Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,576 recruiting studies in this area right now.
By phase
- Not applicable2,951
- Phase 4240
- Phase 2131
- Phase 3102
- Phase 193
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University60
- Beijing Tiantan Hospital34
- Tanta University33
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University21
Where studies are running
- California152
- New York79
- Massachusetts65
- Florida64
- Texas50
- North Carolina41
- Illinois40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,576 total
- NCT06638528Recruiting
Can Walking and Breath-Holding Reduce Pain Sensitivity?
This study tests a special breathing technique called 'walking apnea' (holding your breath while walking) to see if it can reduce pain sensitivity. Healthy volunteers will do this exercise, and researchers will measure how it affects your pain perception.
MadridAges 18–65 - NCT06638515Recruiting
Walking and breathing exercise for pain relief
This study tests whether a specific breathing exercise (walking while breathing at a low lung volume) can reduce pain sensitivity. It's looking for healthy people who have no ongoing medical conditions or pain.
MadridAges 18–65 - NCT07712406Recruiting
Nerve block for lower back pain from nerve entrapment
This trial tests whether a nerve block can help people with chronic lower back or buttock pain caused by a trapped nerve near the hip bone. You may be eligible if you have had this pain for at least 3 months and it did not get better with other treatments.
Gaziosmanpaşa, IstanbulAges 18–75 - NCT07709598RecruitingPhase 2/Phase 3
HL-1186 for pain after abdominal surgery
This study tests a new painkiller called HL-1186 for people having abdominal surgery. If you qualify and enroll, you will receive the drug after surgery to see if it safely helps reduce your pain better than a placebo (a pill with no medicine).
Chengdu, SichuanAges 18–75 - NCT07706777RecruitingPhase 2
Testing a new drug for acute gout flares
This trial tests an oral medication (HRS-2129) to see if it can calm a sudden gout flare and reduce joint pain. It may help if you are currently having a moderate-to-severe gout attack and are otherwise in good health.
Guangzhou, GuangdongAges 18 years+ - NCT07712913RecruitingPhase 3
Pregabalin for nerve pain from diabetes or shingles
This trial tests an extended-release version of pregabalin (a pain medication) for people with long-term nerve pain caused by diabetes or shingles. It aims to see if this once-daily pill can reduce pain with fewer side effects.
Salvador, Estado de BahiaAges 18–75 - NCT07706348RecruitingPhase 1/Phase 2
Pain relief with ondansetron and lidocaine after abdominal cancer surgery
This trial tests if rinsing the belly with ondansetron (a nausea medicine) and lidocaine (a numbing medicine) during surgery can reduce pain afterward. It is for people having major lower abdominal cancer surgery who are otherwise healthy.
AsyutAges 20–70 - NCT07711626Recruiting
Foot massage and ear stimulation for head and neck cancer symptoms
This study tests whether foot massage (reflexology) and a mild nerve-stimulation device on the ear can help reduce side effects during chemotherapy and radiation for head and neck cancer.
Hualien CityAges 30–75 - NCT07712354Recruiting
Acupuncture and magnetic therapy for neck pain that travels to the arm
This study tests if high-frequency electroacupuncture (needles with mild electric current) at specific points on the neck, combined with electromagnetic field therapy, can help relieve pain from cervical spondylotic radiculopathy. It may be an option if you have neck pain that travels to your shoulder or arm and are not using strong painkillers.
Ho Chi Minh CityAges 30 years+ - NCT07711041Recruiting
Comparing three treatments for chronic neck pain
This trial compares three therapies—integrated neuromuscular inhibition, dry cupping, and dry needling—to see which works best for long-lasting mechanical neck pain. It may help if you have had neck pain for over six months with trigger points in your upper shoulder muscle.
GizaAges 18–40 - NCT07708740Recruiting
Two doses of ketamine for preventing slow heart rate during eye surgery
This study tests whether two doses of ketamine (a medicine given through a vein) can reduce a reflex that slows the heart during eye surgery. If you are having eye surgery that involves moving the eye muscles, you may be eligible.
