Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,578 recruiting studies in this area right now.
By phase
- Not applicable2,954
- Phase 4240
- Phase 2129
- Phase 3103
- Phase 193
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University59
- Beijing Tiantan Hospital34
- Tanta University33
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University21
Where studies are running
- California151
- New York79
- Massachusetts65
- Florida64
- Texas50
- North Carolina41
- Illinois40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,578 total
- NCT06857838Recruiting
Bypass surgery for symptomatic myocardial bridge
This trial tests whether bypass surgery is effective for people with a myocardial bridge (a heart muscle that arches over an artery) that still causes symptoms despite medication. It aims to see if surgery can improve symptoms and outcomes.
Xi'an, ShaanxiAges 18–80 - NCT06852378Recruiting
Pain blocks for hip fracture surgery
This study compares two types of nerve blocks to see which one provides better pain relief during hip fracture surgery. It may help reduce pain and improve recovery after your procedure.
CairoAges 18–65 - NCT07351253Recruiting
Nerve block comparison for open appendix surgery
This study tests two types of nerve blocks (Erector Spinae Plane Block and Lateral Transversus Abdominis Plane Block) to see which provides better pain relief after open appendectomy. This could help reduce pain and the need for stronger painkillers after surgery.
Cairo, Cairo GovernorateAges 21 years+ - NCT07345221Recruiting
Cold therapy for nerve pain from breast cancer chemo
This trial tests whether cooling the hands and feet during taxane chemotherapy can prevent or reduce nerve pain (peripheral neuropathy). It may help breast cancer patients who have not had nerve problems before.
IstanbulAges 18 years+ - NCT07348614RecruitingPhase 4
Knee manipulation: best numbing method for less pain
This study tests different numbing techniques to see which works best for pain during a knee manipulation procedure. It may help you have less pain and a smoother recovery.
Durham, North CarolinaAges 18–75 - NCT07350148Recruiting
Text messages to support opioid medication adherence
This study tests whether daily supportive text messages help people stay on track with their methadone or buprenorphine treatment for opioid use disorder. It is designed for adults who recently started or resumed this medication and have a cellphone.
Albuquerque, New MexicoAges 18 years+ - NCT07348523Recruiting
Comparing two types of back pain blocks after lumbar spine surgery
This trial compares two ways of delivering a pain-blocking injection (erector spinae plane block) after a single-level lower back surgery. The goal is to see which approach provides better pain relief after surgery.
SamsunAges 18–70 - NCT07351812Recruiting
Two treatments for jaw muscle pain
This study compares two different treatments for people who have pain in their jaw muscles (not the joint itself). It aims to find which treatment works better for muscle-related temporomandibular disorders (TMD).
AlexandriaAges 18–45 - NCT07352514Recruiting
Natural supplements and exercise for chemo nerve pain
This study tests if a combination of two natural supplements (PEA and Scutellaria) plus a specific exercise program can help reduce nerve pain caused by chemotherapy. It is for people who have had chemotherapy in the last 6 months and still have moderate to severe nerve pain.
Palermo, ItaliaAges 18 years+ - NCT07352683Recruiting
Nerve block for kids having belly surgery
This trial tests a nerve block to reduce pain in children aged 1–15 who are having open abdominal surgery. It aims to see if this approach improves recovery.
UppsalaAges 1–15 - NCT07345962Recruiting
Pregnant patients' hopes and fears about walking epidural
This study asks pregnant women at the CMCO about their hopes and concerns regarding walking epidural (pain relief during labor that allows you to move). It aims to understand what patients think and feel about this option.
StrasbourgAges 18 years+ - NCT07349914Enrolling by invitation
Shoulder Pain and Function with Heart Devices
This study looks at shoulder pain and how well the shoulder works in people who have a heart device like a pacemaker. It aims to understand if having the device affects shoulder function over time.
