Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,841 recruiting studies in this area right now.
By phase
- Not applicable3,975
- Phase 2223
- Phase 4196
- Phase 1191
- Phase 3149
- Phase 1/Phase 274
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis185
- Rheumatoid Arthritis142
- Fibromyalgia102
- Osteoporosis88
- Osteoarthritis74
- Osteoarthritis, Knee72
- Rheumatoid Arthritis (RA)64
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Chronic Pain38
- Degenerative Disc Disease38
- Total Knee Arthroplasty38
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California210
- New York94
- Florida80
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,841 total
- NCT06973226Recruiting
Testing the safety of Neocement bone cement
This trial tests a new bone cement (Neocement®) for treating bone defects caused by surgery or injury. It aims to see if the cement is safe and works well to fill the gap.
BarcelosAges 18 years+ - NCT07468968Enrolling by invitation
Balance vs. breathing training for older adults
This study compares two types of training—one focusing on balance exercises and one on breathing muscle exercises—to see which helps older adults more. If you are 60 or older and able to walk on your own, you may be able to join.
IstanbulAges 60 years+ - NCT06598644Recruiting
Comparing two gentle neck pain treatments
This study tests two hands-on treatments for long-lasting neck pain: a gentle gliding movement called Sustained Natural Apophyseal Glide (SNAG) and a soft-tissue release technique called Instrument Assisted Soft Tissue Mobilization (IASTM). If you have had neck pain for more than 3 months, this trial may help find which method works better for you.
Rawalpindi, Punjab ProvinceAges 20–45 - NCT07483853Recruiting
MRI scoring test for chronic bone inflammation in children
This study checks if a new MRI scoring system can reliably measure bone inflammation in children with a rare bone disease called CRMO. The goal is to improve how doctors monitor the disease.
BolognaAges Up to 32 years - NCT06641206Recruiting
Dexmedetomidine injection for chronic knee pain
This trial tests whether a single injection of dexmedetomidine into the knee joint can reduce chronic knee pain. It is for people who are not scheduled for knee surgery and have no serious health problems.
Tanta, El GharbyiaAges 40–75 - NCT06641102Recruiting
Healing track for chronic back pain
This trial tests a non-drug, talk-based therapy approach for chronic back pain. It may help you manage pain without medication, and all study activities can be done from home using your smartphone.
New York, New YorkAges 21–70 - NCT07488039Recruiting
Labral repair for shoulder instability with minor bone loss
This trial tests a surgery to repair a torn shoulder socket rim (labrum) in people with recurrent shoulder dislocations and minor bone loss. It aims to restore shoulder stability and prevent future dislocations.
Cairo, Cairo GovernorateAges 16 years+ - NCT06640491RecruitingPhase 1/Phase 2
Antibiotics via bone injection for knee replacement
This study tests giving antibiotics (cefazolin and vancomycin) through a small needle into the shin bone during knee replacement surgery. The goal is to see if this way of giving antibiotics works well to prevent infection.
Houston, TexasAges 18 years+ - NCT07484646Recruiting
EMS with resistance training for weight lifters
This trial tests combining electrical muscle stimulation (EMS) with your regular weightlifting to see if it boosts strength and performance. It may help you build muscle more effectively.
Lahore, Punjab ProvinceAges 18–40 - NCT07484425Recruiting
Jump training at different heights for soccer players
This study tests how different heights of jumping exercises affect soccer players. If you are a healthy, active soccer player looking to improve your performance, this trial may be a good fit.
Lahore, Punjab ProvinceAges 18–30 - NCT07161726RecruitingPhase 1/Phase 2
Cocoa and exercise for older adults
This trial tests whether eating cocoa can boost the benefits of a supervised exercise program for older adults who walk a bit more slowly. You could help find out if this natural product makes exercise work better.
Birmingham, AlabamaAges 55 years+ - NCT07520409Recruiting
Exercise for Abdominal Separation After Pregnancy
This trial tests two types of exercises to help close the gap that forms between your abdominal muscles after pregnancy. The study compares a specific core exercise with ankle resistance to see which helps your abdominal muscles come back together more effectively.
