Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,753 recruiting studies in this area right now.
By phase
- Not applicable3,099
- Phase 4251
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Tanta University30
- Mayo Clinic27
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California158
- New York81
- Massachusetts68
- Florida65
- Texas52
- Ohio48
- Maryland42
- Minnesota42
- North Carolina38
- Illinois37
Recruiting studies3,752 total
- NCT04909138Recruiting
Intermittent nerve stimulation instead of daily low-frequency therapy
This study tests whether switching from continuous implanted nerve stimulation to an intermittent schedule can keep pain relief for people with chronic back and/or leg pain. You would be compared in a structured study plan to see if the alternate dosing works for you and is safe.
Chicago, IllinoisAges 18–90 - NCT04912531Recruiting
Virtual reality and smell tools to ease surgery pain
This trial tests whether a combination of virtual reality and guided smells can reduce pain and anxiety around major heart and chest surgeries. If you’re scheduled for one of the listed operations, the study may help make recovery feel more comfortable by using sensory-based distraction.
Boston, MassachusettsAges 18 years+ - NCT04918329Recruiting
Digestive symptom check-in study for adults
This study follows adults with long-lasting “functional” digestive symptoms as part of routine care. It may help researchers better understand these conditions and improve how they are managed.
RouenAges 18 years+ - NCT04930887RecruitingPhase 2
Numbing injection in the face to ease craniofacial pain
This trial tests whether an injection of a numbing medicine (bupivacaine) guided by an endoscope can reduce craniofacial pain. It may help people with certain headache or facial pain conditions by targeting the pain area more precisely.
Stanford, CaliforniaAges 18–80 - NCT04929951RecruitingPhase 1
Micro fat injection to treat shoulder arthritis
This Phase 1 study tests whether a micro-fragmented fat (MFAT) injection can reduce symptoms and improve shoulder function in people with shoulder osteoarthritis. It’s early research, so the goal is mainly to see if the treatment is safe and possibly helpful.
Stanford, CaliforniaAges 25–75 - NCT04933370Recruiting
Testing a brain or nerve stimulator settings approach
This study is for people who are planning to get a device implanted that delivers stimulation to the brain or nerves. The trial tests whether different stimulation settings work better, which could improve symptom control for participants.
Calgary, AlbertaAges 18–100 - NCT07699601RecruitingPhase 2/Phase 3
Testing a pain tablet after orthopedic surgery
This trial tests an investigational tablet called HL-1186 for controlling pain after orthopedic surgery. It explores whether the drug can safely reduce moderate to severe pain when given after the procedure.
Changsha, HunanAges 18–75 - NCT07698665Recruiting
Ketamine vs dexmedetomidine in scalp block for brain tumor surgery
This trial compares two medicines, ketamine and dexmedetomidine, added to a scalp nerve block during brain tumor removal surgery. The goal is to see which provides better pain control and recovery after surgery.
Cairo, GovernorateAges 20–60 - NCT07699224Recruiting
Menstrual cycle symptoms and women's health study
This study looks at the natural menstrual cycle symptoms and overall health in women who are not using hormonal birth control. It aims to understand how cycle-related symptoms affect daily life.
MadridAges 18–45 - NCT05579496Recruiting
Rebooting infant pain care using skin-to-skin contact
This trial tests how skin-to-skin contact affects pain and brain activity in premature babies during a routine heel prick. It may help find better ways to manage pain for infants in the NICU.
Toronto, OntarioAges 6 months–8 months - NCT05543694RecruitingPhase 4
Testing epidural pain relief for labor
This study is testing how well a combination of two medicines (bupivacaine and lidocaine) works for epidural pain relief during early labor. The goal is to find the best dose to help manage labor pain.
Boston, MassachusettsAges 18–50 - NCT04267588Recruiting
Using technology to track your chronic pain
This trial uses technology to follow how your pain changes over time and how it affects your daily life. It may help researchers understand pain patterns and improve pain care, as long as you can safely and consistently take part.