Ankara, SamanpazariAges 18 years+ - NCT07350460Recruiting
Comparing two pain blocks for hemorrhoid surgery
This study tests two types of numbing injections (a pudendal block and a sacral ESP block) to see which works better for pain after hemorrhoid surgery. If you're scheduled for this surgery, you might qualify to help find a better way to manage pain.
BellinzonaAges 18–80 - NCT07349810RecruitingPhase 4
Post-surgery pain pump study
This trial tests a pain pump after specific shoulder or knee surgeries to see how well it controls pain. It may help you recover more comfortably after surgery.
Somerset, New JerseyAges 18 years+ - NCT07344467Recruiting
Melatonin vs. Pregabalin for pain and anxiety after spine surgery
This trial compares two medications—melatonin and pregabalin—to see which works better at reducing pain and anxiety after spine surgery. It aims to find a safer, effective option for recovery.
Tanta, El-GharbiaAges 21–60 - NCT07345377Enrolling by invitation
Personalized brain stimulation for irritable bowel syndrome
This study uses brain stimulation (TMS) customized for each person to treat IBS. It uses MRI scans to see how the brain responds, aiming to find better ways to predict who will benefit from this therapy.
Hangzhou, ZhejiangAges 18–75 - NCT07348419Recruiting
Pain blocks after single-level lumbar disc surgery
This study compares two types of pain-blocking injections (Quadro-Iliac vs Thoracolumbar Interfascial Plane Block) to see which provides better pain relief after a single-level lumbar disc surgery. If you are having this surgery, the trial may help you have less pain and use fewer pain medicines afterwards.
SamsunAges 18–70 - NCT07352384Enrolling by invitation
Brain stimulation for chronic face and mouth pain
This trial tests if a non-invasive brain stimulation technique (called TMS or tDCS) can help reduce long-lasting pain in the face, jaw, or mouth. It's for people who have tried other treatments without enough relief.
Almada, Setúbal DistrictAges 18–75 - NCT07347054Recruiting
Trigger point injection for shoulder arthritis pain
This study tests whether injecting a medication into painful knots in the shoulder muscle can reduce pain from shoulder arthritis. It may be a good option if you have had shoulder pain for at least 3 months and other treatments haven't worked well enough.
Beijing, Beijing MunicipalityAges 45 years+ - NCT07347457Enrolling by invitation
Rehab and pain relief for chronic low back pain
This trial tests whether a functional rehabilitation program can improve how your body naturally reduces pain after exercise. It may help people with chronic low back pain who are starting a rehab program.
Villeneuve-d'AscqAges 18–60 - NCT07350252RecruitingPhase 4
Nerve blocks with local pain relief for knee replacement
This study tests if adding a nerve block to standard local pain relief medicine helps control pain better after knee replacement surgery. It may lead to less pain and faster recovery.
TrelleborgAges 18 years+ - NCT07347067Recruiting
Trigger point injections for chronic migraine
This study tests if injecting medication into specific painful spots in your muscles (called trigger points) can help reduce chronic migraine pain. It may be an option if you've tried other treatments but still have significant pain.
Beijing, Beijing MunicipalityAges 18–65 - NCT05784857Recruiting
Testing touch methods to reduce pain during suction in preterm babies
This study tests whether different types of gentle touch can lessen pain and stress signals when preterm babies need suction through a breathing tube. If it helps, it could offer a comforting, non-medicine way to improve comfort during this procedure.
Istanbul, AtaşehirAges 6 months–9 months - NCT06237647Recruiting
Comparing injections for partial rotator cuff tears
This study compares three types of injections—steroids, PRP (platelet-rich plasma), and PRP combined with hyaluronic acid—to see which works best for partial rotator cuff tears. If you have shoulder pain from a partial tear, this trial may help find the most effective treatment for you.
Kaohsiung City, SanminAges 20–85
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,578 recruiting pain medicine studies from the U.S. registry right now, out of 6,493 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.