Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,575 recruiting studies in this area right now.
By phase
- Not applicable2,950
- Phase 4240
- Phase 2131
- Phase 3102
- Phase 193
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University59
- Beijing Tiantan Hospital34
- Tanta University33
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University20
Where studies are running
- California151
- New York79
- Massachusetts65
- Florida64
- Texas51
- Illinois40
- North Carolina40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,575 total
- NCT07414706RecruitingPhase 3
Numbing medicines for faster recovery after keyhole colorectal surgery
This study tests whether giving a numbing medicine (lidocaine) through an IV plus a local anesthetic at the surgery site can help you recover faster and with less pain after keyhole surgery for colorectal cancer.
AmiensAges 18 years+ - NCT05780450Recruiting
Brain stimulation for long covid headaches and pain
This trial tests a safe, non-invasive brain stimulation technique (transcranial direct current stimulation, or tDCS) to see if it can reduce persistent headaches and chronic pain in people with long covid. If you have ongoing pain after a confirmed covid infection, this could offer a new way to find relief.
Paiporta, ValenciaAges 16 years+ - NCT07846878Recruiting
Predicting pain after orthopedic surgery
This study tests a tool that doctors can use before surgery to predict whether you might have longer-lasting pain after bone or joint surgery. Knowing this in advance could help your care team plan better pain relief for you.
ChongqingAges 18–90 - NCT07874789Recruiting
Curcumin spray for faster healing after tooth extraction
This trial tests a curcumin (turmeric) spray applied to the extraction site after removing a lower molar, to see if it helps the wound heal faster and better. If you're a healthy adult having this tooth pulled, you might be able to join.
Istanbul, IstanbulAges 18–40 - NCT07524751Recruiting
Cultural Pain Management Program for Indigenous People
This study tests a pain management program designed specifically for American Indian and Alaska Native communities. If you have chronic pain (lasting over 3 months), this program teaches coping strategies that respect your culture and background.
Yakima, WashingtonAges 18 years+ - NCT07571837Recruiting
Nano-medication to reduce inflammation after root canal retreat
This study tests a special nano-sized (extremely tiny) medication placed inside a tooth after a previous root canal treatment failed. The goal is to reduce inflammation and swelling in the bone around the tooth's tip so it can heal better.
Cairo, Nasr CityAges 20–40 - NCT07453004RecruitingPhase 2
Study of plonmarlimab for frequent gout attacks
This trial tests a new investigational drug called plonmarlimab for people with frequent, painful gout flares who cannot take standard treatments. The goal is to see if it can reduce pain and inflammation from the flare.
Bengbu, AnhuiAges 18 years+ - NCT07441421Recruiting
Improved pain relief for brain tumor surgery
This study tests a combination of pain-relief methods given before, during, and after brain surgery to see if they better control pain and help you recover with fewer side effects. It's for adults having surgery to remove a brain tumor.
BeijingAges 18–65 - NCT06997016Enrolling by invitationPhase 4
Recovery program for living donor kidney transplant
This trial tests a special recovery program (ERAS) for people who get a kidney from a living donor. The program aims to help you heal faster and feel better after surgery.
Fort Worth, TexasAges 18 years+ - NCT06685107Recruiting
Virtual reality for pain relief in older ER patients
This trial tests if using virtual reality along with standard pain medication helps reduce pain better than medication alone for older adults with muscle or joint pain in the emergency room.
Brooklyn, New YorkAges 65–120 - NCT04209504Recruiting
Nerve block study for one-sided breathing muscle weakness after shoulder surgery
This trial tests whether a longer-lasting nerve block during shoulder surgery can better manage pain and affect one-sided diaphragm (breathing muscle) weakness. It may help people having planned (first-time) shoulder surgery who are able to follow study pain-checks.
Durham, North CarolinaAges 18–80 - NCT07254806RecruitingPhase 3
Cell therapy for low back pain from disc disease
This study tests if injecting a special cell therapy into a damaged spinal disc can reduce chronic low back pain. It is for people who have had low back pain for at least 6 months and haven't gotten enough relief from other treatments like physical therapy or pain medication.
Birmingham, AlabamaAges 18–75 - NCT06886906Recruiting
Movement and Pain in Older Adults
This study explores how movement and physical activity relate to pain in older adults with muscle or joint pain. It could help you understand your pain patterns and find better ways to manage them.
Indianapolis, IndianaAges 55–85 - NCT06010251Recruiting
Body awareness therapy for spinal cord injury pain
This trial tests a multisensory approach to help people with spinal cord injury better perceive their body and reduce long-term nerve pain. It combines body awareness exercises with sensory feedback to see if it can ease pain and improve quality of life.
Miami, FloridaAges 18–70 - NCT07040397Recruiting
Massage therapy study for lower back pain
This study tests whether an electronic approach to massage therapy can help relieve lower back pain. It may be an option if you have persistent lower back pain and haven't used pain medications recently.
Rochester, MinnesotaAges 18 years+ - NCT05563792Recruiting
Non-drug options for managing chronic pain
This study tests non-drug treatments for chronic pain in the back, neck, or joints. It aims to help people manage pain and improve daily function without relying on medications.
Indianapolis, IndianaAges 18 years+ - NCT00001373Recruiting
Understanding the genetics of autoinflammatory diseases
This study collects genetic samples and medical histories from people with autoinflammatory diseases (like Familial Mediterranean Fever), their relatives, and healthy volunteers to understand how these conditions run in families and what causes them. Participation mainly involves providing a mail-in DNA sample.
Washington D.C., District of ColumbiaAges 2 months–115 years - NCT03371121Recruiting
AMIC cartilage repair for ankle cartilage damage in adults
This trial studies outcomes after a specific ankle cartilage repair surgery called AMIC. It looks at clinical results and imaging (pictures) after surgery to see how well the treatment works.
MilanAges 18–65 - NCT02321423Recruiting
Research registry for pachyonychia congenita patients
This study builds an international database of people with pachyonychia congenita (or a closely related condition). Sharing your information may help researchers understand the condition better and improve future treatments.
Salt Lake City, UtahAges Any age - NCT03825809RecruitingPhase 2/Phase 3
Non-narcotic pain medicine after labral shoulder surgery
This trial studies whether a non-narcotic pain plan after labral (shoulder) surgery can control pain as well as or better than usual treatment. It may help patients avoid opioid (narcotic) pain medicines after surgery.
Detroit, MichiganAges 18 years+ - NCT03949400Recruiting
Exercise therapy and a soft knee brace for knee arthritis
This study tests whether an exercise program plus education, along with a soft brace, helps improve symptoms and function in adults with knee osteoarthritis. It may help people who have knee pain by combining movement training with daily support.
Aalborg, NothernAges 18 years+ - NCT04102566RecruitingPhase 4
Better pain control during TURP surgery
This trial tests whether a pain-control approach can make TURP (prostate surgery through the urine tube) more comfortable. It may help you manage pain with the study medicines during and after your procedure.
Seattle, WashingtonAges 18 years+ - NCT01840930Recruiting
Study of severe cerebral palsy in children
This study looks at children ages 2 to 10 who have severe, long-term cerebral palsy to better understand this condition. It may help clinicians learn what to expect and how to support children with the most significant mobility needs.
BronAges 2–10 - NCT02362685Recruiting
Metabolic exercise testing study
This study is about doing a breathing-and-heart performance test while you exercise to better understand how your body uses energy. You may join if you’re referred for this type of test and can safely complete it.
BrestAges 5 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,575 recruiting pain medicine studies from the U.S. registry right now, out of 6,452 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.