Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,756 recruiting studies in this area right now.
By phase
- Not applicable3,101
- Phase 4252
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Tanta University29
- Mayo Clinic28
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California160
- New York81
- Massachusetts68
- Florida63
- Texas52
- Ohio48
- Maryland42
- Minnesota42
- North Carolina38
- Illinois37
Recruiting studies3,755 total
- NCT06981494Recruiting
Study of two medicines for relaxing blood pressure during ear and nose surgery
This trial tests if adding a second medicine, ketamine, to dexmedetomidine helps control blood pressure better during ear or nose surgery. It may lead to safer and smoother anesthesia for patients needing controlled low blood pressure.
SohagAges 18–60 - NCT06628895Recruiting
Modified Poco-Poco exercise for pre-frailty
This study tests whether a special exercise routine called Modified Poco-Poco can improve frailty and certain biological markers (DNA changes, GDF15, and Lamin A). It may help people who are beginning to feel weaker and want to try a gentle exercise program.
Bandung, West JavaAges 60 years+ - NCT05786599RecruitingPhase 2/Phase 3
Low-dose methadone for chemotherapy nerve pain
This trial studies whether methadone can reduce painful nerve damage caused by certain chemotherapy drugs. It is for adults who have ongoing nerve pain for months after chemotherapy ended and may help by lowering neuropathic (nerve) pain.
Nanaimo, British ColumbiaAges 19 years+ - NCT07576192Recruiting
Massage treatments for heel pain in pregnant women
This study compares two hands-on massage techniques to relieve plantar fasciitis (heel pain) in pregnant women during the second trimester. The goal is to find the most effective, safe way to reduce pain without medication.
Lahore, Punjab ProvinceAges 18–40 - NCT06781554Recruiting
Collagen device for thumb arthritis
This trial tests a new collagen-based medical device injected into the thumb joint to treat thumb base arthritis (rhizarthrosis). It aims to see if it safely reduces pain and improves hand function without surgery.
Milan, MIAges 18–75 - NCT06749964Recruiting
Personalized internet CBT for cancer-related pain
This trial tests a personalized internet-based cognitive behavioral therapy (CBT) program designed to help people with cancer-related chronic pain. It aims to improve how you cope with pain and daily life challenges.
LundAges 18 years+ - NCT06765772Recruiting
Nerve blocks for pain relief during tummy tuck surgery
This trial compares two types of nerve blocks (with numbing medicine) to reduce pain during and after tummy tuck surgery. The goal is to see if combining two blocks works better than one block alone.
Cairo, Cairo GovernorateAges 21–60 - NCT07724470Recruiting
Stretching techniques for neck and arm pain
This study tests two types of stretching to see which one works better for neck pain that spreads into the arm. If you have had this pain for more than a month, this trial might help find a way to move better and feel less pain.
Lahore, Punjab ProvinceAges 30–60 - NCT07526051Recruiting
Stretching techniques for lower back pain and muscle tightness
This study compares two stretching methods to help relieve lower back pain caused by muscle imbalances. You'll be tested to confirm the pattern of muscle tightness, then receive one of two types of stretching therapy to see which works better for your pain.
Islamabad, Punjab ProvinceAges 25–50 - NCT07491354Recruiting
Predicting chronic pain after ICU trauma
This study looks at how biological, psychological, and social factors might help predict long-term pain after a traumatic injury that required ICU care. If you are an adult with a serious injury and at least one broken bone, you may be eligible.
MontpellierAges 18 years+ - NCT07719699Recruiting
Vibration and Pilates for chronic low back pain
This study tests if whole-body vibration or Pilates exercises can reduce pain and improve balance and movement in people with long-lasting low back pain. It aims to find a helpful treatment for chronic back pain that has lasted more than 12 weeks.
Lahore, Punjab ProvinceAges 18–40 - NCT06980870RecruitingPhase 2
Pain medicine before root canal for less discomfort
This study tests whether taking ibuprofen or dexamethasone before a root canal can help reduce pain afterward. It's for people with a painful, inflamed tooth nerve who haven't already taken pain medicine for it.
