Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,856 recruiting studies in this area right now.
By phase
- Not applicable2,770
- Phase 2282
- Phase 1235
- Phase 3215
- Phase 1/Phase 2204
- Phase 497
- Phase 2/Phase 353
Top conditions
- Sickle Cell Disease140
- Atopic Dermatitis129
- Congenital Heart Disease86
- Cystic Fibrosis78
- Down Syndrome54
- Genetic Disease42
- Duchenne Muscular Dystrophy39
- Fabry Disease38
- Hemophilia A38
- Cystic Fibrosis (CF)37
- Cardiac Amyloidosis35
- Huntington Disease32
- Lynch Syndrome32
- Heart Failure31
- Retinitis Pigmentosa31
- Bronchopulmonary Dysplasia30
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)27
Leading sponsors
- Assistance Publique - Hôpitaux de Paris62
- Boston Children's Hospital42
- National Institute of Allergy and Infectious Diseases (NIAID)38
- Mayo Clinic37
- Children's Hospital Medical Center, Cincinnati33
- Hospices Civils de Lyon32
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Riphah International University26
- Massachusetts General Hospital23
- National Cancer Institute (NCI)23
Where studies are running
- California340
- Maryland161
- Alabama132
- Massachusetts116
- New York84
- Arizona79
- Texas73
- Minnesota67
- Pennsylvania65
- Ohio57
Recruiting studies3,856 total
- NCT07182474Recruiting
Turkish version of a baby neurological exam
This study is testing a Turkish version of a brief exam for babies with a high risk of cerebral palsy (CP). The goal is to see if the exam can help doctors spot brain development problems early, so your baby can get the right support sooner.
Kahramanmaraş, OnikişubatAges 3 months–1 year - NCT07183423Recruiting
New skin barrier product vs. Vaseline for dry, irritated skin
This study tests a new skin barrier product against a standard moisturizer (petrolatum) to see which works better for mild to moderate skin problems like eczema, psoriasis, or dry skin. It may help improve your skin's barrier and reduce symptoms.
Makati City, National Capital RegionAges 18 years+ - NCT07183462RecruitingPhase 4
Antibiotic treatment for late preterm water breaking
This trial tests whether a combination of two antibiotics (azithromycin and ampicillin) can help pregnant people whose water has broken between 34 and 36 weeks of pregnancy. The goal is to see if this treatment improves outcomes for both the parent and baby without causing early labor or infection.
Ramat Gan, IsraelAges 18–50 - NCT07183579Recruiting
Finding the right dose of burosumab for XLH
This study looks at how young people with X-linked hypophosphataemia (XLH) respond to different doses of burosumab. The goal is to find the best dose to manage the condition.
NottinghamAges 2–18 - NCT07183644Recruiting
Laser treatment for port-wine birthmarks in children
This study tests how well laser therapy works for children with port-wine stains (red or purple birthmarks). It aims to find the best way to use lasers to lighten or remove these marks safely.
Dallas, TexasAges 2 months–18 years - NCT07184476Recruiting
Measuring small blood vessels in kids having heart surgery
This study looks at tiny blood vessels in children with specific heart defects during surgery. It may help doctors better understand circulation and improve care.
Boston, MassachusettsAges 1 day–17 years - NCT07185256RecruitingPhase 1/Phase 2
Gene therapy for Best disease retinal trial
This trial tests a gene therapy called OPGx-BEST1 injected under the retina to treat vision loss from Best vitelliform macular dystrophy or a related condition. It may help people with advanced disease who have a specific genetic change in the BEST1 gene.
Los Angeles, CaliforniaAges 18 years+ - NCT07186179Recruiting
Stem cell mobilization for diamond blackfan anemia
This trial tests whether a medication can help move your own blood stem cells from your bone marrow into your bloodstream, so they can be collected. This is a first step toward possibly using those cells in a future treatment for diamond blackfan anemia.
New Hyde Park, New YorkAges 3–30 - NCT07187206RecruitingPhase 3
Fetoscopic surgery for severe diaphragmatic hernia
This trial tests if a special surgery (FETO) done while the baby is still in the womb can improve survival for babies with a severe form of congenital diaphragmatic hernia (CDH). The surgery places a small balloon in the baby's windpipe to help the lungs grow. We are looking for pregnant women whose baby has a left-sided CDH with a lung-to-head ratio (LHR) less than 30%, or a right-sided CDH with LHR less than 45%, and whose liver is herniated into the chest.
Cincinnati, OhioAges 18–50 - NCT07187440Recruiting
Study of Fabry disease treatment in Chinese children and adults
This study tests an enzyme replacement therapy (agalsidase alfa) for Fabry disease in Chinese children and adults. It's an observational study that follows patients who receive the treatment as part of their regular care.
