Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,753 recruiting studies in this area right now.
By phase
- Not applicable3,099
- Phase 4251
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Tanta University30
- Mayo Clinic27
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California158
- New York81
- Massachusetts68
- Florida65
- Texas52
- Ohio48
- Maryland42
- Minnesota42
- North Carolina38
- Illinois37
Recruiting studies3,752 total
- NCT04606459Recruiting
Device trial for hard-to-treat heart chest pain from small vessels
This trial tests whether a small pressure-reducing device placed in a heart vein (the coronary sinus) can reduce symptoms in people with ongoing chest pain from tiny blood vessel problems. It is for angina that has not improved despite standard heart medicines, and only if special heart tests show reversible reduced blood flow.
Mainz, Rhineland-PalatinateAges 18–85 - NCT04612322Recruiting
Study registry for microvascular angina patients
This registry study collects information from adults with microvascular angina (chest pain from small blood vessels in the heart). It may help researchers better understand how to assess and manage this condition over time.
Mainz, RLPAges 18–85 - NCT04636879Recruiting
Testing dry needling for neck pain expectations
This study looks at how people’s expectations and experiences relate to treatment with dry needling for neck pain. It may help researchers understand who benefits most from this therapy for upper trapezius muscle pain.
Alcalá de Henares, MadridAges 18–65 - NCT04643951Recruiting
Study of dental students’ and professionals’ child-patient experiences
This study explores how dental students and child-focused dental professionals understand and handle pain in pediatric dentistry. Your experience and perceptions will help researchers describe common challenges and what support works best.
Malmö, Skåne CountyAges 18–65 - NCT04646707Recruiting
Nerve block to reduce opioid use after neck spine surgery
This trial tests whether a targeted back/neck numbing injection (an erector spinae block) can help reduce the amount of opioid pain medicine needed after posterior cervical spine surgery. It also aims to support an “enhanced recovery” pathway so patients may recover more comfortably and potentially faster.
Toronto, OntarioAges 18–80 - NCT04653064Recruiting
Brain imaging study of how people feel heat and pain
This study uses MRI scans to understand how your brain responds to different feelings, including mild heat pain. It may help researchers learn more about pain and brain processing by comparing your responses during the tests.
Hanover, New HampshireAges 18 years+ - NCT04659317RecruitingPhase 3
Opioid-free pain plan for joint and arm surgeries
This Phase 3 study tests an opioid-free approach to pain control for certain orthopedic (bone/joint) surgeries. The goal is to help people manage surgical pain without using opioid pain medicines.
Atlanta, GeorgiaAges 18 years+ - NCT04662905Recruiting
Testing a closed-loop spinal cord stimulator for chronic pain
This study tests a new way to deliver spinal cord stimulation for chronic pain using a system that adjusts automatically based on what your body is doing. You may be able to join if you’re using the Evoke system as part of the approved treatment plan.
Garran, Australian Capital TerritoryAges 18 years+ - NCT04666714RecruitingPhase 3
Tested a new medicine to reduce diabetic nerve pain
This Phase 3 study tests Praga formulation to see if it safely reduces nerve pain caused by diabetes. You may qualify if you’re an adult with painful diabetic neuropathy and have certain symptom and pain scores on questionnaires.
Campinas, São PauloAges 18 years+ - NCT04673981Recruiting
Follow-up study for oral and throat cancer pain
This study looks at nerve-related symptoms and pain in the mouth and throat in people who have been treated for oral or oropharynx cancer. You may be able to take part if you’re within 1 to 5 years after treatment and can follow study steps.
Clermont-FerrandAges 18 years+ - NCT04674449Recruiting
Tests a targeted plan for people with chest pain from heart artery disease
This study aims to match people with angina (chest pain from heart artery problems) to the most helpful treatment plan based on their test results. It’s done around the time doctors are planning an invasive heart scan to look at the coronary arteries.
