Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,756 recruiting studies in this area right now.
By phase
- Not applicable3,101
- Phase 4252
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Tanta University29
- Mayo Clinic28
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California160
- New York81
- Massachusetts68
- Florida63
- Texas52
- Ohio48
- Maryland42
- Minnesota42
- North Carolina38
- Illinois37
Recruiting studies3,755 total
- NCT07026890Recruiting
Virtual reality for elderly with psychomotor disadaptation
This trial tests if using virtual reality can help older adults who have trouble moving and adapting to their surroundings (psychomotor disadaptation syndrome). It aims to improve their care while in a hospital geriatric unit.
DijonAges 65 years+ - NCT07700108RecruitingPhase 2
Pain relief for epidural needle insertion in pregnant women
This study compares two ways to numb the skin before placing an epidural needle: a lidocaine patch placed on the back versus a lidocaine injection under the skin. The goal is to find which method is more comfortable for pregnant women during labor or cesarean delivery.
Columbus, OhioAges 18 years+ - NCT06961045Enrolling by invitation
Nerve repositioning study for dental implants in lower jaw
This study tests a computer-guided technique to move a nerve in the lower jaw so that dental implants can be placed in areas with thin bone. It looks at whether this procedure causes any numbness afterward.
Tanta, Gharbia GovernorateAges 30–75 - NCT07695168Recruiting
Digital course and rehab for knee osteoarthritis
This study tests whether a digital program with special sensors and a digital twin can help reduce knee pain and improve mobility in older adults with knee osteoarthritis. It also includes healthy adults for comparison.
TaipeiAges 20–80 - NCT06715085RecruitingPhase 4
PRGF injections for chronic low back pain
This trial tests whether injections of a blood-based treatment called PRGF can help people with long-term low back pain caused by worn discs. It is for those who haven't gotten relief from standard treatments like medication.
Vitoria-Gasteiz, AlavaAges 18 years+ - NCT07504653Recruiting
Game rehab for shoulder blade issues in Frisbee players
This trial tests a fun, game-based rehab program for Ultimate Frisbee players with a shoulder blade condition called scapular dyskinesia. It focuses on improving your shoulder movement and strength through interactive exercises.
Seremban, Negeri SembilanAges 18–40 - NCT06707363Recruiting
Psychological factors and pain after orthopedic surgery
This study looks at how your thoughts and feelings affect your pain after orthopedic surgery. Researchers want to understand these factors to improve care for future patients.
Krakow, MalopolskaAges 18–65 - NCT06995352Enrolling by invitationPhase 4
Better pain relief after ankle surgery
This trial compares two methods of pain management after ankle surgery: a one-time injection of long-lasting numbing medicine (liposomal bupivacaine) versus a continuous nerve block via a small tube (catheter) placed near the nerve. The goal is to find which approach provides better pain relief with fewer side effects.
La Jolla, CaliforniaAges 18 years+ - NCT07689045Recruiting
Comparing two nerve blocks for shoulder surgery pain
This trial compares two types of nerve blocks for pain control during and after Bankart or Latarjet shoulder surgery. The goal is to see which block provides better pain relief and preserves arm strength.
Cairo, Cairo GovernorateAges 18–65 - NCT07687290Recruiting
Comparing two nerve blocks for hip fracture pain before spinal anesthesia
This trial tests two types of nerve blocks to see which one works better for managing pain while positioning hip fracture patients before they receive spinal anesthesia. The goal is to find a more comfortable way to prepare for surgery.
CairoAges 18–70 - NCT06703671Recruiting
Acupuncture for disc-related low back pain
This trial tests whether electroacupuncture (a type of acupuncture with mild electric pulses) can help people with low back pain caused by a damaged disc. If you have had back pain for at least a month and have not had certain other treatments recently, you may be eligible.
Beijing, Beijing MunicipalityAges 18–70 - NCT07600203Recruiting
Low-level laser therapy for chronic jaw pain
This study tests whether a special laser device called the Erchonia EVRL can reduce chronic jaw pain caused by TMJ (temporomandibular joint) disorders. You would receive laser treatment and rate your pain over time to see if the laser helps more than a placebo.
