Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,425 recruiting studies in this area right now.
By phase
- Not applicable9,762
- Phase 2784
- Phase 1574
- Phase 3535
- Phase 4342
- Phase 1/Phase 2305
- Phase 2/Phase 3123
Top conditions
- Stroke845
- Parkinson Disease426
- Multiple Sclerosis343
- Alzheimer Disease341
- Dementia226
- Ischemic Stroke200
- Epilepsy197
- Obstructive Sleep Apnea155
- Spinal Cord Injuries154
- Insomnia153
- Sarcopenia149
- Traumatic Brain Injury149
- Acute Ischemic Stroke139
- Cerebral Palsy131
- Mild Cognitive Impairment129
- Pain Management114
- Migraine112
- Amyotrophic Lateral Sclerosis108
Leading sponsors
- Beijing Tiantan Hospital133
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic99
- Xuanwu Hospital, Beijing94
- VA Office of Research and Development93
- Hospices Civils de Lyon79
- Johns Hopkins University70
- National Taiwan University Hospital70
- University of Minnesota64
Where studies are running
- California678
- Massachusetts300
- New York292
- Florida275
- Texas267
- Maryland245
- Arizona213
- Alabama211
- Illinois189
- Pennsylvania178
Recruiting studies12,423 total
- NCT05115929Recruiting
Surgery for dangerously high pressure after head injury
This trial compares two emergency surgery approaches for people with traumatic brain injury who have dangerously high pressure inside the skull that does not improve with standard treatments. The goal is to see which approach leads to better long-term outcomes.
ClamartAges 18–65 - NCT05116904Recruiting
Sleep and eye-movement study in Smith-Magenis autism
This study looks at sleep and certain eye/vision reflexes in children who have Smith-Magenis syndrome and autism. The goal is to better understand sleep-related differences and how they may be measured using a safe eye-reflex test.
BronAges 5–12 - NCT05116930RecruitingPhase 2
Medicine for headache after a labor spinal needle
This Phase 2 study tests neostigmine plus glycopyrrolate to treat a specific type of severe headache that happens after a dural puncture during labor. If you have a new headache starting within 72 hours of delivery and no other cause, this treatment may help relieve your pain.
Rochester, MinnesotaAges 18–54 - NCT05119387Recruiting
Genetic study for amyotrophic lateral sclerosis (ALS) in Norway
This study looks at genetic (inherited) factors in people with ALS. Your participation may help researchers better understand why ALS happens and who might be at risk.
BergenAges 16–100 - NCT05116943Recruiting
ALS and related brain disease biospecimen biobank
This study builds a blood and spinal fluid (lumbar puncture) sample library from people with ALS, ALS-FTD, or similar neurodegenerative diseases. Your samples help researchers study these conditions, even if you are not receiving a new treatment.
Jacksonville, FloridaAges 18 years+ - NCT05118997Recruiting
Irrigation procedure to help clear brain bleeding
This trial tests a method to actively flush (irrigate) and help remove an active brain bleed inside the brain. It may help some adults recover better by improving how the blood is cleared after bleeding starts.
HelsinkiAges 18 years+ - NCT05119842Recruiting
Implant study for permanent voice weakness from vocal cord closure
This study tests a voice implant device in people with permanent vocal cord weakness (UVFP) who have trouble closing their vocal cords. It aims to improve voice strength and reduce voice-related burden, while checking safety over the study period.
Phoenix, ArizonaAges 18–80 - NCT05121012Recruiting
PET brain scan study for synaptic loss in MSA or PSP
This study uses brain scans (PET, and possibly spinal fluid) to measure changes linked to “synaptic loss” in people with multiple system atrophy (MSA) or progressive supranuclear palsy (PSP). It may help researchers understand disease changes and how they relate to symptoms, which could guide future treatments.
ExeterAges 45–80 - NCT05121324RecruitingPhase 3
Tested higher-dose seizure medicine for children during EMS care
This trial studies the best dose of a seizure medicine for children who are actively seizing while emergency medical teams are treating them. It may help EMS crews give safer, more effective treatment during transport.
Tucson, ArizonaAges 6 months–13 years - NCT05122403Recruiting
MRI-guided brain procedure for stubborn nerve pain
This trial tests a brain treatment guided by MRI to treat chronic nerve (neuropathic) pain that hasn’t improved with many prior treatments. It may help reduce pain intensity when standard pain medicines and procedures have not worked.
