Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,858 recruiting studies in this area right now.
By phase
- Not applicable2,771
- Phase 2283
- Phase 1235
- Phase 3216
- Phase 1/Phase 2204
- Phase 497
- Phase 2/Phase 352
Top conditions
- Sickle Cell Disease140
- Atopic Dermatitis128
- Congenital Heart Disease86
- Cystic Fibrosis78
- Down Syndrome54
- Genetic Disease42
- Duchenne Muscular Dystrophy39
- Fabry Disease38
- Hemophilia A38
- Cystic Fibrosis (CF)37
- Cardiac Amyloidosis35
- Huntington Disease32
- Lynch Syndrome32
- Heart Failure31
- Retinitis Pigmentosa31
- Bronchopulmonary Dysplasia30
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)27
Leading sponsors
- Assistance Publique - Hôpitaux de Paris62
- Boston Children's Hospital42
- National Institute of Allergy and Infectious Diseases (NIAID)38
- Mayo Clinic37
- Children's Hospital Medical Center, Cincinnati33
- Hospices Civils de Lyon32
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Riphah International University26
- Massachusetts General Hospital23
- National Cancer Institute (NCI)23
Where studies are running
- California340
- Maryland161
- Alabama132
- Massachusetts116
- New York84
- Arizona78
- Texas73
- Minnesota67
- Pennsylvania65
- Ohio57
Recruiting studies3,858 total
- NCT06988605Recruiting
Nemolizumab for teens and adults with moderate-to-severe eczema
This study looks at how well nemolizumab works in everyday practice for people with moderate-to-severe atopic dermatitis (eczema). It helps researchers understand the real-world benefits and safety of this treatment.
Birmingham, AlabamaAges 12 years+ - NCT06989216Recruiting
Skin imaging study for adults
This trial uses advanced imaging to take detailed pictures of your skin. It may help doctors better understand and diagnose skin conditions.
StockholmAges 18 years+ - NCT06989593Recruiting
Storytelling study for parents of children with urogenital conditions
This study tests whether guided journaling (writing or dictating stories) can help parents cope and connect. It involves a 5-week journaling activity and one follow-up interview.
Boston, MassachusettsAges 18 years+ - NCT06989814Recruiting
Liquid biopsy test for Lynch syndrome cancer patients
This trial tests a simple blood test to measure tumor DNA in people with Lynch syndrome who have been newly diagnosed with cancer but haven't started treatment yet. It aims to see if this test can help monitor the cancer.
Leiden, South HollandAges 18 years+ - NCT06989918RecruitingPhase 3
Study of MHB018A for active thyroid eye disease
This trial tests a new medicine called MHB018A for people with active, moderate to severe thyroid eye disease. It aims to see if the drug can reduce eye symptoms like bulging and inflammation.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06991400Recruiting
A study of a new surgical approach for TTTS and TAPS
This trial tests a new surgical technique for twin-to-twin transfusion syndrome (TTTS) or twin anemia-polycythemia sequence (TAPS). It places a stitch through the amniotic sac during surgery to see if it helps. The study is for pregnant people between 18 and 23 weeks with healthy cervical length and a safe access point for surgery.
Cincinnati, OhioAges 18 years+ - NCT06992076Recruiting
Hemophilia patients' experience with marstacimab treatment
This registry study follows people with hemophilia A or B who are taking marstacimab as their regular preventive treatment. It aims to understand how the medicine works in real life and how patients feel during treatment.
Xiamen, FujianAges 12 years+ - NCT06993844RecruitingPhase 1/Phase 2
Study of ETX-636 for advanced solid tumors with PIK3CA mutation
This trial tests an experimental drug called ETX-636 in people whose cancer has a specific gene change (PIK3CA mutation) and has not responded to at least one prior treatment. The goal is to see if the drug can shrink tumors or stop them from growing.
Newport Beach, CaliforniaAges 18 years+ - NCT06994754Recruiting
Expanding the upper jaw with clear aligners in cleft lip and palate patients
This trial tests whether clear aligners can safely widen the upper jaw in children with cleft lip and palate who still have some baby teeth. It may be an option for those needing jaw expansion without braces.
Cairo, SelectAges 6–12 - NCT06995339RecruitingPhase 2
Metformin vs. Febuxostat for gout in obesity without diabetes
This study compares two medicines—metformin (usually for diabetes) and febuxostat (for gout)—in people who have both gout and obesity but not diabetes. The goal is to see which works better for controlling gout and related health markers.
