Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,610 recruiting studies in this area right now.
By phase
- Not applicable3,771
- Phase 2215
- Phase 4199
- Phase 1182
- Phase 3139
- Phase 1/Phase 270
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis171
- Rheumatoid Arthritis131
- Fibromyalgia105
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee65
- Shoulder Pain48
- Hip Osteoarthritis43
- Psoriatic Arthritis40
- Degenerative Disc Disease39
- Chronic Pain38
- Total Knee Arthroplasty38
- Systemic Lupus Erythematosus37
- Duchenne Muscular Dystrophy36
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University66
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital25
- Hacettepe University23
- Tanta University22
Where studies are running
- California207
- New York87
- Florida82
- Maryland76
- Arizona72
- Massachusetts71
- Texas66
- Alabama60
- Illinois51
- Pennsylvania48
Recruiting studies4,610 total
- NCT07501429RecruitingPhase 1
Shockwave therapy for arm spasticity after spinal cord injury
This trial tests whether shockwave therapy can reduce muscle tightness in the elbow and wrist caused by spinal cord injury. It may help make daily tasks like dressing or bathing easier.
West Orange, New JerseyAges 18 years+ - NCT07505914Recruiting
Breathing exercises for better thinking in older adults
This trial tests whether simple breathing exercises can improve memory and thinking skills in adults aged 65 and older. You would attend two sessions each week for 8 weeks.
IstanbulAges 65 years+ - NCT07502989Recruiting
Study of Muscle Health Using Electrical Impedance Myography
This study uses a simple electrical test (EIM) and an MRI scan to check muscle health in people with muscle diseases. It may help researchers learn how to measure muscle changes without a biopsy.
Boston, MassachusettsAges 18–89 - NCT07501013Recruiting
Shoulder and knee surgery outcomes study
This study looks at how well different types of shoulder and knee surgeries work for sports injuries. It aims to help improve future care by following patients' recovery after common procedures like fixing torn cartilage or repairing ligaments.
Hangzhou, ZhejiangAges 8–80 - NCT07503821Recruiting
Using joint tissue as a marker for pigmented villonodular synovitis
This study looks at whether tissue from the joint lining (synovium) can be used as a biomarker to help guide treatment for pigmented villonodular synovitis (PVNS), a condition that causes joint swelling and damage. If you have PVNS and are scheduled for treatment, your joint tissue may be collected during your procedure to help doctors better understand the disease.
LyonAges 18 years+ - NCT07507175Recruiting
Calf muscle release for women with knee arthritis
This trial tests whether releasing tight calf muscles can help women with knee osteoarthritis feel less pain. It focuses on women who have moderate knee arthritis and a tight spot in their calf muscle.
Giza, Giza GovernorateAges 45–55 - NCT07500883Recruiting
Adding body awareness therapy to scoliosis exercises for teens
This trial tests whether adding Basic Body Awareness Therapy (a gentle movement practice that helps you notice how your body feels and moves) to standard scoliosis exercises can improve posture and reduce discomfort in teenagers with scoliosis.
Ankara, AnkaraAges 10–17 - NCT07502209Recruiting
Two types of nerve treatment for chronic shoulder pain
This study compares two methods of treating chronic shoulder pain by using a needle to deliver a special type of electrical pulse to a nerve in the shoulder. The goal is to find which method provides better pain relief for people with shoulder pain from a rotator cuff problem.
AnkaraAges 40–80 - NCT06767280Recruiting
Testing calf muscle in chronic nerve pain patients
This study looks at how a muscle in your calf (gastrocnemius) responds to a gentle electrical test in people with long-term nerve pain from the lower back. It aims to learn more about how the condition affects muscle function, which could help improve future treatments.
Sixth of October, Giza GovernorateAges 18–55 - NCT07493226Recruiting
NSAIDs for Frozen Shoulder Pain Study
This study tests different types of nonsteroidal anti-inflammatory drugs (NSAIDs) to see which works best for people with frozen shoulder. It may help you if you have ongoing shoulder pain and stiffness without other shoulder injuries.
Konya, SelçukluAges 18–75 - NCT07493213Recruiting
Ultrasound-guided shoulder injections for frozen shoulder
This study tests whether ultrasound-guided injections into the shoulder can improve pain and movement in people with frozen shoulder. It may help if you have had shoulder pain for at least 3 months and other treatments haven't worked well.
