Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,462 recruiting studies in this area right now.
By phase
- Not applicable9,797
- Phase 2786
- Phase 1574
- Phase 3538
- Phase 4342
- Phase 1/Phase 2304
- Phase 2/Phase 3121
Top conditions
- Stroke854
- Parkinson Disease424
- Multiple Sclerosis342
- Alzheimer Disease340
- Dementia226
- Ischemic Stroke199
- Epilepsy196
- Obstructive Sleep Apnea155
- Spinal Cord Injuries154
- Insomnia152
- Traumatic Brain Injury152
- Sarcopenia148
- Acute Ischemic Stroke141
- Cerebral Palsy130
- Mild Cognitive Impairment129
- Pain Management114
- Migraine113
- Amyotrophic Lateral Sclerosis107
Leading sponsors
- Beijing Tiantan Hospital134
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic99
- Xuanwu Hospital, Beijing95
- VA Office of Research and Development93
- Hospices Civils de Lyon79
- Johns Hopkins University70
- National Taiwan University Hospital70
- Cairo University63
Where studies are running
- California675
- Massachusetts301
- New York292
- Florida277
- Texas267
- Maryland244
- Arizona216
- Alabama211
- Illinois193
- Pennsylvania177
Recruiting studies12,460 total
- NCT06660602Recruiting
Brain function check before and after heart surgery
This study checks how well your brain works before and after heart surgery. It uses safe tests like a CT scan and an EEG to see if surgery affects brain function.
BeijingAges 18–80 - NCT06660719RecruitingPhase 3
New stroke medicine SP-8203 with clot-busting therapy
This trial tests a new medicine called SP-8203 added to standard clot-busting treatment for people having a moderate to severe stroke. The goal is to see if it helps improve recovery and is safe.
BusanAges 19–85 - NCT06661564Recruiting
Testing tears for Alzheimer's disease diagnosis
This study looks at whether tears can help detect Alzheimer's disease. You will have your tears collected and tested for possible biomarkers.
Tours, FranceAges 18 years+ - NCT06662045Recruiting
Iron deficiency and child brain development study
This study looks at whether iron deficiency anemia affects how babies and toddlers (6 to 24 months old) develop their thinking, learning, and behavior. It compares children who have iron-deficiency anemia with those who do not, to help doctors understand the impact on early brain development.
Shenzhen, China/GuangdongAges 6 months–6 years - NCT06662448Recruiting
Light stimulation for nerve damage in the eye
This study tests if a gentle electrical current, like a light flicker, can help people with optic neuropathy (damage to the nerve connecting the eye to the brain). You would attend 30 sessions over 8 weeks. It might improve your vision if you still have some sight left.
New York, New YorkAges 18 years+ - NCT06662461Recruiting
Nerve block for stubborn migraines: Stellate vs occipital
This trial tests which nerve block works better for stubborn migraines: one on the stellate ganglion (a cluster of nerves in the neck) or the greater occipital nerve (at the back of the head). They will also check how these blocks affect a chemical linked to migraine pain. If you have chronic migraines that haven't improved with multiple treatments, you may be eligible.
CairoAges 18 years+ - NCT06663111Recruiting
Rituximab and Ocrelizumab levels in Multiple Sclerosis
This trial looks at two medicines, rituximab and ocrelizumab, in the blood of people with multiple sclerosis. It only includes people who are already in another study called OVERLORD-MS and can give blood samples on a schedule.
Bergen, VestlandAges 18–60 - NCT06663306RecruitingPhase 1
Intrathecal pemetrexed and bevacizumab for lung cancer brain spread
This trial tests a treatment given directly into the fluid around the brain and spinal cord (intrathecal injection) using two drugs—pemetrexed and bevacizumab—for people with non-small cell lung cancer that has spread to that area (leptomeningeal metastases). It may be an option if your current treatment is no longer working.
ShanghaiAges 18 years+ - NCT06663358Recruiting
Safety and effectiveness of Elfabrio in Fabry disease patients
This study is for people with Fabry disease who are taking or planning to take the medication Elfabrio (pegunigalsidase alfa). It will look at how safe and effective the treatment is in real-world use.
Birmingham, AlabamaAges 18 years+ - NCT06663631RecruitingPhase 1
Hibernation-like therapy for stroke recovery after clot removal
This trial tests if a hibernation-like therapy can improve recovery after a stroke caused by a large blood clot in the brain. It is for people who are having a stroke and are scheduled for a procedure to remove the clot.
