Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,578 recruiting studies in this area right now.
By phase
- Not applicable2,954
- Phase 4240
- Phase 2129
- Phase 3103
- Phase 193
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University59
- Beijing Tiantan Hospital34
- Tanta University33
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University21
Where studies are running
- California151
- New York79
- Massachusetts65
- Florida64
- Texas50
- North Carolina41
- Illinois40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,578 total
- NCT07311369RecruitingPhase 2
Testing a new pain tablet after abdominal surgery
This trial tests a new pain tablet (HL-1186) for people having abdominal surgery. It aims to see if the tablet is safe and works well to manage pain after the operation.
Changsha, HunanAges 18–75 - NCT07308834RecruitingPhase 1/Phase 2
Knee injection study for moderate to severe osteoarthritis pain
This study tests a new knee injection called CX-011 to see if it can reduce pain and improve function in people with knee osteoarthritis. It may be a good option if you have tried other treatments without enough relief.
Los Angeles, CaliforniaAges 40–75 - NCT07311889Enrolling by invitation
Patient satisfaction with ELIXIR MD during plastic surgery recovery
This study looks at how satisfied patients are with their recovery after plastic surgery when the ELIXIR MD device is used. It aims to understand if this device helps improve the recovery experience.
Irvine, CaliforniaAges 18 years+ - NCT06515925Recruiting
Virtual group program for managing chronic pain
This study tests a virtual group program that combines medical care with integrative approaches like mindfulness and gentle movement to help adults manage chronic musculoskeletal pain.
Malden, MassachusettsAges 18 years+ - NCT07310004Recruiting
VR vs Music for Breast Biopsy Anxiety
This trial compares using a virtual reality headset versus listening to relaxing music to help lower your anxiety and pain during a breast biopsy. Both methods are non-drug ways to help you feel more comfortable during the procedure.
Los Angeles, CaliforniaAges 18 years+ - NCT07308873Recruiting
Gait and knee osteoarthritis pain study
This study looks at how walking patterns relate to knee pain from osteoarthritis. It aims to understand individual differences to improve future treatments.
Pittsburgh, PennsylvaniaAges 45–80 - NCT07308587Recruiting
Nerve pain after chest tube for broken ribs
This study looks at nerve pain that can happen after a chest tube is placed to treat broken ribs from an injury. The goal is to understand how common it is and how it affects recovery, so doctors can better support patients.
Toronto, OntarioAges 18 years+ - NCT07314450Recruiting
Pain and sedation for fracture and dislocation treatment in the ER
This study tests how well pain and sedation medicines work in the emergency department when treating adults with certain broken bones or dislocated joints that need to be set or casted. It aims to see which approach is safest and most comfortable for patients.
Holbæk, Region SjællandAges 18 years+ - NCT07311525Recruiting
Nerve blocks for pain after weight-loss surgery
This study compares two types of nerve blocks to see which one provides better pain relief after weight-loss surgery (sleeve gastrectomy). If you qualify, you will receive one of these nerve blocks before surgery to help manage your recovery pain.
Banī Suwayf, Beni Suweif GovernorateAges 18–65 - NCT07307703Recruiting
TENS for pain and anxiety after gallbladder surgery
This trial tests whether TENS, a mild electrical therapy, can reduce pain and anxiety after gallbladder removal. If you are having planned gallbladder surgery and are in good health, you may be able to participate.
Niğde, AdanaAges 18 years+ - NCT07315308Recruiting
Nerve block before heart surgery and painkiller use
This study tests whether a numbing injection in the chest before heart surgery can reduce the amount of pain medicine needed during the operation. It may help you manage pain better and recover more comfortably.
Gaziantep, SahinbeyAges 18–65 - NCT07308730Recruiting
Pain diary after gallbladder surgery
This study looks at whether using a pain diary can help people manage pain better after gallbladder removal surgery. If you are having this surgery for the first time and can read and write in Turkish, you may be able to join.
Muğla, MenteşeAges 18 years+ - NCT07313345Recruiting
Predicting pain relief from endometriosis surgery
This study looks at whether surgery can help reduce pelvic pain caused by advanced endometriosis. It aims to predict who will get the most benefit from the operation.
Oxford, OxfordshireAges 18–50 - NCT07309874Recruiting
Dry needling for headache relief
This study tests if a specific type of dry needling (using a thin needle on tight neck muscles) can help reduce headaches. You may join if you've had headaches recently and have tender muscles at the base of your skull.
Lubbock, TexasAges 18–65 - NCT07315334Recruiting
Understanding nerve damage from chemotherapy
This study looks at how chemotherapy-related nerve damage affects daily activities like walking and standing. It includes people who currently have or have had nerve-damaging chemotherapy and are experiencing nerve pain or weakness.
SalzburgAges 18 years+ - NCT07310823Enrolling by invitation
Manual therapy for neck-related headaches
This study tests if manual therapy (hands-on treatment) can help people whose headaches start from neck problems. If you have headaches at least once a week and limited neck movement, this trial may be an option.
GizaAges 20–40 - NCT07313280Enrolling by invitation
PTSD and chronic pain therapy study for women
This study looks at how a psychological program can help women with chronic pain conditions linked to central sensitization (where the nervous system stays on high alert) and PTSD. It aims to reduce pain and stress symptoms.
Málaga, MálagaAges 18–65 - NCT07307495Recruiting
Pain relief after back surgery and its effect on recovery
This study tests a new painkiller, oliceridine fumarate, given through a pump after lumbar spine surgery. The goal is to see if it helps the bowels and stomach recover faster compared to standard pain relief.
Xi'an, ShaanxiAges 18–75 - NCT07307976Recruiting
Testing a new pain drug for shingles pain
This trial tests a new medicine called crisugabalin to see if it safely reduces shingles pain. It may help if you have moderate to severe pain from a shingles rash that started less than 3 months ago.
BeijingAges 18 years+ - NCT07307170Recruiting
Mirogabalin for shingles pain study
This trial tests a new pain medicine called mirogabalin for people with shingles pain that started within the last 30 days. It aims to see if the drug can safely reduce moderate to severe pain.
BeijingAges 18 years+ - NCT07308951Recruiting
Electrical acupoint stimulation for chronic cancer pain relief
This trial tests if a small, patient-controlled device that sends mild electrical pulses to acupoints (like acupuncture without needles) can improve quality of life for people with ongoing cancer pain. It may offer a drug-free way to manage pain at home.
Zhejiang, HangzhouAges 18–80 - NCT07310953Recruiting
Using new pain scales to guide rescue pain medicine after surgery
This trial tests if a simple pain scale (the NVS and PFAS) can help doctors better decide when to give extra pain medicine after surgery. It may help control pain more quickly and effectively after a procedure called VATS.
VigoAges 18 years+ - NCT06873893Recruiting
Nerve blocks for pain relief after mastectomy surgery
This study compares two types of ultrasound-guided nerve blocks to see which one provides better pain relief after a mastectomy. The blocks are injected near the chest wall to numb the area during and after surgery.
Cairo , AbbassyaAges 35–65 - NCT06875804Recruiting
Compressive release for knee cap tracking in knee pain
This trial tests a hands-on therapy called compressive myofascial release for the muscle on the outside of your thigh. It aims to see if it helps with kneecap tracking problems that cause pain during daily activities.
Lahore, Punjab ProvinceAges 20–40
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,578 recruiting pain medicine studies from the U.S. registry right now, out of 6,493 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.