Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,497 recruiting studies in this area right now.
By phase
- Not applicable9,839
- Phase 2787
- Phase 1573
- Phase 3531
- Phase 4344
- Phase 1/Phase 2304
- Phase 2/Phase 3119
Top conditions
- Stroke856
- Parkinson Disease424
- Alzheimer Disease341
- Multiple Sclerosis341
- Dementia228
- Ischemic Stroke201
- Epilepsy196
- Insomnia156
- Obstructive Sleep Apnea155
- Traumatic Brain Injury154
- Spinal Cord Injuries151
- Sarcopenia149
- Acute Ischemic Stroke141
- Cerebral Palsy129
- Mild Cognitive Impairment128
- Migraine113
- Pain Management113
- Amyotrophic Lateral Sclerosis107
Leading sponsors
- Beijing Tiantan Hospital135
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic98
- Xuanwu Hospital, Beijing94
- VA Office of Research and Development92
- Hospices Civils de Lyon79
- Johns Hopkins University71
- National Taiwan University Hospital69
- University of Minnesota63
Where studies are running
- California675
- Massachusetts305
- New York294
- Florida277
- Texas270
- Maryland245
- Alabama213
- Arizona211
- Illinois193
- Pennsylvania177
Recruiting studies12,495 total
- NCT02784977Recruiting
Sleep apnea study using a national sleep database
This study collects information from adults who are getting a sleep test because obstructive sleep apnea is suspected. It helps researchers better understand sleep apnea and who develops it, without giving a new treatment.
IstanbulAges 18–80 - NCT02423395RecruitingPhase 3
Orphenadrine for muscle cramps in people with cirrhosis
This trial tests whether orphenadrine (a medication used to reduce muscle cramping) can lessen muscle cramps in people who have cirrhosis of the liver. It may help if your cramps happen often, but you must avoid certain medication conflicts and health situations.
TantaAges Any age - NCT02639325Recruiting
Seizure treatment study for people with brain tumors
This study looks at how a brain tumor-related seizure condition is handled in children and adults. It may be a good option if your seizures started soon after your brain tumor was found or is in the same brain area as your seizure symptoms.
Bethesda, MarylandAges 8–99 - NCT02504788Recruiting
Protect the brain’s memory area during whole-brain radiation
This study tests whether avoiding the hippocampus (a part of the brain important for memory) during whole-brain radiotherapy can slow down thinking and memory decline. It may help some people preserve neurocognitive function while still treating brain metastases.
TaoyuanAges 18–84 - NCT02593565Recruiting
Pregnancy blood-vessel disease registry study
This is a pregnancy registry that collects information from people with certain blood-vessel inflammatory diseases during pregnancy. It helps researchers better understand these conditions in pregnancy and may guide future care.
Tampa, FloridaAges 18–50 - NCT02426255Recruiting
Study of serious injuries and complications after trauma
This study follows people with severe injuries (including head injuries and bleeding) to better understand serious complications that can happen after trauma. Your experience may help doctors predict and prevent these complications in the future.
AngersAges 15 years+ - NCT02841553Recruiting
Online registry for Wolfram syndrome worldwide
This study builds an international online registry to learn how Wolfram syndrome (and related WFS1 conditions) changes over time. It may help researchers understand the disease course and improve future care by collecting health and family history data.
St Louis, MissouriAges birth+ - NCT02879123Recruiting
Recovery after stroke treatment with a clot-removal procedure
This trial studies how the brain and nervous system recover about 3 months after a clot-removal treatment for an acute ischemic stroke. It may help doctors better understand what recovery looks like after this kind of stroke care.
ParisAges Any age - NCT02851043Recruiting
Non-invasive monitor to measure breathing
This study tests a device that checks breathing without needles or painful procedures. It may help doctors learn how well breathing can be measured in people with mild breathing problems, or in healthy volunteers.
Wilmington, DelawareAges 11–17 - NCT02310399Recruiting
Auditory brainstem implant for children without cochleae or hearing nerves
This study looks at whether an auditory brainstem implant (ABI) can help children hear sounds and develop listening/communication skills when the usual inner-ear hearing structures or hearing nerves are missing or not working. It may help some children who cannot benefit from a cochlear implant, but spoken language may not be the main outcome.
New York, New YorkAges 1.5 years–21 years - NCT02414347Recruiting
Tau PET scan study for Alzheimer’s disease
This study uses a PET brain scan with a small injected tracer to look for “tau” protein changes linked to Alzheimer’s disease. It may help researchers better understand how tau appears in people who are cognitively normal or have mild dementia.