Linyi, ShandongAges 18–80 - NCT06663917Recruiting
Testing sound frequency settings for cochlear implant users with a hearing aid
This study tests different ways to set sound frequencies for people who have a cochlear implant and also use a hearing aid in the other ear. The goal is to find which setting helps you hear speech better.
New York, New YorkAges 18 years+ - NCT06663969Recruiting
Temporal Interference Stimulation for Epilepsy
This trial tests a new, gentle way to stimulate specific brain areas using a special electrical signal. It aims to see if this can help people with epilepsy that hasn't improved with medication.
Beijing, Beijing MunicipalityAges 14–65 - NCT06664229Recruiting
Dementia and fall prevention program for older adults
This study tests a pressure sensor-based program to help prevent dementia and falls in older adults. If you are 65 or older, can walk independently, and have no dementia or other conditions that affect thinking, you may be able to join.
Seoul, SeoulAges 65 years+ - NCT06664203Recruiting
Nerve block for arm surgery pain relief
This trial tests a special type of nerve block (called variable volume truncal block) for pain relief during arm, elbow, forearm, hand, or wrist surgery. It may help reduce pain and the need for strong pain medicines.
IstanbulAges 18–65 - NCT06664450Recruiting
Brain fog in sleep apnea
This study looks at brain fog (difficulty thinking or concentrating) in people with severe sleep apnea, both before and after starting CPAP therapy. It aims to understand how sleep apnea treatment affects brain function.
Milan, MIAges 18 years+ - NCT06664697Recruiting
Study of the IotaSOFT Insertion System for cochlear implants
This trial tests a new robotic system that helps doctors insert cochlear implant electrodes more gently. It may lead to safer surgery and better hearing outcomes for people with severe hearing loss.
Indianapolis, IndianaAges 12 years+ - NCT06664710Recruiting
Robot-assisted cochlear implant surgery with hearing monitoring
This study tests a new robotic system that helps place a cochlear implant while measuring your inner ear's natural electrical signals during surgery. The goal is to make the procedure more precise and possibly improve hearing outcomes.
Iowa City, IowaAges 12 years+ - NCT06665113Recruiting
Ear nerve stimulation for early Parkinson's disease
This trial tests whether a non-invasive nerve stimulation device (taVNS) worn on the ear can protect brain cells and slow Parkinson's disease progression in early-stage patients. It is for people who have been diagnosed within the last 3 years and are already on standard medication.
Nanjing, JiangsuAges 55–75 - NCT06665165RecruitingPhase 1
Study of AMX0114 for people with ALS
This study tests an experimental drug called AMX0114 for people recently diagnosed with ALS. It is an early-phase trial to see if the drug is safe and how it affects the body.
La Jolla, CaliforniaAges 18 years+ - NCT06665386Recruiting
Cooling infusion with clot removal for severe stroke
This study tests whether cooling the brain during clot removal (thrombectomy) can improve recovery after a severe stroke caused by a large blood vessel blockage. Researchers will use blood tests to find markers that may predict who benefits most.
Dalian, LiaoningAges 18–80 - NCT06665607Recruiting
Foot muscle training for people with MS
This study tests whether training the small muscles in your feet can improve your walking and balance if you have multiple sclerosis (MS). It is for people with moderate disability, so you can still walk but may have some trouble.
ValladolidAges 18–70 - NCT06665867Recruiting
Video Follow-Up for Kids With Stomach Pain
This trial tests whether video consultations (video calls) are a good option for follow-up appointments in children with functional abdominal pain disorders. It aims to make check-ups easier for families.
AmsterdamAges 4–17 - NCT06666413RecruitingPhase 4
Study of Nexviazyme in children with infantile Pompe disease
This study tests the safety and effects of the enzyme replacement therapy avalglucosidase alfa (Nexviazyme) in children with infantile-onset Pompe disease. It is for children who have had Pompe symptoms since infancy and heart problems at diagnosis.
ShanghaiAges Up to 17 years - NCT06666712RecruitingPhase 1
Chronic brain infusion of topotecan for recurrent glioma
This trial tests a treatment called topotecan that is delivered directly into the brain through a small tube (convection-enhanced delivery). It is for people whose IDH-mutant glioma has come back despite standard treatment. The goal is to see if this approach can help control the tumor.
New York, New YorkAges 18 years+
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,462 recruiting neurology studies from the U.S. registry right now, out of 19,649 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.