Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,841 recruiting studies in this area right now.
By phase
- Not applicable3,975
- Phase 2223
- Phase 4196
- Phase 1191
- Phase 3149
- Phase 1/Phase 274
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis185
- Rheumatoid Arthritis142
- Fibromyalgia102
- Osteoporosis88
- Osteoarthritis74
- Osteoarthritis, Knee72
- Rheumatoid Arthritis (RA)64
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Chronic Pain38
- Degenerative Disc Disease38
- Total Knee Arthroplasty38
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California210
- New York94
- Florida80
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,841 total
- NCT07130513Recruiting
Can krill oil help muscle function in long-term conditions?
This study is testing whether taking krill oil supplements can help improve muscle strength and function in adults with long-term health conditions like diabetes, arthritis, or heart disease.
Glasgow, LanarkshireAges 18 years+ - NCT07130552Recruiting
Comparing two pain relief methods after knee replacement
This study tests two different nerve-block techniques to see which provides better pain control after total knee replacement surgery. The goal is to help you recover more comfortably.
KaramanAges 18–85 - NCT07544732Recruiting
Tape comparison for heel pain relief
This study tests two types of taping methods to reduce heel pain caused by plantar fasciitis. You'll wear special tape on your foot for a few weeks to see which method works better for your pain and movement.
Islamabad, Punjab ProvinceAges 19–44 - NCT04744402RecruitingPhase 2
Cartilage repair treatment test for knee joint damage
This Phase 2 study tests CartiLife® to help repair a specific type of damaged knee cartilage. You may be considered if you have a moderate-sized cartilage defect in the knee and enough pain and function limits to need treatment.
Irvine, CaliforniaAges 18 years+ - NCT05660161Recruiting
Knee cartilage repair using a new nanofracture technique
This trial studies a newer surgical technique (called “nanofractures”) to repair cartilage defects in the knee. It may help restore cartilage where the joint surface is damaged, as part of planned knee surgery.
LuganoAges 16–50 - NCT07424066Recruiting
Knee vibration therapy to improve movement and sensation
This trial tests if gentle vibrations on knee muscles can improve how your brain senses knee movement, which may help you move better. It is for healthy adults who want to see if this non-invasive treatment boosts motor performance.
Milan, MilanAges 18 years+ - NCT06624982Recruiting
Bone Changes After Tooth Extraction and Grafting
This study looks at how your jawbone changes after a tooth is pulled and a bone graft is put in. If you need a single tooth removed and have good general health, you may be able to join.
Milwaukee, WisconsinAges 18–75 - NCT07028268RecruitingPhase 2
Testing a new drug for bone metastases from solid tumors
This trial tests a new drug called SHR-2017 for people with solid tumors that have spread to the bones. The study aims to see if the drug can help manage pain and other effects of bone metastases.
Guangzhou, GuangdongAges 18 years+ - NCT07410650Enrolling by invitation
Shoulder replacement that spares a key muscle
This study is testing a shoulder replacement surgery that avoids cutting a key muscle (the subscapularis). It may help patients recover shoulder function more quickly with less pain.
Salt Lake City, UtahAges 18–90 - NCT07456787Recruiting
Cold therapy after knee replacement surgery
This trial tests a cold therapy approach (cryopressotherapy) to improve recovery after total knee replacement. It may help reduce pain and swelling so you can move better sooner.
Milan, ItalyAges 18–80 - NCT06218238Recruiting
Testing the Ossur Power Knee for above-knee amputees
This study tests a new bionic knee called the Ossur Power Knee for people with an above-knee amputation. It looks at how well the knee helps with walking and balance, which may lead to better mobility.
Chicago, IllinoisAges 45–75 - NCT07456137Enrolling by invitation
Studying MRI vs. X-ray for spine pain
This trial compares two types of CT scans (upright vs. lying down) to see which gives better images of the lower back. It may help doctors choose the best scan for spine problems.
Kansas City, KansasAges 18 years+ - NCT07004218Enrolling by invitation
Ultrasound follow-up after massive rotator cuff tear surgery
This trial uses ultrasound imaging to check how the shoulder heals over the first year after surgery for a large tear in the rotator cuff (the group of tendons that helps lift and rotate your arm). The goal is to better understand recovery and improve care for people with this injury.
Çankaya, AnkaraAges 18–80 - NCT05780021Recruiting
Support program for long-term low back pain after rehab
This trial tests whether a structured motivational support program can help people with long-term low back pain after they finish a rehab program. It may help you stay motivated and improve your day-to-day progress after treatment.
ParisAges 18 years+ - NCT06454955RecruitingEarly Phase 1
PET scan imaging study for solid tumors using a new probe
This trial tests a new imaging agent that targets a protein called B7-H3 found on many solid tumors. It uses PET/CT to help doctors see and stage tumors more clearly.
Beijing, Beijing MunicipalityAges 18–75 - NCT07454356Recruiting
Device to help knee bending after replacement
This study tests a non-surgical device called Knee Flexionater to help people who have limited knee bending after total knee replacement. The goal is to improve knee motion and avoid a second surgery.
Houston, TexasAges 40 years+ - NCT07454252Recruiting
Study on biomarkers for bone, muscle, and energy health
This study looks at blood samples already collected from patients to find markers related to bone, muscle, and energy metabolism. It may help doctors better understand these processes and identify potential health issues.
Milan, ItalyAges 18 years+ - NCT06610591Recruiting
Surgery for idiopathic toe walking in children
This trial studies whether surgery to lengthen tight calf muscles helps children who walk on their toes without a known medical cause. It aims to see if the surgery improves walking pattern and reduces toe walking.
Tooting, LondonAges 8–16 - NCT07449078Recruiting
Cognitive functional therapy for chronic ankle sprain
This trial tests a type of talk therapy that teaches you new ways to move and think about your ankle. It may help people who have ongoing pain or instability from an old sprain.
Istanbul, AtaşehirAges 18–65 - NCT06963671Enrolling by invitation
Blood flow restriction therapy for ulnar-sided wrist pain
This study tests using a blood pressure cuff during hand therapy to see if it helps reduce ulnar-sided wrist pain and improve hand function.
Redwood City, CaliforniaAges 18 years+ - NCT07448857Recruiting
Scapula movement and muscle activity in upper string players with neck pain
This study looks at how the shoulder blade moves and muscles work in violin and viola players who have neck pain. It may help understand why neck pain happens and how to treat it better.
Taipei, TaiwanAges 18 years+ - NCT06991192Recruiting
ACL recovery with exercise and emotional support
This study tests a rehab program for teens and young adults who had ACL surgery. It combines physical therapy with extra mental and emotional support to help them get back to sports safely.
Bloomington, MinnesotaAges 15–21 - NCT05675527RecruitingPhase 4
Platelet gel (PRP) for shoulder arthritis pain
This trial tests whether platelet-rich plasma (PRP), a blood-based treatment, can reduce pain from shoulder (glenohumeral) osteoarthritis. It also looks at whether PRP works for people who had temporary relief from a numbing/shock injection into the joint.
New York, New YorkAges 18–100 - NCT06775197RecruitingPhase 4
Partial meniscus replacement with Spongioflex sponge
This trial tests a sponge-like implant (Spongioflex) to replace part of a torn meniscus in the knee. It may help people with pain on the inner or outer side of the knee who have enough healthy rim left to hold the implant.
Greven, North Rhine-WestphaliaAges 18–60
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,841 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,937 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.