Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,749 recruiting studies in this area right now.
By phase
- Not applicable3,095
- Phase 4251
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University32
- Tanta University30
- Foundation University Islamabad27
- Mayo Clinic26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California158
- New York80
- Massachusetts68
- Florida65
- Texas52
- Ohio48
- Maryland42
- Minnesota41
- North Carolina38
- Illinois37
Recruiting studies3,748 total
- NCT06518421Recruiting
Emotions and Memory in Chronic Facial Nerve Pain
This study looks at how emotions and memory are affected in people with chronic trigeminal neuralgia (a type of facial nerve pain). Participants will have an MRI scan and fill out questionnaires to help researchers understand the link between chronic pain and cognitive changes.
Toronto, OntarioAges 35–60 - NCT06519136Recruiting
Second level Reiki for pain and quality of life in dialysis
This study tests whether a second level of Reiki (a gentle energy healing practice) can help reduce pain and improve quality of life for people on dialysis. If you already received Reiki level 1 in a previous round of this study, you may be able to join.
ÇorumAges 28–84 - NCT06520150Recruiting
Comparing two numbing methods for S-ICD heart device placement
This study compares two ways of numbing the chest area (regional anesthesia) for people getting an S-ICD heart device. The goal is to find which method works better and is safer for patients who are at higher risk for general anesthesia.
Wroclaw, Lower Silesian VoivodeshipAges 18–90 - NCT06522620Recruiting
Nerve block for knee pain after total knee replacement
This trial tests whether a nerve block can reduce pain on the back and outer side of the knee after total knee replacement surgery. If effective, it may help you recover more comfortably.
Yinchuan, NingxiaAges 45–80 - NCT06522529Recruiting
Project to improve care with proven methods
This project helps hospital and nursing home teams improve daily care by using proven methods for hand hygiene and another health topic like pain, falls, or smoking. It’s a chance for your unit to join a quality-improvement effort that can make care safer and more effective.
MadridAges Any age - NCT06526143Recruiting
Pain care pathway for recent veterans
This study tests a new approach to help veterans manage pain in their back, neck, knee, or shoulder after leaving the military. It includes phone or online check-ins and support tailored to your needs.
West Haven, ConnecticutAges 18 years+ - NCT06526325Recruiting
Tendon release for cervical disc herniation
This study tests whether a tendon release technique (a specialized hands-on therapy) can help relieve symptoms for people with a herniated disc in their neck. It might be a good fit if you have a neck disc problem and are looking for a non-surgical option.
IstanbulAges 18–65 - NCT06528288Recruiting
Numbing injection for pain relief after back fusion surgery
This study tests whether a special numbing injection (called an erector spinae plane block) given near the spine during surgery can reduce pain after lumbar fusion. If you qualify, you might have less pain and need fewer painkillers after your operation.
Worcester, MassachusettsAges 18 years+ - NCT06528574Recruiting
Pain after root canal cleaning methods
This trial compares two methods of cleaning a tooth's root canal to see which causes less pain after the procedure. It is for people with a specific type of tooth nerve pain (acute pulpitis) in a lower back molar.
Cleveland, OhioAges 18–50 - NCT06530459RecruitingPhase 2/Phase 3
The MUSE Study for Menopausal Joint Pain
This study tests whether a treatment can help women with joint pain and stiffness that started or worsened during menopause. It focuses on women who are within 5 years of menopause and have pain in multiple joints.
SingaporeAges 30–59 - NCT06531317Recruiting
EEG and brain stimulation for nerve pain after spinal cord injury
This study tests whether a personalized brain stimulation treatment (using a non-invasive technique called tDCS) can help reduce nerve pain in people with spinal cord injury. The researchers will also use EEG (a cap that records brain activity) to see how your brain responds.
Badalona, BarcelonaAges 18–99 - NCT06531590Recruiting
New emergency approach for shoulder dislocation
This trial tests a new way to treat a dislocated shoulder in the emergency room. It might help people with a first-time or repeat shoulder dislocation get back to normal faster.
