Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,580 recruiting studies in this area right now.
By phase
- Not applicable2,955
- Phase 4240
- Phase 2129
- Phase 3103
- Phase 194
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University61
- Beijing Tiantan Hospital34
- Tanta University34
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University21
Where studies are running
- California151
- New York79
- Florida65
- Massachusetts65
- Texas51
- Illinois40
- North Carolina40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,580 total
- NCT05634031Recruiting
Study of heart vessel dysfunction seen on heart imaging
This study looks at coronary microvascular dysfunction (small blood vessel problems in the heart) using heart imaging. It may help researchers understand causes of chest tightness with activity and shortness of breath when the main heart arteries are not blocked.
New York, New YorkAges 18 years+ - NCT05620719Recruiting
Study delayed headache after head injury in veterans
This study looks at treatment for ongoing headache that starts or gets worse after a mild or moderate head/neck injury in veterans or active-duty service members. It may help by testing an approach aimed at reducing headache burden and improving daily functioning.
Los Angeles, CaliforniaAges 18–70 - NCT05602636RecruitingPhase 4
Nerve-block pain options during forearm surgery
This trial compares three ways to control pain during forearm surgery: different nerve blocks versus using a PCA pain pump. It may help find the approach that gives better pain relief and comfort after surgery, especially for longer procedures.
DamiettaAges 18–70 - NCT05555576Recruiting
Vitamin C to reduce opioid use after an ER visit
This trial tests whether taking vitamin C after an emergency room visit for a new, short-term muscle or joint pain can lower how many opioid pain pills you use. It may help by reducing opioid consumption while you recover.
Montreal, QuebecAges 18 years+ - NCT05584007RecruitingPhase 3
Choosing the best antibiotic length for leg cellulitis
This Phase 3 study compares 5 days versus 7 days of antibiotic treatment for new leg cellulitis (skin infection). It may help you get the right treatment duration while keeping side effects and recovery in mind.
SouthamptonAges 18 years+ - NCT05575323Recruiting
Same-day radiation and stabilization for spine metastases
This trial tests whether giving focused radiation (SBRT) on the same day as spine surgery to stabilize the spine helps control symptoms from spinal metastases. It may help reduce pain and improve stability, especially when tumors threaten or affect the spine’s strength.
UtrechtAges 18 years+ - NCT05579496Recruiting
Rebooting infant pain care using skin-to-skin contact
This trial tests how skin-to-skin contact affects pain and brain activity in premature babies during a routine heel prick. It may help find better ways to manage pain for infants in the NICU.
Toronto, OntarioAges 6 months–8 months - NCT05556902Recruiting
Testing how epidural spinal cord stimulation may help chronic pain
This study looks at how a device that sends mild signals to the area around your spinal cord may work for long-lasting (chronic) pain. You may be asked to visit a research lab, have blood taken, and follow the study plan so researchers can understand the treatment’s effects.
Birmingham, AlabamaAges 18–89 - NCT05563038Recruiting
Scrambler therapy for pain after stroke
This trial studies whether “scrambler therapy” can reduce ongoing pain in the body areas affected by a past stroke. It may help people who are at least a month past stroke and still have stroke-related pain.
Baltimore, MarylandAges 18 years+ - NCT05555459Recruiting
Testing a screw system for foot and ankle surgery
This study checks how safe and well an “Inion CompressOn” screw system works during foot and ankle operations. It may help patients by improving how surgeons fix bones while also collecting safety and recovery information.
TampereAges 18 years+ - NCT05513417Enrolling by invitation
Digital pelvic health program for women with pelvic pain
This study tests a digital (phone/app-based) program to help women with pelvic pain or pelvic health symptoms. It may help by guiding pelvic-focused exercises and care, especially if you’re recovering from pelvic surgery or managing ongoing symptoms.
Draper, UtahAges 18–99 - NCT05508360Recruiting
Testing an artificial spacer implant for one-level low back pain
This study tests whether inserting a small artificial implant into a single painful disc can reduce long-term low back pain and disability. It’s for people who tried non-surgical treatments for at least 6 months but still have significant symptoms from degenerative disc disease.
