Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,749 recruiting studies in this area right now.
By phase
- Not applicable3,095
- Phase 4251
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Mayo Clinic28
- Tanta University28
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California160
- New York81
- Massachusetts68
- Florida63
- Texas51
- Ohio47
- Maryland42
- Minnesota42
- North Carolina38
- Illinois37
Recruiting studies3,748 total
- NCT07564167Recruiting
Dextrose Injection for Tailbone Pain Relief
This study tests whether injecting dextrose (a sugar solution) under ultrasound guidance can relieve chronic tailbone pain that hasn't improved with standard treatments like physical therapy or medication. The injection is designed to stimulate healing in the painful area.
IstanbulAges 18–75 - NCT07537036Recruiting
Pain Relief Methods for Hip Replacement Surgery
This trial compares two nerve-blocking techniques to reduce pain after hip replacement surgery. Both methods use numbing medication around specific areas near your hip to help you feel more comfortable after the operation.
Tanta, El-GharbiaAges 18 years+ - NCT06974643Recruiting
Numbing methods for awake chest surgery
This study compares two types of numbing medicine (epidural vs. paravertebral block) to see which works better for people who are awake during chest surgery. It may help find a more comfortable option for you.
CairoAges 18–60 - NCT06741579RecruitingPhase 3
Pain relief study for nerve injury pain
This trial tests how well two types of peripheral nerve stimulation (PNS) devices relieve chronic pain caused by a single nerve injury. It looks for people who already have a referral for PNS therapy as part of their usual care and who have gotten at least 50% relief from a diagnostic nerve block.
Palo Alto, CaliforniaAges 18 years+ - NCT06150599Recruiting
Sacral nerve stimulation for chronic pelvic pain
This study tests whether a pacemaker-like device placed near the tailbone can reduce long-term pelvic pain in women who haven't gotten relief from other treatments.
Royal Oak, MichiganAges 22–70 - NCT07588061Recruiting
Neck Pain Treatment: Mobilization and Posture Exercises
This study tests whether combining two types of physical therapy—manual joint mobilization and specific posture-strengthening exercises—can reduce neck and upper back pain and improve how you hold your body. You may qualify if you have persistent neck pain linked to poor posture.
Peshawar, KPKAges 18–45 - NCT07078201RecruitingPhase 4
Comparing two pain meds in spinal anesthesia for leg surgery
This study compares two medicines (dexmedetomidine and fentanyl) added to a spinal numbing shot for people having planned leg or knee surgery. The goal is to see which one works better to keep your blood pressure stable, and to make the numbing last while keeping you comfortable.
Port SaidAges 20–60 - NCT07061106Recruiting
Balance exercise study for seniors to reduce fall risk
This study tests two types of balance exercises (Otago and Kitchen Sink) in people 65 and older to see if they improve strength, reduce falls, and make daily activities easier.
RawalpindiAges 65–80 - NCT06977009Recruiting
Does tooth grinding relief help with post-dental pain?
This study tests whether reducing a tooth's contact with its opposite tooth before root canal treatment can lower pain after the procedure. It's for people with a dead nerve in a back molar that needs a crown.
Amman, Amman GovernorateAges 18–70 - NCT06409156Recruiting
Comparing two nerve blocks for upper abdominal surgery pain
This trial tests two different types of nerve blocks to see which one provides better pain relief after upper belly surgery. If you are having open surgery on your stomach, liver, pancreas, or spleen, this study may help reduce your need for strong opioids.
Cleveland, OhioAges 18 years+ - NCT07538024Recruiting
Reduced-dose radiation for spine cancer spread
This trial tests whether lower radiation doses work well for treating cancer that has spread to the spine. If you have a few spine tumors that are stable or causing symptoms, this study might help doctors find safer, faster treatment options.
Negrar, VeronaAges 18 years+ - NCT07142304Recruiting
A study of compression gloves and boots to prevent chemo nerve damage
This trial is testing a wearable device (gloves and boots) that applies gentle compression to your hands and feet during chemotherapy. It aims to prevent or reduce nerve damage (numbness, tingling, pain) that some chemotherapy drugs can cause.
