Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,578 recruiting studies in this area right now.
By phase
- Not applicable2,954
- Phase 4240
- Phase 2129
- Phase 3103
- Phase 193
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University59
- Beijing Tiantan Hospital34
- Tanta University33
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University21
Where studies are running
- California151
- New York79
- Massachusetts65
- Florida64
- Texas50
- North Carolina41
- Illinois40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,578 total
- NCT07316166RecruitingPhase 4
Nerve Block With or Without Extra Medicine for Hip Replacement
This trial compares two types of nerve blocks for pain relief after total hip replacement. One block uses a standard numbing medicine, and the other adds a medication (dexmedetomidine) that may extend the pain relief. The goal is to see which approach works better for managing pain after surgery.
Providence, Rhode IslandAges 18–80 - NCT07324538Recruiting
Movement training with coaching and touch for chronic low back pain
This study tests whether combining movement control exercises with verbal and manual cues (coaching and gentle touch) can improve how your back moves and reduce pain. It's for people with long-lasting (more than 12 weeks) low back pain that is not linked to a specific cause.
Taipei, TaiwanAges 18 years+ - NCT07315646Recruiting
Pain from IUD insertion: traditional vs. ultrasound-guided
This study tests if using ultrasound during IUD (intrauterine system) insertion reduces pain compared to the standard method. If you are getting a Kyleena or Mirena IUD, your experience may help improve comfort for other women.
GhentAges 18–60 - NCT07318987Recruiting
Nerve release surgery for knee pain relief
This study tests if surgically releasing a nerve in the knee (the saphenous nerve) can reduce pain in people with patellofemoral pain syndrome (pain around the kneecap). If you've had anterior knee pain for at least six weeks and the nerve test is positive, this trial may offer relief.
CairoAges 18–35 - NCT07317271Recruiting
Virtual reality for burn symptoms
This trial tests a virtual reality program to help with symptoms like pain, trouble sleeping, and itching after a burn injury. You can join from home using your own device.
Baltimore, MarylandAges 18 years+ - NCT07323043Recruiting
Comparing tegileridine and sufentanil for cough during anesthesia
This trial tests whether tegileridine causes less coughing than sufentanil when given as part of anesthesia for surgery. It aims to find a better painkiller option for patients having surgery with a breathing tube.
Lianyungang, JiangsuAges 18–65 - NCT07322445Recruiting
Study of neck and shoulder pain with special MRI
This study uses special MRI scans to look at muscles and nerves in people with long-term neck or shoulder pain caused by trigger points (tender spots in muscles). The goal is to understand what happens in the body with this type of pain—so doctors can find better ways to treat it.
St Louis, MissouriAges 18–80 - NCT07317518Recruiting
Taping for chronic low back pain
This trial tests two different kinesio taping methods for people with chronic low back pain. The goal is to see how taping affects the fascia (connective tissue) in the lower back and whether it can help relieve pain.
Center, Kirşehi̇rAges 18–65 - NCT07318519Recruiting
Virtual reality for chronic cancer pain
This study tests whether virtual reality (VR) can help reduce chronic pain in people with cancer. If you have had cancer pain for at least three months and rate your pain as 4 or more out of 10, you may be able to join.
Washington D.C., District of ColumbiaAges 18 years+ - NCT07319806Enrolling by invitation
Two ways to help kids feel better during breathing tube removal
This study tests two different methods to lower pain, fear, and emotional upset when a breathing sample is taken from hospitalized children aged 6 to 12. The goal is to find which approach works best to make the experience easier for your child.
DüzceAges 6–12 - NCT07324499Recruiting
Dexamethasone with nerve block for shoulder surgery
This trial tests if adding dexamethasone to a standard numbing medicine (bupivacaine) affects how much of the medicine stays in your blood. It may help improve pain relief after shoulder surgery.
SantiagoAges 18–90 - NCT07323914RecruitingPhase 3
Pain management for people with Alzheimer's and chronic pain
This study tests if opioid pain medicine is safe and effective for people with Alzheimer's disease who also have chronic pain. It aims to find better ways to manage pain in dementia.
