Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,575 recruiting studies in this area right now.
By phase
- Not applicable2,950
- Phase 4240
- Phase 2131
- Phase 3102
- Phase 193
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University59
- Beijing Tiantan Hospital34
- Tanta University33
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University20
Where studies are running
- California151
- New York79
- Massachusetts65
- Florida64
- Texas51
- Illinois40
- North Carolina40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,575 total
- NCT07726550Recruiting
Comparing two nerve blocks for open kidney surgery pain relief
This study compares two different nerve-block techniques to see which works better for pain control after open kidney surgery. One block targets muscles between the ribs, the other targets muscles around the spine. You will be randomly assigned to one of the two groups.
Tekirdağ, TekirdağAges 18–65 - NCT07729930Recruiting
Creatine supplement study for healthy middle-aged women
This study is testing a creatine supplement (a substance that may help with energy and muscle function) in healthy middle-aged women. You may join if you are between 35 and 65, a non-smoker, and have a certain activity level.
LoughboroughAges 35–65 - NCT07729488Recruiting
Nerve blocks for better recovery after lung surgery
This study compares two types of nerve blocks to see which one helps people recover better after lung surgery. It tests a block around the spine versus one near the shoulder blade to improve comfort and recovery.
Diyarbakır, Outside of the USAges 18–85 - NCT07729722Enrolling by invitation
Chiropractic vs physiotherapy for chronic neck pain
This study compares two different treatments for people with long-term neck pain: chiropractic care and physical therapy. The goal is to see which approach works better to reduce pain and improve function.
IstanbulAges 18–65 - NCT07729774Recruiting
Spray-and-stretch vs. gentle pressure for back pain
This study compares two hands-on techniques—spray-and-stretch and strain-counterstrain—to see which better relieves nonspecific low back pain. It may help if you have muscle-related back pain without nerve problems or other serious conditions.
Multan, Punjab ProvinceAges 35–50 - NCT07731295Recruiting
Pain management study for teens getting wisdom teeth removed
This study looks at how to improve pain management after wisdom tooth extraction. It focuses on teens and young adults who use cannabis regularly, to see how it affects pain and recovery.
Providence, Rhode IslandAges 15–20 - NCT07726797Recruiting
Pelvic control training vs core stability for low back pain
This trial compares two types of exercises — pelvic control training with a pressure sensor versus core stability training — to see which one works better for relieving low back pain. It may help if you are a young adult with no other health issues affecting your back or balance.
Lahore, Punjab ProvinceAges 18–30 - NCT07727551Recruiting
Nerve block before knee replacement for better recovery
This trial tests if a nerve block given a few weeks before knee replacement surgery can improve pain and function after the operation. It is designed for people who have certain risk factors that might make recovery harder.
BrusselsAges 18–60 - NCT07730216Recruiting
Ultrasound-Guided Knee Block Study for Knee Replacement
This study looks at whether using ultrasound to guide a numbing injection around the knee can improve pain control after knee replacement surgery. It aims to make recovery more comfortable.
Konya, KonyaAges 18 years+ - NCT07724470Recruiting
Stretching techniques for neck and arm pain
This study tests two types of stretching to see which one works better for neck pain that spreads into the arm. If you have had this pain for more than a month, this trial might help find a way to move better and feel less pain.
Lahore, Punjab ProvinceAges 30–60 - NCT07724704Recruiting
Exercise comparison for long-term low back pain
This study compares two sets of exercises (called McGill and Sahrmann) to see which is better at reducing chronic low back pain. If you have had non-specific low back pain for more than 12 weeks, this trial may help you strengthen your core and feel better without surgery or medication.
Lahore, Punjab ProvinceAges 20–50 - NCT07724691Recruiting
Comparing two shoulder therapies for frozen shoulder
This study compares two types of gentle shoulder movements (mobilizations) to treat frozen shoulder. The goal is to reduce pain and help you move your arm more easily.