Ankara, YenimahalleAges 18 years+ - NCT06531928Recruiting
Chest tube removal and anxiety after lung surgery
This study looks at whether the way a chest tube is removed after lung surgery affects how anxious patients feel. If you had keyhole lung surgery with one chest tube, this trial may help understand your experience.
Ankara, KeçiörenAges 18–65 - NCT06532708Recruiting
Pain Medicine Use After Laparoscopic Hysterectomy
This study looks at how doctors prescribe pain medicine after laparoscopic hysterectomy (a type of keyhole surgery to remove the uterus). It aims to find better ways to manage pain after surgery.
Memphis, TennesseeAges 18–80 - NCT06533345Recruiting
Pain-free research for chronic pain
This trial studies a collaborative approach to help people with chronic pain, which is pain that lasts beyond a recent injury. It may be a good fit if you're not currently seeking medication for your pain.
Auburn, AlabamaAges 21–80 - NCT06533917Recruiting
Spinal cord stimulation for chronic abdominal pain
This trial tests whether spinal cord stimulation (a device that sends mild electrical pulses to nerves in your spine) can reduce chronic abdominal pain that hasn't improved with standard care. It might be an option if you've tried medications or nerve blocks without success.
LeedsAges 18–130 - NCT06534372Recruiting
Factors affecting chronic pain after open-heart surgery
This study looks at factors that may lead to long-term pain after open-heart surgery. It follows patients who have coronary bypass or valve surgery to understand what might cause ongoing pain.
Ankara, AnkaraAges 18–80 - NCT06534788Recruiting
Comparing two muscle therapies for piriformis syndrome
This study tests two different hands-on therapy techniques (reciprocal inhibition and post-facilitation muscle energy) along with standard physical therapy to see which works better for relieving piriformis syndrome—a condition that causes deep buttock pain. You may benefit if you have chronic hip/buttock pain and a shortened piriformis muscle.
Rawalpindi, Punjab ProvinceAges 20–50 - NCT06534710Recruiting
Electronic moxibustion for pain and healing after brain surgery
This trial tests if a special heating device (electronic moxibustion) can reduce pain and help wounds heal faster after brain surgery. It may be an option if you are recovering well three days after surgery.
Yiwu, ZhejiangAges 18–80 - NCT06535178Recruiting
Sleep and heart health in fibromyalgia
This study looks at how sleep affects heart health in people with fibromyalgia (a condition causing widespread pain). Researchers will test if improving sleep can help your heart work better.
Portland, OregonAges 18–50 - NCT06536504Recruiting
Music before brain surgery for stress and pain
This study looks at whether listening to live or recorded music before brain or spine surgery can help reduce stress, improve mood, and lessen pain. You may be able to join if you are scheduled for neurosurgery and can hear and speak English.
Houston, TexasAges 18 years+ - NCT06536829Recruiting
Muscle release and nerve gliding for sciatica in cricketers
This study tests two hands-on treatments—myofascial release and sciatic nerve slider exercises—to see which helps male cricketers with sciatica feel less pain and move better.
Lahore, Punjab ProvinceAges 18–35 - NCT06537219Recruiting
Fascia stiffness and pain in young adults with chronic back pain
This study looks at how stiffness in the connective tissue (fascia) of the lower back relates to pain in young people with chronic low back pain. It may help find new ways to treat this common problem.
AnkaraAges 18–50 - NCT06537323Recruiting
Comparing nerve blocks and fentanyl for hip surgery pain
This trial tests different ways to manage pain during hip surgery, comparing a femoral nerve block, a newer nerve block called PENG, and a pain medicine given before surgery. It aims to see which method gives the best pain relief.
CairoAges 55–69
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,749 recruiting pain medicine studies from the U.S. registry right now, out of 6,811 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.