Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,753 recruiting studies in this area right now.
By phase
- Not applicable3,099
- Phase 4251
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Tanta University30
- Mayo Clinic27
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California158
- New York81
- Massachusetts68
- Florida65
- Texas52
- Ohio48
- Maryland42
- Minnesota42
- North Carolina38
- Illinois37
Recruiting studies3,752 total
- NCT05325580RecruitingPhase 3
IV magnesium vs placebo for sudden non-injury headaches
This trial tests whether giving magnesium sulfate through a vein in the emergency room can reduce sudden (non-injury) acute headaches compared with a placebo. It may help people whose headache comes on suddenly and is not caused by an injury.
MonastirAges 18–85 - NCT05335070RecruitingPhase 2
Study to reduce pain from wisdom tooth extractions
This Phase 2 study tests ways to reduce pain during and after wisdom (back) tooth extractions done with IV sedation. It may help you have a more comfortable experience by improving how pain is managed after the procedure.
Newark, New JerseyAges 18–64 - NCT05335668Recruiting
Brain scan study of pain changes after stroke
This study looks at how brain wiring changes in people who have central post-stroke pain. It uses clinical checks and detailed brain scans (including a 7T MRI) to understand what may be driving the pain and how the brain changes over time.
BernAges 18–75 - NCT05344716Recruiting
Erbium laser treatment for urethral pain in women
This trial tests whether an erbium:YAG laser can reduce urethral and lower pelvic pain that has lasted for at least 6 months. It may help people whose pain has not improved with at least one non-surgical treatment.
Frauenfeld, ThurgauAges 18 years+ - NCT05344612Recruiting
Testing CT scan first to guide treatment for chest pain
This trial studies whether doing a special heart scan (CTCA) right away can better guide treatment for people with chest pain who might have coronary artery disease. It compares this “scan-first” strategy to standard care to see which approach leads to better outcomes and fewer unnecessary procedures.
Amsterdam, North HollandAges 18 years+ - NCT05345015Recruiting
Radio waves for muscle or low back pain and function
This trial tests whether a high-frequency radio-wave treatment can reduce pain and improve movement in adults with a muscle strain (hamstring) or acute or chronic low back pain. It may help you feel less pain and function better, depending on your specific injury and medical details.
KavalaAges 18–65 - NCT05347069RecruitingPhase 4
Aspirin study for people with stable heart artery disease
This trial tests whether daily aspirin is safe and effective for people who have stable (chronic) coronary artery disease but cannot have procedures to open blocked arteries. It may help reduce future heart problems, while also checking for side effects and risks from aspirin.
KyotoAges 20 years+ - NCT05351099Recruiting
Nerve-block shot for emergency dental pain relief
This study tests whether a dental nerve-block shot can safely help reduce pain for adults who come to the emergency department with tooth pain. If the ED clinician plans to use the block, you may be asked to rate your pain during the visit.
Fresno, CaliforniaAges 18 years+ - NCT05351229RecruitingPhase 4
Spinal morphine for pain control after lung surgery
This trial tests whether putting morphine into the spinal area during lung surgery can reduce pain after surgery for people having certain minimally invasive lung operations. It aims to improve comfort and possibly reduce the need for other pain medicines.
Chicago, IllinoisAges 18–80 - NCT05351801RecruitingPhase 2
Test cannabis-based treatment for nerve pain
This Phase 2 study tests cannabis-derived products to see if they reduce neuropathic (nerve-related) pain in veterans. It may help people whose pain is persistent and causes significant daily impact, especially if certain exam tests show allodynia (pain from normally non-painful touch).
San Diego, CaliforniaAges 21 years+ - NCT05357157Recruiting
Electroacupuncture for fibromyalgia pain and quality of life
This trial studies whether electroacupuncture can reduce fibromyalgia pain and improve quality of life. It also looks at changes in certain immune cells, which may help explain how treatments work.
HeraklionAges 18–80 - NCT05366140Recruiting
Implanet Jazz spine fusion for adults needing thoracolumbar stabilization
This trial looks at using the Implanet Jazz system during spine fusion surgery for adults who need stabilization in the middle-to-lower back. It may help patients by improving how well the fused spine heals and stays in place.
