Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,580 recruiting studies in this area right now.
By phase
- Not applicable2,955
- Phase 4240
- Phase 2129
- Phase 3103
- Phase 194
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University61
- Beijing Tiantan Hospital34
- Tanta University34
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University21
Where studies are running
- California151
- New York79
- Florida65
- Massachusetts65
- Texas51
- Illinois40
- North Carolina40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,580 total
- NCT05676827Enrolling by invitation
Study pain and stress in people with long-term jaw muscle pain
This trial looks at how long-lasting jaw (masticatory) muscle pain relates to the nervous system and emotional stress. It may help researchers understand why symptoms persist and guide future treatments.
WroclawAges 18–80 - NCT05702801Recruiting
Vibration training to help balance recover after a stumble
This study tests whether vibration exercises can help older adults regain balance more effectively after losing it. If you’re at risk of falls or balance problems, the trial may offer a structured way to improve recovery.
Newark, New JerseyAges 65 years+ - NCT05675527RecruitingPhase 4
Platelet gel (PRP) for shoulder arthritis pain
This trial tests whether platelet-rich plasma (PRP), a blood-based treatment, can reduce pain from shoulder (glenohumeral) osteoarthritis. It also looks at whether PRP works for people who had temporary relief from a numbing/shock injection into the joint.
New York, New YorkAges 18–100 - NCT03230565RecruitingPhase 4
Continuous vs bolus pain medication through nerve catheter
This study compares two ways of delivering numbing pain medicine through a nerve catheter after surgery: a steady infusion versus scheduled bolus doses. It aims to see which method works better and is easier to use for post-operative pain control.
Stanford, CaliforniaAges 18 years+ - NCT05640232RecruitingPhase 3
Test medicine CDE100 for severe menstrual cramp pain
This Phase 3 study tests whether CDE100 can reduce menstrual cramp pain in people with primary dysmenorrhea (cramps that are not caused by another medical condition). It also checks how safe the treatment is and how it’s tolerated over time.
Hortolândia, São PauloAges 16–35 - NCT05666726Recruiting
Understanding how the body and mind influence choices
This study looks at how your body's signals and your ability to reflect on them affect the decisions you make. It involves tasks that may include mild stress, pain, food cravings, or brain scans to better understand these processes.
Bethesda, MarylandAges 18–55 - NCT05642611RecruitingPhase 3
Cooling and compression for nerve protection during chemotherapy
This study tests whether using cooling and/or compression on the arms or legs can prevent nerve damage that can happen from certain chemotherapy drugs. If you get eligible chemo soon, this may help lower the chance of painful numbness or tingling during treatment.
Birmingham, AlabamaAges 18 years+ - NCT05658575RecruitingPhase 2/Phase 3
Tablets to treat sudden gout flare pain
This trial studies dapansutrile tablets (OLT1177) to see how well they work for people in the first 4 days of an acute gout flare. It may help reduce pain and inflammation in the specific joint where your gout is flaring.
Birmingham, AlabamaAges 18 years+ - NCT05645224Enrolling by invitation
Virtual reality for pain and anxiety during laser skin treatment
This study tests whether using virtual reality (VR) during a laser procedure for a skin condition helps children and teens feel less pain and anxiety. If you are having your first laser treatment, you might be able to use a VR headset to distract you during the procedure.
Columbus, OhioAges 5–25 - NCT05654168Enrolling by invitation
Ultrasound study of muscle changes in professional dancers
This study uses ultrasound to look at how dancers’ muscles look and develop over time. It may help researchers understand muscle health and patterns in professional dancers.
Madrid, MadridAges 18 years+ - NCT05669027Recruiting
Mobile brain training to help low back pain
This study tests whether mobile “neurofeedback” training can reduce low back pain and improve how much it affects your daily life. You would likely use sensors that measure brain and body signals to guide the training.
Durham, North CarolinaAges 18–90 - NCT05661903RecruitingPhase 2
Spinal cord stimulator study for nerve pain and brain effects
This Phase 2 study looks at how spinal cord (or nerve-root) stimulation affects pain signals in the brain and body. You may qualify if you already have a stimulator set to a comfort mode that avoids “tingling” sensations.
