Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,752 recruiting studies in this area right now.
By phase
- Not applicable3,096
- Phase 4253
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Mayo Clinic28
- Tanta University28
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California160
- New York81
- Massachusetts68
- Florida63
- Texas51
- Ohio47
- Maryland42
- Minnesota42
- Illinois38
- North Carolina38
Recruiting studies3,751 total
- NCT06569615Recruiting
Comparing shock wave, laser, and cold therapy for sacroiliitis pain
This trial compares three different treatments (shock wave therapy, laser therapy, and cold therapy) for people with sacroiliitis, a condition that causes pain in the lower back, buttocks, or hips. The goal is to see which treatment works best for reducing pain and improving movement.
Najran, Najran RegionAges 20–50 - NCT07707401Recruiting
WeChat neck exercises for recovery after thyroid surgery
This study tests whether simple neck exercises, guided through the WeChat app, can help you recover more quickly after thyroid surgery. If you have no serious complications and don't have neck problems, you may be able to join.
Shanghai, Shanghai MunicipalityAges 18–60 - NCT07430228Enrolling by invitationPhase 2
Can oxytocin help you recover faster after hip replacement?
This study tests if a medicine called oxytocin, given through a vein during surgery, can help people recover more quickly after a total hip replacement. It is for adults in generally good health who are scheduled for a first-time hip replacement.
Winston-Salem, North CarolinaAges 18–75 - NCT07017192Recruiting
Comparing anesthesia methods for hip replacement surgery
This study compares two types of anesthesia for people having a hip replacement through the front (anterior) approach. The goal is to see which method provides better pain control and recovery after surgery.
Torino, TOAges 18–85 - NCT07094451Recruiting
Virtual reality for pain during needle procedures
This study tests whether using a virtual reality headset can help reduce pain during ultrasound-guided needle procedures in pregnancy. It may offer a drug-free way to feel more comfortable during the procedure.
New York, New YorkAges 18 years+ - NCT05517434RecruitingPhase 2/Phase 3
Autologous bone and fat injections versus saline for knee OA
This trial compares different knee injections made from your own bone marrow and/or fat, plus platelet-rich plasma (a blood-derived healing factor), against saline (placebo) to treat painful knee osteoarthritis. It aims to see whether these “autologous” injections reduce knee pain and improve function.
Toronto, OntarioAges 30 years+ - NCT05645224Enrolling by invitation
Virtual reality for pain and anxiety during laser skin treatment
This study tests whether using virtual reality (VR) during a laser procedure for a skin condition helps children and teens feel less pain and anxiety. If you are having your first laser treatment, you might be able to use a VR headset to distract you during the procedure.
Columbus, OhioAges 5–25 - NCT07788027Recruiting
Comparing two root canal cleaning methods for reducing post-procedure discomfort
This study compares two different methods of delivering a cleaning solution during root canal treatment to see which one causes less pain and discomfort after the procedure. Participants will be randomly assigned to one of the two methods.
MinyaAges 18–45 - NCT07125027Recruiting
Exercise and mindfulness for sciatica pain
This study tests a program called Move-MORE that combines exercise and mindfulness to help people with nerve-related leg pain (sciatica) that has lasted at least 3 months. You would use the program at home, attend weekly video sessions for 8 weeks, and complete questionnaires and daily surveys to see if the program improves your pain and quality of life.
Portland, OregonAges 18–75 - NCT07787221Recruiting
Nerve blocks for pain relief after kidney removal surgery
This study compares two types of nerve blocks to see which one provides better pain relief after surgery to remove a kidney. The blocks are injected near the spine to numb the area and may reduce the need for pain medications.
CairoAges 18–65 - NCT07787871Recruiting
Acupressure for pain after laparoscopic hernia repair
This study tests whether acupressure can reduce pain after laparoscopic hernia repair surgery. If you are having this type of surgery, acupressure might help you manage pain without extra medication.