Konya, SelçukluAges 18–75 - NCT05778006Recruiting
Registry for people with ME/CFS
This study is a registry, meaning it collects information from people who have ME/CFS. It helps researchers better understand ME/CFS and may guide future studies that could improve care.
Munich, BavariaAges birth+ - NCT07491939Recruiting
Living Well with Arthritis: A Palliative Care Study
This study explores how palliative and supportive care can help people with arthritis feel better and live well. You can join even if you are not currently receiving palliative care.
Bath, WiltshireAges 18 years+ - NCT07489963Recruiting
Does keeping the posterior cruciate ligament help after knee replacement?
This trial compares two ways of doing robotic-assisted knee replacement: one that keeps the posterior cruciate ligament (a natural knee stabilizer) and one that doesn't. Researchers will see if saving the ligament leads to better knee function a year after surgery.
BordeauxAges 18 years+ - NCT07491302RecruitingPhase 2
Platelet-rich plasma injection for thumb osteoarthritis
This study tests whether a platelet-rich plasma (PRP) injection into the thumb joint can reduce pain and improve function better than a placebo (inactive) injection. PRP uses a concentration of your own blood platelets to potentially help heal the joint, and the goal is to see if it's an effective non-surgical option for thumb osteoarthritis.
Breda, North BrabantAges 18 years+ - NCT07490366Recruiting
Exercise vs needle treatment for shoulder muscle pain
This study compares three treatments for long-term shoulder muscle pain: exercises, dry needling (tiny needles into tight muscle spots), and a numbing shot between muscle layers. It aims to find which works best for myofascial pain syndrome.
Istanbul, IstanbulAges 18–55 - NCT07497100Recruiting
Arm function and daily life in hemiplegic cerebral palsy
This study looks at how arm and hand function affects daily activities in children with hemiplegic cerebral palsy. It aims to help understand how to improve participation in everyday tasks.
CairoAges 5–8 - NCT07493096Recruiting
Intensive therapy program for children with brain-based conditions
This trial tests an intensive therapy program designed to help children with brain-based conditions like cerebral palsy or autism improve their skills in movement, thinking, and daily activities. The program runs for 2 weeks with daily sessions, and researchers will check for changes in your child's abilities.
The Woodlands, TexasAges 4–12 - NCT07489937Recruiting
Arm exercise effects on the shoulder tendon
This study compares how two different arm exercises affect the shoulder tendon (supraspinatus) in people with and without shoulder pain. It may help find better ways to exercise without causing injury.
Gainesville, FloridaAges 18–45 - NCT07490041RecruitingEarly Phase 1
CAR-NK cell therapy for refractory childhood rheumatic diseases
This trial is testing a new type of cell therapy (CAR-NK cells) that targets two markers on immune cells (CD19 and BCMA) to treat severe forms of childhood rheumatic diseases. It aims to see if this treatment is safe and can help when other medicines have failed.
Hangzhou, ZhejiangAges 5 years+ - NCT07495306Recruiting
Measuring nerve changes after frozen shoulder surgery
This study checks how shoulder nerves change after a surgery called capsular release for frozen shoulder. It may help doctors understand recovery better.
Istanbul, IstanbulAges 21–70 - NCT07496463Enrolling by invitationPhase 2
Setmelanotide for weight loss in pseudohypoparathyroidism type 1a
This study tests an experimental medication called setmelanotide to see if it can help with weight loss in people who have pseudohypoparathyroidism type 1a (PHP1a), a rare genetic condition that often leads to obesity. The goal is to find a new treatment option for weight problems related to PHP1a.
Boston, MassachusettsAges Any age - NCT07491016Recruiting
Telitacicept plus baricitinib for hard-to-treat rheumatoid arthritis
This study tests a combination of two drugs (telitacicept and baricitinib) for people with stubborn rheumatoid arthritis that hasn't improved with other treatments. The goal is to see if this combination is safe and effective in reducing joint pain and inflammation.
Hangzhou, ZhejiangAges 18–85 - NCT07494344Recruiting
Joint replacement surgery study for bleeding disorders
This study looks at how people with inherited bleeding disorders, like hemophilia, do after joint replacement surgery. Researchers want to learn what works best for managing bleeding during and after surgery to improve recovery.
Pavia, LombardyAges 18 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,610 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,508 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.