Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,858 recruiting studies in this area right now.
By phase
- Not applicable2,771
- Phase 2283
- Phase 1235
- Phase 3216
- Phase 1/Phase 2204
- Phase 497
- Phase 2/Phase 352
Top conditions
- Sickle Cell Disease140
- Atopic Dermatitis128
- Congenital Heart Disease86
- Cystic Fibrosis78
- Down Syndrome54
- Genetic Disease42
- Duchenne Muscular Dystrophy39
- Fabry Disease38
- Hemophilia A38
- Cystic Fibrosis (CF)37
- Cardiac Amyloidosis35
- Huntington Disease32
- Lynch Syndrome32
- Heart Failure31
- Retinitis Pigmentosa31
- Bronchopulmonary Dysplasia30
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)27
Leading sponsors
- Assistance Publique - Hôpitaux de Paris62
- Boston Children's Hospital42
- National Institute of Allergy and Infectious Diseases (NIAID)38
- Mayo Clinic37
- Children's Hospital Medical Center, Cincinnati33
- Hospices Civils de Lyon32
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Riphah International University26
- Massachusetts General Hospital23
- National Cancer Institute (NCI)23
Where studies are running
- California340
- Maryland161
- Alabama132
- Massachusetts116
- New York84
- Arizona78
- Texas73
- Minnesota67
- Pennsylvania65
- Ohio57
Recruiting studies3,858 total
- NCT06855745RecruitingPhase 2
Testing a new gel for mild to moderate eczema
This study tests a new gel called Zabalafin Hydrogel to see if it helps people with mild to moderate atopic dermatitis (eczema). The gel is applied directly to the skin. If you or your child has eczema on the head, neck, trunk, or limbs, this trial may be an option.
Brookvale, New South WalesAges 2 years+ - NCT06856330Recruiting
Trial on a new surgery for speech in children with cleft lip and palate
This trial tests a surgical technique (Furlow palatoplasty with a cheek muscle flap) to see if it improves speech development in young children who had a complete cleft lip and palate repaired previously. It may help children between 3 and 5 years old with non-syndromic conditions.
Al FayyumAges 3–5 - NCT06857838Recruiting
Bypass surgery for symptomatic myocardial bridge
This trial tests whether bypass surgery is effective for people with a myocardial bridge (a heart muscle that arches over an artery) that still causes symptoms despite medication. It aims to see if surgery can improve symptoms and outcomes.
Xi'an, ShaanxiAges 18–80 - NCT06858670Recruiting
A device to correct deep curve in back molars
This trial tests a small device (auxiliary segmental lingual appliance) placed on the inside of your lower back teeth to help correct a deep curve in your bite. It may be an option for people already in braces whose second molars tilt inward.
HanoiAges 18 years+ - NCT06859177Recruiting
Remote fetal monitoring trial for complicated pregnancies
This study tests if women with high-risk pregnancies can safely use a remote monitor at home instead of staying in the hospital. You would use a belly patch to send your baby's heart rate and your contractions to your care team.
Veldhoven, North BrabantAges 18 years+ - NCT06859411Recruiting
Posterior corneal transplant study
This study looks at how well people do after a specific type of corneal transplant called posterior lamellar keratoplasty. It aims to understand long-term outcomes for patients who had this surgery.
MetzAges 18 years+ - NCT06860919Recruiting
Transition care for young adults with esophageal atresia
This trial studies a special follow-up program for young adults born with a connection problem in their esophagus (the tube that carries food). The goal is to see if a transitional consultation helps manage long-term health needs.
ParisAges 18–30 - NCT06861309Recruiting
Placental imaging study for pregnant women
This study uses special imaging techniques to look at the placenta during pregnancy. It aims to learn more about normal pregnancies and those where the baby is growing more slowly than expected.
Roanoke, VirginiaAges 18–45 - NCT06861998Recruiting
Sleep help before heart surgery for infants and toddlers
This trial tests if helping young children with sleep problems before heart surgery can reduce confusion or agitation after surgery. It is for children ages 0 to 3 who have sleep issues and are scheduled for heart repair surgery.
BeijingAges 1 day–3 years - NCT06862596RecruitingPhase 2/Phase 3
Mexiletine for spinal and bulbar muscular atrophy
This trial tests whether mexiletine hydrochloride can help men with spinal and bulbar muscular atrophy (SBMA) by improving muscle strength and function. It may be an option if you have mild to moderate symptoms and meet heart and medication safety checks.
Bunkyō CityAges 18–80 - NCT06862895Recruiting
Chest therapy for babies with bronchiolitis
This trial tests whether gentle chest physiotherapy can help babies with bronchiolitis (a lung infection) recover better. It looks at how the therapy affects their breathing and overall health.
