Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,858 recruiting studies in this area right now.
By phase
- Not applicable2,771
- Phase 2283
- Phase 1235
- Phase 3216
- Phase 1/Phase 2204
- Phase 497
- Phase 2/Phase 352
Top conditions
- Sickle Cell Disease140
- Atopic Dermatitis128
- Congenital Heart Disease86
- Cystic Fibrosis78
- Down Syndrome54
- Genetic Disease42
- Duchenne Muscular Dystrophy39
- Fabry Disease38
- Hemophilia A38
- Cystic Fibrosis (CF)37
- Cardiac Amyloidosis35
- Huntington Disease32
- Lynch Syndrome32
- Heart Failure31
- Retinitis Pigmentosa31
- Bronchopulmonary Dysplasia30
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)27
Leading sponsors
- Assistance Publique - Hôpitaux de Paris62
- Boston Children's Hospital42
- National Institute of Allergy and Infectious Diseases (NIAID)38
- Mayo Clinic37
- Children's Hospital Medical Center, Cincinnati33
- Hospices Civils de Lyon32
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Riphah International University26
- Massachusetts General Hospital23
- National Cancer Institute (NCI)23
Where studies are running
- California340
- Maryland161
- Alabama132
- Massachusetts116
- New York84
- Arizona78
- Texas73
- Minnesota67
- Pennsylvania65
- Ohio57
Recruiting studies3,858 total
- NCT07014007Recruiting
Testing a new moisturizer for eczema in different age groups
This study tests a new moisturizing product (RV4421B) for people with mild to moderate atopic dermatitis (eczema). Participants will use the product along with their usual steroid cream for 12 weeks to see how well it works and if it’s safe for different ages, from babies to adults.
Quatre Bornes, MauritiusAges 3 months+ - NCT07015073Recruiting
Comparing laser combinations for port-wine stains
This trial tests whether using two different lasers one after the other works better than a single laser for treating port-wine stains (a type of birthmark). The goal is to see if the combination treatment can improve appearance with fewer sessions.
Madrid, SpainAges 18 years+ - NCT07015203Recruiting
First trimester combined screening study
This study offers a combined screening test for pregnant women in their first trimester. It helps check for potential health issues early in pregnancy.
Most, CzechiaAges 18 years+ - NCT07015684RecruitingPhase 1
Radioactive antibody and transplant for advanced sickle cell disease
This trial tests a radioactive antibody (131I-apamistamab) as part of conditioning before a stem cell transplant from a matched sibling donor. It aims to make the transplant safer and more effective for people with severe sickle cell disease.
New York, New YorkAges 12–50 - NCT07015762RecruitingPhase 1
Testing IBI3002 for moderate-to-severe eczema
This trial tests a new drug called IBI3002 in people with moderate-to-severe atopic dermatitis (eczema) to see if it is safe and tolerable. It may help reduce skin inflammation and itching.
Suzhou, JiangsuAges 18–65 - NCT07016009Recruiting
Thrive program for young adults with fetal alcohol spectrum disorders
This trial tests a person-centered planning program called Thrive for young adults aged 18–25 with fetal alcohol spectrum disorders (FASD). The program aims to help them set goals and build skills using video calls.
Rochester, New YorkAges 18–25 - NCT07016750RecruitingPhase 3
Study of KB803 eye drops for eye scrapes in DEB
This study tests an experimental eye drop (KB803) to see if it can reduce painful scrapes on the surface of the eye in people with dystrophic epidermolysis bullosa. You would be randomly assigned to receive either the study drops or a placebo (an inactive drop) for several months.
Rancho Santa Margarita, CaliforniaAges 6 months+ - NCT07017842Recruiting
Predicting outcomes for hypospadias surgery
This study follows boys having their first surgery for hypospadias (where the pee hole is not at the tip of the penis) to find out what factors lead to the best results. The goal is to help doctors better predict who will have a smooth recovery.
Doha, Baladiyat ad DawhahAges 1–12 - NCT07018765Recruiting
Mindfulness program for birth memory and trauma
This study tests if an 8-week online mindfulness program (MBSR) can help women who had a vaginal birth feel better about their birth memory and reduce feelings of trauma. You would join online group sessions from home.
Malatya, Leave BlankAges 18–45 - NCT07019558Recruiting
Eye disorders in dominant spinal-cerebellar ataxias
This trial looks for eye problems in people with certain genetic forms of spinocerebellar ataxia (SCA1, SCA2, SCA3, or SCA27B). You have to be between 18 and 80 years old and have a specific genetic mutation. You can join if you already have symptoms or if you are at risk but do not have symptoms yet.
