Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,578 recruiting studies in this area right now.
By phase
- Not applicable2,954
- Phase 4240
- Phase 2129
- Phase 3103
- Phase 193
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University59
- Beijing Tiantan Hospital34
- Tanta University33
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University21
Where studies are running
- California151
- New York79
- Massachusetts65
- Florida64
- Texas50
- North Carolina41
- Illinois40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,578 total
- NCT06974643Recruiting
Numbing methods for awake chest surgery
This study compares two types of numbing medicine (epidural vs. paravertebral block) to see which works better for people who are awake during chest surgery. It may help find a more comfortable option for you.
CairoAges 18–60 - NCT06975761RecruitingPhase 2
Comparing two root canal fillings for pain
This study compares two types of root canal filling materials to see which one is better at reducing pain after the procedure. If you have a painful lower back tooth that needs a root canal and you are a healthy man aged 20-40, you may be able to join.
Rawalpindi, Punjab ProvinceAges 20–40 - NCT06974474RecruitingPhase 4
Guselkumab for pain in psoriatic arthritis
This study tests if guselkumab can reduce pain and inflammation in people with psoriatic arthritis. You may join if standard treatments have not worked well enough or caused side effects.
Rome, ItalyAges 18–80 - NCT07078682Recruiting
Study of two supplements for uterine fibroid symptoms
This trial tests two supplements (Elix Cycle Balance and Elix Daily Harmony) to see if they can reduce pain and other symptoms caused by uterine fibroids. It is for women who have regular but painful periods and want to try a non-medicine option.
Las Vegas, NevadaAges 20–45 - NCT06974617Recruiting
Nerve block vs. Botox for chronic migraine
This study compares two treatments for chronic migraine: a nerve block (sphenopalatine block) and Botox injections. It aims to see which one works better for reducing headache days.
CairoAges 18–65 - NCT06977009Recruiting
Does tooth grinding relief help with post-dental pain?
This study tests whether reducing a tooth's contact with its opposite tooth before root canal treatment can lower pain after the procedure. It's for people with a dead nerve in a back molar that needs a crown.
Amman, Amman GovernorateAges 18–70 - NCT07080892Recruiting
Comparing two ways to give a knee nerve block for pain after knee replacement
This study compares two different ways of giving a nerve block (called iPACK) to see which works better for pain after total knee replacement. The goal is to find the best spot for the injection to help you feel more comfortable after surgery.
BratislavaAges 18–80 - NCT07085065Recruiting
Virtual reality for pain and anxiety during blood cancer procedures
This trial tests whether watching a virtual reality experience during a medical procedure can help reduce pain and anxiety for people with blood cancers. You may be able to take part if you are getting a bone marrow biopsy, spinal tap, blood draw, or chemotherapy.
Tunis, Sfax GovernorateAges 6 years+ - NCT07084714Recruiting
Can moderate exercise help with period symptoms?
This trial tests whether moderate aerobic exercise can help manage menstrual cycle symptoms in people who are not very active. You would exercise for a few weeks while tracking your symptoms to see if exercise makes a difference.
Colorado Springs, ColoradoAges 18–40 - NCT07081373Recruiting
Repeat dose of liposomal bupivacaine for pain after anal fistula surgery
This trial tests if a repeat dose of liposomal bupivacaine (a long-acting numbing medicine) helps reduce pain after surgery for anal fistula. It may be a good option if you are having this surgery and want better pain control.
Guangzhou, GuangdongAges 18–60 - NCT07077148Recruiting
Swaddling or tucking for comfort on CPAP
This study tests whether gentle swaddling or a technique called 'facilitated tucking' (holding the baby in a curled, comfortable position) helps premature babies feel more comfortable while they are on nasal CPAP breathing support. The goal is to see if these simple comfort measures can reduce stress and improve care for late preterm infants.