Erbil, KurdistanAges 1 month–1 year - NCT06863350Recruiting
Closing a heart hole to treat drug-resistant epilepsy
This trial tests if closing a small hole in the heart (called a PFO) can reduce seizures in people whose epilepsy isn't controlled by medication. It might offer a new treatment option for those who have both drug-resistant epilepsy and this heart condition.
Chengdu, SichuanAges 18–60 - NCT06863701RecruitingPhase 3
Combination therapy for acute gout flare
This trial tests a combination of two medicines, etoricoxib and betamethasone, for quickly treating a painful gout flare. It is for people who have had gout before and whose current attack started within two days.
Mexico CityAges 18 years+ - NCT06864351Recruiting
Study of a new thyroid dosing method for children
This study tests a new way to adjust thyroid medication doses for children with either congenital hypothyroidism or Graves' disease. It aims to help find the right dose more easily and improve treatment outcomes.
ParisAges Up to 18 years - NCT06864975RecruitingPhase 4
Different doses of ADVATE for immune tolerance in boys with hemophilia A and inhibitors
This trial tests how different doses and schedules of the factor VIII medicine ADVATE can train the immune system to accept factor VIII again in boys with hemophilia A who have developed inhibitors. The goal is to find a better way to help their bodies stop blocking the treatment.
Beijing, Beijing MunicipalityAges birth–18 years - NCT06866912Recruiting
Observational study of amyloidosis and TTR gene carriers
This study is observing people with amyloidosis or those who carry a specific gene mutation (transthyretin) to learn more about the condition. It does not test any new treatment, but may help researchers understand how the disease affects people.
BolognaAges 18–99 - NCT06866925Recruiting
Brain stimulation for depression with catatonia in Down syndrome
This study tests whether a gentle brain stimulation treatment called tDCS can help people with Down syndrome who are also experiencing severe depression with symptoms like being very still or not speaking. The goal is to see if this safe, non-invasive treatment can improve mood and movement.
Lyon, Auvergne-Rhône-AlpesAges 18 years+ - NCT06867471Recruiting
Ketone drink study for kidney disease patients
This study tests if a ketone supplement can reduce protein in urine and protect kidney function in people with chronic kidney disease or polycystic kidney disease. You drink a special supplement and researchers measure how it affects your kidneys.
Herning, JutlandAges 18 years+ - NCT06868979Recruiting
Eye imaging for X-linked disorders
This study uses special eye imaging to look at changes in the brain and eyes of people with creatine transporter deficiency (a condition that affects brain energy) or fragile X syndrome. It aims to find a way to see these brain changes without needing a biopsy or spinal tap.
BronAges 5–60 - NCT06869954Recruiting
Bicuspid aortic valve repair: comparing two surgical techniques
This trial tests two different ways to repair a leaky bicuspid aortic valve (a valve with two flaps instead of three). The goal is to see which repair method works better. If you need surgery for a severely leaking valve and your valve is the right shape, you may be able to join.
Augsburg, BavariaAges 18 years+ - NCT06872333RecruitingPhase 2
Stem cell transplant from a matched sibling for blood disorders
This trial tests whether a stem cell transplant from a fully matched sibling donor can help people with serious blood disorders like sickle cell disease or thalassemia. It aims to replace the faulty blood system with a healthy one from the donor.
Minneapolis, MinnesotaAges Up to 55 years - NCT06873841Recruiting
Cognitive therapy with or without biofeedback for tics in teens and young adults
This trial tests a talking therapy that helps manage tics by changing thoughts and feelings. Some people also get biofeedback, which uses sensors to help control body responses. Researchers want to see which approach works better for reducing tics in teens and young adults with Tourette's syndrome or bothersome tics.
Montreal, QuebecAges 14–21 - NCT06874010RecruitingPhase 1/Phase 2
Study of DT-216P2 in adults with Friedreich's ataxia
This trial tests an investigational drug called DT-216P2 in people with Friedreich's ataxia. It aims to find the right dose and see how safe and tolerable it is.
Sydney, New South WalesAges 18–65 - NCT06875245RecruitingPhase 4
Comparing 8-Week vs 12-Week Faricimab for Wet AMD
This trial compares two different schedules (8 weeks vs 12 weeks) for follow-up injections of faricimab in people who are starting treatment for wet AMD. It aims to see if a longer gap between doses works just as well as the shorter interval.
PragueAges Any age
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,858 recruiting medical genetics studies from the U.S. registry right now, out of 5,779 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.