Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,749 recruiting studies in this area right now.
By phase
- Not applicable3,095
- Phase 4251
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Mayo Clinic28
- Tanta University28
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California160
- New York81
- Massachusetts68
- Florida63
- Texas51
- Ohio47
- Maryland42
- Minnesota42
- North Carolina38
- Illinois37
Recruiting studies3,748 total
- NCT06974474RecruitingPhase 4
Guselkumab for pain in psoriatic arthritis
This study tests if guselkumab can reduce pain and inflammation in people with psoriatic arthritis. You may join if standard treatments have not worked well enough or caused side effects.
Rome, ItalyAges 18–80 - NCT03476213Recruiting
Compare two anesthesia infusion methods after brain tumor surgery
This trial compares two ways of giving anesthesia during brain tumor surgery to see how they affect awareness and dreaming after surgery. It may help doctors choose a method that improves comfort while keeping patients safely asleep and recovering normally.
Hradec KrálovéAges 18 years+ - NCT05599776Recruiting
Smart ring-guided rehab after knee replacement surgery
This study tests whether using a smart ring along with physical therapy after knee replacement helps people recover better. It mainly looks at people’s rehab progress in the weeks after surgery.
Tampere, PirkanmaaAges 18–70 - NCT05267093Recruiting
Acupuncture for hand osteoarthritis pain
This study compares real acupuncture to sham (placebo) acupuncture to see which one better reduces pain and improves function in people with hand osteoarthritis. It may help you understand whether acupuncture provides meaningful relief beyond placebo.
BeijingAges 18–80 - NCT03747146Recruiting
Enhanced recovery plan for knee replacement pain control
This study tests an “enhanced recovery” approach for people getting total knee replacement, focused on better pain control using regional anesthesia and a home pain medicine plan. It may help you recover more comfortably and follow the care plan more smoothly after surgery.
New York, New YorkAges 18–65 - NCT07294131RecruitingPhase 2
Preventing muscle loss in hospitalized older adults
This trial tests a special exercise approach using blood-flow restriction and a video game to help older adults in the hospital keep their muscle strength. The goal is to find a safe way for bedridden patients to exercise and recover better.
AntwerpAges 65 years+ - NCT03569839Recruiting
Testing automatic control of anesthesia depth during surgery
This trial studies a monitoring and computer-based system that may automatically adjust anesthesia “depth” so patients stay at the right level during surgery or ICU sedation. It may help reduce swings in anesthesia and improve safety during procedures like eye, brain, or intensive care sedation.
Ljubljana, LjubljanaAges 20–70 - NCT06812611Recruiting
High intensity laser therapy for muscle injuries
This trial tests if high intensity laser therapy helps heal severe muscle tears in the leg. If you have a recent, serious muscle tear from sports, this treatment might speed up your recovery.
BariAges 16 years+ - NCT07158736Recruiting
Nerve block for knee pain in the emergency room
This trial tests whether a nerve block can reduce knee pain in the emergency room. If you have knee pain without an injury and are at least 18 years old, this treatment may offer quick relief.
Philadelphia, PennsylvaniaAges 18 years+ - NCT03168802Recruiting
Ultrasound and nerve treatment for facet-joint low back pain
This study tests whether a procedure that uses focused ultrasound (MRgFUS) and/or a radiofrequency nerve treatment can reduce long-lasting low back pain caused by facet-joint arthritis. It may help people whose pain improves strongly after a targeted numbing injection to specific back nerves.
Taipei, Please SelectAges 20–79 - NCT07120659Recruiting
Comparing vacuum and tactile massage for chronic neck pain
This study compares two types of massage (vacuum massage and tactile massage) to see which one works better for people with long-term neck pain. If you have had neck pain for at least 3 months, you may be able to join.
Tromsø, TromsAges 21–75 - NCT03584815Recruiting
Test of physiotherapy versus surgery for exercise leg muscle pressure
This trial compares a physiotherapy program to a surgical procedure (fasciotomy) for chronic “compartment” pressure in the lower leg triggered by exercise. If you have symptoms that reliably come on with walking/running and improve with rest, the study may offer a structured way to find the best treatment for you.