Lexington, KentuckyAges 18–100 - NCT05369130Recruiting
Predict pain after major aortic surgery
This study tries to understand and predict persistent pain after elective surgery on the thoraco-abdominal aorta (a major blood vessel in the chest and belly). The goal is to learn what factors may help patients have less long-lasting pain after surgery.
LondonAges 18 years+ - NCT05382845Recruiting
Screening for pelvic pain in early pregnancy
This study looks to identify pregnancy-related pelvic girdle pain in pregnant people early in pregnancy (before 20 weeks). It may help doctors spot who is likely to develop pelvic pain and guide earlier support.
Karlskrona, Blekinge CountyAges Any age - NCT05382962Recruiting
Using an app to help teens cope with post-surgery pain
This trial tests whether a phone app (iCanCope) can help teens better manage pain after surgery for scoliosis or certain chest conditions (pectus carinatum/excavatum). If you’re having one of these surgeries soon, the app may help with coping and day-to-day comfort after the operation.
Boston, MassachusettsAges 12–18 - NCT05383157Recruiting
Brief mindfulness program for chronic pain in Ukraine
This study tests whether a short mindfulness practice can help people manage long-term (chronic) pain. You may be able to take part if your chronic pain diagnosis is confirmed by a doctor and you can complete the study activities.
VinnitsaAges 18 years+ - NCT05398003Recruiting
Stimulating nerves to treat long-lasting neck and arm pain
This trial tests whether a nerve-stimulation treatment can reduce chronic neck and upper arm pain when other treatments haven’t worked. It includes adults who can consent and attend follow-up visits, and it checks for safety with pregnancy prevention and a specific early test after implantation.
NantesAges 18–85 - NCT05401630Recruiting
Mental stress testing in postmenopausal women with chest pain
This study looks at how your heart reacts to mental stress in postmenopausal women, including those with chest pain and those with or without blocked heart arteries. It uses a special heart scan (MIBG) and stress tasks to understand differences that may help guide future care.
Atlanta, GeorgiaAges 45 years+ - NCT05404581Recruiting
Insula brain stimulation for long-term nerve pain
This trial tests whether stimulating a specific brain area (the insula) can reduce chronic nerve pain. It is for people whose pain has lasted at least 6 months and has not improved enough with several pain medicines and other procedures.
Charlottesville, VirginiaAges 18–80 - NCT05406063Recruiting
Focused radiation for bone metastases causing pain
This trial studies a precise type of radiation given in multiple small sessions to treat bone metastases that are causing pain. It may help shrink or control the spots in the bone while aiming to reduce side effects by targeting the area closely.
Winterthur, Canton of ZurichAges 18 years+ - NCT05407610Recruiting
Compare two types of nerve pain treatments for knee pain
This study compares conventional versus cooled radiofrequency treatments for long-lasting knee pain. It aims to see which method reduces pain better and helps patients function more comfortably.
AntwerpAges 18 years+ - NCT05415020Recruiting
Behavior program for chronic migraine
This trial tests a behavioral (talk/skills-based) program to help people with chronic migraine. It may help reduce migraine frequency or improve day-to-day coping.
Phoenix, ArizonaAges 18 years+ - NCT05417737Recruiting
Ozone therapy for chronic pain when standard treatments fail
This study offers a palliative (comfort-focused) ozone treatment to adults with chronic pain when usual treatments don’t work or are too risky. Researchers will check whether adding ozone can help symptoms and whether it’s safe for selected patients.
Las Palmas, Las PalmasAges 18 years+ - NCT05421273Recruiting
Testing two spinal stimulation patterns for long-term back pain
This study compares two ways of delivering spinal cord stimulation to see which better reduces pain in people with persistent spinal pain syndrome type 2. You would be assigned to one of the stimulation “burst” patterns and followed for changes in your pain experience.
Arnhem, GelderlandAges 18–70
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,753 recruiting pain medicine studies from the U.S. registry right now, out of 6,795 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.