Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,753 recruiting studies in this area right now.
By phase
- Not applicable3,099
- Phase 4251
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Tanta University30
- Mayo Clinic27
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California158
- New York81
- Massachusetts68
- Florida65
- Texas52
- Ohio48
- Maryland42
- Minnesota42
- North Carolina38
- Illinois37
Recruiting studies3,752 total
- NCT04218409RecruitingEarly Phase 1
Tests a spray to reduce opioid use and pain
This early trial studies whether Syntocinon can lower pain and help reduce how much opioids people use. It checks safety and the best dose by giving participants the study drug under close medical monitoring.
Gainesville, FloridaAges 21–45 - NCT04218422Recruiting
Battlefield-style ear acupuncture for hidradenitis pain
This trial tests a type of ear acupuncture (“battlefield acupuncture”) to reduce pain from hidradenitis suppurativa, a long-term skin condition. You may be eligible if your hidradenitis pain is frequent and your treatments are stable.
Dearborn, MichiganAges 18 years+ - NCT04219956Recruiting
Low-sugar diet aims to reduce belly-surgery pain
This study tests whether a special diet low in polyamines (a food-related substance) can reduce pain after major abdominal surgery. It compares pain control while you use a patient-controlled morphine pump or take opioid tablets by mouth after surgery.
BrestAges 18 years+ - NCT04226716Recruiting
Studying pelvic pain causes in multiple or first pregnancies
This study looks at why pelvic girdle pain happens during pregnancy, focusing on body sensing (proprioception), stress factors, and inflammation. You may be able to help researchers understand the causes and who is most at risk.
HasseltAges 18–40 - NCT04248205RecruitingPhase 4
Ketamine to reduce pain after hemorrhoid surgery
This trial tests whether ketamine can lessen pain after hemorrhoidectomy (surgery for severe hemorrhoids). It may help reduce how much pain medicine you need during recovery.
Oklahoma City, OklahomaAges 18–100 - NCT04273828Recruiting
Study of muscle changes in chronic low back pain surgery
This study looks at how muscle degeneration relates to nerve-related symptoms in people with chronic low back pain. You may be eligible if you’ve tried non-surgical care but still need surgery to relieve nerve pressure.
São Paulo, São PauloAges 18 years+ - NCT04299893RecruitingPhase 2/Phase 3
Ozone treatment for chemotherapy nerve pain
This trial tests whether ozone therapy can reduce painful nerve damage caused by chemotherapy. It is for adults with ongoing moderate-to-severe pain in the hands or feet after chemotherapy.
Las Palmas de Gran Canaria, Las PalmasAges 18–100 - NCT04321408Recruiting
Study of ziconotide pain treatment in routine care
This study follows adults with severe, long-lasting pain that has not responded to other treatments, to see how the pain medicine ziconotide works in everyday clinical practice. You may be considered if you’re being evaluated for an implanted pain-delivery system that gives ziconotide into the spinal fluid.
AngersAges 18 years+ - NCT04347200Recruiting
Long-term blood-thinner therapy registry for heart disease
This study follows people with known coronary artery disease to understand how long-term “blood thinner” treatments are used and how they affect health over time. You may be asked to share medical information and come in for follow-up to help researchers compare outcomes.
MoscowAges 18 years+ - NCT04354649RecruitingPhase 2
Test triage and treatment for immune-related arthritis from immunotherapy
This trial studies how doctors assess and manage immune-related arthritis or joint pain that happens after PD-1/PD-L1 cancer immunotherapy (sometimes with CTLA-4). It may help people get faster, more targeted care while monitoring safety.
Edmonton, AlbertaAges 18 years+ - NCT04379115Recruiting
Brain stimulation study for people with opioid addiction
This study tests a non-invasive brain stimulation approach to reduce opioid cravings in people who are actively using non-prescribed opioids while on stable methadone. It may help people feel less craving and improve recovery support.