Boston, MassachusettsAges 18–80 - NCT05657964Recruiting
Study of a back pain exercise program for chronic low back pain
This trial tests whether a structured exercise/education program can help people with chronic lower back pain. You may qualify if your pain and disability scores are high enough and you can complete study activities in English.
Redwood City, CaliforniaAges 18–65 - NCT05662722Recruiting
Needle electrolysis for “cold nose/patch” headache pattern
This trial tests a small procedure that uses a needle on the ear (near the concha) to treat headaches. It focuses on people whose headaches match a specific pattern called the “cold nose” and/or “cold patch” pattern.
Alcalá de Henares, MadridAges 18–70 - NCT05645003Recruiting
Brain stimulation therapy for nerve pain after spinal cord injury
This trial tests whether painless magnetic stimulation of the brain (non-surgical) can reduce long-lasting nerve pain after spinal cord injury. It may help people whose spinal cord injury-related pain has been present for at least six months.
AfyonkarahisarAges 20–70 - NCT05653778Recruiting
Nerve-stimulation treatment for painful corticobasal syndrome
This trial tests “scrambler therapy,” a type of skin-based nerve stimulation, to reduce ongoing pain from corticobasal syndrome. You may be eligible if your average pain is moderate to severe and you can safely take part in the treatment schedule.
Baltimore, MarylandAges 50–89 - NCT05673551Enrolling by invitation
VR during at-home burn dressing changes for kids
This trial tests whether virtual reality (VR) can help children feel better during daily burn dressing changes at home. It will study comfort and pain around the first time you do dressings after leaving the hospital.
Columbus, OhioAges 6–17 - NCT05598723RecruitingPhase 3
Botox versus Xeomin for chronic migraine in adults
This Phase 3 study compares two headache injections—Botox and Xeomin—for people with chronic migraine. It may help find out which option works better to reduce frequent, long-lasting migraine days.
Jacksonville, North CarolinaAges 18–89 - NCT05635929Recruiting
Topical treatment to reduce mouth sores during or after radiation
This study tests a new cream/gel applied to the mouth to lower the chance of severe mouth sores in people receiving radiation for head and neck cancer. It also looks at how treatment affects quality of life using patient questionnaires.
Madrid, MadridAges 18 years+ - NCT05619588Recruiting
Long-term follow-up for a new ankle replacement (U.S. only)
This study checks how well an Exactech total ankle replacement works over many years. You may be asked to complete follow-up forms for up to 10 years to help track safety and outcomes.
Jacksonville, FloridaAges 21 years+ - NCT05607381Recruiting
Meditation program study for opioid-treated chronic low back pain
This trial studies how meditation may change brain activity and help people with long-lasting low back pain who are already taking prescription opioids. The goal is to understand the “neural” (brain) effects of meditation to improve pain treatment.
La Jolla, CaliforniaAges 18–65 - NCT05612750Recruiting
Online therapy for chronic pain: CBT vs one-session relief
This study compares two online treatments for chronic pain: an 8-session cognitive behavioral therapy (CBT) program versus a single “empowered relief” session. It aims to see which approach helps people manage pain better over time.
Phoenix, ArizonaAges 18 years+ - NCT05636137Enrolling by invitation
Study links internet habits with pain and body awareness
This study asks high school students about internet use, musculoskeletal pain (pain in muscles and bones), and body awareness (how well you notice your body). It aims to understand whether these things are connected and may help guide future supports for teens.
Muğla, MenteşeAges 15–18 - NCT05618392Recruiting
Pain check after feeding tube placement
This trial studies how much pain people feel after a radiology-guided feeding tube is placed through the skin while you’re awake with local numbing medicine. It also looks at factors that might help predict pain, to improve comfort for future patients.
ValenceAges 18 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,580 recruiting pain medicine studies from the U.S. registry right now, out of 6,510 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.