RawalpindiAges 18–50 - NCT06441071Recruiting
Patient position and pain relief from ESPB block
This trial tests whether the position of patients during a nerve block (ESPB) affects pain relief after video-assisted lung surgery. It aims to find the best way to give the block for better comfort after surgery.
Nanjing, JiangsuAges 18–80 - NCT06970626RecruitingPhase 2/Phase 3
Comparing pain relief methods after sleeve gastrectomy
This study compares two ways to manage pain after laparoscopic sleeve gastrectomy: one uses a medication called dexmedetomidine given through an IV, and the other uses a combination of nerve blocks (TAP block and paragastric block) to see which leads to a better recovery.
AlexandriaAges 20–60 - NCT06310226Recruiting
Studying spinal cord stimulation for chronic low back pain
This study is looking at how people with chronic low back pain respond to spinal cord stimulation (a device that sends gentle electrical pulses to the spine to reduce pain). If you already have a spinal cord stimulator, you may help researchers understand how well it works and how it affects your brain.
Los Angeles, CaliforniaAges 18–80 - NCT06746168Recruiting
Better pain control after knee replacement surgery
This study tests a new way to manage pain after total knee replacement. It aims to see if a specific local pain block can reduce the need for strong opioids and improve recovery.
Hasselt, LimburgAges 18–85 - NCT07513974Recruiting
Pain sensitivity test to predict opioid needs in heart surgery
This study measures how sensitive you are to pain using a special device, then tracks how much pain medication you need during heart surgery. The goal is to see if pain sensitivity can predict opioid requirements and help doctors customize pain control for you.
Brussels, AnderlechtAges Any age - NCT07470021Recruiting
Numbing injection for pain relief after ankle surgery
This study tests whether a numbing injection around the ankle nerves before surgery can reduce pain and help you recover faster after ankle arthroscopy. It is for people having this keyhole surgery and staying in the hospital for a short time.
Hangzhou, ZhejiangAges 18–65 - NCT07708233RecruitingPhase 4
Benfotiamine vs vitamin B complex for diabetic nerve pain
This study compares two types of vitamin B supplements to see which one better relieves nerve pain and numbness in people with diabetes. It may help if you have diabetic neuropathy and are looking for a safe, non-drug option.
Pathumthani, BangkokAges 18 years+ - NCT07526831Recruiting
Pain Relief Methods for Knee Surgery: Two Nerve Block Approaches
This study compares two ways of numbing nerves around the knee during surgery to see which method reduces pain better after the operation. Both methods use safe, well-established pain-relief techniques.
Kayseri, TalasAges 18 years+ - NCT07708740Recruiting
Two doses of ketamine for preventing slow heart rate during eye surgery
This study tests whether two doses of ketamine (a medicine given through a vein) can reduce a reflex that slows the heart during eye surgery. If you are having eye surgery that involves moving the eye muscles, you may be eligible.
CairoAges 18–65 - NCT07525219RecruitingPhase 3
Pain Relief During Stereotactic Head Frame Placement
This study compares a new pain medication called suzetrigine with acetaminophen (Tylenol) for patients who need a stereotactic head frame placed as part of their scheduled medical procedure. The frame holds your head still during brain imaging or treatment.
Winston-Salem, North CarolinaAges 21 years+ - NCT07705698Recruiting
Nordic exercise for young female pole vaulters
This study compares two types of Nordic hamstring exercises—one with blood flow restriction and one without—to see which better helps elite young female pole vaulters strengthen their hamstrings and reduce injury risk.
AdanaAges 12–18 - NCT07269106RecruitingPhase 4
Testing anrikefon for pain relief after eye surgery
This trial tests a new painkiller called anrikefon for people having eye surgery under general anesthesia. It aims to see if it's safe and effective for controlling pain after the procedure.
Guangzhou, GuangdongAges 18–70
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,756 recruiting pain medicine studies from the U.S. registry right now, out of 6,776 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.