Hinsdale, IllinoisAges 18–85 - NCT04381208Recruiting
Using health and movement data to diagnose sacroiliac pain
This study looks at medical records and physical/neurological exam findings to help diagnose sacroiliac joint dysfunction, a common source of chronic low back or buttock pain. It may help your care team better sort out what’s causing your pain and choose the right next steps.
Valencia, ValenciaAges 18 years+ - NCT04439552Recruiting
MRI study during cornea cross-linking for keratoconus
This trial uses an MRI scan (and a close-up eye scan) to study what happens in the cornea during treatment for keratoconus. It may help doctors better understand how treatment works and who benefits most.
Boston, MassachusettsAges 8–35 - NCT04441034RecruitingPhase 4
Compare two medicines for long-term pain in real life
This trial compares two types of medicines—anti-convulsants and anti-depressants—for people with persistent pain lasting more than 3 months. It aims to find out which option works better in everyday care and for which patients.
Redwood City, CaliforniaAges 18 years+ - NCT04481321Recruiting
Study of endometriosis and adenomyosis in people with pelvic pain
This study looks at people who have pelvic pain and/or trouble getting pregnant, and who may have endometriosis or adenomyosis. Researchers also collect clinical and lab (molecular) information to better understand these conditions and potentially improve care.
ParisAges 18–42 - NCT04512755Recruiting
AIMS medical outcomes study for new or established patients
This is an observational study where the AIMS team collects information from patients during a first visit or ongoing care. It helps the clinic understand patients’ experiences and outcomes, but it does not test a new medicine.
Seattle, WashingtonAges Any age - NCT04533113Recruiting
Tooth filling study using selective removal on back teeth
This study looks at a careful way of removing decayed tooth material on permanent back teeth. It is meant for people with early, reversible tooth nerve irritation, to see if the approach is effective and safe.
Sant Cugat del Vallès, BarcelonaAges 18–75 - NCT04546685Recruiting
Spanish online group program to help manage long-term pain
This trial tests a one-time, Spanish-language online group program (“Empowered Relief”) for people with long-term pain. It may help you learn coping skills and strategies to reduce the impact of chronic pain.
Palo Alto, CaliforniaAges 18 years+ - NCT04576078RecruitingPhase 2
Nefopam for less pain after knee replacement surgery
This Phase 2 study tests whether oral nefopam can reduce pain after total knee replacement done with spinal anesthesia. It looks at whether this medicine works better than the usual post-surgery pain plan and how safely it can be used.
Lyon, LyonAges 18–75 - NCT04577690RecruitingPhase 4
PECS pain study for children getting a chest device implanted
This trial tests a pain-control method (PECS) during surgery for children who are having a small chest device implanted. It may help reduce discomfort during and after the operation.
Toronto, OntarioAges 3–18 - NCT04587791RecruitingEarly Phase 1
Cannabidiol (CBD) for opioid use disorder and chronic pain
This early study tests whether CBD can reduce symptoms of chronic pain in people receiving opioid maintenance treatment for opioid use disorder. It also looks at safety and whether CBD can be added without causing major problems.
West Haven, ConnecticutAges 18–70 - NCT04599621Recruiting
Testing treatment for heart pain with anxiety or depression
This trial looks at people who have coronary artery disease and unstable or certain stable chest-pain symptoms, especially when anxiety or depressive symptoms are also present. The goal is to see how the study approach helps heart symptoms when mental health symptoms occur at the same time.
SamarkandAges Any age - NCT04600089RecruitingPhase 2
Ketamine during aortic surgery to help prevent spinal nerve injury
This Phase 2 study tests whether ketamine, given during a specific type of major aortic surgery, can help prevent spinal “nerve injury” (called spinal prophylaxis). You might be considered because your planned surgery and current plan for spinal protection match the trial’s needs.
Lexington, KentuckyAges 18–90 - NCT04605445Recruiting
One vs two dentist visits for infected root canals
This study compares whether treating an infected, dead tooth in one visit works as well as using two visits. It may help you and your dentist choose the simplest schedule while still clearing infection and supporting healing.
Vaxjo, Kronoberg CountyAges 18 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,753 recruiting pain medicine studies from the U.S. registry right now, out of 6,795 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.