Beijing, Beijing MunicipalityAges 18–75 - NCT05122728Recruiting
Tracking injury risk after concussion and body movement changes
This study looks at how being recently concussion-affected changes musculoskeletal (muscle/joint) injury risk and recovery during physical activity. It compares a group who is currently recovering after concussion with a similar healthy group to better understand risk factors over time.
Athens, GeorgiaAges 18–40 - NCT05123443Recruiting
Study tracks iron changes in MS brain spots over time
This study looks at how “iron rims” in brain MRI scans change over time in people with multiple sclerosis (MS). It may help researchers understand MS activity better and how iron changes relate to disease progression.
NottinghamAges 16 years+ - NCT05124912Recruiting
Laser treatment for recurrent brain metastases after prior SRS
This study tests whether repeating treatment with a laser (along with a small biopsy) can control brain metastases that have come back after earlier radiation called SRS. It may help people whose cancer is stable enough for surgery and who have a specific, reachable brain spot to target.
Los Angeles, CaliforniaAges 18 years+ - NCT05124236Recruiting
Pre-surgery vs post-surgery focused radiation for brain metastases
This trial compares two ways of giving focused radiation for brain metastases: before surgery or after surgery. It aims to see which timing works better to control tumors while keeping you safe.
InnsbruckAges 18 years+ - NCT05124600Recruiting
Personalized MS app study for 21-day daily use
This study looks at an individualized health eLibrary app for people with multiple sclerosis (MS). You may use the app for 21 days and help researchers compare outcomes between a group using the app and a comparison group.
Champaign, IllinoisAges 18 years+ - NCT05125146Recruiting
Internet CBT for insomnia versus medicines
This study compares an online form of CBT (a structured therapy for sleep) with sleep medicines for adults with insomnia. It may help you see which approach improves how easily you fall asleep and stay asleep.
Kingston, OntarioAges 18 years+ - NCT05126914Recruiting
Follow-up study for rare epilepsy in children
This study follows children and teens with rare forms of epilepsy to better understand their condition over time in real-life care. It may help doctors improve future care plans and support for families.
AngersAges Up to 15 years - NCT05127265Recruiting
AI and sensors to monitor patients in the ICU
This study uses AI and sensor data to better monitor people while they are in an intensive care unit (ICU). It may help teams notice changes sooner and improve care for ICU patients.
Gainesville, FloridaAges 18 years+ - NCT05127980Recruiting
Study of immune antibodies after first-time EBV infection
This study looks at how the immune system’s antibodies behave after a first-time EBV infection, including whether they mistakenly react with the body’s own tissues. You might be offered a chance to help doctors understand why some people get longer or more intense symptoms from infectious mononucleosis.
BaselAges 18 years+ - NCT05128149Recruiting
PKU care guidelines and how they affect daily well-being
This study looks at whether following specific care guidelines for phenylketonuria (PKU) leads to better metabolic control (blood phenylalanine levels) and better patient well-being. You may be asked to complete questionnaires and follow the study plan while receiving the usual PKU treatment your clinic recommends.
ZurichAges 10 years+ - NCT05129748RecruitingPhase 2
Prevent hearing damage during cisplatin chemotherapy
This Phase 2 trial tests whether sodium thiosulfate and mannitol can reduce hearing damage (ototoxicity) in adults receiving cisplatin chemotherapy. It may help protect hearing while you get cancer treatment.
Toronto, OntarioAges 18 years+ - NCT05130203Recruiting
Exergaming for long-term care residents and caregivers
This study tests a new “exergaming” activity—games that encourage movement—made for older adults in long-term care. It may help residents stay active and engaged, with participation also involving family, friends, or staff feedback.
TorontoAges 55 years+ - NCT05131399Recruiting
Test an off-the-shelf carbon ankle brace for drop foot walking
This trial studies whether a ready-made carbon ankle-foot brace (AFO) improves walking when someone has “drop foot” (trouble lifting the front of the foot). It’s meant to help with standing and stability by supporting the ankle and foot.
AngersAges 18 years+ - NCT05132517Recruiting
Magnesium to support thinking after stroke
This trial studies whether magnesium can help improve or protect thinking skills after a stroke. It may be offered to people who did not already have memory or thinking problems before their stroke.
Hessisch Oldendorf, Lower SaxonyAges 18 years+
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,425 recruiting neurology studies from the U.S. registry right now, out of 19,436 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.