Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,749 recruiting studies in this area right now.
By phase
- Not applicable3,095
- Phase 4251
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University32
- Tanta University30
- Foundation University Islamabad27
- Mayo Clinic26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California158
- New York80
- Massachusetts68
- Florida65
- Texas52
- Ohio48
- Maryland42
- Minnesota41
- North Carolina38
- Illinois37
Recruiting studies3,748 total
- NCT06503328Recruiting
Cluster headache microRNA study
This study aims to understand how certain tiny molecules in the blood (called microRNAs) are different in people with cluster headache. It could help find better ways to diagnose or treat this condition.
PaviaAges 18–65 - NCT06503432Recruiting
Does PD-L1 affect pain after lung cancer surgery?
This study looks at how a protein called PD-L1 relates to pain after lung cancer surgery. If you're having a VATS procedure, researchers want to see if PD-L1 levels affect your recovery and pain experience.
Beijing, Beijing MunicipalityAges 18–80 - NCT06503523Recruiting
Brain activity during pain and itch
This study tests whether imagining movements changes brain activity when you feel pain or itch. It could help scientists understand how the brain responds to these sensations.
GistrupAges 18–60 - NCT06504277Recruiting
Lower gas pressure during surgery for shoulder pain reduction
This study compares two different gas pressures used during laparoscopic surgery to see if lower pressure reduces shoulder pain afterward. It may help if you're having surgery to remove an ovary, fallopian tube, or ovarian cyst.
Toronto, OntarioAges 18 years+ - NCT06504537Recruiting
Theragun vs compression therapy for migraine relief
This study compares two handheld massage devices—a percussive therapy device (Theragun) and a compression therapy device—to see which works better for migraine pain. If you have frequent migraines without aura, this could help you find a simple, drug-free treatment option.
Lahore, Punjab ProvinceAges 18–65 - NCT06506565RecruitingPhase 4
Low-dose ketamine for burn wound pain
This trial tests a low-dose ketamine infusion during burn wound dressing changes to see if it reduces pain. It might help people who are hospitalized with a thermal burn injury.
Memphis, TennesseeAges 18 years+ - NCT06507267Recruiting
Pain and symptoms in pelvic congestion syndrome
This study looks at how pain and other symptoms relate to a condition called pelvic congestion syndrome, which happens when veins in the pelvis become enlarged. It may help doctors better understand and treat this cause of long-term pelvic pain.
IstanbulAges 18–50 - NCT06507293Recruiting
Pain relief methods comparison for lung surgery
This trial tests two numbing injections to see which reduces pain medicine use during lung surgery. A special pain monitor guides the treatment. It may help you need fewer opioids during your procedure.
KocaeliAges 18–65 - NCT06507345Recruiting
Non-opioid pain relief after breast surgery
This trial tests whether non-opioid pain medicines can effectively control pain after mastectomy or lumpectomy, allowing you to go home the same day without needing strong opioids.
Montreal, QuebecAges 18 years+ - NCT06507761Recruiting
Heat therapy for recent neck pain
This study tests whether heat therapy (like heat packs) can help people with new or recent neck pain that has no specific known cause. You will receive heat treatments and be checked over 4 weeks to see if it reduces pain.
IstanbulAges 18–65 - NCT06507748Recruiting
Measuring pain with a finger device in NF1
This study tests a new way to measure pain and other sensations in people with NF1 using a device that clips onto a finger or toe. The device looks at how your pupil reacts to mild pulses, which may help doctors better understand your pain.
Washington D.C., District of ColumbiaAges 1–120 - NCT06508385Recruiting
How improvement affects fibromyalgia: A brain study
This study looks at how women with fibromyalgia perceive their improvement. It uses a brain scan (fMRI) to understand this better. The goal is to help improve treatments.