Baltimore, MarylandAges 21 years+ - NCT07697222Recruiting
Pain block comparison for pectus excavatum repair
This trial compares two types of nerve blocks to control pain after a minimally invasive surgery to fix a sunken chest. It aims to see which block works better for recovery.
Istanbul, IstanbulAges 15–25 - NCT07562412Recruiting
Audio Mindfulness for Quick Pain Relief
This study tests whether listening to brief guided mindfulness audio recordings can help reduce acute (sudden, short-term) pain. Researchers will see how different amounts of listening affect pain levels.
Tallahassee, FloridaAges 18 years+ - NCT06146842RecruitingPhase 4
Pain relief study for labor epidurals
This study tests two different epidural techniques to find the best dose of pain medicine for labor. It aims to improve comfort during childbirth.
Boston, MassachusettsAges Any age - NCT07511959Enrolling by invitation
Blood-derived treatment for chronic jaw pain
This trial tests whether a treatment made from your own blood (platelet-rich plasma exosomes) can help relieve long-term jaw joint pain and improve function. If you qualify, you would receive injections directly into your jaw area.
WroclawAges 18 years+ - NCT03912519Enrolling by invitation
Testing two ways to numb lumbar back pain with radiofrequency
This study compares two needle-based techniques to treat long-lasting low back pain by stopping overactive pain signals from specific back joints. If you’ve already tried physical therapy and pain medicines without enough relief, this trial may test which technique works better for pain reduction.
Nashville, TennesseeAges 40 years+ - NCT06101303Recruiting
Endometriosis pain study using surgery and surveys
This study looks at pain in people with or without endometriosis who are having laparoscopic surgery. Researchers want to understand more about pelvic pain by collecting information before, during, and after surgery.
St Louis, MissouriAges 12–45 - NCT04938245Recruiting
Testing improvements to spinal cord stimulation with ECAPS
This study looks at a method (ECAPS) to improve how spinal cord stimulation works. It may help people who are already scheduled to have a spinal cord stimulator trial started.
Minneapolis, MinnesotaAges 22 years+ - NCT04939207Recruiting
Test safer, cheaper scans for suspected coronary artery disease
This study compares new imaging methods to see how well they work and whether they can lower costs for people with suspected coronary artery disease. It may help by using different scan approaches while keeping patient safety in mind.
Eindhoven, North BrabantAges 18 years+ - NCT04939623RecruitingPhase 2
Probenecid to ease opioid withdrawal symptoms while tapering
This Phase 2 study tests whether probenecid can lessen discomfort from opioid withdrawal in adults who are gradually lowering their opioid pain medicine. If it works, it may make tapering feel more tolerable and safer.
Calgary, AlbertaAges 18–80 - NCT04964206Recruiting
Epidural pain relief in labor and baby brain development
This trial studies how epidural pain relief during vaginal labor may affect a child’s early brain and development. It’s for first-time, term pregnancies where you plan a vaginal birth.
Beijing, Beijing MunicipalityAges 18–35 - NCT04970121RecruitingPhase 2
Duloxetine for chemotherapy nerve pain in solid tumor patients
This Phase 2 trial tests duloxetine to see if it safely reduces painful nerve damage caused by chemotherapy (especially taxanes) in people with solid tumors. If you have moderate-to-severe nerve pain and meet lab and heart-safety checks, this study may be an option.
Bengbu, AnhuiAges 18–75 - NCT04982965RecruitingEarly Phase 1
Study brain changes behind cannabis pain relief
This early study looks at how the brain may respond to cannabis to reduce long-lasting lower back pain. You may be asked to follow strict rules about cannabis, opioids, and safety checks (including MRI) to help researchers understand the brain mechanisms.
La Jolla, CaliforniaAges 21–65
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,753 recruiting pain medicine studies from the U.S. registry right now, out of 6,795 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.