Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,753 recruiting studies in this area right now.
By phase
- Not applicable3,099
- Phase 4251
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Tanta University30
- Mayo Clinic27
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California158
- New York81
- Massachusetts68
- Florida65
- Texas52
- Ohio48
- Maryland42
- Minnesota42
- North Carolina38
- Illinois37
Recruiting studies3,752 total
- NCT04748237Recruiting
CT heart scan for intermediate-risk chest pain
This study tests whether a special heart CT scan can help evaluate the cause of chest pain in people at intermediate risk for blocked heart arteries. It may help doctors decide what to do next after an emergency room visit.
StockholmAges 18 years+ - NCT04772768Recruiting
Checking problems in vein bypass grafts in people with recurring chest pain
This study looks at how vein bypass grafts are working over time in people who had heart bypass surgery and now have recurring angina (chest discomfort). It may help doctors better understand why symptoms come back and how the heart and grafts change.
AmsterdamAges 18–90 - NCT04783454Recruiting
Preventing neck and back pain in teleworkers
This study tests ways to prevent neck and back pain in people who work at a computer from home or an office. If you qualify, you may be assigned to an intervention aimed at reducing pain and improving comfort.
Ghent, East FlandersAges 18–69 - NCT04787848Recruiting
Testing pain causes and treatments in people with HIV
This study looks at why chronic widespread pain happens in people with HIV and tests new ways to understand and treat it. You may be able to join if your HIV is stable on treatment and you meet pain and safety requirements.
Miami, FloridaAges 19–65 - NCT04791891Recruiting
Study collecting information about low back pain
This study asks adults with low back pain to complete an online questionnaire so researchers can better understand how low back pain affects daily life. Your answers may help build a larger “core dataset” for future research.
Montreal, QuebecAges 18 years+ - NCT04798469RecruitingPhase 2
Testosterone to reduce long-term spine pain in men on opioids
This Phase 2 study tests whether taking testosterone can lessen chronic non-cancer spinal pain in men who have low testosterone while using opioid pain medicines. It may help by improving hormone levels that could be affecting pain and overall wellbeing.
Boston, MassachusettsAges 18 years+ - NCT04803773Recruiting
MRI-guided ultrasound to treat painful bone tumors
This feasibility study tests an MRI-guided focused ultrasound treatment for certain painful bone tumors, including bone metastases and osteoid osteoma. The goal is to see if the treatment can be safely delivered to the right spot and help with pain.
StrasbourgAges 18 years+ - NCT04827498Recruiting
Testing heart blood-flow problems without clogged arteries
This study looks at how well the heart’s blood vessels work in people who have symptoms of reduced blood flow but no major artery blockage. It uses special heart tests with medicines to check how the vessels respond and may help guide better diagnosis and treatment.
MadridAges 18 years+ - NCT04832100Recruiting
Study of a fat marker in fibromyalgia
This study looks at whether a specific fat-related marker (called LPC16:0) is linked to fibromyalgia. Your participation could help researchers understand what role this marker may play in the condition.
Kaohsiung CityAges 18–70 - NCT04831346Recruiting
Laser treatment to improve jaw opening in young women
This study tests whether low-level laser therapy can improve how far you can open your jaw and changes in jaw muscle activity in people with one-sided jaw muscle temporomandibular disorder (TMD). It may help reduce jaw movement limits related to that condition.
GizaAges 18–30 - NCT04843865Recruiting
Chinese herbal add-on for joint pain from letrozole
This trial studies whether Chinese herbs, used alongside letrozole, can reduce ongoing joint and muscle pain or stiffness in postmenopausal women with hormone-receptor positive breast cancer. It’s mainly for people whose pain started or worsened after beginning letrozole and who have completed cancer treatments.
Bukit Bintang, Kuala LumpurAges 18 years+ - NCT04849455RecruitingPhase 4
Nerve-block catheters plus spinal morphine for liver surgery pain
This trial tests whether placing pain-relief catheters near the back muscle plus giving morphine into the spinal fluid can improve comfort during and after liver surgery. It may help reduce the need for stronger opioid pain medicines afterward.