Istanbul, KartalAges 25–55 - NCT06508814Recruiting
Pain with different gas pressures during laparoscopic hysterectomy
This trial compares two different gas pressure levels used during laparoscopic hysterectomy (a minimally invasive surgery to remove the uterus) to see which one causes less pain after the procedure. It may help you and your doctor choose the best pressure for your surgery.
Memphis, TennesseeAges 18–80 - NCT06509594Recruiting
Exercises for neck pain from Upper Crossed Syndrome
This study compares two types of exercises—scapular stabilization exercises and eccentric muscle energy techniques—to see which works better for neck pain caused by Upper Crossed Syndrome. It's designed for people ages 18 to 35 with neck pain that isn't spreading into the arms or head.
Sargodha, Punjab ProvinceAges 18–35 - NCT06510244Recruiting
Measuring pain during dental treatment with brain waves
This trial uses EEG (a brain-wave test) and a pain scale to measure how much discomfort you feel during dental treatment on your upper front tooth. It may help dentists understand pain better and improve care.
Cleveland, OhioAges 20–60 - NCT06511674Recruiting
Nerve pain risk study for cancer patients
This study looks at why some people with cancer develop nerve pain (neuropathic pain) during treatment. By tracking your health and symptoms, researchers hope to find ways to predict and prevent this side effect.
AjaccioAges 18 years+ - NCT06511765RecruitingPhase 3
Nerve block for acute lower back pain: a pilot study
This study tests whether a single injection of a numbing medicine (ropivacaine) into the muscles of the lower back can quickly relieve sudden, severe back pain that has lasted less than a week. The goal is to see if this nerve block can help when standard pain pills aren't working.
Saint-HerblainAges 18 years+ - NCT06512727Recruiting
Pain management study for Black older adults with long-term joint pain
This study tests two different approaches to help Black adults aged 50–92 manage chronic muscle or joint pain in their hips, knees, lower back, or ankles. It aims to find which method works better to reduce pain and improve daily life.
Gainesville, FloridaAges 50–92 - NCT06514365Recruiting
Comparing nerve blocks for pain after knee replacement
This trial compares two different ways of numbing the leg to provide better pain relief after total knee replacement surgery. It tests whether adding a popliteal sciatic nerve block (behind the knee) to a saphenous block (inner thigh) works better than adding an IPACK block (back of the knee).
Badalona, BarcelonaAges 18 years+ - NCT06514469Recruiting
Painkiller (sufentanil) given by paramedics for severe trauma pain
This trial tests whether paramedics can safely give a strong painkiller (sufentanil) to adults with severe pain from a recent injury. It aims to see if it works well and is safe when given in the field.
Karlovy Vary, Karlovy Vary RegionAges 18 years+ - NCT06514716Recruiting
Steroid shot vs. standard procedure for knee arthritis
This study tests whether a corticosteroid shot (a strong anti-inflammatory medicine) into the knee joint works better than the standard GAE procedure for people with knee osteoarthritis. It aims to see which approach provides better pain relief and function.
ZagazigAges 18–80 - NCT06515691Recruiting
Nerve block for pain after weight loss surgery
This study tests a nerve block (an injection near the nerves) to see if it helps reduce pain after laparoscopic sleeve gastrectomy. The block is called a modified thoracoabdominal nerve plane block, and it may lead to better pain control and recovery.
Istanbul, BagcilarAges 18–65 - NCT06515925Recruiting
Virtual group program for managing chronic pain
This study tests a virtual group program that combines medical care with integrative approaches like mindfulness and gentle movement to help adults manage chronic musculoskeletal pain.
Malden, MassachusettsAges 18 years+ - NCT06517069Recruiting
Acupuncture plus medication for pain after gynecologic surgery
This study tests whether adding a type of acupuncture (TEAS) to pain medication can better control pain after laparoscopic gynecologic surgery. It aims to improve recovery and comfort.
Yangzhou, JiangsuAges 18–65
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,749 recruiting pain medicine studies from the U.S. registry right now, out of 6,811 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.