Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,749 recruiting studies in this area right now.
By phase
- Not applicable3,095
- Phase 4251
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University32
- Tanta University30
- Foundation University Islamabad27
- Mayo Clinic26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California158
- New York80
- Massachusetts68
- Florida65
- Texas52
- Ohio48
- Maryland42
- Minnesota41
- North Carolina38
- Illinois37
Recruiting studies3,748 total
- NCT06466330Recruiting
Knee embolization for post-replacement pain
This trial tests a non-surgical treatment called microparticle geniculate artery embolization for people with persistent knee pain after a total knee replacement. It aims to reduce pain by blocking tiny blood vessels that may be causing inflammation.
CréteilAges 40–80 - NCT06466941Recruiting
Understanding acute pain after surgery
This study surveys surgical patients about their pain and emotional experience to better understand acute pain. You may help by answering questions or sharing your story.
Boston, MassachusettsAges 18 years+ - NCT06467409RecruitingPhase 2
Study of LPM3480392 for pain after knee surgery
This trial tests an injection called LPM3480392 to see if it safely reduces moderate to severe pain after knee replacement or ligament repair surgery. It aims to help people who need strong pain relief after this type of surgery.
WuhanAges 18 years+ - NCT06469632Recruiting
Radiofrequency for pelvic pain after first vaginal birth
This trial tests whether a non-surgical treatment called radiofrequency can help relieve pelvic pain that starts after a first vaginal birth. The study focuses on a type of muscle pain called myofascial pain syndrome.
Alcalá de Henares, MadridAges 18–45 - NCT06469905Recruiting
Nerve block for pain from herniated disc
This study tests a nerve block injection (called an erector spinae plane block) to see if it helps reduce pain from a herniated disc in the lower back. It may be a good fit if you have ongoing low back pain and have not had spine surgery before.
ElâzığAges 18–65 - NCT06471075Recruiting
Mindfulness for Pain Before Orthopedic Procedure
This study tests whether a short mindfulness (calm focus) exercise before an in-clinic orthopedic procedure can help reduce pain. If you are getting kyphoplasty or radiofrequency ablation at Tallahassee Orthopedic Center, this brief program might make your experience more comfortable.
Tallahassee, FloridaAges 18 years+ - NCT06471348Recruiting
Pain control after scoliosis surgery: comparing two numbing medicines
This study compares two types of numbing medicine used during scoliosis surgery to see which provides better pain relief after the operation. One is a long-acting version (liposomal bupivacaine) and the other is a standard short-acting mix (bupivacaine with epinephrine). If you are a teen having surgery for Adolescent Idiopathic Scoliosis, this trial may help find a way to reduce pain and possibly lessen the need for opioids afterward.
Boston, MassachusettsAges 10–17 - NCT06471426Recruiting
Osteopathic treatment for neck pain and headaches
This study tests whether a type of hands-on treatment called osteopathic manipulation can help relieve neck pain and headaches. It's for people who have had these symptoms for more than a month.
Auburn, AlabamaAges 19–65 - NCT06471790Recruiting
Wearable sensor study for walking after epidural
This study tests a small, wearable sensor to track how well you walk after receiving a low-dose epidural during labor. The goal is to see if the sensor can help doctors monitor your recovery and safety.
LyonAges 18–40 - NCT06472622RecruitingEarly Phase 1
Brain imaging study of pain and effort
This study uses brain scans to understand how people experience pain and effort. It compares healthy volunteers to people with ME/CFS to see if there are differences in brain activity.
Bethesda, MarylandAges 18–50 - NCT06473389Recruiting
A treatment for shoulder pain after stroke
This trial tests a treatment called suprascapular radiofrequency ablation (a targeted heat procedure) to help relieve shoulder pain after a stroke. It is for people who have had a stroke at least 3 months ago and still have severe shoulder pain.