Montpellier, HéraultAges 18–80 - NCT07019857Recruiting
Thymus removal and immunity in infant heart surgery
This study looks at how removing the thymus gland during infant heart surgery affects the immune system. It compares babies who have their thymus removed with those who have heart surgery without removing it, and with babies having other types of surgery.
NantesAges Up to 6 months - NCT07021495Recruiting
Skin disease study to improve treatment choices
This study looks at different skin diseases to find markers that can help guide treatment. It tests new treatments for several conditions like eczema, psoriasis, and lupus, with the goal of personalizing care.
Nijmegen, GelderlandAges 18 years+ - NCT07023367Recruiting
Parent navigator program for Latino families of babies with heart disease
This study offers a parent navigator program to help Latino families whose baby had early heart surgery. The program aims to support both the child's recovery and the parents' well-being.
Los Angeles, CaliforniaAges birth+ - NCT07023666RecruitingPhase 2
Early heart screening and treatment for sickle cell disease
This trial tests early screening and treatment to prevent heart problems in people with sickle cell disease. It focuses on those with high iron levels or heart symptoms, using regular heart imaging to monitor and treat complications early.
Fairfax, VirginiaAges 18 years+ - NCT07024316RecruitingPhase 1/Phase 2
Oral ciclopirox for skin sensitivity in CEP
This trial tests an oral medication called ciclopirox (ATL-001) to see if it can reduce skin sensitivity to sunlight in adults with CEP. It aims to improve the skin lesions caused by this rare disease.
Cleveland, OhioAges 18 years+ - NCT07024693RecruitingPhase 2
Study of DT-168 for corneal transplant patients with Fuchs dystrophy
This trial tests an investigational eye drop (DT-168) in people with Fuchs endothelial corneal dystrophy who are already scheduled for a corneal transplant. The goal is to see if DT-168 can improve outcomes or delay the need for surgery.
Indianapolis, IndianaAges 30 years+ - NCT07027020RecruitingPhase 3
Bladder oxybutynin for children with spina bifida
This trial tests a liquid form of the medication oxybutynin placed directly into the bladder (via catheter) for children with spina bifida who have bladder overactivity. It may be an option if oral medications haven't worked well or caused side effects.
BesançonAges 6–17 - NCT07029594Recruiting
Thermal spa for Primary Ciliary Dyskinesia (PCD)
This trial tests whether a stay at a thermal spa can improve symptoms of Primary Ciliary Dyskinesia (PCD), a genetic lung condition. It's for adults with stable PCD who haven't had a recent infection or spa treatment.
NiceAges 18 years+ - NCT07029984Recruiting
Testing a bowel control scale for anorectal malformation
This study tests if a scale called the Baylor Continence Scale works well for children who had surgery for anorectal malformation. It helps measure bowel control, which can guide better care.
IzmirAges 6–18 - NCT07031323Recruiting
OnTrackCF: Using a smartphone app to help manage CF treatment
This study tests a smartphone app designed to help people with cystic fibrosis stay on track with their twice-daily CFTR modulator medication. Researchers want to see if the app is easy to use and helpful.
Birmingham, AlabamaAges 18 years+ - NCT07035028Recruiting
Scalp stimulation test for baby's oxygen levels during labor
This trial tests a simple, non-invasive scalp stimulation on your baby's head during labor to see if it can predict whether your baby is getting enough oxygen, potentially avoiding the need for a more invasive blood test.
MadridAges 18–50 - NCT07035990RecruitingPhase 1
Testing combinations of three study drugs in healthy volunteers
This trial tests how safe and tolerable three different study drugs (SION-451, SION-2222, and SION-109) are when taken together in healthy adults. The goal is to find a good dose combination for future studies in people with cystic fibrosis.
Brisbane, QueenslandAges 18–55 - NCT07036731Recruiting
Urine test study for second bladder surgery
This trial compares the need for a second surgery for people with early-stage bladder cancer. It uses a simple urine test to see if the test can help decide whether a second operation is necessary, which could save some patients from an extra procedure.
Nanjing, JiangsuAges 18–80 - NCT07036848Recruiting
Surgery for type IVa bile duct cyst
This study tests how well and safely a surgery works for treating a certain type of bile duct cyst (Todani type IVa). It aims to improve outcomes for people who need this operation for the first time.
Beijing, Beijing MunicipalityAges Up to 80 years
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,858 recruiting medical genetics studies from the U.S. registry right now, out of 5,779 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.