Acton, MassachusettsAges 22–75 - NCT06995690Recruiting
Ketamine to prevent low blood pressure during orthopedic surgery
This study tests if a low dose of ketamine (a pain medicine) given before spinal anesthesia can prevent dangerously low blood pressure during orthopedic surgery. It might help keep your blood pressure steady, making the procedure safer.
CairoAges 18 years+ - NCT06719180RecruitingPhase 4
Pain relief after a hysterectomy
This study tests if numbing the top of the vagina (vaginal cuff) with a local anesthetic can reduce the need for pain medicine after a hysterectomy done by laparoscopy (small cuts in the belly). If you are having this surgery for a non-cancerous condition or cancer, you may be able to join.
Flushing, New YorkAges 18 years+ - NCT06468904Recruiting
Neck exercises for hand strength in chronic neck pain
This trial tests whether special neck exercises can improve hand grip strength in people with long-term neck pain caused by muscle knots. If you have chronic neck pain and hand weakness, this study may help you get stronger while reducing pain.
GizaAges 20–45 - NCT07677917Enrolling by invitationPhase 1
Medicine to reduce restlessness after sinus surgery
This trial tests two inhaled medicines, dexmedetomidine and magnesium sulfate, to see which is better at preventing agitation and restlessness as patients wake up from functional endoscopic sinus surgery. It may help you recover more calmly.
CairoAges 21–50 - NCT07517367RecruitingPhase 4
Cooling before numbing for tooth nerve pain
This study tests whether applying cold to your gum before a numbing injection helps the anesthetic work better for a severely painful lower front tooth. Researchers want to see if this simple cooling step reduces pain during the procedure.
Samsun, AtakumAges 18–60 - NCT05994833Recruiting
Virtual physical therapy for injured runners
This study tests whether virtual physical therapy sessions can help runners with long-lasting injuries like runner's knee or Achilles tendinitis. You would join online therapy for a month instead of in-person visits, and they will check how you improve.
Gainesville, FloridaAges 18–65 - NCT06471920Recruiting
Telerehab for chronic low back pain in rural areas
This study tests whether a video-based physical therapy program can help people with chronic low back pain who live in rural areas. If you qualify, you'll get telerehabilitation (rehab done at home through video calls) to reduce pain and improve function.
Baltimore, MarylandAges 18 years+ - NCT06686706Recruiting
Treating Plantar Fasciitis with Special Taping and Massage
This study tests two treatments for heel pain caused by plantar fasciitis: a special scraping technique (IASTM) and kinesio taping. It may help if you stand for long hours and have morning heel pain that gets better then worse with activity.
Rawalpindi, Punjab ProvinceAges 20–40 - NCT07672093Recruiting
Dry needling for forearm muscle knots
This study tests whether inserting a thin needle (dry needling) into a tight muscle knot in your forearm can help release it without causing pain. It's for healthy adults who have a non-painful knot in their dominant arm.
Reus, TarragonaAges 18–40 - NCT05821517RecruitingPhase 4
Breathing or virtual reality to treat shoulder dislocation pain
This trial compares two ways to help control pain after an anterior (front) shoulder dislocation: methoxyflurane breathing and a virtual reality headset, versus usual pain treatment. It may help some people by making pain control easier during treatment.
NiceAges 18 years+ - NCT06472349Recruiting
Upper trapezius muscle and chronic shoulder pain study
This study looks at how the upper trapezius muscle works and how it may be linked to long-term shoulder pain. Researchers will measure muscle shape, activity, and how you move your shoulder to understand pain better.
TaipeiAges 18–50 - NCT07664904Recruiting
Periostin protein levels and quality of life in back pain patients
This study looks at how a protein called periostin relates to back function and quality of life in people with disc herniations or spinal stenosis. You'll fill out two questionnaires and have your periostin measured from a blood draw or MRI.
Daegu, DaeguAges 20–80
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,756 recruiting pain medicine studies from the U.S. registry right now, out of 6,776 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.