Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,841 recruiting studies in this area right now.
By phase
- Not applicable3,975
- Phase 2223
- Phase 4196
- Phase 1191
- Phase 3149
- Phase 1/Phase 274
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis185
- Rheumatoid Arthritis142
- Fibromyalgia102
- Osteoporosis88
- Osteoarthritis74
- Osteoarthritis, Knee72
- Rheumatoid Arthritis (RA)64
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Chronic Pain38
- Degenerative Disc Disease38
- Total Knee Arthroplasty38
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California210
- New York94
- Florida80
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,841 total
- NCT07374679Recruiting
Long-term safety and effectiveness of stem cells for rotator cuff disease
This study follows up with people who already received an experimental stem cell treatment for rotator cuff disease in a previous trial. It aims to check if the treatment remains safe and effective over time.
Seoul, KoreaAges 19 years+ - NCT07376915Recruiting
Mental imagery for ankle weakness: A pilot study
This study tests a new way of using mental imagery and gentle movements to help people with long-term ankle weakness. It may improve ankle stability without the need for surgery.
IstanbulAges 18–40 - NCT05653102Recruiting
Collecting data on a knee replacement system after surgery
This study collects real-world health and surgery records to better understand how the Truliant total knee replacement performs. It may help doctors and patients by improving future guidance on this knee system’s safety and effectiveness.
Aurora, ColoradoAges 18 years+ - NCT06782295RecruitingPhase 4
Comparing two implant types in knee revision surgery
This study compares two types of knee implants (CCK vs PS) used during revision total knee replacement. The goal is to see which one works better in patients who need a second knee surgery.
Chicago, IllinoisAges 18 years+ - NCT07414017Recruiting
Virtual reality exercise for older adults with low back pain
This study tests if using virtual reality during exercise helps older adults with long-term low back pain. You'll do exercises while focusing your attention in different ways, and researchers will see which method works best for reducing pain and improving movement.
Center, Kirşehi̇rAges 65–80 - NCT06233539Recruiting
Study on diagnosis and treatment for neck bone dislocation
This trial aims to find the best ways to diagnose and treat a specific type of neck bone problem called atlantoaxial dislocation. It is for people who have this condition and are having surgery.
Beijing, Beijing MunicipalityAges Any age - NCT07371572RecruitingPhase 3
Steroid Injection for Hand Osteoarthritis
This study tests whether a steroid injection into the muscle can reduce pain and improve hand function in people with hand osteoarthritis. It is for those whose pain is moderate to severe and hasn't been helped enough by standard pain medications.
Ubbergen, GelderlandAges 16 years+ - NCT05824845Recruiting
Join a study collecting information for hip or knee replacement care
This study asks people in the UK who are getting their first hip or knee replacement to answer questionnaires and let researchers use linked health data. The goal is to improve understanding of outcomes and help set up future studies for better care.
AshingtonAges 18 years+ - NCT07448584Recruiting
Study of shoulder repair with Lok™ suture anchors
This trial tests how well Lok™ suture anchors work for repairing certain shoulder problems like rotator cuff tears, shoulder instability, or partial tears. It is for people whose MRI confirms the injury and who haven't had prior shoulder surgery on that side.
Valence, Auvergne-Rhône-AlpesAges 18 years+ - NCT06904326Recruiting
Stability check for spine surgery
This trial checks if a specific imaging test before lumbar spine surgery can help predict how stable your spine is after the procedure. It focuses on people having one or two levels of decompression using a special technique called UBE.
MontpellierAges 50 years+ - NCT07367464Recruiting
Bone Grafting Methods for Upper Jaw Implants
This trial tests two ways to rebuild the jawbone so there's enough space for a tooth implant. One method uses a mix of man-made bone and donated bone, the other uses man-made bone and your own bone chips. It might help you if you need more bone for an implant in your upper jaw.
