Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,753 recruiting studies in this area right now.
By phase
- Not applicable3,099
- Phase 4251
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Tanta University30
- Mayo Clinic27
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California158
- New York81
- Massachusetts68
- Florida65
- Texas52
- Ohio48
- Maryland42
- Minnesota42
- North Carolina38
- Illinois37
Recruiting studies3,752 total
- NCT05231265Recruiting
Lumbar surgery effect on walking complexity in chronic low back pain
This study looks at how lumbar spine surgery (fusion or artificial disc “prosthesis” on one or two levels) affects how complex your walking looks and feels. It may help doctors better understand what to expect from surgery and how it changes movement in people with long-term low back pain.
NîmesAges 18 years+ - NCT05232604Recruiting
Exercise vs local pain exercises for jaw and neck pain
This study compares two types of treatment: aerobic exercise versus exercises aimed at the painful jaw/neck area. It may help people with long-term jaw and neck pain by testing which approach improves pain and function.
Osnabrück, Lower SaxonyAges 18–60 - NCT05253326Recruiting
Relaxing muscle exercises after spine surgery
This trial tests whether a structured “progressive muscle relaxation” routine can reduce pain and help recovery after spine surgery. You may be asked to learn and practice the relaxation steps even if you’ve never done them before.
Istanbul, ÜsküdarAges 18 years+ - NCT05254574RecruitingPhase 1
Acoustic therapy for ongoing joint pain from osteoarthritis
This Phase 1 study tests a sustained acoustic medicine device to help reduce pain from osteoarthritis (wear-and-tear arthritis) in joints like knees or hips. Because it’s early-stage research, you may be asked to follow strict rules about pain medicines and device use while the team monitors safety and comfort.
Tampa, FloridaAges 35–85 - NCT05255705Recruiting
Registry study of revascularisation after heart scan
This study collects information about people who had a heart scan (angiogram) and then a procedure to improve blood flow to the heart. It helps researchers understand outcomes after this treatment using a research database.
LondonAges 16 years+ - NCT05260320Recruiting
Testing the best anesthesia plan for teens having jaw surgery
This study looks at whether a standardized anesthesia plan works best for kids and teens having Le Fort jaw surgery at Johns Hopkins. If you qualify, the team may use or adjust anesthesia to improve safety and comfort during surgery.
Baltimore, MarylandAges 14 years+ - NCT05263297Recruiting
Testing two ways to reduce anxiety during blood draws
This study compares two combined programs to help children feel less stressed during a blood draw. It uses simple, child-friendly activities to see which approach works better for coping during the procedure.
KaramanAges 8–10 - NCT05266040RecruitingPhase 2
Valacyclovir to reduce pain from infected tooth abscess
This Phase 2 study tests whether valacyclovir, an antiviral medicine, can help reduce moderate-to-severe pain from an acute infected tooth abscess. Participants also receive standard dental treatment, and the study looks at whether the added medicine helps with pain.
San Francisco, CaliforniaAges 18–80 - NCT05269212Recruiting
Help people with ongoing back pain return to work
This study looks at how to help people with long-lasting spinal pain (PSPS-Type II) get back to work. It may help by testing a plan for managing persistent pain so work becomes more doable.
GhentAges 18–60 - NCT05269628RecruitingPhase 2
Cannabidiol for multiple sclerosis sleep and pain patterns
This study looks at whether cannabidiol (CBD, a cannabis-related medicine) can improve symptoms in people with multiple sclerosis (MS), especially how sleep and pain type affect outcomes. It’s mainly for people with MS and ongoing moderate-to-severe pain, while carefully checking safety and medication interactions.
Ann Arbor, MichiganAges 18–65 - NCT05271331Recruiting
Numbing injection options for back surgery pain
This trial compares two ways of numbing tissue during a planned back surgery called a laminectomy: an “ESPB block” versus numbing the wound directly. It aims to see which method works better for pain control and comfort after surgery.
