Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,575 recruiting studies in this area right now.
By phase
- Not applicable2,950
- Phase 4240
- Phase 2131
- Phase 3102
- Phase 193
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University59
- Beijing Tiantan Hospital34
- Tanta University33
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University20
Where studies are running
- California151
- New York79
- Massachusetts65
- Florida64
- Texas51
- Illinois40
- North Carolina40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,575 total
- NCT03781492Recruiting
Treatment study for stable angina symptoms
This study looks at managing and treating stable angina, a type of chest discomfort that happens predictably with activity or stress. It may help find better ways to control symptoms and improve daily life, but you must not have certain recent heart events to join.
Zabrze, Silesian VoivodeshipAges 18 years+ - NCT03168958RecruitingPhase 4
Methadone to improve recovery after planned heart surgery
This trial looks at whether giving methadone during planned heart surgery can improve how patients feel and recover afterward. It will mainly compare recovery quality using a patient questionnaire.
Evanston, IllinoisAges 18–90 - NCT03646955Recruiting
Partial breast radiation versus no radiation after lumpectomy
This trial compares giving radiation only to part of the breast versus not giving radiation at all after breast-conserving surgery. It’s meant for women with early, hormone-driven breast cancer to see if skipping radiation can be safe and reduce treatment burden.
SantiagoAges 60 years+ - NCT04599621Recruiting
Testing treatment for heart pain with anxiety or depression
This trial looks at people who have coronary artery disease and unstable or certain stable chest-pain symptoms, especially when anxiety or depressive symptoms are also present. The goal is to see how the study approach helps heart symptoms when mental health symptoms occur at the same time.
SamarkandAges Any age - NCT04699734Recruiting
Nerve block for nerve pain from diabetes
This trial studies whether a numbing “nerve block” can reduce long-lasting nerve pain caused by diabetic neuropathy. You may keep your usual pain medicines, and the study will mainly check whether you fit the safety and diagnosis criteria.
Aarhus N, JutlandAges 18 years+ - NCT04704297RecruitingPhase 4
Trigger point shots for low back muscle pain
This trial tests whether injecting sore “trigger points” in low back muscles helps improve chronic low back pain. It compares treatments in people with specific low back muscle pain patterns and excludes several other causes of pain.
Tacoma, WashingtonAges 18 years+ - NCT04196244RecruitingPhase 4
IV-contrast CT vs no-contrast CT for urgent abdominal pain
This study compares two types of CT scans—using IV contrast dye versus not using dye—in people who need an emergency abdominal scan but have reduced kidney function. It aims to see which approach is safer and works well enough to help doctors find the cause.
EspooAges 18 years+ - NCT04827498Recruiting
Testing heart blood-flow problems without clogged arteries
This study looks at how well the heart’s blood vessels work in people who have symptoms of reduced blood flow but no major artery blockage. It uses special heart tests with medicines to check how the vessels respond and may help guide better diagnosis and treatment.
MadridAges 18 years+ - NCT03420638RecruitingPhase 4
Pain relief after tonsillectomy
This study tests a long-lasting numbing medicine (bupivacaine) injected during tonsillectomy to see if it helps reduce pain after surgery. It may offer better pain control than standard care.
Ann Arbor, MichiganAges 18 years+ - NCT01301885Recruiting
Tests new diagnosis and treatments for endometriosis
This trial studies people who definitely have endometriosis (confirmed by surgery and tissue testing) and compares them with people whose endometriosis was ruled out during laparoscopy. It aims to improve how endometriosis is diagnosed and to explore new treatment approaches.
HelsinkiAges 19–48 - NCT03906617RecruitingPhase 4
Pain-relief shots for lung surgery: three drug options compared
This study compares different pain-relief medications given during lung surgery to see which one controls pain better. It may help people have less post-surgery pain after robotic wedge resection or lobectomy.
Camden, New JerseyAges 18–90 - NCT05172739RecruitingPhase 4
Opioid-free anesthesia during lung surgery for early lung cancer
This study tests whether an opioid-free pain/anesthesia plan during elective lung surgery can reduce surgical “stress” on the body and affect the immune system. You may be eligible if you have early-stage non-small cell lung cancer and are scheduled for a specific type of surgery (VATS lobectomy).