CairoAges 20–50 - NCT07365800Enrolling by invitationPhase 4
Combination pain control after complex spine surgery
This study tests a combination of three medications (methadone, dexmedetomidine, and ketamine) to control pain after major spine surgery. If you are having complex spine surgery, this trial may offer better pain relief without needing as much opioid medication.
Columbia, MissouriAges 18–79 - NCT06320158Recruiting
Understanding muscle loss and obesity in older adults
This study looks at the link between muscle loss (sarcopenia) and obesity in older adults. It aims to understand why some older people who are overweight or obese also lose muscle strength and function, and how this affects recovery after hip surgery.
MilanAges 65–99 - NCT07367243Recruiting
Percussive massage therapy and muscle structure study
This trial tests how percussive massage therapy affects muscle structure in healthy young adults. It may help understand if this type of massage can improve muscle function.
TrabzonAges 18–30 - NCT07366736Recruiting
Cold and compression after knee replacement – a study
This study tests if a cooling and compression device applied to the knee after replacement surgery helps with pain and recovery. It compares the device to standard care in people having their first knee replacement.
ÉchirollesAges 18 years+ - NCT07366827Recruiting
Motorized back support for low back pain
This trial tests a motorized lumbar support device to see if it can relieve non-specific lower back pain. It may help if your pain gets better with gentle stretching or pulling of the spine (called manual traction).
Québec, QuebecAges 18–65 - NCT07366424Recruiting
Testing new shoes to prevent falls in seniors
This trial is testing if special shoes called 'CHUT OTONOM®' can improve walking and reduce fall risk in older adults who have fallen before. It may help you find better balance and confidence.
LilleAges 65 years+ - NCT06613607Recruiting
Core exercises for lower back pain and balance
This study tests whether core-strengthening exercises can improve pelvic alignment, balance, and agility for people with lower cross syndrome—a pattern of muscle tightness and weakness that often causes low back pain. If you have mild to moderate lower back pain that gets better when you move, you may be a candidate.
Rawalpindi, Punjab ProvinceAges 19–35 - NCT03652753RecruitingPhase 4
NAC injection during staged surgery for pilon fractures
This study looks at whether injecting N-acetylcysteine (NAC) into the joint during staged surgery can improve care for certain high-energy pilon fractures. It may help support healing where the joint is involved.
Columbia, MissouriAges 18 years+ - NCT07709104Enrolling by invitation
One-leg or two-leg warm-up for better volleyball jumps
This study looks at whether doing a simple leg exercise (one leg at a time or both together) before a jump can help volleyball players jump higher. If you are a healthy, trained volleyball player, this could show you a better way to warm up.
Katowice, Silesian VoivodeshipAges Any age - NCT06889701RecruitingPhase 1/Phase 2
Testing TNP-2092 for knee infection after joint replacement
This trial tests a new antibiotic, TNP-2092, given as a shot directly into the knee joint for people with a persistent infection after knee replacement. It is for those whose infection is caused by certain bacteria and who are willing to stay in the hospital for 2 weeks.
Ürümqi, XinjiangAges 18 years+ - NCT07299734RecruitingEarly Phase 1
Augmented reality + electrical stimulation for hand grasp
This trial tests a system that combines a video-like overlay (augmented reality) with small electrical pulses to help you grasp objects. It may improve your hand function and control.
Toronto, OntarioAges 18–65 - NCT07362277Recruiting
Mat Pilates for Sedentary Young Women
This study tests if Mat Pilates helps young women who are not active feel more connected to their bodies and become more physically active. You may join if you are between 18 and 29, live a mostly inactive lifestyle, and have not exercised regularly in the last 2 months.
Konya, TyrkeyAges 18–29 - NCT06407063Recruiting
Long-term results after surgery for lumbar spinal stenosis
This study looks at patients who had back surgery for lumbar spinal stenosis and a condition called spondylolisthesis between 2007 and 2015. They want to see how many people needed another operation years later.
TromsøAges 18 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,841 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,937 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.