St Louis, MissouriAges 18 years+ - NCT02910180Recruiting
Biobank study of genetic and metabolic data in brain blood vessel disease
This study collects genetic and other health information from people with brain blood vessel (cerebrovascular) problems. It aims to help researchers understand causes and patterns that could lead to better care in the future.
Los Angeles, CaliforniaAges 18 years+ - NCT02824822Recruiting
Genetic test study for heart rhythm risk in people with seizures
This study checks whether genetic markers are linked to heart rhythm problems in people with epilepsy or seizure-related events, and in some close relatives. It may help doctors better spot who is at risk for dangerous heart rhythm issues.
Rochester, MinnesotaAges 18–50 - NCT02800395Recruiting
Study links brain changes to diet and blood markers in Alzheimer’s
This study looks at how diet-related and blood “stress” markers relate to how thinking and memory decline over time in people with Alzheimer’s. It may help researchers find useful biomarkers to better track progression and guide future care.
Pierre-BéniteAges 55 years+ - NCT02659956Recruiting
Study brain and eye changes on MRI in MS
This study looks at how multiple sclerosis (MS) affects MRI scans and other measurements in the brain, spinal cord, and eyes. It may help researchers better understand MS changes over time, using follow-up visits and, in the future, donated tissue after death.
Bethesda, MarylandAges 18–120 - NCT02649985RecruitingPhase 1/Phase 2
PET brain scan study for several brain and mood conditions
This early-phase study uses PET and MRI brain scans to better understand brain changes in multiple sclerosis, Alzheimer’s disease, and other neurological or mood conditions. The goal is to test whether these scans can show disease-related differences and guide future treatments.
Boston, MassachusettsAges 18–85 - NCT02592291Recruiting
Using a phone app to help manage long-term health needs
This study tests a mobile phone system that helps people with long-term, complex health conditions manage daily life and get support. If you can use a smartphone and pass the study checks, you may be able to try the self-management tools.
Pittsburgh, PennsylvaniaAges 12 years+ - NCT02390752RecruitingPhase 1
Early drug study for children and young adults with hard-to-treat cancers
This Phase 1 trial tests pexidartinib (TURALIO) to see how safe it is and how well it works against refractory (hard-to-treat) leukemias and solid tumors, including tumors seen with NF1 and MPNST. It mainly helps researchers learn the best way to dose the medication and gather early signals of benefit.
Bethesda, MarylandAges 3–35 - NCT02531880RecruitingPhase 1
MRI test of a brain barrier issue in hard-to-treat epilepsy
This early-phase study uses a special MRI approach to look for signs that the “blood-brain barrier” is breaking down in people with drug-resistant epilepsy. It may help researchers understand what is happening in the brain and guide future treatments, though it is primarily a testing/study study.
Bethesda, MarylandAges 18–60 - NCT02896348Recruiting
Home therapy training for hand function after stroke
This trial tests a physio-and-neuro “platform” to help retrain hand movement at home in people who are at least 6 months out from a stroke. It may help improve hand function and confidence doing daily tasks using an at-home retraining program.
Boston, MassachusettsAges 21–80 - NCT02346396Recruiting
At-home brain stimulation trial for long-lasting nerve pain
This study tests a device that delivers mild electrical stimulation to the brain from home to help reduce chronic nerve pain. It focuses on people whose pain has not improved enough despite stable pain medicines.
BronAges 18–80 - NCT02703207Recruiting
Sleep apnea and COPD effects in older veterans
This study looks at how sleep apnea affects thinking skills and overall health in older veterans who also have COPD. It may help researchers understand what changes to target to improve daytime functioning and wellbeing.
Detroit, MichiganAges 60–89 - NCT02431507Recruiting
First test of an implant device to prevent sleep apnea pauses
This trial is testing whether a new implanted device is safe and feasible for people with moderate to severe obstructive sleep apnea. It may help if you cannot tolerate CPAP (a common breathing device) and your apnea is caused by airflow blockage at the back of the tongue area.
San Francisco, CaliforniaAges 21–70 - NCT02535936Recruiting
Brain plasticity study after rhizotomy surgery for spastic diplegia
This study looks at how the brain adapts after selective dorsal rhizotomy surgery in children with spastic diplegia. It may help doctors better understand recovery and treatment effects over time.
Houston, TexasAges 3–18
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,497 recruiting neurology studies from the U.S. registry right now, out of 19,911 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.