Heraklion, CreteAges 18–80 - NCT05127005Recruiting
Compare thumb arthritis surgery versus placebo surgery
This study compares a real thumb basal joint surgery (trapeziectomy) with a sham/placebo operation to see which option helps pain and daily function better. It is for people with thumb arthritis who have tried non-surgical treatments but still have significant thumb pain.
HelsinkiAges 45 years+ - NCT01566175Recruiting
Neovasc device trial for hard-to-treat chest pain
This trial tests a device called the Neovasc Coronary Sinus Reducer to help people with long-lasting, hard-to-control chest pain (angina) who cannot have artery-opening procedures. It may improve symptoms by changing blood flow in the heart’s vein system.
Tel AvivAges 18 years+ - NCT05230446Recruiting
Testing full stent treatment for heart artery blockages
This study looks at how well doctors can treat multiple blocked heart arteries using a specific drug-eluting stent, aiming to fully open them. It may help patients whose blockage pattern fits the study, but it does not include certain high-risk or special cases.
Rotterdam, South HollandAges 18–85 - NCT04791891Recruiting
Study collecting information about low back pain
This study asks adults with low back pain to complete an online questionnaire so researchers can better understand how low back pain affects daily life. Your answers may help build a larger “core dataset” for future research.
Montreal, QuebecAges 18 years+ - NCT04612322Recruiting
Study registry for microvascular angina patients
This registry study collects information from adults with microvascular angina (chest pain from small blood vessels in the heart). It may help researchers better understand how to assess and manage this condition over time.
Mainz, RLPAges 18–85 - NCT03819062Recruiting
Stomach–bowel nerve stimulation for long-term constipation
This trial studies a device that stimulates nerves near the lower back (sacrum) to improve bowel function in people with severe constipation that hasn’t responded to standard treatments. It may help if your constipation involves problems coordinating bowel movement and the muscles around the rectum.
Hamilton, OntarioAges 6–70 - NCT03096366Recruiting
Blood flow restriction rehab after ACL knee surgery
This trial studies whether a special exercise method that limits blood flow to the thigh (called blood flow restriction training) can improve quadriceps strength and function during recovery after arthroscopic ACL surgery. If you qualify, you would join a structured physical therapy program and follow the study’s rehab plan.
Houston, TexasAges 14–55 - NCT04849455RecruitingPhase 4
Nerve-block catheters plus spinal morphine for liver surgery pain
This trial tests whether placing pain-relief catheters near the back muscle plus giving morphine into the spinal fluid can improve comfort during and after liver surgery. It may help reduce the need for stronger opioid pain medicines afterward.
San Diego, CaliforniaAges 18 years+ - NCT05069363Recruiting
Light therapy for widespread chronic pain
This trial tests whether using a whole-body light treatment (photobiomodulation) can reduce widespread chronic pain. It may help if you have long-lasting, widespread pain and can safely use the device for about 6 weeks.
BirminghamAges 18–100 - NCT05357157Recruiting
Electroacupuncture for fibromyalgia pain and quality of life
This trial studies whether electroacupuncture can reduce fibromyalgia pain and improve quality of life. It also looks at changes in certain immune cells, which may help explain how treatments work.
HeraklionAges 18–80 - NCT05009433Recruiting
Exercise plans in pregnancy and afterward for mom and baby health
This study compares two types of exercise—short, intense intervals versus moderate steady activity—during pregnancy and looks at effects on mothers and children. It also checks how participants do on health, fitness, and well-being tests before, during, and after pregnancy.
Gdansk, Pomeranian VoivodeshipAges 18–45 - NCT04709900Recruiting
Tests for stable chest pain using heart scans and pressure measurements
This trial studies how well different heart tests (imaging the blood flow and measuring blood pressure in the heart) work for people with stable chest pain. It may help guide safer, more accurate evaluation when you are not having a heart attack.
CopenhagenAges Any age
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,575 recruiting pain medicine studies from the U.S. registry right now, out of 6,452 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.