Ankara, YenimahalleAges 18 years+ - NCT06473597RecruitingPhase 4
Comparing Nurtec and Maxalt for migraine in the ER
This trial tests two fast-dissolving migraine medicines, Nurtec ODT and Maxalt MLT-ODT, in adults coming to the emergency room with a migraine. The goal is to see which one works better and faster for pain relief.
Brooklyn, New YorkAges 18–65 - NCT06477094Recruiting
Comparing two radiofrequency tools for lower back pain
This trial compares two techniques for radiofrequency ablation (a heat treatment) to relieve lower back pain from the small joints of the spine. It is for people whose pain did not improve with physical therapy or medications and who have had successful test injections.
Little Rock, ArkansasAges 18 years+ - NCT06476977Recruiting
Numbing method for trigger finger injection
This trial tests a special way of numbing the finger before a corticosteroid injection for trigger finger. The goal is to see if it makes the injection more comfortable and effective.
Toronto, OntarioAges 18 years+ - NCT06477796Recruiting
Improving sleep in veterans with TBI and sleep problems
This study tests a new way to help Veterans with both a traumatic brain injury (TBI) and sleep problems get better rest. If you are a Veteran with sleep trouble and a history of TBI, this program may help improve your sleep without needing extra medication.
Portland, OregonAges 18–89 - NCT06477965Recruiting
Registry for artery embolization to treat chronic pain
This is a registry study that gathers information from people who have had an artery embolization procedure to treat long-term pain from conditions such as arthritis. The goal is to track outcomes and better understand the procedure's effectiveness.
Cary, North CarolinaAges 18 years+ - NCT06479122RecruitingPhase 4
Pain relief after C-section: acetaminophen with or without ibuprofen
This study compares two common pain relievers after C-section: acetaminophen alone versus acetaminophen plus ibuprofen. It aims to see if the combination offers better pain control after childbirth.
SeoulAges 19 years+ - NCT06479161RecruitingPhase 2
Oral tranexamic acid study for knee replacement patients
This trial tests if taking tranexamic acid (TXA) as a pill can reduce bleeding after total knee replacement surgery. It may help you if you have knee osteoarthritis and are scheduled for a first-time knee replacement.
Hartford, ConnecticutAges 18–89 - NCT06480175Recruiting
Neck Pain Relief: Radiofrequency Plus Nerve Block
This study tests whether a procedure that uses radiofrequency (a type of heat) plus a nerve block can reduce neck pain from arthritic joints in the spine. It is for people who have not gotten enough relief from other treatments.
CairoAges 30–70 - NCT06480786Recruiting
Spinal cord stimulator for diabetic nerve and artery pain
This study tests if a spinal cord stimulator (a device that sends mild electrical pulses to the spine) can relieve severe leg pain caused by diabetic nerve damage and poor blood flow. It may help people who have not found enough relief from other treatments.
Omaha, NebraskaAges 19–89 - NCT06483035Recruiting
Treating phantom limb pain with visual simulation therapy
This study tests a computer-based therapy that uses visual exercises to help reduce phantom limb pain after amputation. If you have chronic pain in a missing limb, this treatment might offer relief without medication.
OsloAges 18 years+ - NCT07691840Recruiting
Intrathecal therapy vs. standard care for severe cancer pain
This trial compares a treatment that delivers pain medicine directly to the spinal cord (intrathecal therapy) with usual pain control. It is for people with severe cancer pain that is not helped by oral or intravenous opioids.
JetteAges 18 years+ - NCT07694141Recruiting
Pain Relief After Chest Surgery
This trial studies how well different pain medications work after thoracic (chest) surgery. It aims to find the best way to manage pain and improve recovery.
Las Palmas de Gran Canaria, Las PalmasAges 18 years+ - NCT05999721Recruiting
Nerve block for better breathing after heart surgery
This trial is testing a nerve block (a numbing injection) placed near the breastbone to see if it helps your lungs work better after heart surgery. If you are having planned heart surgery through a breastbone cut, you may be able to join.
Petah TikvaAges 18 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,749 recruiting pain medicine studies from the U.S. registry right now, out of 6,811 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.