Guiranwala, Punjab ProvinceAges 20–45 - NCT07127042RecruitingPhase 2
Testing a drug to reduce bleeding during knee replacement
This trial tests an experimental drug called BT-114143 to see if it reduces bleeding during and after total knee replacement surgery. It may be a good option for people with osteoarthritis who are having their first knee replacement.
Chengdu, Si'ChuanAges 18–70 - NCT07478822RecruitingPhase 3
Botulinum toxin study for arm spasticity after stroke
This study tests a new botulinum toxin injection (YY001) for adults whose arm muscles are tight or stiff after a stroke. It looks at whether repeated treatments help with daily activities like washing and dressing.
BeijingAges 18–75 - NCT07515144Enrolling by invitation
Nerve Stretching for Muscle Strength in Older Adults
This study tests whether a gentle nerve-stretching technique in the leg can help older adults with age-related muscle loss regain strength and muscle size. You'll attend sessions where a therapist guides your leg through specific movements designed to mobilize nerves and improve muscle function.
Seremban, Negeri SembilanAges 60 years+ - NCT07128602Recruiting
Brain stimulation to help quadriceps after ACL surgery
This study tests whether a gentle, non-invasive brain stimulation can improve thigh muscle function in women recovering from ACL reconstruction. If you are between 2 and 6 months post-surgery, you may be able to join.
Glenside, PennsylvaniaAges 18–35 - NCT07528144Recruiting
Exoskeleton vs. Lead Apron for Surgeon Protection During Aortic Repair
This study compares a new exoskeleton device (a wearable support system) to standard lead aprons for protecting surgeons from radiation during endovascular aortic repair procedures—a minimally invasive surgery to fix problems in the main artery in the abdomen. The trial tests whether the exoskeleton provides better protection and comfort.
Szczecin, West Pomeranian VoivodeshipAges 35 years+ - NCT06463262Recruiting
Personalized markers for chordoma before surgery and radiation
This trial tests whether analyzing blood and tumor samples before and after radiation and surgery can help find personalized markers for chordoma. It is for patients with chordoma of the skull base, spine, or sacrum who will receive radiation before surgery.
Baltimore, MarylandAges 18 years+ - NCT07515092Enrolling by invitation
Virtual Reality Training for Hip Socket Screw Placement
This study tests whether practicing hip socket screw placement in virtual reality helps orthopedic residents learn the procedure better. You would use a VR simulator to practice before doing the actual surgery with supervision.
Bangkok, BangkokAges Any age - NCT07470359RecruitingPhase 2
ACL surgery with and without platelet-rich plasma injection
This study compares standard ACL knee reconstruction using a peroneus longus tendon graft to the same procedure plus an injection of platelet-rich plasma (a concentrated portion of your blood that may help healing). It aims to see if adding the plasma improves knee function after surgery.
Lahore, Punjab ProvinceAges 18–50 - NCT07470190Recruiting
Shoulder tendonitis treatments: ultrasound and movement study
This trial compares different physical therapy combinations for people with shoulder tendonitis (supraspinatus tendinitis). It uses ultrasound and motion tests to see how well the treatments work.
Lahore, Punjab ProvinceAges 40–60 - NCT07469787Recruiting
Transition from pediatric to adult rheumatology care study
This study looks at how to improve the shift from pediatric to adult rheumatology care for young people with chronic inflammatory rheumatic diseases. It aims to understand how healthcare services can better support this transition.
Le Kremlin-BicêtreAges 18 years+ - NCT07692126Recruiting
Neck pain and hand strength: core vs shoulder exercises
This study compares two types of exercises to see which better improves hand grip strength and neck pain. If you have had chronic myofascial neck pain (trigger points) in the upper shoulder muscle for over 6 months, this trial may help find which exercise works best for you.
Giza, Giza GovernorateAges 25–45 - NCT07412145Recruiting
A study testing your balance
This study tests a simple way to check your balance. If you are an adult who can talk and agree to participate, you may be able to join.
Saint Paul, MinnesotaAges 20 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,841 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,937 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.