San Diego, CaliforniaAges 18 years+ - NCT04860141RecruitingPhase 4
Gabapentin before wisdom tooth removal to reduce pain
This trial tests whether taking gabapentin before extracting a wisdom tooth helps with pain and comfort after the procedure. It may help people who need a third-molar removal, if they meet the safety and health requirements.
Loma Linda, CaliforniaAges 18–59 - NCT04864080Recruiting
Online study to measure brain-related signals in pain or depression
This trial uses an online study platform to look for “cognitive biomarkers,” which are measurable patterns in thinking or brain-related responses. It compares people with pain or depression to healthy controls to see how these patterns differ and could help future research or care.
Minneapolis, MinnesotaAges 18 years+ - NCT04867187Recruiting
Brain stimulation plus mirror therapy for nerve pain
This trial tests whether a noninvasive brain stimulation treatment (repeated TMS) combined with mirror therapy can reduce nerve pain. It may help people whose nerve pain has lasted for months and hasn’t improved enough with usual medicines.
BronAges 18–85 - NCT04874038RecruitingPhase 3
Lidocaine infusions to prevent long-lasting pain after breast surgery
This Phase 3 study tests whether receiving lidocaine through an IV during breast surgery can lower the chance of ongoing pain afterward. If it works, it may help some people avoid chronic, surgery-related pain in the chest wall, shoulder, or arm.
Calgary, AlbertaAges 18–100 - NCT04873687Recruiting
ECP treatment for stable angina while waiting for heart care
This trial studies whether ECP (a non-surgical treatment that improves blood flow to the heart) can reduce symptoms in people with stable angina who may need or are waiting for heart bypass surgery, or are being managed with medicines instead. It may help you feel better and need less urgent care—if you meet the study’s medical and personal requirements.
Bandung, West JavaAges 18 years+ - NCT04880096Recruiting
Study of people living with chronic pain
This study follows people with long-term (chronic) pain to better understand their experience. It may help researchers evaluate what support or care could be more helpful for chronic pain patients.
Clermont-Ferrand, AURAAges 18 years+ - NCT04880707RecruitingPhase 2
Pain medication options for lower wisdom tooth removal
This study compares pain-medication approaches during and after removing at least one lower impacted wisdom tooth (a tooth that’s stuck). It may help find a safer or more effective way to control dental pain after surgery.
Newark, New JerseyAges 18 years+ - NCT04883411Recruiting
First-in-human test of new cervical spine plate and cage
This study tests a new implanted metal plate and cage to treat problems in the neck caused by worn spinal discs and nerve or spinal cord compression. It is aimed at people whose symptoms have not improved with non-surgical care for at least 6 weeks (or who have worsening nerve/spinal cord symptoms).
Union, New JerseyAges 22–79 - NCT04893954Recruiting
Study of spine changes after weight loss from bariatric surgery
This study looks at how rapid weight loss after bariatric surgery may affect your spine over the following year or more. It may help doctors better predict who gets spine-related problems or improvements after surgery.
ParisAges 18 years+ - NCT04894864RecruitingPhase 4
Opioid-free anesthesia for elective abdominal aortic aneurysm surgery
This trial studies an “opioid-free” anesthesia and pain plan during planned open surgery for an abdominal aortic aneurysm. The goal is to see whether this approach reduces surgical stress and pain compared with usual care.
Heraklion, CreteAges 40–85 - NCT04898491Recruiting
Pain behavior scale study for adults who cannot speak
This study checks whether a “pain behavior” checklist works well and gives consistent results in adults who can’t communicate verbally and who have an artificial airway. It may help clinicians better recognize pain in people who cannot tell them directly.
Madrid, MadridAges 18 years+ - NCT04907643Recruiting
Virtual reality program to reduce stomach-cancer pain
This trial tests whether virtual reality (VR) can improve pain and other day-to-day symptoms in people with certain gastrointestinal cancers. You’d use VR for pain relief while researchers measure how you’re feeling.
Los Angeles, CaliforniaAges 18–99
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,753 recruiting pain medicine studies from the U.S. registry right now, out of 6,795 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.