Istanbul, IstanbulAges 18–75 - NCT07780942Recruiting
Testing a smartwatch for detecting heart attacks in people with chest pain
This study is testing how well a smartwatch can detect a specific type of heart attack (STEMI) in people who come to the hospital with chest pain. It aims to see if the smartwatch's ECG feature is accurate compared to standard hospital tests.
Cartagena, MurciaAges 18 years+ - NCT07786688Enrolling by invitation
Childhood maltreatment in women with painful periods
This study looks at how many women with painful periods have experienced childhood maltreatment. It involves answering a questionnaire about your history and symptoms.
Clermont-FerrandAges 18–53 - NCT07784192Recruiting
Nerve block versus spinal morphine for hip surgery pain
This study compares two ways to manage pain after hip surgery: a nerve block (a numbing injection near the hip) versus a spinal injection of morphine. The goal is to see which method provides better pain relief and fewer side effects.
Konya, SelcukluAges 18–65 - NCT06380244Recruiting
Pain Relief Without Opioids for Abdominal Surgery
This study tests if a completely opioid-free anesthesia approach works as well as standard general anesthesia for people having laparoscopic or robotic urological surgery. It aims to offer effective pain control without using strong opioid painkillers.
Krakow, Lesser Poland VoivodeshipAges 18–75 - NCT06066853RecruitingEarly Phase 1
MDMA plus therapy for fibromyalgia pain
This trial tests whether MDMA (a drug sometimes called 'ecstasy') can help people with fibromyalgia when used alongside therapy sessions. The goal is to see if it reduces pain and improves quality of life.
Charlestown, MassachusettsAges 21–65 - NCT07754305Recruiting
Breathing and pelvic floor training for painful periods
This study tests a special breathing and muscle training program to see if it can reduce period pain in young women. It may help you manage your symptoms without medication.
Islamabad, Punjab ProvinceAges 18–24 - NCT04685772Recruiting
Medrol Dose Pack for new concussion headache relief
This trial tests whether a Medrol “dose pack” (a short course of steroid medicine taken by mouth) can reduce acute headache pain after a concussion. It may help people whose concussion headaches are frequent and severe soon after injury.
Manhasset, New YorkAges 18 years+ - NCT06908538Recruiting
Cryo nerve block for pain after amputation
This study is testing a treatment called a cryo nerve block to reduce pain after amputation, including phantom limb pain. It will look at whether freezing the nerve during surgery helps people feel less pain and use less pain medicine.
Pittsfield, MassachusettsAges 18 years+ - NCT07466446Recruiting
Tracking movement after ICU to support recovery
This study uses a small device (accelerometer) to track your movement after leaving the ICU. It aims to see if monitoring physical activity can help improve recovery for patients at higher risk of setbacks.
EdinburghAges 18 years+ - NCT06845969Recruiting
Physiotherapy dry needling accuracy study
This study tests how accurately physiotherapists can place dry needling needles. If you are a licensed physiotherapist or a volunteer who can safely receive dry needling, you may be able to join.
Edmonton, AlbertaAges 18 years+ - NCT06948162Recruiting
Dental MRI for routine dental care
This study tests whether a special MRI machine can take detailed images of teeth and jaws for routine dental care. It may help find problems without using X-rays.
Minneapolis, MinnesotaAges 18 years+ - NCT07785973Recruiting
Comparing two root canal fillings for pain and healing
This study compares two types of root canal filling materials to see which one causes less pain after the procedure and helps the infection at the tooth root heal better. It focuses on upper front teeth with an active infection.
MinyaAges 20–40 - NCT07716813Recruiting
Breast milk or sugar water for pain during heel prick in babies
This study tests whether giving breast milk or sugar water (10% or 20% dextrose) just before a routine heel prick can reduce pain and keep your baby's heart rate and oxygen levels more stable. It is designed for moderately premature babies in the NICU.
MersinAges 7 months–3.1 years
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,752 recruiting pain medicine studies from the U.S. registry right now, out of 6,746 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.