Padova, VenetoAges 18 years+ - NCT05272280Recruiting
Ultrasound nerve blocks for pain after gallbladder surgery
This trial compares two ultrasound-guided nerve block techniques to control pain after laparoscopic gallbladder (cholecystectomy) surgery. It may help by finding which method gives better pain relief with fewer side effects.
Asyut, Assiut, Asyut Governorate, Egypt,Ages 18–65 - NCT05272488Recruiting
Manual therapy plus vagus nerve stimulation for jaw muscle pain
This trial tests whether combining hands-on jaw treatment with a vagus nerve stimulator can reduce jaw muscle pain and improve jaw movement. It may help people whose jaw pain has been present recently and who have not had recent physiotherapy.
Alcalá de Henares, MadridAges 18 years+ - NCT05275881Recruiting
Virtual reality during procedures for young blood or cancer patients
This trial tests whether using virtual reality (VR) during certain procedures can make them easier for children, teens, and young adults with blood or cancer-related conditions. Participants must be able to safely use a VR headset and be willing to take part.
PoitiersAges 7–24 - NCT05278494Recruiting
Dextromethorphan to reduce pain after knee replacement
This trial studies whether dextromethorphan (a medicine sometimes used for cough) can reduce pain after total knee replacement surgery. If you’re having this operation and meet safety criteria, it may help improve how you feel during recovery.
Los Angeles, CaliforniaAges 18 years+ - NCT05285683RecruitingPhase 2
Study brain dopamine in people with chronic pain
This Phase 2 study looks at how a brain chemical called dopamine is involved in long-lasting pain. You may be able to join if you have chronic pain for over a year and your pain score is high enough, and if MRI and health checks are safe for you.
Rochester, New YorkAges 18 years+ - NCT05295498Recruiting
Brain stimulation trial for nerve pain relief
This trial studies whether repeated magnetic stimulation of the brain can reduce ongoing nerve pain. It may help people whose nerve pain has been steady for at least a month and who still need pain medicine more than once a week.
KrakowAges 18 years+ - NCT05303415Recruiting
Low-intensity ultrasound study during brain MRI
This study tests how low-power focused ultrasound changes brain signals measured during MRI. You may help researchers understand how ultrasound can affect brain activity, even if you don’t have a known brain condition.
Roanoke, VirginiaAges 18–65 - NCT05303805RecruitingPhase 4
Sevoflurane gel for painful, slow-healing leg ulcers
This trial studies a topical (skin-applied) form of sevoflurane to help painful leg ulcers that are not healing on their own. If you have ongoing ulcer pain and can report it reliably, you may be considered for this treatment study.
PragueAges 18 years+ - NCT05304286Recruiting
Study of brain and pain in long-lasting post-surgery pain
This trial studies what’s happening in the brain and how pain is processed in people with pain that lasts long after surgery. It may help researchers understand chronic post-surgical pain and find better ways to treat it.
Boston, MassachusettsAges 12 years+ - NCT05306899RecruitingPhase 3
IV ketamine for chronic daily headaches
This trial tests whether an IV dose of ketamine can reduce chronic daily headaches and is safe for people with this condition. It may help by lowering headache frequency and severity, but it also has several medicine and health-related safety checks.
Toronto, OntarioAges 18–75 - NCT05322018Recruiting
Check how well a thermometer scale measures dental pain
This study tests whether a simple “faces thermometer” tool can accurately measure pain in children during dental visits. If it works well, it could help dentists and doctors better understand and manage children’s discomfort.
Malmö, Skåne CountyAges 8–17 - NCT05324254Recruiting
Weighted blankets to help after breast surgery pain
This study tests whether sleeping with a weighted blanket can reduce pain after breast surgery. You may use a smartphone app to quickly report how your pain and comfort feel over time for up to 3 months.
La Jolla, CaliforniaAges 18 years+ - NCT05323383Recruiting
Brief mindfulness and hypnosis for ongoing pain relief
This trial studies whether brief mindfulness meditation or hypnosis can help people who live with long-lasting or recurring pain. It also looks at how these approaches might reduce pain over time.
Brisbane, QueenslandAges 18 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,753 recruiting pain medicine studies from the U.S. registry right now, out of 6,795 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.