Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,497 recruiting studies in this area right now.
By phase
- Not applicable9,839
- Phase 2787
- Phase 1573
- Phase 3531
- Phase 4344
- Phase 1/Phase 2304
- Phase 2/Phase 3119
Top conditions
- Stroke856
- Parkinson Disease424
- Alzheimer Disease341
- Multiple Sclerosis341
- Dementia228
- Ischemic Stroke201
- Epilepsy196
- Insomnia156
- Obstructive Sleep Apnea155
- Traumatic Brain Injury154
- Spinal Cord Injuries151
- Sarcopenia149
- Acute Ischemic Stroke141
- Cerebral Palsy129
- Mild Cognitive Impairment128
- Migraine113
- Pain Management113
- Amyotrophic Lateral Sclerosis107
Leading sponsors
- Beijing Tiantan Hospital135
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic98
- Xuanwu Hospital, Beijing94
- VA Office of Research and Development92
- Hospices Civils de Lyon79
- Johns Hopkins University71
- National Taiwan University Hospital69
- University of Minnesota63
Where studies are running
- California675
- Massachusetts305
- New York294
- Florida277
- Texas270
- Maryland245
- Alabama213
- Arizona211
- Illinois193
- Pennsylvania177
Recruiting studies12,495 total
- NCT02855476Recruiting
Collecting spinal fluid samples to help Huntington’s research
This study gathers small samples of spinal fluid from people affected by Huntington’s disease. Researchers use these samples to better understand the disease and support future treatments. If you join, you’ll need to follow their sample and visit schedule.
Englewood, ColoradoAges 11–75 - NCT02864108Recruiting
Study of Trisomy in people with and without Down syndrome
This study includes people of many ages to help researchers learn more about Trisomy (an extra chromosome condition) in those with and without Down syndrome. It may help improve understanding and future care for people affected by chromosome differences.
Denver, ColoradoAges 6 months–89 years - NCT02754544Recruiting
Brain mapping during tumor surgery while you are awake
This study uses special recording sensors during brain tumor surgery to map the brain areas that control movement and speech. It may help the surgical team protect these key functions while removing the tumor.
Houston, TexasAges 18 years+ - NCT02304913Recruiting
Acupuncture to reduce bad taste during chemotherapy
This trial studies whether hypoglossal acupuncture can reduce dysgeusia, or a persistently bad/altered taste, in people who are receiving chemotherapy. If you qualify, it may help improve taste-related eating and quality of life during treatment.
Essen, North Rhine-WestphaliaAges 18 years+ - NCT02240862Recruiting
Carotid artery disease registry for symptom and risk groups
This is a registry that enrolls adults with narrowed carotid arteries (with symptoms or no symptoms). It collects health and treatment information to better understand which patients benefit from procedures and when.
Baltimore, MarylandAges 18–80 - NCT02900521Recruiting
Brest stroke and clot registry for local adults
This study is a population registry that records information from people in a specific area of Brest who had certain types of brain blood vessel events. It helps researchers understand how these conditions happen in the real world and may improve future care planning.
BrestAges 15 years+ - NCT02662751Recruiting
Low-dose whole-body scan after stroke or TIA
This study looks at whether a low-dose whole-body imaging scan soon after a stroke or TIA (sometimes called a “mini-stroke”) can help doctors evaluate you. It also includes long follow-up to see how patients do over time.
MontpellierAges 18–89 - NCT02302482Recruiting
Tracking memory changes and personal independence over time
This study follows people who are newly evaluated in a memory clinic to better understand what predicts how memory and independence may change. It may help clinicians plan care that supports autonomy as the condition progresses.
Caluire-et-CuireAges 65 years+ - NCT02331979Recruiting
Neuromodulation trial to improve bladder function after spinal injury
This trial tests a nerve-stimulation approach to improve bladder control in people with spinal cord injury. It specifically targets bladder problems that require clean intermittent catheter use and includes regular testing over 6 months.
Los Angeles, CaliforniaAges 18–45 - NCT02910323Recruiting
Study for cluster headaches and trigeminal nerve pain
This study looks at people with certain severe headache disorders (cluster-type headaches or SUNCT/SUNA) or trigeminal neuralgia (sharp facial nerve pain). Researchers want to better understand these conditions and see how study testing/record review may help care.
Houston, TexasAges 18 years+ - NCT02369770Recruiting
Rehab training for ankle and leg function after a stroke
This study tests a sensory-motor rehabilitation program to improve movement of the ankle and affected leg after a first stroke. It may help people regain safer, more controlled walking and leg movement.