Hefei, AnhuiAges 7 years+ - NCT07188012RecruitingEarly Phase 1
Gene therapy trial for Duchenne muscular dystrophy in young boys
This trial tests a new gene therapy called SPOT-03 to see if it can help the body make dystrophin, a protein that is missing in Duchenne muscular dystrophy (DMD). It is for boys ages 2 to under 8 who can still walk at least 10 meters.
Shanghai, Shanghai MunicipalityAges 2–7 - NCT07188415Recruiting
CMT Gait, Mobility, and Balance Study
This study looks at how CMT affects walking, balance, and movement. It compares two groups of people with CMT: those who use an ankle-foot orthosis (AFO) and those who have had surgery to correct a foot deformity. The goal is to understand which approach works better for improving mobility.
North Liberty, IowaAges 25–55 - NCT07188766Recruiting
Different IV fluid amounts for sickle cell pain crisis
This study compares two ways of giving IV fluids (lighter vs. more fluids) to adults with sickle cell disease who are in the hospital for a painful crisis. The goal is to see which approach helps you feel better sooner.
Dammam, Eastern ProvinceAges 18–60 - NCT07189208RecruitingPhase 2
Preventing syphilis during pregnancy
This study tests whether taking an antibiotic (penicillin) during pregnancy can prevent syphilis infection in women who are at higher risk. If you are pregnant and have certain risk factors, this trial may help keep you and your baby safe from syphilis.
Duque de Caxias, Rio de JaneiroAges 18–45 - NCT07190300RecruitingPhase 1/Phase 2
Testing tulmimetostat with hormone therapy for metastatic prostate cancer
This trial tests a new drug, tulmimetostat, combined with standard hormone therapies like darolutamide or abiraterone for men with metastatic prostate cancer that still responds to hormone treatment. The goal is to see if the combination works better than standard therapy alone.
Birmingham, AlabamaAges 18 years+ - NCT07190859Recruiting
Probiotic for crying and fussing in babies with colic
This trial tests if a probiotic (Limosilactobacillus reuteri) can help reduce crying and fussing in breastfed babies with colic. If your baby is 3-12 weeks old, has colic (cries or fusses 3+ hours a day), and is mostly breastfed, this study may be an option.
BurgasAges 3 weeks–3 months - NCT07192679Recruiting
MAGNIFY Study: New MRI for cystic fibrosis lung health
This study tests a new type of MRI scan that uses either special gas (xenon) or regular MRI to take detailed pictures of the lungs in people with cystic fibrosis. The goal is to see how well these scans can track lung health over time, without using X-ray radiation.
SheffieldAges 1 year+ - NCT07193134RecruitingPhase 1/Phase 2
Gene-modified skin graft for RDEB
This trial tests a new skin graft made with your own cells that have been genetically modified to produce a missing protein (collagen 7). It's for people with RDEB, a severe blistering condition, and aims to see if the graft can heal wounds safely.
Toronto, OntarioAges 7 years+ - NCT07193589RecruitingPhase 2
Testing ZL-82 tablets for moderate to severe eczema
This study tests if an oral tablet called ZL-82 can help people with moderate to severe atopic dermatitis (eczema) that hasn't responded well to other treatments. It aims to find a new option for controlling this chronic skin condition.
Chengdu, SichuanAges 18–75 - NCT07193719RecruitingPhase 1/Phase 2
Personalized breathing support for kids after heart surgery
This study tests a personalized breathing technique to improve lung function and heart performance in children who have had heart surgery or are on ECMO. The goal is to find the best way to open up the lungs safely.
BerlinAges birth–18 years - NCT07194174Recruiting
Exercise training for periodic paralysis patients
This study tests whether a physical training program can help people with hypokalemic or hyperkalemic periodic paralysis improve their muscle strength and daily function.
CopenhagenAges 18 years+ - NCT07195071Recruiting
Combining pregnancy carrier and cancer risk screening
This study combines routine obstetrical carrier screening with hereditary cancer risk screening in one blood draw. It aims to see if offering both tests together is feasible and helpful for patients receiving OB care.
New York, New YorkAges 18–55 - NCT07195253Recruiting
Down syndrome and sleep apnea study in infants
This study looks at mouth and face features and sleep apnea in 6-month-old infants with Down syndrome. It may help doctors understand and treat sleep problems better.
BronAges 5 months–6 months - NCT07196839Recruiting
Study of heart medication and amyloid levels over time
This study looks at how a heart medication (tafamidis) affects amyloid protein levels in the blood over time. It may help doctors understand how well the treatment works for people with a specific type of heart disease caused by amyloid buildup (ATTR-CM).
Dallas, TexasAges 30–80
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,856 recruiting medical genetics studies from the U.S. registry right now, out of 5,791 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.