Damietta, New DamiettaAges 18–65 - NCT06996756RecruitingPhase 1
Gene therapy for alpha-1 antitrypsin deficiency
This trial tests a gene therapy to fix the genetic cause of alpha-1 antitrypsin deficiency, aiming to stop or slow emphysema. It is for people with the most common harmful gene variants who have mild to moderate lung damage and are otherwise healthy enough to take steroids safely.
New York, New YorkAges 18–70 - NCT06996951RecruitingPhase 3
Sinus treatments in cystic fibrosis with modern modulator therapy
This study looks at how different sinus treatments affect people with cystic fibrosis who are taking modern modulator therapy. It aims to understand which rinses work best for chronic sinus problems.
Indianapolis, IndianaAges 18 years+ - NCT06997042Recruiting
Comparing Two Fistula Creation Techniques for Dialysis
This study compares two surgical techniques for creating an arteriovenous fistula (AV fistula), a special connection between an artery and a vein in the arm that makes dialysis easier. If you need dialysis for advanced kidney disease, this trial aims to see which method works better and lasts longer.
Barcelona, BarcelonaAges 18 years+ - NCT06998043RecruitingPhase 2
Phage therapy for cystic fibrosis with pseudomonas lung infection
This trial tests a new treatment using phages (viruses that kill bacteria) for people with cystic fibrosis who have a chronic pseudomonas lung infection. It aims to see if adding phages to your usual care can help control the infection.
Birmingham, AlabamaAges 18 years+ - NCT06998446Recruiting
Sodium in the skin and eczema study
This study looks at sodium levels in the skin of older adults with eczema. It uses an MRI scan to measure sodium and may help us understand how sodium affects eczema severity.
San Francisco, CaliforniaAges 50 years+ - NCT06999954Recruiting
Global survey for Shwachman-Diamond syndrome and related conditions
This trial is a global survey and registry for people with Shwachman-Diamond Syndrome and related inherited blood disorders. It aims to connect patients, families, and researchers to better understand these conditions and improve care.
Woburn, MassachusettsAges Any age - NCT07000747Recruiting
Dengue and sickle cell disease study
This study looks at how severe dengue fever affects people with sickle cell disease. It aims to understand why some people with sickle cell get very sick from dengue and how their cells react.
Pointe-à-PitreAges 6–25 - NCT07000838Recruiting
Corrective insoles for foot overpronation in healthcare workers
This study tests whether special rubber insoles can help healthcare workers with flat feet (overpronation) reduce foot strain while standing and walking for long shifts. If you work in a hospital or clinic and spend most of your shift on your feet, this may help you understand if the insoles improve comfort and foot alignment.
Milan, ItalyAges 18–65 - NCT07001189Recruiting
Numbing for sickle cell pain crisis: a study
This trial tests whether numbing a specific area (regional anesthesia) can reduce inflammation and pain during a sickle cell pain crisis. It may offer a new way to manage severe pain without strong medications.
Pointe-à-PitreAges 18 years+ - NCT07001280Recruiting
Garadacimab for hereditary angioedema (HAE)
This study looks at how well a drug called garadacimab works and how safe it is for people with hereditary angioedema (HAE), a condition that causes sudden swelling. It tests the drug in people who are starting it for the first time as part of their regular care.
Phoenix, ArizonaAges 12 years+ - NCT07001631Recruiting
EMDR for pain relief in children with sickle cell disease
This trial tests if EMDR therapy can help children with sickle cell disease reduce pain interference in daily life. If you or your child has sickle cell disease and experiences significant pain, this study may offer a new way to manage it.
AmsterdamAges 6–18 - NCT07002762Recruiting
Burdock root extract for high uric acid without symptoms
This trial tests whether burdock root extract can lower uric acid levels in people who have high uric acid but no symptoms of gout. It may help prevent future health problems related to high uric acid.
KyivAges 35–65 - NCT07006649Recruiting
Study of blood flow in the eye for pseudoxanthoma elasticum
This study looks at blood flow in a layer of the eye called the choriocapillaris in people with pseudoxanthoma elasticum (PXE). It compares these findings with healthy volunteers to understand eye changes before they become severe.
AngersAges 18 years+ - NCT07013292Recruiting
Omaveloxolone for swallowing issues in Friedreich's ataxia
This study looks at whether omaveloxolone (a medication) can help improve swallowing problems in people with Friedreich's ataxia. If you have been taking omaveloxolone for at least 6 months, your data may help researchers understand if it helps with swallowing.
Nice, Alpes MaritimesAges 16 years+
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,858 recruiting medical genetics studies from the U.S. registry right now, out of 5,779 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.