Baltimore, MarylandAges 18–80 - NCT02420067Recruiting
Screening for inner-ear tumors in people with Von Hippel-Lindau
This trial focuses on checking whether a specific inner-ear tumor (called an endolymphatic sac tumor) can be found earlier in people with Von Hippel-Lindau (vHL) disease. It may help doctors detect problems sooner so you can discuss treatment options earlier, if needed.
Copenhagen, Copenhagen NAges 15 years+ - NCT02323945Recruiting
Low-oxygen breathing to improve leg movement after spinal injury
This study tests whether breathing brief, mild low-oxygen air (under supervision) can improve leg mobility in people with a certain type of spinal cord injury. It may help with regaining movement, especially if you can already move your legs voluntarily but still have mobility limits.
Cambridge, MassachusettsAges 18–75 - NCT02630121RecruitingPhase 4
Nasal spray treatment to reduce mild sleep apnea congestion
This study tests whether using oxymetazoline with fluticasone nasal spray can improve mild obstructive sleep apnea by lowering nasal congestion. If your nose stays blocked most days despite current spray use, this may help your breathing during sleep.
Tampa, FloridaAges 18–65 - NCT02897063RecruitingPhase 1
Test medicines for low blood pressure in nerve-related disorders
This early (Phase 1) study tests whether midodrine and droxidopa can improve blood-flow pooling in the belly in people with nerve problems that affect blood pressure when standing. It’s looking at safety and how the body responds, which may help reduce dizziness or fainting for some participants.
Nashville, TennesseeAges 40–80 - NCT02398786Recruiting
Join a family registry for myotonic dystrophy (DM1 or DM2)
This study builds a registry of people and families affected by myotonic dystrophy types 1 and 2. It helps researchers learn about the condition over time and may support future studies that could lead to better care.
Oakland, CaliforniaAges Any age - NCT02422641RecruitingPhase 2
High-dose methotrexate for breast cancer in the brain lining
This Phase 2 trial tests whether giving high-dose methotrexate into the bloodstream can help treat breast cancer that has spread to the thin lining covering the brain and spinal cord. It may help reduce cancer in the leptomeningeal (brain-lining) area and control symptoms.
Baltimore, MarylandAges 18 years+ - NCT02734069Recruiting
Testing whether muscle mass affects carboplatin side effects
This study looks at how your body’s “fat-free mass” (mostly muscle and organs) may change the dose of carboplatin and the risk of chemotherapy side effects. It’s for people with advanced lung cancer who are starting treatment with carboplatin plus paclitaxel for the first time.
Mexico CityAges 18 years+ - NCT02552511Recruiting
Study of seizures in newborns and how often they occur
This study looks at newborns (up to 28 days old) who have seizures to understand them better, using EEG brain-wave testing. If you agree to participate and can follow the study plan, your child’s information may help researchers learn more about neonatal seizures.
Shanghai, Shanghai MunicipalityAges Up to 4 weeks - NCT02448992RecruitingPhase 2/Phase 3
Brain radiation that avoids the memory area in lung cancer
This trial studies a “prophylactic” (preventive) type of brain radiation for people with lung cancer that has spread to nearby lymph nodes but not to the brain. It aims to lower the chance of brain metastases while protecting the hippocampus, an area linked to memory.
TaoyuanAges 18–80 - NCT02521311RecruitingPhase 2
Clemastine to help restore nerve covering in optic neuritis
This Phase 2 trial tests whether clemastine can help regrow the protective covering around the optic nerve after acute optic neuritis (an inflammation-related vision problem). It may help improve vision recovery and signal how well “remyelination” happens.
San Francisco, CaliforniaAges 18–55 - NCT02472028RecruitingPhase 4
Lower blood pressure to protect the brain in older adults
This study tests whether better blood pressure control can slow changes seen on brain scans in older people. It focuses on people with high blood pressure and “wear-and-tear” type brain lesions on MRI.
Bordeaux, Pellegrin Hospital GroupAges 60–88 - NCT02497534Recruiting
Biomarker testing study for Friedreich’s ataxia
This study looks at “biomarkers” (measurable signs in the body, like test results from blood or other checks) in people with Friedreich’s ataxia. It may help researchers understand the disease better and track changes over time.
Gainesville, FloridaAges 6–70 - NCT02605785Recruiting
Imaging study to track tau protein in PSP
This study uses brain imaging to look at a protein called tau in people with progressive supranuclear palsy (PSP). It aims to better understand the disease and how tau changes over time, which may help future treatments.
Rochester, MinnesotaAges 35 years+
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,497 recruiting neurology studies from the U.S. registry right now, out of 19,911 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.