RizeAges Any age - NCT07081048Recruiting
Reducing newborn pain during a heel stick blood test
This study tests two pain-relief methods during a heel stick blood draw in full-term newborns. The goal is to find which method helps babies feel less pain and stay more comfortable.
MersinAges 1 day–1 month - NCT07080788Recruiting
Native American Pain Risk Study: Smoking Cessation
This study looks at how quitting smoking affects pain in Native American adults. Eligible participants are daily smokers who own a smartphone and do not have heart problems or chronic pain.
Tulsa, OklahomaAges 18 years+ - NCT07083219Enrolling by invitation
Exercise and pain processing in healthy adults
This study tests how aerobic exercise affects the way your body processes pain. If you are a healthy adult without chronic pain, you may be able to join.
El Paso, TexasAges 18–50 - NCT07085247Recruiting
Role of bacteria in lower back disc disease
This trial looks at whether a specific bacteria, Cutibacterium acnes, is linked to disc problems in the lower back. If you're having surgery for a herniated disc, your tissue sample may help researchers understand the cause.
BrnoAges 18 years+ - NCT07081009Recruiting
Heart injury after planned back surgery study
This study is looking at whether patients having planned lower back surgery experience any heart stress afterward. It aims to understand how common this is and what might help protect the heart.
AnkaraAges 18 years+ - NCT07078201RecruitingPhase 4
Comparing two pain meds in spinal anesthesia for leg surgery
This study compares two medicines (dexmedetomidine and fentanyl) added to a spinal numbing shot for people having planned leg or knee surgery. The goal is to see which one works better to keep your blood pressure stable, and to make the numbing last while keeping you comfortable.
Port SaidAges 20–60 - NCT07079865Recruiting
Nerve stimulation for pain after spine fracture
This trial tests a 60-day nerve stimulation treatment to reduce pain and improve mobility after a recent spine fracture caused by osteoporosis. It may help patients who still have significant pain despite over-the-counter pain relievers.
Avenel, New JerseyAges 18 years+ - NCT04643951Recruiting
Study of dental students’ and professionals’ child-patient experiences
This study explores how dental students and child-focused dental professionals understand and handle pain in pediatric dentistry. Your experience and perceptions will help researchers describe common challenges and what support works best.
Malmö, Skåne CountyAges 18–65 - NCT04609735Recruiting
Compare manual therapy, exercise, and ultrasound for golfer’s elbow
This study compares two treatment plans for golfer’s elbow—manual therapy plus exercise, and whether adding ultrasound helps more. It aims to reduce elbow and inner-forearm pain and improve how well you can use your arm.
Fort Wayne, IndianaAges 18–60 - NCT03968614Recruiting
Needling plus exercises for Achilles tendon pain
This trial studies whether electrical “deep needling” (a clinician inserts very thin needles and uses electricity) added to stretching and exercises can reduce Achilles tendon pain. It’s mainly for people with Achilles tendinopathy that started at least 3 months ago.
Columbia, South CarolinaAges 18 years+ - NCT05322018Recruiting
Check how well a thermometer scale measures dental pain
This study tests whether a simple “faces thermometer” tool can accurately measure pain in children during dental visits. If it works well, it could help dentists and doctors better understand and manage children’s discomfort.
Malmö, Skåne CountyAges 8–17 - NCT06666621RecruitingPhase 4
Naloxone injection for low back pain
This trial tests whether naloxone, a drug that blocks opioid effects, can change how your body responds to pain injections in the lower back. It may help find new ways to treat low back pain that hasn't improved with physical therapy or oral medications.
Nashville, TennesseeAges 18 years+ - NCT06766916RecruitingPhase 2
Testing Crisugabalin for nerve pain after radiation
This trial tests a drug called Crisugabalin to see if it helps people with nerve pain caused by radiation treatment for head and neck cancer. The study aims to find a better way to manage this type of pain that does not go away.
Fuzhou, FujianAges 18 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,578 recruiting pain medicine studies from the U.S. registry right now, out of 6,493 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.