Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,749 recruiting studies in this area right now.
By phase
- Not applicable3,095
- Phase 4251
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University32
- Tanta University30
- Foundation University Islamabad27
- Mayo Clinic26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California158
- New York80
- Massachusetts68
- Florida65
- Texas52
- Ohio48
- Maryland42
- Minnesota41
- North Carolina38
- Illinois37
Recruiting studies3,748 total
- NCT05097976RecruitingPhase 4
Medrol tablets to reduce pain after knee replacement
This trial tests whether a short course of Medrol (methylprednisolone) can improve recovery after outpatient total knee replacement done for osteoarthritis. You would be randomly assigned to receive Medrol or a comparison treatment.
Oak Brook, IllinoisAges 18 years+ - NCT07694063Recruiting
Online yoga for frequent migraines
This trial tests if online Hatha yoga classes can help adults who have frequent migraines (but not daily). If you have migraines 8–14 days a month and are already on stable medication, this study may offer a gentle addition to your treatment.
Seville, SevillaAges 18–65 - NCT03446456RecruitingPhase 1/Phase 2
Vasopressin and pain perception study
This trial tests whether vasopressin, a nasal spray, changes how your brain processes pain. You will receive either the spray or a placebo and have an MRI scan to see brain activity.
Baltimore, MarylandAges 18–65 - NCT06420336Recruiting
Pain relief after cleft palate surgery
This study compares two ways to manage pain after cleft palate repair surgery that uses a bone graft from the hip. The goal is to see which method provides better pain control for children and teens.
Charleston, South CarolinaAges 6–18 - NCT07575555Recruiting
Lipedema's role in knee arthritis in women
This study compares women with knee arthritis who do or don't have lipedema (a condition causing painful fat buildup, usually in the legs) to understand how lipedema affects knee joint health. Results may help doctors better treat knee arthritis in women with lipedema.
Izmir, İzmirAges 30–65 - NCT06788717Enrolling by invitation
Study on Hip Revision Stem Performance
This study is checking how well a specific hip implant (the Comprehensive Revision Stem) works in people who need hip replacement. It helps make sure the implant is safe and effective over time.
Los Angeles, CaliforniaAges 18–100 - NCT04214561Enrolling by invitation
Studies how sleep measures relate to teeth grinding
This study looks at sleep testing results to understand what relates to sleep bruxism, which is teeth grinding or clenching during sleep. It may help researchers better understand the causes and patterns behind this condition.
WroclawAges 18–70 - NCT07693998Enrolling by invitation
Pain education class for fibromyalgia or chronic back pain
This trial tests a class to help people with fibromyalgia or chronic low back pain learn about their pain and how to manage it. It might help you feel better and understand your pain.
Valencia, ValenciaAges 18 years+ - NCT06486246Recruiting
Nerve block options for ACL surgery recovery
This trial compares two types of nerve blocks for pain relief after ACL reconstruction. It aims to find which approach provides better comfort and faster recovery.
BarcelonaAges 18–50 - NCT06487754Recruiting
Chronic pelvic pain in trans people on testosterone therapy
This study explores why some trans masculine people develop new or worsening pelvic pain after starting testosterone therapy. Researchers want to understand your experience through interviews.
Saint-Martin-d'HèresAges 18 years+ - NCT06488547Recruiting
Stress and muscle health study for Greek workers
This trial looks at how stress affects muscle and bone health in employees. If you join, you'll answer questions and be measured with simple electronic devices. The goal is to find ways to help workers stay healthy.
Larissa, Biopolis- LarissaAges 19 years+ - NCT06489353Recruiting
Watching video or blowing pinwheel for kids during IV
This study tests whether watching a video or blowing a paper pinwheel helps children feel more comfortable during an IV or blood draw. It is for children ages 3 to 6 who are in the hospital and do not have certain health conditions.
TaichungAges 3–6 - NCT06491992Recruiting
Chitosan gel with ultrasound for neck pain from phone use
This trial tests if applying a special gel (chitosan) with ultrasound on the neck can help reduce pain in teens who use smartphones a lot. It might offer a non-drug way to ease discomfort from phone addiction.
Al Jīzah, Select StateAges 16–18 - NCT06492148Recruiting
Myofascial Release for Period Pain in Women
This study tests a gentle hands-on technique called myofascial release to see if it can reduce period pain in women who have primary dysmenorrhea (painful periods without an underlying condition). If you have moderate to severe cramps and don't use hormonal birth control, you may be able to join.
AnkaraAges 18–35 - NCT06494280Recruiting
Epidural method comparison for first-time mothers
This trial compares two ways of giving epidural pain medicine during early labor to see which provides better pain relief for first-time mothers. It may help you have fewer breakthrough pain episodes.
NazarethAges Any age - NCT06495632RecruitingPhase 4
Scheduled or as-needed pain medicine after surgery?
This study compares taking pain medicine on a fixed schedule versus only when you need it after common outpatient surgeries. It aims to find which approach works better for controlling pain and reducing side effects.
Fayetteville, North CarolinaAges 18–65 - NCT06497140RecruitingPhase 3
Genicular artery embolization for painful knee osteoarthritis
This trial tests a new procedure called genicular artery embolization to treat knee pain from osteoarthritis. If you have moderate to severe knee pain and are not a candidate for knee replacement or other surgery, this treatment may help reduce pain and improve function.
ParisAges 40–90 - NCT06497712Recruiting
Hypnosis for pain during emergency room stitches
This trial tests if hypnosis can reduce pain when getting stitches in the emergency room. If you have a stitchable wound and are at least 18 years old, you may be able to join.
Clermont-FerrandAges 18 years+ - NCT06498037RecruitingPhase 4
Better fentanyl dosing for cancer pain
This trial is testing a new way to give fentanyl under the skin for cancer-related pain. The goal is to find the right dose quickly and safely to make sure you get enough pain relief.
Rotterdam, South HollandAges 18–120 - NCT06500780Recruiting
Pain and depression support for African Americans
This study tests a program that helps people with both long-term pain and depression. It includes coaching and support to help you feel better and manage your health. The study is for Black or African American adults.
Indianapolis, IndianaAges 18 years+ - NCT06501430Recruiting
Treatment for shin splints in amateur football players
This trial tests two muscle-relaxation techniques to reduce pain from shin splints in amateur football players. It may help you recover faster and get back to playing.
Lahore, Punjab ProvinceAges 18–30 - NCT06502457Recruiting
Virtual reality hypnosis for labor pain
This study tests whether using a virtual reality hypnosis program can help manage pain during early labor in women with low-risk pregnancies. If you are in the beginning stages of labor and want a non-drug option for comfort, this might be for you.
AmiensAges 18 years+ - NCT06502587Recruiting
Blood flow restriction with low-intensity exercises for knee osteoarthritis
This study tests if using a special cuff to slightly reduce blood flow while doing gentle exercises can help reduce knee pain and improve function in people with knee osteoarthritis. It may offer a way to get stronger without heavy weights.
Lahore, Punjab ProvinceAges 40–65 - NCT06502951Recruiting
Treatment for headache and neck pain after whiplash
This study tests if combining spinal manipulation and dry needling can reduce headache and neck pain in people who have had whiplash from a car accident. It may help if you've had symptoms for more than 4 weeks.
Montgomery, AlabamaAges 18–65
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,749 recruiting pain medicine studies from the U.S. registry right now, out of 6,811 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.