CairoAges 18–65 - NCT07710352Recruiting
Comparing gas pressure settings for robotic surgery
This study compares two different gas pressure levels used during robotic surgery to see if one is better for patients. If you are having robotic surgery, it may help doctors improve safety and recovery.
New York, New YorkAges 18 years+ - NCT07709975Recruiting
Pain relief and early movement for older ICU patients
This study tests different ways to manage pain and help older patients get moving again sooner after major surgery. If you are 65 or older and in the ICU, this trial may help you recover more comfortably and quickly.
Istanbul, IstanbulAges 65 years+ - NCT07707609Recruiting
Pain and brain changes in chronic pancreatitis
This study looks at how chronic pancreatitis pain affects the nervous system and mental health. It aims to understand pain better and may help develop new ways to manage it.
Hyderabad, TelanganaAges 18–60 - NCT07712211Recruiting
Pain Catastrophizing and Nausea After Gallbladder Surgery
This study looks at how a person's tendency to focus on and feel overwhelmed by pain (called 'pain catastrophizing') might affect nausea and vomiting after gallbladder surgery. If you are scheduled for keyhole gallbladder removal, you may help doctors better predict and prevent post-surgery nausea.
TrabzonAges 18–65 - NCT07707726Recruiting
Virtual reality for ingrown toenail surgery
This study tests if using virtual reality (VR) during ingrown toenail surgery can help reduce anxiety or pain. It might be an option for people having this surgery at a specific hospital in Turkey.
Ankara, AnkaraAges 18–65 - NCT07707401Recruiting
WeChat neck exercises for recovery after thyroid surgery
This study tests whether simple neck exercises, guided through the WeChat app, can help you recover more quickly after thyroid surgery. If you have no serious complications and don't have neck problems, you may be able to join.
Shanghai, Shanghai MunicipalityAges 18–60 - NCT07711795Recruiting
Mindfulness texts for pain and medication
This study tests if text messages with meditation tips and medication reminders can help people with chronic pain stick to their treatment for opioid use. If you recently started or restarted methadone or buprenorphine, this might be for you.
Albuquerque, New MexicoAges 18 years+ - NCT07713108Recruiting
Pelvic floor muscle function and endometriosis pain study
This study looks at how pelvic floor muscles work in women with endometriosis-related pelvic pain compared to healthy women. It aims to understand if muscle function is linked to pain, which could help improve treatments.
Pécs, BaranyaAges 18–48 - NCT07711431Recruiting
Connection between gum disease and ongoing neck pain
This study looks at whether there is a link between gum (periodontal) disease and long-term neck pain without a clear cause. If you are between 30 and 55, have most of your own teeth, and don't take regular pain medicine, you may be able to help doctors understand this connection.
Niğde, Niğde ProvinceAges 30–55 - NCT07709416Recruiting
Testing toludesvenlafaxine for long-lasting low back pain
This study tests an experimental medication called toludesvenlafaxine to see if it can help people with long-lasting low back pain that has no clear cause. If you have moderate to severe lower back pain for more than 3 months and haven't taken antidepressants before, this may be an option for you to explore.
BeijingAges 18–75 - NCT07714837Recruiting
Orofacial pain and oral health in amateur orchestra musicians
This study looks at how playing in an amateur orchestra may relate to orofacial pain (pain in the face, jaw, or mouth) and oral health-related quality of life. By completing a questionnaire, you can help researchers understand these connections.
GöttingenAges 18 years+ - NCT07706751Recruiting
Predicting headache after spinal anesthesia during C-section
This study looks at whether certain factors can predict headaches that sometimes happen after getting spinal anesthesia for a planned C-section. The goal is to help doctors identify women at higher risk so they can offer better care.
AmasyaAges 18–45 - NCT07714031Recruiting
Wrist Release Therapy for Overuse Syndrome
This study tests a special hands-on therapy technique for people with wrist pain from overuse, like computer workers. It may help improve movement and reduce pain without surgery.
Faisalabad, Punjab ProvinceAges 20–50
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,576 recruiting pain medicine studies from the U.S. registry right now, out of 6,474 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.