better relief and recovery.
Chon Buri, Changwat Chon BuriAges 30–80 - NCT06692400Recruiting
Suctioning, pain, and blood markers in intubated patients
This study looks at how routine suctioning of the breathing tube affects pain levels and certain substances in the blood in adults who are on a breathing machine for serious infections like flu, pneumonia, COVID, or sepsis. It may help doctors better understand and manage your comfort during this procedure.
Loma Linda, CaliforniaAges 18 years+ - NCT06684665Enrolling by invitation
How emotions and social factors affect low back pain
This study looks at how social, psychological, and emotional factors might cause problems with movement and daily life in people with back pain. It could help doctors better understand and treat your pain.
Wenzhou, ZhejiangAges 18–75 - NCT06685120Recruiting
PRP and hyaluronic acid for knee osteoarthritis
This study tests a combination of platelet-rich plasma (PRP) and hyaluronic acid injections for knee osteoarthritis. It aims to see if these injections together can reduce pain and improve function better than standard treatments.
BolognaAges 40–75 - NCT06688864Recruiting
App-based support for chronic pain in underserved adults
This study tests a smartphone app (EPIO) to help people with chronic pain manage their daily life. It is designed for adults who are Black and/or LGBTQ+ and face added challenges because of limited resources.
Rochester, MinnesotaAges 18 years+ - NCT06686875Enrolling by invitation
Chronic belly pain after sleeve gastrectomy study
This study looks at long-term belly pain in people who had a sleeve gastrectomy 3 months to 5 years ago. It aims to understand the pain better to help future patients.
WarsawAges 18 years+ - NCT06692335Recruiting
Comparing HIFU and surgery for uterine fibroids
This trial compares two treatments for painful or heavy menstrual bleeding caused by uterine fibroids: high-intensity focused ultrasound (HIFU) and myomectomy (surgery to remove fibroids). It may help you decide which option fits your needs.
Hong KongAges 18–50 - NCT06688344Recruiting
Shock wave therapy after ACL surgery
This trial tests if adding focused shock wave therapy to standard rehab can improve recovery after ACL reconstruction using a hamstring graft. It may help reduce pain and speed up healing.
IstanbulAges 18–45 - NCT06690060Recruiting
Mind-body program for chronic migraine
This study tests whether a mind-body program, done remotely, can help people with chronic migraines reduce headache impact. It is for adults who have migraines at least 5 days a month and are willing to learn relaxation and stress-management techniques.
Boston, MassachusettsAges 18 years+ - NCT06691269Recruiting
Light therapy for pain-free dental care in kids
This study tests a special light therapy called photobiomodulation to see if it can reduce pain during routine dental care in children. It may offer a safe, non-drug way to help kids feel more comfortable at the dentist.
Baltimore, MarylandAges 6–12 - NCT06556121Recruiting
Numbing shot for gender-affirming surgery pain
This trial tests a numbing shot given during penile inversion vaginoplasty to see if it reduces pain after surgery. It might help people manage pain with less need for strong painkillers.
Toronto, OntarioAges 18–70 - NCT05973045Recruiting
Warm or cool fluid during hysteroscopy: comfort and safety
This study looks at whether the temperature of the fluid used during hysteroscopy affects image quality, risk of low blood sodium, and pain after the procedure. It may help find a safer, more comfortable way to do hysteroscopy for certain uterine growths.
IzmirAges 18–65 - NCT06677216Enrolling by invitation
Botox for jaw muscle pain study
This study tests if Botox injections can reduce pain in the jaw muscles caused by a jaw joint disorder (TMD). If you have this type of pain and are interested in Botox treatment, you may be able to join.
Utrecht, UtrechtAges 18 years+ - NCT06670053Recruiting
Testosterone and brain development in teens
This study looks at how starting testosterone therapy affects brain development in transgender and gender-diverse youth. It may help you and your doctor understand the changes to expect.
Aurora, ColoradoAges 12–20 - NCT06671925Recruiting
Support program for chronic pain and loneliness in older adults
This trial tests a program led by community health workers to help older adults manage chronic pain and reduce loneliness. It aims to improve your well-being through support and guidance.
Ann Arbor, MichiganAges 60 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,580 recruiting pain medicine studies from the U.S. registry right now, out of 6,510 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.