BeijingAges 50–90 - NCT07318896Recruiting
Agar and collagen supplement study for knee pain
This trial tests whether a supplement made from agar and collagen can help reduce knee pain in people with mild to moderate osteoarthritis. If you are between 40 and 70 and have knee pain, this may be an option for you.
Reus, TarragonaAges 40–70 - NCT07318116Enrolling by invitation
Cabbage Leaf for Knee Osteoarthritis Pain
This study tests whether applying cabbage leaves to the knee can reduce pain in people with knee osteoarthritis. If you have had knee pain for at least 6 months and are not allergic to cabbage, you may be able to join.
Şirnak, MerkezAges 18–80 - NCT07324109Recruiting
Testing a system for phantom limb pain after leg amputation
This trial is testing a system called Suralis to see if it can help evaluate phantom limb pain — pain that feels like it's coming from a missing leg. It's for people who have had a leg amputated below or above the knee, use a prosthetic regularly, and have daily pain scoring at least 3 out of 10.
Wiesbaden, HesseAges 18 years+ - NCT07321483Recruiting
Reflex therapy for jaw pain
This trial tests if a special reflex therapy can help people with jaw muscle pain that isn't caused by joint damage. It might be a new way to reduce discomfort and improve function.
OlomoucAges 18 years+ - NCT06328751Recruiting
Virtual reality meditation for cancer pain relief
This study tests whether using meditation with virtual reality can help reduce pain in people with cancer. If you have chronic pain from cancer and can use a simple VR headset, this might be a gentle way to find relief.
Manaus, AmazonasAges 18–75 - NCT06871605Recruiting
Nerve blocks for chronic groin pain after hernia surgery
This study compares two types of nerve blocks (injections near the nerves) to treat chronic groin pain after hernia surgery. The goal is to find which block provides better pain relief.
AnkaraAges 18 years+ - NCT04273828Recruiting
Study of muscle changes in chronic low back pain surgery
This study looks at how muscle degeneration relates to nerve-related symptoms in people with chronic low back pain. You may be eligible if you’ve tried non-surgical care but still need surgery to relieve nerve pressure.
São Paulo, São PauloAges 18 years+ - NCT06691750Recruiting
Barbed Suture Study for Cesarean Wound Healing
This trial tests if a special type of stitch (barbed suture) used to repair the uterus during cesarean section can reduce the chance of developing a small pocket or gap in the uterine scar, called isthmocele. If you are having a planned or emergency c-section at Hospital Clinic of Barcelona, you may be able to join.
BarcelonaAges 18 years+ - NCT06444919RecruitingPhase 4
Capsaicin patch for finger osteoarthritis with nerve pain
This study tests if a capsaicin patch (a hot pepper extract) can reduce finger pain in people with osteoarthritis who also have nerve-like pain. It's for those who haven't gotten enough relief from standard painkillers.
Clermont-FerrandAges 18 years+ - NCT07309731Recruiting
Hot vs. cold radiofrequency for chronic low back pain from facet joints
This trial compares two types of radiofrequency treatment (cooled vs. thermal) to see which works better for chronic pain coming from the small joints in your lower back. It is for people who have had back pain for at least 3 months and haven't gotten enough relief from usual treatments like pain medicine or physical therapy.
Zagazig, ElsharqyaAges 30–70 - NCT07315451Enrolling by invitation
Measuring spine space with ultrasound in different body positions
This study compares two positions (lying on your side vs. sitting upright) for measuring the space between the bones in your lower back using ultrasound. It aims to find which position gives a clearer view, especially for people with a higher body mass index.
KocaeliAges 18 years+ - NCT06436092Recruiting
Stent treatment for left main coronary artery disease
This trial studies a new way to treat blockages in the left main coronary artery using a drug-coated stent. It aims to find out if a careful approach with a single stent and temporary side-branch support works well for people with heart disease.
Ichinomiya, Aichi-kenAges 18 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,578 recruiting pain medicine studies from the U.S. registry right now, out of 6,493 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.