Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,611 recruiting studies in this area right now.
By phase
- Not applicable3,768
- Phase 2217
- Phase 4200
- Phase 1182
- Phase 3139
- Phase 1/Phase 271
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis172
- Rheumatoid Arthritis132
- Fibromyalgia105
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee64
- Shoulder Pain48
- Hip Osteoarthritis43
- Psoriatic Arthritis40
- Degenerative Disc Disease39
- Chronic Pain38
- Total Knee Arthroplasty38
- Duchenne Muscular Dystrophy37
- Systemic Lupus Erythematosus37
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital25
- Hacettepe University23
- Tanta University22
Where studies are running
- California207
- New York87
- Florida82
- Maryland76
- Arizona72
- Massachusetts71
- Texas67
- Alabama59
- Illinois51
- Pennsylvania48
Recruiting studies4,611 total
- NCT07574762Recruiting
Knee Replacement: Computer Navigation vs. Robotic Surgery
This study compares two advanced surgical techniques for knee replacement in patients with knee arthritis. Researchers want to see if robotic-assisted surgery offers any advantages over computer-guided navigation surgery for placing the artificial knee.
Paris, ParisAges 18 years+ - NCT07569731Recruiting
Understanding Fibrous Dysplasia Through Patient Data and Tissue
This study collects information from patients with fibrous dysplasia (a bone condition where normal bone is replaced by fibrous tissue) and related syndromes to better understand the disease. Researchers will review your medical records, imaging scans, and stored tissue samples to learn more about how the disease develops and progresses.
Bologna, BOAges Any age - NCT07571122Recruiting
Brain Training to Help Heel Pain and Balance
This study tests whether cognitive training (exercises that challenge your thinking and memory) combined with physical exercises can reduce heel pain, improve balance, and strengthen foot function in people with plantar fasciitis. The goal is to see if training your brain alongside your body helps more than physical therapy alone.
CairoAges 18–60 - NCT07569796Recruiting
Nerve Stimulation to Help Recover After ACL Surgery
This study tests whether stimulating your sciatic nerve (a major nerve in your leg) can help you recover better after ACL reconstruction surgery. The goal is to reduce pain and help you regain strength and movement.
Madrid, MadridAges 18–60 - NCT07575009RecruitingPhase 3
Home-based continuous antibiotic infusion for children
This study tests whether children can safely receive antibiotics continuously through a pump at home instead of in the hospital. The goal is to help children recover while staying with their family and avoiding prolonged hospital stays.
TampereAges Up to 16 years - NCT07575555Recruiting
Lipedema's role in knee arthritis in women
This study compares women with knee arthritis who do or don't have lipedema (a condition causing painful fat buildup, usually in the legs) to understand how lipedema affects knee joint health. Results may help doctors better treat knee arthritis in women with lipedema.
Izmir, İzmirAges 30–65 - NCT07576816Recruiting
Hip vs. Knee Exercises for Flat Feet
This study compares two types of exercises—one focusing on hip muscles and one on knee muscles—to see which better improves flat feet, balance, and leg strength. If you have flexible flat feet without pain, this trial may help you strengthen your feet and improve stability.
Faisalābad, Punjab ProvinceAges 25–40 - NCT07573527Recruiting
Online therapy for upper back muscle pain from trigger points
This study tests whether remote physical therapy (done online) can help relieve neck and upper back pain caused by tight knots in your rhomboid muscles. You would receive guided exercises and treatment through video calls instead of visiting a clinic in person.
Karachi, SindhAges 18–35 - NCT07575425Recruiting
Balance Platform Exercises for Knee Osteoarthritis
This study tests whether special balance exercises on a moving platform can improve steadiness and walking in people with moderate knee osteoarthritis. The goal is to see if this type of training helps reduce pain and improve mobility.
AnkaraAges 45–65 - NCT07576127Recruiting
Gongs Mobilization and Stretching for Frozen Shoulder
This study tests two hands-on treatment techniques—gongs mobilization and proprioceptive neuromuscular facilitation (a type of guided stretching)—to help reduce stiffness and improve movement in frozen shoulder. Frozen shoulder causes pain and loss of motion in the shoulder joint; this trial aims to see if these treatments can help restore function.