Lahore, Punjab ProvinceAges 30–50 - NCT07731750Recruiting
Smart pain treatment plan for chronic low back pain
This study tests a computer-based tool to help choose the best pain treatments for people with chronic low back pain. It compares different treatments to see which ones work best for each person.
Ann Arbor, MichiganAges 25 years+ - NCT07731243Recruiting
Vibration, massage and myofascial release for period pain
This study tests whether combining vibration, massage, and myofascial release (a gentle stretching technique) can help relieve pain from primary dysmenorrhea (period pain without an underlying condition). If you are a woman with regular periods and moderate to severe menstrual pain, this trial may offer a non-drug treatment option.
Istanbul, IstanbulAges 18–30 - NCT07729735Enrolling by invitation
Physiotherapy after breast reduction surgery
This study tests whether adding physical therapy after breast reduction surgery helps you recover faster and feel better. You must be between 18 and 50, have had cosmetic breast reduction, and be free of certain health conditions like arm swelling or nerve problems.
IstanbulAges 18–50 - NCT07726030Recruiting
Exercises for chronic rotator cuff pain in overhead athletes
This trial compares two types of exercises to see which better reduces chronic shoulder pain in male athletes who play overhead sports. If you have ongoing rotator cuff tendinopathy and are an active overhead athlete, this study may help find the best exercise approach for you.
Faisalābad, Punjab ProvinceAges 17–35 - NCT07725198Recruiting
Neck muscle responses after upper neck therapy
This trial looks at how a specific neck therapy affects a small muscle at the top of your neck. It may help researchers understand how hands-on treatment works for neck pain or stiffness.
Fort Myers, FloridaAges 18–65 - NCT05824338RecruitingEarly Phase 1
Testing ropivacaine spinal anesthesia for lower back surgery
This early study tests whether using ropivacaine (a local numbing medicine) in spinal anesthesia is safe and workable for certain lower back operations. If you qualify, it may help doctors refine anesthesia choices for your type of surgery.
New Westminster, British ColumbiaAges 19–80 - NCT06633068RecruitingPhase 2
Pain relief study: nalbuphine added to numbing medicine for thyroid surgery
This study tests if adding nalbuphine to the numbing medicine (bupivacaine) given as a nerve block before thyroid surgery provides better pain relief. It is for adults having planned thyroid surgery.
Giza, الجيزةAges 18–60 - NCT05295498Recruiting
Brain stimulation trial for nerve pain relief
This trial studies whether repeated magnetic stimulation of the brain can reduce ongoing nerve pain. It may help people whose nerve pain has been steady for at least a month and who still need pain medicine more than once a week.
KrakowAges 18 years+ - NCT07719452Enrolling by invitation
Strengthening exercise for chronic low back pain
This study tests if adding a specific low back strengthening exercise to standard physical therapy helps people with long-lasting low back pain. It is for Tricare beneficiaries who have had back pain for at least 3 months without leg pain.
Fort Sam Houston, TexasAges 18–65 - NCT07719608Recruiting
MySalvia system for resistant migraine
This trial tests a device called MySalvia that is implanted in the head to reduce migraine attacks. It is for people whose migraines have not improved with at least three different preventive treatments.
Newnan, GeorgiaAges 22–84 - NCT07717021Enrolling by invitation
Patient feedback after umbilical hernia surgery
This study looks at how patients feel and function after surgery to fix a small, first-time umbilical hernia (a bulge near the belly button). Your feedback will help doctors understand what matters most to people like you.
Karlskrona, Blekinge CountyAges 18–75 - NCT07718217Recruiting
Mindfulness education for women with PCOS
This study tests whether a 4-week online mindfulness program can help women with PCOS manage stress and improve well-being. You'll attend group sessions and complete surveys from home.
BursaAges 18–49
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,575 recruiting pain medicine studies from the U.S. registry right now, out of 6,452 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.