Copenhagen, CopehagenAges 18–50 - NCT02503228Enrolling by invitation
Registry study of a preserved bone-cartilage graft
This registry study follows people who get a preserved graft to repair damaged bone and cartilage in a joint. It helps doctors understand how well the graft is preserved and how patients do after surgery over time.
Columbia, MissouriAges 13 years+ - NCT06232473RecruitingPhase 4
Education and duloxetine for multisystem functional somatic disorder
This trial tests whether a combination of patient education and the medication duloxetine can help people with a condition that causes multiple unexplained physical symptoms (functional somatic disorder). It aims to see if using both treatments together works better than either alone.
AarhusAges 18–60 - NCT06524531RecruitingEarly Phase 1
Pulse Energy and Blood Injection for Stubborn Back Pain
This trial tests a new treatment for stubborn low back pain that involves a short pulse of radio waves (a type of energy) and an injection of your own blood cells (called PRP) to help the muscles in your back work better. It is for people whose pain comes from a specific muscle problem and has not gone away with other care.
Lahore, Punjab ProvinceAges 30–70 - NCT06460792Recruiting
Ultrasound-guided nerve blocks database study
This trial is building a database to study ultrasound-guided nerve blocks (injecting numbing medicine around nerves using ultrasound). It may help researchers learn how to better manage pain.
HillerødAges 2 years+ - NCT06505187RecruitingPhase 2
Celecoxib for Pain After Parotid Gland Surgery
This trial is testing whether the pain reliever celecoxib (Celebrex) can help control pain after a specific type of salivary gland surgery called superficial parotidectomy. If you're having this surgery, you may be able to join and take celecoxib for pain rather than other common pain medicines.
Madison, WisconsinAges 18 years+ - NCT06201676RecruitingPhase 4
Low-dose short-term ketorolac to cut opioid use after bone surgery
This study tests whether giving a low dose of a non-steroidal anti-inflammatory drug (NSAID) called ketorolac for a short time after orthopedic surgery can reduce the need for strong painkillers like opioids. It is for people who have broken bones that need surgery with metal plates, screws, or rods.
Boston, MassachusettsAges 18–70 - NCT06208267Recruiting
Tranexamic acid for pain and bleeding after hip or knee replacement
This study tests whether a medicine called tranexamic acid (TXA) can reduce pain, improve movement, and lessen bleeding after hip or knee replacement surgery. It is for adults having their first joint replacement at St. Mary's Hospital.
Montreal, QuebecAges 18 years+ - NCT06467747Recruiting
Music therapy for pain during surgery recovery
This trial studies whether listening to music can help reduce pain and improve recovery after common laparoscopic surgeries. It is for adults having gallbladder or appendix removal as same-day surgery.
Taichung, Not in USAAges 20–80 - NCT06201611RecruitingPhase 2/Phase 3
Nebivolol for diabetic nerve damage study
This study tests whether the drug nebivolol (a type of beta-blocker) can help slow or reverse nerve damage caused by diabetes. It is for people with recent diabetes and confirmed neuropathy.
Bangalore, KarnatakaAges Up to 18 years - NCT06487013Recruiting
Focused ultrasound for painful bone metastases
This trial tests a focused ultrasound treatment called ArcBlate to relieve pain from bone cancer that has spread. It is for people who have moderate to severe pain despite cancer therapy and have chosen not to have surgery or radiation for that pain.
New Taipei CityAges 18 years+ - NCT06523426Recruiting
Outpatient spine surgery for adults over 75
This trial tests a minimally invasive spine surgery (endoscopic decompression) done as an outpatient procedure in people 75 and older. It aims to see if this approach is safe and effective for treating a single-level lumbar spine problem.
BordeauxAges 75 years+ - NCT06471907Recruiting
Comparing pain relief and blood flow during back injections
This study tests a new way to give a pain-relieving injection for lower back problems. If you have ongoing back pain from a disc, narrowing, or slipped bone, this treatment may help reduce your pain.
DaeguAges 20–80
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,749 recruiting pain medicine studies from the U.S. registry right now, out of 6,757 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.