Rawalpindi, Punjab ProvinceAges 40–60 - NCT07573553Recruiting
Rib Mobilization and Posture Exercises for Upper Crossed Syndrome
This study tests whether combining rib mobilization (hands-on therapy to improve rib movement) with posture-correction exercises can reduce neck pain and improve posture in people with upper crossed syndrome (a postural condition causing rounded shoulders and forward head tilt). It may help you understand if this combination therapy works better than standard treatment.
Chak Six Hundred Twenty-four, Khyber PakhtunkhwatAges 20–45 - NCT07576582Recruiting
Mud therapy for jaw joint pain
This trial tests whether a special mud treatment (peloid therapy) can reduce jaw joint pain and improve function in people with temporomandibular joint disorder. It is a non-drug approach that may help those who have had jaw pain for at least 4 weeks.
Uşak, MerkezAges 18–65 - NCT07576296Recruiting
Shoulder exercises for rounded shoulders after pregnancy
This study tests whether specific shoulder blade exercises and stretches can help new mothers with rounded shoulders and shoulder discomfort. It aims to improve posture and reduce pain during the postpartum period.
Lahore, Punjab ProvinceAges 20–35 - NCT07569549Recruiting
Thumb base arthritis surgery: joint replacement vs bone removal
This study compares two common surgeries for thumb base arthritis to see which one gives better pain relief and hand function. The results could help you and your doctor choose the best treatment option.
UppsalaAges 40–80 - NCT07574606Recruiting
Soft Tissue Coverage for Zygomatic Implants in Jaw Bone Loss
This study compares two surgical methods to cover zygomatic implants (special anchor posts for teeth) in patients with severe jawbone loss. Researchers will measure how much soft tissue (gum and fat) builds up over the implants to see which method produces better, longer-lasting results.
Cairo, New CairoAges 18 years+ - NCT07574229Recruiting
Support System for Teens Wearing Scoliosis Braces
This study tests a new computer-based support system designed to help teenagers stay motivated and consistent with wearing their prescribed scoliosis braces. The system uses interactive tools and feedback to make brace-wearing easier and more manageable.
Shanghai, Shanghai MunicipalityAges 10–18 - NCT07569848Recruiting
Custom ankle replacement for severe bone loss
This study tests a custom-designed ankle replacement device for people with severe ankle bone damage or loss. The device is made specifically for each patient at the Rizzoli Institute in Italy to help restore ankle function and reduce pain.
BolognaAges 35–75 - NCT07573761Enrolling by invitation
Tooth Grafts to Help Bone Grow for Dental Implants
This trial tests whether material made from extracted teeth can help bone regrow in the jaw after tooth removal, so you can get a dental implant. Researchers will compare this new approach to see if it works better for rebuilding bone in areas where teeth need to be replaced.
Istanbul, UskudarAges 18–65 - NCT07571993Recruiting
Tracking Rheumatoid Arthritis Remission and Treatment Changes
This study follows people with rheumatoid arthritis (RA) who have achieved remission—meaning their disease is well-controlled—to see how safely doctors can reduce or stop their medications over time. You would be monitored regularly to ensure your RA stays in remission.
Pavia, PaviaAges 18 years+ - NCT07569835Recruiting
Long-Term Outcomes of Childhood Flatfoot Surgery
This study follows up with patients who had surgery to correct flat feet in childhood using special implants. Researchers want to see how well the surgery worked over 10 years and whether any changes occurred in the foot structure.
BolognaAges Any age - NCT06354790Recruiting
LAMA2-related dystrophy natural history study in children
This study follows children with LAMA2-related muscular dystrophy to learn how the condition changes over time. It does not test a new treatment, but helps researchers understand the disease better.
GarchesAges 2–15 - NCT06535633Recruiting
Exercise program for older adults with chronic pain
This study looks at whether a community exercise program can help older adults with long-term muscle or joint pain. It is designed for people who are not already active and want to try a gentle, guided exercise program.
LimerickAges 50 years+ - NCT06655701Recruiting
Bladder leaks and muscle loss in postmenopausal women with bone thinning
This study looks at whether women with osteoporosis (thin bones) after menopause also have bladder leaks and loss of muscle mass. It may help understand links between these conditions.
IstanbulAges 50–75 - NCT06723678Recruiting
Bone changes around implants with All-on-Four technique
This trial tests a special technique called 'All-on-Four' for people who need full-arch dental implants. It looks at how the bone around the implants changes over time. If you are in good general health and have a healthy jawbone, this study might help you understand if this approach works well for you.
Cairo, Nasr CityAges 50–65
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,611 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,492 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.