Medellín, AntioquiaAges 22 years+ - NCT05511012Recruiting
Testing movement-control assessment in low back pain
This study checks whether a therapist’s judgment about how your back controls movement matches objective measurements (more technical testing). It may help improve how low back pain rehabilitation is assessed and planned.
Brest, FinistèreAges 18–99 - NCT05541276RecruitingPhase 3
Melatonin to prevent waking confusion in young children after surgery
This study tests whether giving melatonin before surgery can help prevent agitation and confusion in young children after they wake up from anesthesia. Participation may help your child have a smoother recovery after their procedure.
Copenhagen, Capital RegionAges 1–6 - NCT05543694RecruitingPhase 4
Testing epidural pain relief for labor
This study is testing how well a combination of two medicines (bupivacaine and lidocaine) works for epidural pain relief during early labor. The goal is to find the best dose to help manage labor pain.
Boston, MassachusettsAges 18–50 - NCT05543785Recruiting
Ketorolac pain block for lower-limb surgery with a tourniquet
This trial looks at whether a ketorolac pain medicine given directly to the leg during surgery can reduce pain after lower-limb orthopedic operations. It may help people who are having one leg operated on with spinal anesthesia and a tourniquet, but it has several safety limits.
Al MansurahAges 19–60 - NCT05517434RecruitingPhase 2/Phase 3
Autologous bone and fat injections versus saline for knee OA
This trial compares different knee injections made from your own bone marrow and/or fat, plus platelet-rich plasma (a blood-derived healing factor), against saline (placebo) to treat painful knee osteoarthritis. It aims to see whether these “autologous” injections reduce knee pain and improve function.
Toronto, OntarioAges 30 years+ - NCT05541029Recruiting
Music listening for children on breathing machines
This study tests whether listening to music can help children who are in the Pediatric Intensive Care Unit (PICU) and need a breathing machine. It looks at the “how it works” side—whether music changes things in the body or brain during intensive care.
Pittsburgh, PennsylvaniaAges 2 months–17 years - NCT05540106Recruiting
Art therapy to reduce pain and anxiety in the ER waiting room
This trial studies whether guided art therapy can lower the pain and anxiety you feel while waiting to be seen in the emergency department. It may help you feel more calm and comfortable during the waiting time.
Stony Brook, New YorkAges 18 years+ - NCT05537935RecruitingPhase 4
Low-dose naltrexone for nerve pain in people with HIV
This trial studies whether a low dose of naltrexone can reduce long-lasting nerve-related pain in adults living with HIV. It may help if your pain has been ongoing and you have stable HIV control.
Atlanta, GeorgiaAges 18–75 - NCT04985695Recruiting
Different pain-control methods after major belly surgery
This trial studies whether one pain-control method after midline belly surgery helps your recovery and rehabilitation. You may receive different approaches to pain relief, and the study compares how well you do after surgery.
Metz, MoselleAges 18 years+ - NCT00389142Recruiting
Find genes linked to bladder pain and urinary symptoms
This study looks for genetic (inherited) causes of bladder pain syndrome (IC/BPS), using information from people who have typical urinary symptoms. It may help doctors understand why IC/BPS happens, which could guide better future care.
Boston, MassachusettsAges 1 year+ - NCT05480982Recruiting
Cognitive functional therapy versus Pilates for low back pain
This study compares two exercise-based approaches—cognitive functional therapy and Pilates—to help reduce chronic low back pain in older adults. It may help by improving how you move and manage pain, not just stretching muscles.
Rio de Janeiro, Rio de JaneiroAges 65 years+ - NCT05474274Enrolling by invitation
Home pain app that teaches treatment after outpatient plastic surgery
This trial tests a home-based “pain coaching” system (using a phone app and a TENS device) to help people manage pain after lower-risk outpatient plastic surgery. It may help you feel more in control of pain at home using guided exercises and device-based pain relief.
Jacksonville, FloridaAges 18 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,580 recruiting pain medicine studies from the U.S. registry right now, out of 6,510 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.