CorkAges 18 years+ - NCT04679844Recruiting
Test bone putty for back fusion versus bone graft alternatives
This study compares a ready-to-use bone putty to standard bone graft materials (with or without your own bone) during back fusion surgery for unstable lower back problems. It looks at whether the putty works as well or better to help the bones fuse and heal.
Irvine, CaliforniaAges 18 years+ - NCT04685486Recruiting
Virtual reality program to help burn pain
This trial tests whether virtual reality (immersive computer experiences) can help manage pain in people with burn injuries. It’s for burn patients who can safely participate without heavy sedation or certain mental health or substance-use issues.
New York, New YorkAges 8 years+ - NCT04687215Recruiting
Spinal cord stimulation for painful diabetic nerve pain
This trial studies whether a spinal cord stimulator can reduce pain from diabetic nerve damage in the legs. It focuses on people with long-lasting type 2 diabetes and significant, treatment-resistant pain.
Chicago, IllinoisAges 18 years+ - NCT04689646Recruiting
Mind-body therapy for chronic back pain
This study tests whether a mind-body therapy approach can reduce disability and how bothersome chronic back pain feels. It may help people whose pain has lasted for months and affects daily life.
Boston, MassachusettsAges 18–67 - NCT04699734Recruiting
Nerve block for nerve pain from diabetes
This trial studies whether a numbing “nerve block” can reduce long-lasting nerve pain caused by diabetic neuropathy. You may keep your usual pain medicines, and the study will mainly check whether you fit the safety and diagnosis criteria.
Aarhus N, JutlandAges 18 years+ - NCT04704297RecruitingPhase 4
Trigger point shots for low back muscle pain
This trial tests whether injecting sore “trigger points” in low back muscles helps improve chronic low back pain. It compares treatments in people with specific low back muscle pain patterns and excludes several other causes of pain.
Tacoma, WashingtonAges 18 years+ - NCT04706195Recruiting
Person-centered online rehab for chronic pain on sick leave
This trial tests an early, personalized (person-centered) rehabilitation program delivered through eHealth to help people living with long-term non-cancer pain. It may help reduce pain impact and improve function while you are on sick leave from work.
GothenburgAges 18–65 - NCT04709900Recruiting
Tests for stable chest pain using heart scans and pressure measurements
This trial studies how well different heart tests (imaging the blood flow and measuring blood pressure in the heart) work for people with stable chest pain. It may help guide safer, more accurate evaluation when you are not having a heart attack.
CopenhagenAges Any age - NCT04708808Recruiting
Music therapy during ultrasound-guided abortion procedure
This trial tests whether listening to music during an ultrasound-guided vacuum aspiration procedure can help make the procedure more comfortable or less stressful. It focuses on people having first-trimester pregnancy termination under local anesthesia.
Hong Kong, ShatinAges 18 years+ - NCT04715685Recruiting
Mind-body balance program for children with migraine
This trial studies a mind-body balance approach to help reduce symptoms and disability from pediatric migraine. You may join if your child has migraine headaches and can follow study routines, including keeping a headache diary.
Aurora, ColoradoAges 10–17 - NCT04724252RecruitingPhase 2/Phase 3
Gabapentin to help children use less opioid after surgery
This study tests whether gabapentin can reduce how much opioid pain medicine children need after certain major chest or heart surgeries. If it works, it may lower opioid-related side effects while still helping with postoperative pain.
Sacramento, CaliforniaAges Up to 17 years - NCT04726228Recruiting
Using machine learning to improve pain assessment in advanced cancer
This trial looks at how a computer “learns” to better understand and assess cancer pain at home. It may help people with advanced cancer get more accurate pain evaluation while they are receiving pain treatment.
Naples, CampaniaAges 18 years+ - NCT04729686RecruitingPhase 4
Nerve block during hip replacement for less postoperative pain
This trial tests whether a specific nerve block given during planned hip replacement surgery can reduce pain afterward. It may help you use less opioid pain medicine, but you must meet certain safety and medication criteria.
Baltimore, MarylandAges 18–80
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,753 recruiting pain medicine studies from the U.S. registry right now, out of 6,795 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.