Poway, CaliforniaAges 18 years+ - NCT07712406Recruiting
Nerve block for lower back pain from nerve entrapment
This trial tests whether a nerve block can help people with chronic lower back or buttock pain caused by a trapped nerve near the hip bone. You may be eligible if you have had this pain for at least 3 months and it did not get better with other treatments.
Gaziosmanpaşa, IstanbulAges 18–75 - NCT06981494Recruiting
Study of two medicines for relaxing blood pressure during ear and nose surgery
This trial tests if adding a second medicine, ketamine, to dexmedetomidine helps control blood pressure better during ear or nose surgery. It may lead to safer and smoother anesthesia for patients needing controlled low blood pressure.
SohagAges 18–60 - NCT06628895Recruiting
Modified Poco-Poco exercise for pre-frailty
This study tests whether a special exercise routine called Modified Poco-Poco can improve frailty and certain biological markers (DNA changes, GDF15, and Lamin A). It may help people who are beginning to feel weaker and want to try a gentle exercise program.
Bandung, West JavaAges 60 years+ - NCT05786599RecruitingPhase 2/Phase 3
Low-dose methadone for chemotherapy nerve pain
This trial studies whether methadone can reduce painful nerve damage caused by certain chemotherapy drugs. It is for adults who have ongoing nerve pain for months after chemotherapy ended and may help by lowering neuropathic (nerve) pain.
Nanaimo, British ColumbiaAges 19 years+ - NCT07576192Recruiting
Massage treatments for heel pain in pregnant women
This study compares two hands-on massage techniques to relieve plantar fasciitis (heel pain) in pregnant women during the second trimester. The goal is to find the most effective, safe way to reduce pain without medication.
Lahore, Punjab ProvinceAges 18–40 - NCT06781554Recruiting
Collagen device for thumb arthritis
This trial tests a new collagen-based medical device injected into the thumb joint to treat thumb base arthritis (rhizarthrosis). It aims to see if it safely reduces pain and improves hand function without surgery.
Milan, MIAges 18–75 - NCT06749964Recruiting
Personalized internet CBT for cancer-related pain
This trial tests a personalized internet-based cognitive behavioral therapy (CBT) program designed to help people with cancer-related chronic pain. It aims to improve how you cope with pain and daily life challenges.
LundAges 18 years+ - NCT06765772Recruiting
Nerve blocks for pain relief during tummy tuck surgery
This trial compares two types of nerve blocks (with numbing medicine) to reduce pain during and after tummy tuck surgery. The goal is to see if combining two blocks works better than one block alone.
Cairo, Cairo GovernorateAges 21–60 - NCT07724470Recruiting
Stretching techniques for neck and arm pain
This study tests two types of stretching to see which one works better for neck pain that spreads into the arm. If you have had this pain for more than a month, this trial might help find a way to move better and feel less pain.
Lahore, Punjab ProvinceAges 30–60 - NCT07526051Recruiting
Stretching techniques for lower back pain and muscle tightness
This study compares two stretching methods to help relieve lower back pain caused by muscle imbalances. You'll be tested to confirm the pattern of muscle tightness, then receive one of two types of stretching therapy to see which works better for your pain.
Islamabad, Punjab ProvinceAges 25–50 - NCT07491354Recruiting
Predicting chronic pain after ICU trauma
This study looks at how biological, psychological, and social factors might help predict long-term pain after a traumatic injury that required ICU care. If you are an adult with a serious injury and at least one broken bone, you may be eligible.
MontpellierAges 18 years+ - NCT07719699Recruiting
Vibration and Pilates for chronic low back pain
This study tests if whole-body vibration or Pilates exercises can reduce pain and improve balance and movement in people with long-lasting low back pain. It aims to find a helpful treatment for chronic back pain that has lasted more than 12 weeks.
Lahore, Punjab ProvinceAges 18–40
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,749 recruiting pain medicine studies from the U.S. registry right now, out of 6,757 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.